Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MBCTL1 | 0.0054 | 0.0453 | 0.2343 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0109 | 0.1163 | 0.3296 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0367 | 0.104 |
Brugia malayi | phenylalanyl-tRNA synthetase, mitochondrial precursor, putative | 0.0048 | 0.0366 | 0.1627 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0165 | 0.1889 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0165 | 0.1889 | 0.5354 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0342 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0276 | 0.1399 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0165 | 0.1889 | 1 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0165 | 0.1889 | 0.1889 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0165 | 0.1889 | 0.3269 |
Chlamydia trachomatis | phenylalanine--tRNA ligase subunit alpha | 0.0785 | 0.9974 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0367 | 0.0367 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0463 | 0.578 | 0.578 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0048 | 0.0366 | 0.135 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0109 | 0.1163 | 0.5878 |
Toxoplasma gondii | Ferredoxin-fold anticodon binding domain-containing protein | 0.0048 | 0.0366 | 0.135 |
Echinococcus granulosus | neuropeptide s receptor | 0.0463 | 0.578 | 1 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0048 | 0.0366 | 0.135 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.1889 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0367 | 0.104 |
Brugia malayi | 6-phosphofructokinase | 0.0109 | 0.1163 | 0.6009 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0048 | 0.0366 | 0.135 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0054 | 0.0453 | 0.2108 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.0785 | 0.9974 | 0.5 |
Loa Loa (eye worm) | phenylalanyl-tRNA synthetase | 0.0048 | 0.0366 | 0.1876 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0109 | 0.1163 | 0.2012 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.0524 | 0.0906 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0342 | 0.0968 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0463 | 0.578 | 0.578 |
Echinococcus granulosus | phenylalanyl tRNA synthetase | 0.0048 | 0.0366 | 0.0633 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0367 | 0.1883 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0054 | 0.0453 | 0.0453 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0342 | 0.0342 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.0524 | 0.0524 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0165 | 0.1889 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0342 | 0.1747 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0367 | 0.1634 |
Brugia malayi | 6-phosphofructokinase | 0.0109 | 0.1163 | 0.6009 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0367 | 0.1634 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0165 | 0.1889 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.057 | 0.1616 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0109 | 0.1163 | 0.5878 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0039 | 0.011 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0039 | 0.0067 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0165 | 0.1889 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0109 | 0.1163 | 0.5878 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0342 | 0.0342 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0367 | 0.104 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0048 | 0.0366 | 0.135 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0785 | 0.9974 | 1 |
Brugia malayi | phosphofructokinase | 0.0109 | 0.1163 | 0.6009 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0048 | 0.0366 | 0.135 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0048 | 0.0366 | 0.135 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0109 | 0.1163 | 0.3296 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0165 | 0.1889 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0213 | 0.0213 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0188 | 0.2198 | 0.3802 |
Loa Loa (eye worm) | phosphofructokinase | 0.0109 | 0.1163 | 0.6128 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0301 | 0.1532 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0453 | 0.2343 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0367 | 0.1883 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0245 | 0.1234 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0054 | 0.0453 | 0.0784 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0165 | 0.1889 | 1 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0165 | 0.1889 | 1 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.0785 | 0.9974 | 1 |
Onchocerca volvulus | 0.0048 | 0.0367 | 0.5 | |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0109 | 0.1163 | 0.5878 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0109 | 0.1163 | 0.5878 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0109 | 0.1163 | 0.1163 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0165 | 0.1889 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.0048 | 0.0366 | 0.1036 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0165 | 0.1889 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0054 | 0.0453 | 0.0453 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0109 | 0.1163 | 0.5878 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0342 | 0.1494 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0165 | 0.1889 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0342 | 0.0591 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0367 | 0.0635 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0463 | 0.578 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0244 | 0.096 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0109 | 0.1163 | 0.6128 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0213 | 0.0369 |
Schistosoma mansoni | hypothetical protein | 0.029 | 0.3529 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0014 | 0.0039 |
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.0723 | 0.3592 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0342 | 0.0591 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0668 | 0.3486 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0054 | 0.0453 | 0.0784 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0342 | 0.0968 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0367 | 0.0635 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0109 | 0.1163 | 0.6128 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | 0.0048 | 0.0366 | 0.0366 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0367 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0109 | 0.1163 | 0.5878 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0117 | 0.1268 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0054 | 0.0453 | 0.1284 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0048 | 0.0366 | 0.1036 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0109 | 0.1163 | 0.5878 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0039 | 0.0039 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0188 | 0.2198 | 0.2198 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.