TDR Targets

Basic information

Technical information

TDR Targets ID: 55132
Name: 7-[amino-(4-chlorophenyl)-(3-methylimidazol-4 -yl)methyl]-5-(3-chlorophenyl)-1-methyl-5H-4, 1-benzothiazepin-2-one
MW: 523.477 | Formula: C27H24Cl2N4OS
H donors: 1 H acceptors: 2 LogP: 4.65 Rotable bonds: 4
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1)C(c1cncn1C)(c1ccc2c(c1)C(SCC(=O)N2C)c1cccc(c1)Cl)N
InChi: 1S/C27H24Cl2N4OS/c1-32-16-31-14-24(32)27(30,18-6-9-20(28)10-7-18)19-8-11-23-22(13-19)26(35-15-25(34)33(23)2)17-4-3-5-21(29)12-17/h3-14,16,26H,15,30H2,1-2H3
InChiKey: WVXGQIOPZMEAOO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-[amino-(4-chlorophenyl)-(3-methyl-4-imidazolyl)methyl]-5-(3-chlorophenyl)-1-methyl-5H-4,1-benzothiazepin-2-one
7-[azanyl-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-5-(3-chlorophenyl)-1-methyl-5H-4,1-benzothiazepin-2-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	farnesyltransferase, CAAX box, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium parvum	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium vivax	prenyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Babesia bovis	protein prenyltransferase alpha subunit repeat domain containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Giardia lamblia	Rab geranylgeranyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium berghei	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium falciparum	protein farnesyltransferase subunit alpha	Get druggable targets OG5_128459	All targets in OG5_128459
Neospora caninum	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium knowlesi	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus granulosus	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium hominis	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma mansoni	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Theileria parva	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0028	0.0037	0.0491
Echinococcus multilocularis	protein patched	0.0043	0.0174	0.0138
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0263	0.0263
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0368	0.0368
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0242	0.5664
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0028	0.0037	0.0923
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0193	0.1569	0.1538
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0105	0.075	0.075
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0105	0.075	0.0716
Onchocerca volvulus		0.0028	0.0037	0.0491
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0028	0.0037	0.0037
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.0242	0.5664
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Brugia malayi	Trypsin family protein	0.0105	0.075	0.075
Loa Loa (eye worm)	hypothetical protein	0.0105	0.075	0.075
Onchocerca volvulus		0.0028	0.0037	0.0491
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Echinococcus multilocularis	geminin	0.017	0.1357	0.1325
Brugia malayi	hypothetical protein	0.0028	0.0037	0.0037
Onchocerca volvulus		0.0028	0.0037	0.0491
Brugia malayi	PAN domain containing protein	0.0032	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0077	0.0077
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0174	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Onchocerca volvulus		0.0028	0.0037	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0174	0.0174
Onchocerca volvulus		0.0028	0.0037	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0193	0.1569	0.1569
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0368	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.005	0.0242	0.0242
Brugia malayi	TAR-binding protein	0.0064	0.0368	0.0368
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0028	0.0037	0.0037
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0115	0.0078
Brugia malayi	Protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Brugia malayi	PAN domain containing protein	0.0032	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Entamoeba histolytica	hypothetical protein	0.0036	0.0115	0.0733
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Entamoeba histolytica	hypothetical protein	0.0036	0.0115	0.0733
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0242	0.0242
Brugia malayi	CHE-14 protein	0.0043	0.0174	0.0174
Onchocerca volvulus		0.0032	0.0077	0.1027
Echinococcus granulosus	Niemann Pick C1 protein	0.0142	0.1097	0.1064
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.005	0.0242	0.1543
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0399	0.0399
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0242	1
Onchocerca volvulus		0.0028	0.0037	0.0491
Echinococcus multilocularis	expressed conserved protein	0.0093	0.0645	0.061
Schistosoma mansoni	hypothetical protein	0.017	0.1357	0.1325
Onchocerca volvulus		0.0028	0.0037	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Brugia malayi	Protein kinase domain containing protein	0.0067	0.0399	0.0399
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Entamoeba histolytica	hypothetical protein	0.0036	0.0115	0.0733
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Leishmania major	hypothetical protein, conserved	0.0067	0.0399	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0077	0.0077
Echinococcus granulosus	geminin	0.017	0.1357	0.1325
Onchocerca volvulus		0.0032	0.0077	0.1027
Brugia malayi	hypothetical protein	0.0028	0.0037	0.0037
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0818	0.7381	0.7371
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0242	0.5664
Brugia malayi	PAN domain containing protein	0.0032	0.0077	0.0077
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0077	0.0077
Echinococcus granulosus	expressed conserved protein	0.0093	0.0645	0.061
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0368	0.0332
Onchocerca volvulus		0.0028	0.0037	0.0491
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0242	1
Onchocerca volvulus		0.0032	0.0077	0.1027
Onchocerca volvulus		0.0028	0.0037	0.0491
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0368	0.0332
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0	0.5
Onchocerca volvulus		0.0105	0.075	1
Onchocerca volvulus		0.0028	0.0037	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Onchocerca volvulus		0.0032	0.0077	0.1027
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0	0.5
Echinococcus multilocularis	tumor protein p63	0.0341	0.2946	0.292
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0095	0.0095
Echinococcus multilocularis	tissue type plasminogen activator	0.0067	0.0399	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.11	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.11	1	1
Onchocerca volvulus		0.0028	0.0037	0.0491
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0028	0.0037	0.0037
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0115	0.0078
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0095	0.0095
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0077	0.0077
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0193	0.1569	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Schistosoma mansoni	hypothetical protein	0.0067	0.0399	0.0364
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0101	0.0715	0.0681
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0368	0.0332
Schistosoma mansoni	hypothetical protein	0.017	0.1357	0.1325
Brugia malayi	PAN domain containing protein	0.0032	0.0077	0.0077
Mycobacterium ulcerans	hypothetical protein	0.0024	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0067	0.0399	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0115	0.0078
Brugia malayi	Kringle domain containing protein	0.0067	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Giardia lamblia	Rab geranylgeranyltransferase	0.005	0.0242	0.134
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0193	0.1569	1
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.005	0.0242	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Onchocerca volvulus		0.0032	0.0077	0.1027
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Schistosoma mansoni	hypothetical protein	0.0041	0.016	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Onchocerca volvulus		0.0028	0.0037	0.0491
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0	0.5
Onchocerca volvulus		0.0028	0.0037	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0193	0.1569	0.1538
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Toxoplasma gondii	PAN domain-containing protein	0.03	0.2564	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0193	0.1569	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Entamoeba histolytica	hypothetical protein	0.0036	0.0115	0.0733
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0115	0.0078
Brugia malayi	PAN domain containing protein	0.0032	0.0077	0.0077
Onchocerca volvulus		0.0028	0.0037	0.0491
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0143	0.1105	0.6969
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.005	0.0242	0.0206
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0028	0.0037	0.0037
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.1569	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Onchocerca volvulus		0.0028	0.0037	0.0491
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0105	0.075	0.0716
Plasmodium falciparum	cysteine repeat modular protein 1	0.0067	0.0399	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0077	0.0077
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0193	0.1569	0.1538
Brugia malayi	hypothetical protein	0.0028	0.0037	0.0037
Onchocerca volvulus		0.0032	0.0077	0.1027
Echinococcus granulosus	tissue type plasminogen activator	0.0067	0.0399	0.0364
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.005	0.0242	0.0206
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0241	0.0205
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.005	0.0242	0.0242
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Giardia lamblia	Rab geranylgeranyltransferase	0.0193	0.1569	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0028	0.0037	0.0235
Onchocerca volvulus		0.0032	0.0077	0.1027
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0368	0.0368
Brugia malayi	hypothetical protein	0.0028	0.0037	0.0037
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	TK/ROR protein kinase	0.0067	0.0399	0.0399
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.11	1	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0	0.5
Brugia malayi	PAN domain containing protein	0.0032	0.0077	0.0077
Onchocerca volvulus		0.0032	0.0077	0.1027
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0193	0.1569	1
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0368	0.0332
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0028	0.0037	0.0037
Onchocerca volvulus		0.0032	0.0077	0.1027
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Brugia malayi	Protein-tyrosine phosphatase 1	0.0028	0.0037	0.0037
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0028	0.0037	0.0235
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0174	0.0174
Onchocerca volvulus		0.0028	0.0037	0.0491
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0028	0.0037	0.0235
Brugia malayi	PAN domain containing protein	0.0032	0.0077	0.0077
Onchocerca volvulus		0.0028	0.0037	0.0491
Onchocerca volvulus		0.0028	0.0037	0.0491
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.005	0.0242	0.0242
Brugia malayi	RNA binding protein	0.0064	0.0368	0.0368
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.005	0.0242	0.0206
Toxoplasma gondii	PAN domain-containing protein	0.03	0.2564	1
Onchocerca volvulus		0.0028	0.0037	0.0491
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0193	0.1569	1
Onchocerca volvulus		0.0032	0.0077	0.1027
Brugia malayi	PAN domain containing protein	0.0032	0.0077	0.0077
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Onchocerca volvulus		0.0028	0.0037	0.0491
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0077	0.0077
Echinococcus granulosus	tumor protein p63	0.0341	0.2946	0.292
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0077	0.0077
Toxoplasma gondii	kringle domain-containing protein	0.0067	0.0399	0.1296
Schistosoma mansoni	hypothetical protein	0.0041	0.016	0.0123
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Brugia malayi	PAN domain containing protein	0.0032	0.0077	0.0077
Toxoplasma gondii	hypothetical protein	0.0143	0.1105	0.4133
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.0701	0.0701
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0242	0.0242
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0242	0.5664
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.005	0.0242	0.6064
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.1569	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0077	0.0077
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0368	0.0332
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.0701	0.4466
Onchocerca volvulus		0.0028	0.0037	0.0491
Schistosoma mansoni	hypothetical protein	0.0041	0.016	0.0123
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0174	0.0138
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0368	0.0368
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0028	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.005	0.0241	0.0241
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.005	0.0242	0.0206
Onchocerca volvulus		0.0032	0.0077	0.1027
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0368	0.0332
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Brugia malayi	hypothetical protein	0.0036	0.0115	0.0115
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.005	0.0242	0.0206
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0067	0.0399	0.1184
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0368	0.0332
Leishmania major	tyrosine specific protein phosphatase, putative	0.0028	0.0037	0.0923
Onchocerca volvulus		0.0067	0.0399	0.5323
Trypanosoma brucei	hypothetical protein, conserved	0.005	0.0242	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.11	1	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.005	0.0242	0.134
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Toxoplasma gondii	hypothetical protein	0.005	0.0242	0.0664
Brugia malayi	hypothetical protein	0.0028	0.0037	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0174	0.0894
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Schistosoma mansoni	hypothetical protein	0.0034	0.0095	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0037	0.0037
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0193	0.1569	0.1569
Onchocerca volvulus	4.1 G protein, putative homolog	0.0028	0.0037	0.0491
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0028	0.0037	0.0037
Echinococcus multilocularis	Niemann Pick C1 protein	0.0142	0.1097	0.1064
Onchocerca volvulus		0.005	0.0241	0.3218
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.0701	0.0666
Schistosoma mansoni	patched 1	0.0043	0.0174	0.0138
Onchocerca volvulus		0.0028	0.0037	0.0491
Onchocerca volvulus		0.0085	0.0571	0.7615
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Echinococcus multilocularis	protein dispatched 1	0.0049	0.023	0.0194
Schistosoma mansoni	hypothetical protein	0.0041	0.016	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0701	0.0701
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0037	0.0037
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0174	0.0138
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.0242	0.5664
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.0701	0.0666
Brugia malayi	PAN domain containing protein	0.0032	0.0077	0.0077
Onchocerca volvulus		0.005	0.0242	0.3228

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	0 nM	Inhibition of T24F1H-ras-transformation in NIH 3T3 cells (Not tested)	ChEMBL.	12699751
IC50 (binding)	0 nM	Inhibition of Geranylgeranylprotein transferase-I -catalyzed incorporation of [3H]-GGPP into biotin YRASNRSCAIL substrate (Not tested)	ChEMBL.	12699751
IC50 (binding)	= 29 nM	Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase	ChEMBL.	12699751
IC50 (binding)	= 29 nM	Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase	ChEMBL.	12699751

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10279755

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 55132