TDR Targets

Basic information

Technical information

TDR Targets ID: 557706
Name: (7Z)-7-[(2-hydroxy-3,5-dinitro-phenyl)hydrazo no]-8-oxo-naphthalene-1,6-disulfonic acid
MW: 514.4 | Formula: C16H10N4O12S2
H donors: 4 H acceptors: 12 LogP: 1.2 Rotable bonds: 6
Rule of 5 violations (Lipinski): 3
SMILES: [O-][N+](=O)c1cc(N/N=C\2/C(=O)c3c(C=C2S(=O)(=O)O)cccc3S(=O)(=O)O)c(c(c1)[N+](=O)[O-])O
InChi: 1S/C16H10N4O12S2/c21-15-9(5-8(19(23)24)6-10(15)20(25)26)17-18-14-12(34(30,31)32)4-7-2-1-3-11(33(27,28)29)13(7)16(14)22/h1-6,17,21H,(H,27,28,29)(H,30,31,32)/b18-14+
InChiKey: XOWWPMPMYLBSSL-NBVRZTHBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(7Z)-7-[(2-hydroxy-3,5-dinitrophenyl)hydrazono]-8-oxonaphthalene-1,6-disulfonic acid
(7Z)-7-[(2-hydroxy-3,5-dinitro-phenyl)hydrazinylidene]-8-oxo-naphthalene-1,6-disulfonic acid
(7Z)-7-[(2-hydroxy-3,5-dinitro-phenyl)hydrazono]-8-keto-naphthalene-1,6-disulfonic acid
(7Z)-7-[(2-hydroxy-3,5-dinitrophenyl)hydrazinylidene]-8-oxonaphthalene-1,6-disulfonic acid
picramine-epsilon
29844-04-0
8-Hydroxy-7-((2-hydroxy-3,5-dinitrophenyl)azo) 1,6-naphthalenedisulfonic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0055	0.0553	0.0518
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0055	0.0553	0.2871
Echinococcus granulosus	bloom syndrome protein	0.0022	0.0145	0.0305
Brugia malayi	follicle stimulating hormone receptor	0.0229	0.2757	0.7691
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0055	0.0553	0.146
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0014	0.0037	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0037	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0294	0.3573	1
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0122	0.1398	0.3911
Giardia lamblia	Hypothetical protein	0.0162	0.1913	0.5159
Loa Loa (eye worm)	transcriptional regulator	0.0055	0.0553	0.1535
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0118	0.1352	0.7066
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0055	0.0553	0.2752
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0294	0.3573	1
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0162	0.1913	0.1883
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0162	0.1913	1
Schistosoma mansoni	chromatin regulatory protein sir2	0.0055	0.0553	0.1548
Loa Loa (eye worm)	hypothetical protein	0.0234	0.2818	0.7882
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0294	0.3573	1
Loa Loa (eye worm)	carbonic anhydrase 3	0.0014	0.0037	0.0088
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0014	0.0037	0.0104
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0145	0.2615
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0022	0.0145	0.2086
Schistosoma mansoni	carbonic anhydrase	0.0014	0.0037	0.0104
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0162	0.1913	0.5159
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0055	0.0553	0.0518
Brugia malayi	Bloom's syndrome protein homolog	0.0022	0.0145	0.0305
Echinococcus multilocularis	bloom syndrome protein	0.0022	0.0145	0.0108
Schistosoma mansoni	carbonic anhydrase-related	0.0014	0.0037	0.0104
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0294	0.3573	1
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0162	0.1913	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0145	0.0305
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0464	0.1207
Mycobacterium ulcerans	Sir2-like regulatory protein	0.0055	0.0553	0.5
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0055	0.0553	0.2752
Schistosoma mansoni	DNA helicase recq1	0.0022	0.0145	0.0405
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0055	0.0553	0.5
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0055	0.0553	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0162	0.1913	1
Treponema pallidum	ATP-dependent DNA helicase	0.0011	0.0006	0.5
Loa Loa (eye worm)	RecQ helicase	0.0022	0.0145	0.039
Toxoplasma gondii	hypothetical protein	0.0014	0.0037	0.0668
Giardia lamblia	Transcriptional regulator, Sir2 family	0.0055	0.0553	0.1192
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0162	0.1913	0.5306
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0014	0.0037	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0145	0.039
Entamoeba histolytica	recQ family DNA helicase	0.0011	0.0006	0.0029
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0294	0.3573	1
Onchocerca volvulus		0.0048	0.0464	0.5
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0162	0.1913	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0037	0.0088
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0162	0.1913	0.5306
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0055	0.0553	0.146
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0014	0.0037	0.0165
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0162	0.1913	1
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0022	0.0145	0.0108
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0014	0.0037	0.0165
Giardia lamblia	Sirtuin type 2	0.0055	0.0553	0.1192
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0022	0.0145	0.0574
Schistosoma mansoni	chromatin regulatory protein sir2	0.0162	0.1913	0.5355
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0022	0.0145	0.039
Echinococcus granulosus	chromatin regulatory protein sir2	0.0162	0.1913	0.5306
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0022	0.0145	0.0574
Brugia malayi	hypothetical protein	0.0234	0.2818	0.7863
Trypanosoma brucei	SIR2-like protein 4, putative	0.0055	0.0553	0.2752
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0011	0.0006	0.01
Loa Loa (eye worm)	sirtuin 4	0.0055	0.0553	0.1535
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0055	0.0553	0.1192
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0294	0.3573	1
Toxoplasma gondii	histone deacetylase SIR2-like	0.0055	0.0553	1
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0022	0.0145	0.073
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0055	0.0553	0.146
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0055	0.0553	0.1192
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0162	0.1913	0.5159
Schistosoma mansoni	chromatin regulatory protein sir2	0.0162	0.1913	0.5355
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0294	0.3573	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0006	0.01
Loa Loa (eye worm)	hypothetical protein	0.0239	0.2881	0.8059
Schistosoma mansoni	chromatin regulatory protein sir2	0.0162	0.1913	0.5355
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0055	0.0553	0.1192
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0022	0.0145	0.0305
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0055	0.0553	0.146
Schistosoma mansoni	hypothetical protein	0.0014	0.0037	0.0104
Schistosoma mansoni	carbonic anhydrase-related	0.0014	0.0037	0.0104
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0229	0.2757	0.7711
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0055	0.0553	0.2871
Entamoeba histolytica	hypothetical protein, conserved	0.0055	0.0553	0.2892
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0145	0.0305
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0294	0.3573	1
Leishmania major	sir2-family protein-like protein	0.0055	0.0553	0.2752
Schistosoma mansoni	chromatin regulatory protein sir2	0.0055	0.0553	0.1548
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0055	0.0553	0.1192
Echinococcus granulosus	survival motor neuron protein 1	0.0234	0.2818	0.7863
Leishmania major	silent information regulator 2, putative	0.0162	0.1913	1
Schistosoma mansoni	carbonic anhydrase-related	0.0014	0.0037	0.0104
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0162	0.1913	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0122	0.1398	0.1366
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0037	0.0088
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0145	0.2086
Plasmodium vivax	hypothetical protein, conserved	0.0055	0.0553	1
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0055	0.0553	0.2892
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0122	0.1398	0.3847
Entamoeba histolytica	recQ family helicase, putative	0.0022	0.0145	0.0756
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0145	0.2615
Loa Loa (eye worm)	transcriptional regulator	0.0055	0.0553	0.1535
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0055	0.0553	1
Loa Loa (eye worm)	transcriptional regulator	0.0162	0.1913	0.5347
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0294	0.3573	0.3549
Schistosoma mansoni	blooms syndrome DNA helicase	0.0011	0.0006	0.0015
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0055	0.0553	0.1192
Schistosoma mansoni	chromatin regulatory protein sir2	0.0294	0.3573	1
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0022	0.0145	0.0305
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0055	0.0553	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.00000000032809
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0022	0.0145	0.0108
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0464	0.1298
Toxoplasma gondii	histone deacetylase SIR2	0.0055	0.0553	1
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0014	0.0037	0.0088
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.0055	0.0553	0.5
Schistosoma mansoni	DNA helicase recq5	0.0022	0.0145	0.0405
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0055	0.0553	0.2892
Schistosoma mansoni	hypothetical protein	0.0048	0.0464	0.1298
Echinococcus multilocularis	survival motor neuron protein 1	0.0234	0.2818	0.2791
Schistosoma mansoni	chromatin regulatory protein sir2	0.0055	0.0553	0.1548

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 9578260

Bibliographic References

No literature references available for this target.

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Detailed information for compound 557706