Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0146 | 0.0146 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.0137 | 0.0137 |
Echinococcus multilocularis | GPCR, family 2 | 0.0063 | 0.0391 | 0.0391 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0203 | 0.0551 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0391 | 0.1175 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0376 | 0.2763 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0391 | 0.2756 |
Leishmania major | hypothetical protein, conserved | 0.0067 | 0.0424 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0063 | 0.0391 | 0.2756 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0281 | 0.0804 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0067 | 0.0424 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0188 | 0.1343 | 0.1343 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0281 | 0.1978 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0188 | 0.1343 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0203 | 0.0203 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0281 | 0.0281 |
Plasmodium falciparum | zinc finger Ran-binding domain-containing protein 2, putative | 0.0067 | 0.0424 | 0.3148 |
Onchocerca volvulus | 0.0067 | 0.0424 | 0.2401 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.0914 | 0.2938 |
Onchocerca volvulus | 0.0067 | 0.0424 | 0.2401 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0395 | 0.119 |
Brugia malayi | RNA binding protein | 0.0063 | 0.0395 | 0.2787 |
Echinococcus granulosus | geminin | 0.0337 | 0.2466 | 0.2466 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0196 | 0.1376 |
Brugia malayi | Bromodomain containing protein | 0.0029 | 0.0137 | 0.0961 |
Plasmodium vivax | hypothetical protein, conserved | 0.0188 | 0.1343 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0067 | 0.0424 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0203 | 0.143 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0067 | 0.0424 | 0.2989 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0188 | 0.1343 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0063 | 0.0391 | 0.0391 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0.0424 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0067 | 0.0424 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0337 | 0.2466 | 0.8169 |
Onchocerca volvulus | 0.0188 | 0.1343 | 1 | |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0067 | 0.0424 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0067 | 0.0424 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0337 | 0.2466 | 0.8169 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0196 | 0.0196 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0067 | 0.0424 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.0137 | 0.0318 |
Brugia malayi | jmjC domain containing protein | 0.0095 | 0.0639 | 0.4503 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0137 | 0.0318 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0067 | 0.0424 | 0.238 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0281 | 0.0281 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0146 | 0.0146 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0067 | 0.0424 | 0.0424 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.084 | 0.084 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0146 | 0.0349 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.0196 | 0.1376 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0281 | 0.0804 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0067 | 0.0424 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0188 | 0.1343 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0203 | 0.143 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0203 | 0.143 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0395 | 0.119 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.0395 | 0.2787 |
Onchocerca volvulus | 0.0067 | 0.0424 | 0.2401 | |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0067 | 0.0424 | 0.1286 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.0372 | 0.2619 |
Schistosoma mansoni | fusion | 0.0067 | 0.0424 | 0.1286 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0134 | 0.0307 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0281 | 0.0281 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.084 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0424 | 0.2989 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0203 | 0.143 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0391 | 0.1175 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0942 | 0.6647 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0063 | 0.0391 | 0.0391 |
Echinococcus multilocularis | geminin | 0.0337 | 0.2466 | 0.2466 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0188 | 0.1343 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0203 | 0.143 |
Onchocerca volvulus | Alhambra homolog | 0.0029 | 0.0137 | 0.0027 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0067 | 0.0424 | 0.0424 |
Brugia malayi | YY1-associated factor 2 | 0.0067 | 0.0424 | 0.2989 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0408 | 0.301 | 0.301 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1417 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0067 | 0.0424 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0134 | 0.0937 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0183 | 0.0183 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.0914 | 0.2938 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.0395 | 0.2787 |
Schistosoma mansoni | RNA binding protein | 0.0067 | 0.0424 | 0.1286 |
Loa Loa (eye worm) | brahma associated protein | 0.0188 | 0.1343 | 0.9482 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0281 | 0.1978 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0.0424 | 1 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0067 | 0.0424 | 0.0424 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.0914 | 0.0914 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0157 | 0.1106 | 0.3585 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.0137 | 0.1007 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0188 | 0.1343 | 0.1343 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0067 | 0.0424 | 0.0424 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0134 | 0.0937 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.0328 | 0.1583 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0067 | 0.0424 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0203 | 0.143 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0281 | 0.0804 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0.0424 | 1 |
Toxoplasma gondii | ran binding protein | 0.0067 | 0.0424 | 0.238 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0424 | 0.2989 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0203 | 0.143 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1106 | 0.7806 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0198 | 0.1417 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0223 | 0.0223 |
Onchocerca volvulus | 0.0157 | 0.1106 | 0.8038 | |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0188 | 0.1343 | 0.1343 |
Schistosoma mansoni | zinc finger protein | 0.0067 | 0.0424 | 0.1286 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0203 | 0.143 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.1331 | 1 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0095 | 0.0639 | 0.0639 |
Brugia malayi | brahma associated protein 60 kDa | 0.0188 | 0.1343 | 0.9482 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0188 | 0.1343 | 0.9482 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0294 | 0.2073 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0188 | 0.1343 | 0.9482 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.1343 | 0.4385 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0424 | 0.1286 |
Echinococcus granulosus | dnaJ subfamily B | 0.0408 | 0.301 | 0.301 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.0395 | 0.2787 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0063 | 0.0391 | 0.0391 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0196 | 0.0516 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.0377 | 0.1128 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0203 | 0.143 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0424 | 0.2989 |
Echinococcus granulosus | GPCR family 2 | 0.0063 | 0.0391 | 0.0391 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.084 | 0.2689 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0424 | 0.2989 |
Schistosoma mansoni | jumonji domain containing protein | 0.0076 | 0.049 | 0.1509 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.0395 | 0.0395 |
Onchocerca volvulus | 0.0038 | 0.0203 | 0.0576 | |
Echinococcus granulosus | ring and YY1 binding protein | 0.0067 | 0.0424 | 0.0424 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0067 | 0.0424 | 0.0424 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0137 | 0.0961 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.0395 | 0.0395 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0063 | 0.0391 | 0.2756 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0067 | 0.0424 | 0.2989 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0188 | 0.1343 | 0.1343 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.0395 | 0.2787 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0067 | 0.0424 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.1343 | 0.4385 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0196 | 0.0516 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0391 | 0.1175 |
Brugia malayi | brahma associated protein 60 kDa | 0.0188 | 0.1343 | 0.9482 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0424 | 0.2989 |
Echinococcus granulosus | peregrin | 0.0029 | 0.0137 | 0.0137 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0.0137 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0067 | 0.0424 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0067 | 0.0424 | 0.2989 |
Echinococcus multilocularis | tumor protein p63 | 0.1073 | 0.8044 | 0.8044 |
Chlamydia trachomatis | SWIB complex protein | 0.0188 | 0.1343 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0188 | 0.1343 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0067 | 0.0424 | 0.2989 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0067 | 0.0424 | 0.0424 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.0137 | 0.0137 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0188 | 0.1343 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0203 | 0.143 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0067 | 0.0424 | 0.2401 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0095 | 0.0639 | 0.0639 |
Onchocerca volvulus | 0.0038 | 0.0203 | 0.0576 | |
Chlamydia trachomatis | DNA topoisomerase I | 0.0188 | 0.1343 | 0.5 |
Echinococcus multilocularis | thymidine phosphorylase | 0.1331 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0188 | 0.1343 | 0.1343 |
Schistosoma mansoni | brg-1 associated factor | 0.0188 | 0.1343 | 0.4385 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0067 | 0.0424 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.1073 | 0.8044 | 0.8044 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0067 | 0.0424 | 0.0424 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0203 | 0.0203 |
Schistosoma mansoni | hypothetical protein | 0.0408 | 0.301 | 1 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.1331 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0395 | 0.119 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0223 | 0.0223 |
Onchocerca volvulus | 0.0067 | 0.0424 | 0.2401 | |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.0376 | 0.2763 | 0.2612 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0395 | 0.119 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.0395 | 0.2787 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0242 | 0.1749 | 0.1578 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0203 | 0.1503 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0137 | 0.0961 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0188 | 0.1343 | 0.1343 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0135 | 0.0942 | 0.6647 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0203 | 0.0542 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0203 | 0.143 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.0137 | 0.0961 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0137 | 0.1007 |
Leishmania major | hypothetical protein, conserved | 0.0067 | 0.0424 | 1 |
Echinococcus multilocularis | peregrin | 0.0029 | 0.0137 | 0.0137 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0146 | 0.0349 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0391 | 0.1175 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0203 | 0.143 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0063 | 0.0391 | 0.0391 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0067 | 0.0424 | 1 |
Onchocerca volvulus | 0.0038 | 0.0203 | 0.0576 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0198 | 0.1417 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0067 | 0.0424 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.0942 | 0.3032 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0063 | 0.0391 | 0.2756 |
Mycobacterium ulcerans | anthranilate phosphoribosyltransferase | 0.0376 | 0.2763 | 0.2612 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.1343 | 0.4385 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0395 | 0.119 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0018 | 0.0055 | 0.0381 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0198 | 0.1417 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0203 | 0.0542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.