Detailed information for compound 555161

Basic information

Technical information
  • TDR Targets ID: 555161
  • Name: 5H-pyrazolo[1,5-a]imidazole
  • MW: 107.113 | Formula: C5H5N3
  • H donors: 1 H acceptors: 1 LogP: 0.7 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1cn2c(n1)cc[nH]2
  • InChi: 1S/C5H5N3/c1-2-7-8-4-3-6-5(1)8/h1-4,7H
  • InChiKey: MFGQIJCMHXZHHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • imidazopyrazole
  • 251-80-9
  • 1H-Imidazo(1,2-b)pyrazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0273 0.0266
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.023 0.424 1
Schistosoma mansoni hypothetical protein 0.0033 0.0173 0.0166
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0105 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0226 0.0533
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0236 0.0229
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0804 0.0707
Mycobacterium ulcerans hypothetical protein 0.0038 0.0273 1
Echinococcus granulosus adam 0.0159 0.2779 0.2709
Schistosoma mansoni hypothetical protein 0.003 0.0105 0.0098
Mycobacterium ulcerans lipase LipD 0.0038 0.0273 1
Giardia lamblia PHD finger protein 15 0.003 0.0105 0.5
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0273 0.0644
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.1481 0.1475
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.012 0.0015
Brugia malayi hypothetical protein 0.0035 0.0215 0.0506
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0236 0.0229
Loa Loa (eye worm) hypothetical protein 0.0038 0.0273 0.0644
Mycobacterium tuberculosis Conserved protein 0.0038 0.0273 0.0603
Loa Loa (eye worm) hypothetical protein 0.0093 0.1413 0.3332
Entamoeba histolytica hypothetical protein 0.0035 0.0215 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.424 0.4236
Echinococcus multilocularis adam 0.0159 0.2779 0.2702
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.424 0.4236
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0273 0.0603
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0273 0.0603
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0215 0.012
Loa Loa (eye worm) hypothetical protein 0.0114 0.1846 0.4354
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0273 0.0603
Echinococcus granulosus adam 17 protease 0.0061 0.0737 0.0647
Loa Loa (eye worm) hypothetical protein 0.0038 0.0273 0.0644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.023 0.424 0.4179
Mycobacterium tuberculosis Conserved protein 0.0038 0.0273 0.0603
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0273 0.5
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.012 0.0113
Brugia malayi beta-lactamase family protein 0.0038 0.0273 0.0644
Plasmodium falciparum phd finger protein, putative 0.003 0.0105 0.5
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0804 0.0707
Onchocerca volvulus 0.0038 0.0273 0.0602
Loa Loa (eye worm) angiogenesis inhibito 0.0025 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0096 0.1481 0.3493
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0273 0.017
Onchocerca volvulus 0.0038 0.0273 0.0602
Loa Loa (eye worm) hypothetical protein 0.0031 0.012 0.0282
Loa Loa (eye worm) hypothetical protein 0.0038 0.0273 0.0644
Leishmania major hypothetical protein, conserved 0.0038 0.0273 1
Entamoeba histolytica hypothetical protein 0.0035 0.0215 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.012 0.0015
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0273 1
Schistosoma mansoni transient receptor potential channel 0.0064 0.0804 0.0798
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.012 0.0884
Onchocerca volvulus 0.0038 0.0273 0.0602
Echinococcus granulosus disintegrin and metalloproteinase 0.0121 0.1987 0.1909
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.023 0.424 0.4179
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.012 0.0024
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0226 0.0131
Brugia malayi ADAM-TS Spacer 1 family protein 0.007 0.0939 0.2215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.012 0.0113
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0804 0.0715
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0273 0.0266
Loa Loa (eye worm) reprolysin 0.0222 0.4073 0.9607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.023 0.424 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0273 0.0603
Brugia malayi ADAMTS-like protease 0.007 0.0939 0.2215
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0273 0.5
Schistosoma mansoni transient receptor potential channel 0.0064 0.0804 0.0798
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0273 0.0644
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.1519 0.1429
Brugia malayi PHD-finger family protein 0.003 0.0105 0.0247
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0273 0.0603
Plasmodium vivax SET domain protein, putative 0.0031 0.012 0.0884
Onchocerca volvulus 0.0031 0.012 0.0264
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0273 0.5
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.1481 0.1398
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0273 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0273 0.0603
Onchocerca volvulus Alhambra homolog 0.003 0.0105 0.0231
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0273 0.0603
Brugia malayi Reprolysin 0.0161 0.282 0.665
Loa Loa (eye worm) hypothetical protein 0.007 0.0939 0.2215
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0348 0.0246
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0222 0.4073 0.4069
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0105 0.0247
Schistosoma mansoni jumonji domain containing protein 0.0078 0.1101 0.1095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0492 0.1161
Loa Loa (eye worm) hypothetical protein 0.0045 0.0416 0.098
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.1481 0.1391
Brugia malayi Pre-SET motif family protein 0.0214 0.3921 0.9247
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.3921 0.9247
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.012 0.0113
Echinococcus multilocularis transient receptor potential ion channel A 0.0093 0.1414 0.1323
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0767 0.1808
Echinococcus multilocularis geminin 0.0508 1 1
Echinococcus granulosus peregrin 0.003 0.0105 0.0009
Brugia malayi Bromodomain containing protein 0.003 0.0105 0.0247
Brugia malayi Pre-SET motif family protein 0.0031 0.012 0.0282
Entamoeba histolytica hypothetical protein 0.0035 0.0215 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0376
Trichomonas vaginalis set domain proteins, putative 0.0244 0.4534 1
Loa Loa (eye worm) disintegrin family protein 0.006 0.0734 0.173
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0492 0.1161
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0804 0.0715
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0215 0.0111
Loa Loa (eye worm) hypothetical protein 0.0049 0.0492 0.1161
Entamoeba histolytica hypothetical protein 0.0035 0.0215 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0273 0.0644
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0348 0.0254
Brugia malayi metalloprotease 0.0025 0.0007 0.0016
Schistosoma mansoni hypothetical protein 0.0035 0.0215 0.0208
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.1519 0.1437
Loa Loa (eye worm) hypothetical protein 0.0038 0.0273 0.0644
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0236 0.0556
Brugia malayi jmjC domain containing protein 0.0036 0.0236 0.0556
Echinococcus multilocularis disintegrin and metalloproteinase 0.0121 0.1987 0.1902
Mycobacterium ulcerans beta-lactamase 0.0038 0.0273 1
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0236 0.0141
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0273 1
Brugia malayi beta-lactamase family protein 0.0038 0.0273 0.0644
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0093 0.1413 0.1329
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0492 0.1161
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0273 1
Schistosoma mansoni transient receptor potential channel 0.0096 0.1481 0.1475
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.4529 1
Echinococcus granulosus transient receptor potential ion channel A 0.0093 0.1414 0.1331
Brugia malayi beta-lactamase 0.0038 0.0273 0.0644
Brugia malayi hypothetical protein 0.0159 0.2779 0.6554
Brugia malayi jmjC domain containing protein 0.0098 0.1519 0.3583
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0273 0.0603
Schistosoma mansoni hypothetical protein 0.0508 1 1
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0093 0.1413 0.1322
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0061 0.0738 0.174
Loa Loa (eye worm) beta-lactamase 0.0038 0.0273 0.0644
Brugia malayi Disintegrin family protein 0.0121 0.1987 0.4687
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0247
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0226 0.0533
Schistosoma mansoni hypothetical protein 0.0508 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.424 0.4236
Loa Loa (eye worm) hypothetical protein 0.0051 0.0549 0.1294
Onchocerca volvulus 0.0244 0.4534 1
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0222 0.4073 0.4016
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0236 0.0132
Loa Loa (eye worm) hypothetical protein 0.0033 0.0173 0.0408
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0273 0.0178
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.023 0.424 0.4184
Toxoplasma gondii ABC1 family protein 0.0038 0.0273 1
Loa Loa (eye worm) metalloprotease 0.0025 0.0007 0.0016
Brugia malayi angiogenesis inhibito 0.007 0.0939 0.2215
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0159 0.2779 0.2774
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0215 0.0208
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0226 0.0123
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0173 0.0408
Loa Loa (eye worm) hypothetical protein 0.007 0.0939 0.2215
Loa Loa (eye worm) hypothetical protein 0.0038 0.0273 0.0644
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0222 0.4073 0.4069
Mycobacterium leprae Probable lipase LipE 0.0038 0.0273 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0105 0.0098
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0222 0.4073 0.401
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.012 0.0113
Schistosoma mansoni dihydroceramide desaturase 0.0121 0.1987 0.1982
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.023 0.424 0.4184

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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