Detailed information for compound 562635

Basic information

Technical information
  • TDR Targets ID: 562635
  • Name: 3-hydroperoxy-3-methyl-2-phenyl-indole
  • MW: 239.269 | Formula: C15H13NO2
  • H donors: 1 H acceptors: 1 LogP: 2.69 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OOC1(C)C(=Nc2c1cccc2)c1ccccc1
  • InChi: 1S/C15H13NO2/c1-15(18-17)12-9-5-6-10-13(12)16-14(15)11-7-3-2-4-8-11/h2-10,17H,1H3
  • InChiKey: JIDQYPYCJTXPKO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-hydroperoxy-3-methyl-2-phenylindole
  • 3-hydroperoxy-3-methyl-2-phenyl-3H-indole
  • 39608-24-7
  • 3-Hydroperoxy-3-methyl-2-phenylindolenine
  • 3-Methyl-2-phenyl-3H-indol-3-yl hydroperoxide
  • Hydroperoxide, 3-methyl-2-phenyl-3H-indol-3-yl
  • 2-Phenyl-3-methylindolenyl 3-hydroperoxide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0095 0.3348 0.4872
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0012 0.0141 0.0516
Echinococcus multilocularis beta adrenergic receptor kinase 0.0014 0.0218 0.0125
Echinococcus granulosus regulator of G protein signaling 3 0.0014 0.0218 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0141 0.0516
Leishmania major hypothetical protein, conserved 0.0022 0.0535 0.4894
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0012 0.0141 0.0516
Loa Loa (eye worm) hypothetical protein 0.0184 0.6773 0.8013
Loa Loa (eye worm) hypothetical protein 0.0228 0.8452 1
Giardia lamblia GTOR 0.0032 0.0929 0.1176
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0012 0.0141 0.0516
Echinococcus granulosus axis inhibition protein axin 0.0014 0.0218 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0611 0.6498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0675 0.7204
Trichomonas vaginalis ap endonuclease, putative 0.0011 0.0094 0.0805
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0032 0.0929 0.928
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0218 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.043 0.4499
Onchocerca volvulus 0.0015 0.027 0.5
Echinococcus granulosus regulator of G protein signaling 7 0.0014 0.0218 0.0125
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0411 0.0486
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0126 0.0149
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0032 0.0929 0.1176
Loa Loa (eye worm) PXA domain-containing protein 0.0014 0.0218 0.0257
Brugia malayi hypothetical protein 0.0087 0.3051 1
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0218 0.0185
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0032 0.0929 0.928
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0032 0.0929 0.928
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0126 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0358 0.3713
Mycobacterium tuberculosis Probable oxidoreductase 0.0086 0.3 1
Brugia malayi Intermediate filament tail domain containing protein 0.0015 0.027 0.0887
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0032 0.0929 0.0843
Echinococcus granulosus thioredoxin glutathione reductase 0.0034 0.0994 0.0909
Giardia lamblia DNA repair protein RAD52 0.0195 0.7197 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0012 0.0141 0.0516
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0012 0.0141 0.0516
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0929 0.3047
Plasmodium falciparum glutathione reductase 0.0034 0.0994 1
Leishmania major hypothetical protein, conserved 0.0022 0.0535 0.4894
Giardia lamblia NADH oxidase lateral transfer candidate 0.0012 0.0141 0.0065
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0012 0.0141 0.0516
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0141 0.0516
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0535 0.4894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0748 0.8002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0141 0.0516
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0022 0.0535 0.0445
Leishmania major trypanothione reductase 0.0034 0.0994 1
Plasmodium vivax glutathione reductase, putative 0.0034 0.0994 1
Echinococcus granulosus geminin 0.0095 0.3348 0.3285
Plasmodium falciparum thioredoxin reductase 0.0012 0.0141 0.0516
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0026 0.0676 0.6469
Loa Loa (eye worm) hypothetical protein 0.0015 0.026 0.0307
Trypanosoma brucei membrane transporter protein, putative 0.0022 0.0535 0.4894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0357 0.3702
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0218 0.2163
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0535 0.4894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0218 0.0257
Leishmania major phosphatidylinositol 3-kinase, putative 0.0011 0.0104 0.0112
Toxoplasma gondii NADPH-glutathione reductase 0.0012 0.0141 0.0516
Brugia malayi exodeoxyribonuclease III family protein 0.0011 0.0094 0.0309
Loa Loa (eye worm) hypothetical protein 0.0014 0.0218 0.0257
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0012 0.0141 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0358 0.3713
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0011 0.0104 0.0112
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0014 0.0218 0.2163
Mycobacterium tuberculosis Probable reductase 0.0077 0.2668 0.8856
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0011 0.0126 0.675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0422 0.4418
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0032 0.0929 0.1176
Trichomonas vaginalis glutathione reductase, putative 0.0012 0.0141 0.1316
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0014 0.0218 0.0185
Plasmodium falciparum glutathione reductase 0.0012 0.0141 0.0516
Echinococcus multilocularis expressed protein 0.0268 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0032 0.0929 0.0843
Echinococcus granulosus Regulator of G protein signaling 20 0.0014 0.0218 0.0125
Entamoeba histolytica hypothetical protein 0.0014 0.0218 0.0174
Schistosoma mansoni lamin 0.0015 0.027 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0218 0.2163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0611 0.6498
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0056 0.1825 0.2436
Echinococcus multilocularis regulator of G protein signaling 3 0.0014 0.0218 0.0125
Treponema pallidum NADH oxidase 0.0012 0.0141 1
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0022 0.0535 0.0445
Schistosoma mansoni hypothetical protein 0.0184 0.6773 1
Toxoplasma gondii thioredoxin reductase 0.0034 0.0994 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.002 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0104 0.0916
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0218 0.0185
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0011 0.0104 0.001
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0014 0.0218 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0358 0.3713
Onchocerca volvulus 0.0015 0.027 0.5
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0012 0.0141 0.0047
Trypanosoma cruzi membrane transporter protein, putative 0.0022 0.0535 0.4894
Echinococcus multilocularis axis inhibition protein axin 0.0014 0.0218 0.0125
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0011 0.0104 0.0112
Brugia malayi Cytochrome P450 family protein 0.0011 0.0126 0.0411
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0141 0.0516
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0126 0.0149
Entamoeba histolytica hypothetical protein 0.0014 0.0218 0.0174
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0012 0.0141 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0077 0.2668 0.8856
Loa Loa (eye worm) hypothetical protein 0.0031 0.0874 0.1034
Brugia malayi hypothetical protein 0.0014 0.0218 0.0713
Echinococcus granulosus regulator of G protein signaling 7 0.0014 0.0218 0.0125
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0026 0.0676 0.6469
Loa Loa (eye worm) glutathione reductase 0.0034 0.0994 0.1176
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0011 0.0104 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0675 0.7204
Echinococcus granulosus beta-adrenergic receptor kinase 0.0014 0.0218 0.0125
Echinococcus multilocularis lamin dm0 0.0015 0.027 0.0178
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0012 0.0141 0.0516
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0104 0.0342
Brugia malayi Regulator of G protein signaling domain containing protein 0.0014 0.0218 0.0713
Echinococcus multilocularis regulator of G protein signaling 7 0.0014 0.0218 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0218 0.2163
Loa Loa (eye worm) hypothetical protein 0.0077 0.2645 0.313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0357 0.3702
Echinococcus multilocularis thioredoxin glutathione reductase 0.0034 0.0994 0.0909
Echinococcus multilocularis regulator of G protein signaling 3 0.0014 0.0218 0.0125
Echinococcus granulosus axis inhibition protein axin 0.0014 0.0218 0.0125
Schistosoma mansoni lamin 0.0015 0.027 0.0264
Echinococcus multilocularis regulator of G protein signaling 7 0.0014 0.0218 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0141 0.0516
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0141 0.0516
Loa Loa (eye worm) thioredoxin reductase 0.0034 0.0994 0.1176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0611 0.6498
Brugia malayi regulator of G-protein signaling rgs-7 0.0014 0.0218 0.0713
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0012 0.0141 1
Schistosoma mansoni z-protein (S1r protein) 0.0014 0.0218 0.0185
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.002 0.046 0.037
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0086 0.3 1
Echinococcus granulosus small conductance calcium activated potassium 0.0184 0.6773 0.6742
Schistosoma mansoni multidrug resistance protein 0.0022 0.0535 0.066
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0535 0.4894
Schistosoma mansoni axis inhibition protein axin 0.0014 0.0218 0.0185
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0011 0.0104 0.0112
Loa Loa (eye worm) hypothetical protein 0.0014 0.0218 0.0257
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0535 0.4894
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0032 0.0929 0.1251
Loa Loa (eye worm) hypothetical protein 0.0015 0.027 0.032
Trichomonas vaginalis ap endonuclease, putative 0.0011 0.0094 0.0805
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0013 0.0204 0.1216
Loa Loa (eye worm) intermediate filament protein 0.0015 0.027 0.032
Trichomonas vaginalis mercuric reductase, putative 0.0012 0.0141 0.1316
Trypanosoma brucei MATE efflux family protein, putative 0.0022 0.0535 0.4894
Trypanosoma brucei membrane transporter protein, putative 0.0022 0.0535 0.4894
Plasmodium vivax thioredoxin reductase, putative 0.0034 0.0994 1
Trypanosoma brucei membrane transporter protein, putative 0.0022 0.0535 0.4894
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0077 0.2668 0.8856
Schistosoma mansoni intermediate filament proteins 0.0015 0.027 0.0264
Echinococcus granulosus intermediate filament protein 0.0015 0.027 0.0178
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0012 0.0141 0.0461
Brugia malayi Thioredoxin reductase 0.0034 0.0994 0.3259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0611 0.6498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.043 0.4499
Toxoplasma gondii target of rapamycin (TOR), putative 0.0024 0.0611 0.5746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0611 0.6498
Plasmodium falciparum thioredoxin reductase 0.0034 0.0994 1
Schistosoma mansoni hypothetical protein 0.0095 0.3348 0.4872
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0929 0.11
Echinococcus granulosus lamin dm0 0.0015 0.027 0.0178
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0014 0.0218 0.0185
Brugia malayi Cytochrome P450 family protein 0.0019 0.0411 0.1346
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0012 0.0141 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0011 0.0104 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0218 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0104 0.0916
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0011 0.0094 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0535 0.4894
Loa Loa (eye worm) RGS-3 protein 0.0014 0.0218 0.0257
Echinococcus multilocularis lamin 0.0015 0.027 0.0178
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0126 0.0348
Echinococcus granulosus lamin 0.0015 0.027 0.0178
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0141 0.0516
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0141 0.0516
Echinococcus multilocularis axis inhibition protein axin 0.0014 0.0218 0.0125
Entamoeba histolytica hypothetical protein 0.0014 0.0218 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0218 0.0185
Echinococcus multilocularis geminin 0.0095 0.3348 0.3285
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0218 0.2163
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0012 0.0141 0.5
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0011 0.0104 0.001
Echinococcus granulosus regulator of G protein signaling 3 0.0014 0.0218 0.0125
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.0104 0.0123
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0015 0.0275 0.201
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0011 0.0104 0.0112
Echinococcus multilocularis regulator of G protein signaling 0.0014 0.0218 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0611 0.6498
Echinococcus multilocularis small conductance calcium activated potassium 0.0184 0.6773 0.6742
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0034 0.0994 0.3097
Brugia malayi hypothetical protein 0.0014 0.0218 0.0713
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0218 0.0185
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0141 0.0516
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0218 0.0185
Brugia malayi Regulator of G protein signaling domain containing protein 0.0014 0.0218 0.0713
Brugia malayi regulator of G-protein signaling egl-10 0.0014 0.0218 0.0713
Entamoeba histolytica hypothetical protein 0.0056 0.1825 0.2436
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0012 0.0141 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0494 0.5205
Brugia malayi PXA domain containing protein 0.0014 0.0218 0.0713
Echinococcus multilocularis musashi 0.0015 0.027 0.0178
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0032 0.0929 0.928
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0014 0.0218 0.0257
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0032 0.0929 0.928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.043 0.4499
Brugia malayi PXA domain containing protein 0.0014 0.0218 0.0713
Brugia malayi intermediate filament protein 0.0015 0.027 0.0887
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0032 0.0929 0.928
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0218 0.0185
Trypanosoma brucei trypanothione reductase 0.0034 0.0994 1
Schistosoma mansoni calcium-activated potassium channel 0.0184 0.6773 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0012 0.0141 0.007
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0195 0.7197 1
Trypanosoma cruzi trypanothione reductase, putative 0.0012 0.0141 0.0516
Schistosoma mansoni calcium-activated potassium channel 0.0146 0.5299 0.7794
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0218 0.2163
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0015 0.027 0.032
Brugia malayi glutathione reductase 0.0034 0.0994 0.3259
Trypanosoma brucei cytochrome P450, putative 0.0011 0.0126 0.0348
Schistosoma mansoni axis inhibition protein axin 0.0014 0.0218 0.0185
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0014 0.0218 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0357 0.3702
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0077 0.2668 0.8856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0358 0.3713
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0141 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0675 0.7204
Loa Loa (eye worm) hypothetical protein 0.0014 0.0218 0.0257
Echinococcus multilocularis Regulator of G protein signaling 20 0.0014 0.0218 0.0125
Mycobacterium tuberculosis Probable dehydrogenase 0.0077 0.2668 0.8856
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0012 0.0141 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0929 1
Leishmania major cytochrome p450-like protein 0.0011 0.0126 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0422 0.4418
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0086 0.3 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0675 0.7204
Loa Loa (eye worm) hypothetical protein 0.0014 0.0218 0.0257
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0014 0.0218 0.0257
Brugia malayi Cytochrome P450 family protein 0.0011 0.0126 0.0411
Loa Loa (eye worm) hypothetical protein 0.0069 0.2342 0.2771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0675 0.7204
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0077 0.2668 0.8856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0104 0.0916
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0012 0.0141 0.0516
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0014 0.0218 0.0185
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0086 0.3 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0611 0.6498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0521 0.5501
Loa Loa (eye worm) hypothetical protein 0.0014 0.0218 0.0257
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0012 0.0141 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0014 0.0218 0.0713
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.002 0.0067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0141 0.0516
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0012 0.0141 0.0047
Trypanosoma cruzi target of rapamycin kinase 3 0.0026 0.0676 0.6469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0104 0.0916
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0014 0.0218 0.0257
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0141 0.0516
Schistosoma mansoni hypothetical protein 0.004 0.1233 0.1705
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0218 0.2163
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0126 0.0348
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0994 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0929 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0014 0.0218 0.0713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0104 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0929 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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