Detailed information for compound 574411

Basic information

Technical information
  • TDR Targets ID: 574411
  • Name: 7-[(1R,2R)-2-[(E,3S)-3-(1-butylcyclobutyl)-3- hydroxy-prop-1-enyl]-5-oxo-cyclopentyl]heptan oic acid
  • MW: 378.545 | Formula: C23H38O4
  • H donors: 2 H acceptors: 4 LogP: 4.95 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC1(CCC1)[C@H](C=C[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O
  • InChi: 1S/C23H38O4/c1-2-3-15-23(16-8-17-23)21(25)14-12-18-11-13-20(24)19(18)9-6-4-5-7-10-22(26)27/h12,14,18-19,21,25H,2-11,13,15-17H2,1H3,(H,26,27)/b14-12+/t18-,19-,21+/m1/s1
  • InChiKey: HIZKSBVCUYYKMS-GOOMNDMLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-[(1R,2R)-2-[(E,3S)-3-(1-butylcyclobutyl)-3-hydroxyprop-1-enyl]-5-oxocyclopentyl]heptanoic acid
  • 7-[(1R,2R)-2-[(E,3S)-3-(1-butylcyclobutyl)-3-hydroxy-prop-1-enyl]-5-keto-cyclopentyl]enanthic acid
  • 11-deoxy-16,16-trimethyleneprostaglandin E1
  • 62407-92-5
  • Cyclopentaneheptanoic acid, 2-(3-(1-butylcyclobutyl)-3-hydroxy-1-propenyl)-5-oxo-, (1alpha,2beta(1E,3S*))-(+-)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0272 0.0342
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0302
Schistosoma mansoni hypothetical protein 0.0024 0.0071 0.009
Brugia malayi intermediate filament protein 0.0021 0.0047 0.0521
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0025 0.0079 0.6248
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0105 0.0855 0.9554
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0079 0.0079
Onchocerca volvulus 0.0054 0.0363 0.2356
Trichomonas vaginalis conserved hypothetical protein 0.1048 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0272 0.0795
Echinococcus granulosus carbonic anhydrase 0.0024 0.0071 0.0208
Mycobacterium ulcerans hypothetical protein 0.0035 0.018 0.0153
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0028 0.0111 0.0112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0079 0.0079
Loa Loa (eye worm) fibroinase 0.0025 0.0079 0.0886
Trypanosoma cruzi cysteine peptidase, putative 0.0094 0.0753 0.2282
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0024 0.0071 0.0794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0079 0.0079
Echinococcus granulosus lamin 0.0021 0.0047 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Mycobacterium ulcerans lipase LipD 0.0035 0.018 0.0153
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0024 0.0071 0.0794
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0794
Echinococcus granulosus tumor protein p63 0.0369 0.3417 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0025 0.0079 0.6248
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.018 0.0345
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0028 0.0111 0.0112
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.018 0.2006
Toxoplasma gondii ABC1 family protein 0.0035 0.018 0.3818
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.1011
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0091 0.0064
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0219
Schistosoma mansoni lamin 0.0021 0.0047 0.0059
Onchocerca volvulus 0.0025 0.0079 0.0514
Onchocerca volvulus 0.0025 0.0079 0.0514
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0091 0.1011
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0091 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0079 0.0079
Leishmania major carbonic anhydrase-like protein 0.0105 0.0855 0.1958
Echinococcus granulosus cathepsin l1 0.0025 0.0079 0.0232
Loa Loa (eye worm) beta-lactamase 0.0035 0.018 0.2006
Echinococcus multilocularis carbonic anhydrase II 0.0105 0.0855 0.2399
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0079 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0387 0.1047
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0219
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.2006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0753 0.2282
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0079 0.0079
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0091 0.0033
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0836 0.7946 1
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0835 0.793 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0105 0.0855 0.1078
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0105 0.0855 0.9554
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0091 0.0093
Echinococcus granulosus GPCR family 2 0.0034 0.0174 0.0508
Loa Loa (eye worm) hypothetical protein 0.0054 0.0363 0.4057
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0025 0.0079 0.0079
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.018 0.018
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0091 0.0033
Onchocerca volvulus Cathepsin F homolog 0.0025 0.0079 0.0514
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0302
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0028 0.0111 0.0084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.1011
Echinococcus multilocularis cysteine protease 0.0025 0.0079 0.0097
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0091 0.0224
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0272 0.3033
Brugia malayi Intermediate filament tail domain containing protein 0.0021 0.0047 0.0521
Mycobacterium tuberculosis Conserved protein 0.0035 0.018 0.0205
Brugia malayi beta-lactamase 0.0035 0.018 0.2006
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.018 0.0205
Onchocerca volvulus 0.0035 0.018 0.1165
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0219
Trypanosoma cruzi cysteine peptidase, putative 0.0094 0.0753 0.2282
Trypanosoma cruzi cysteine peptidase, putative 0.0094 0.0753 0.2282
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0302
Echinococcus multilocularis carbonic anhydrase 0.0024 0.0071 0.0072
Mycobacterium leprae conserved hypothetical protein 0.0035 0.018 0.0225
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0024 0.0071 0.0794
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0105 0.0855 0.2628
Schistosoma mansoni carbonic anhydrase 0.0024 0.0071 0.009
Brugia malayi hypothetical protein 0.0025 0.0078 0.0867
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.3037 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0105 0.0855 0.1078
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0272 0.3033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.018 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0753 0.2282
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0174 0.0376
Mycobacterium ulcerans beta-lactamase 0.0035 0.018 0.0153
Onchocerca volvulus 0.0025 0.0079 0.0514
Leishmania major cysteine peptidase A (CPA) 0.0025 0.0079 0.0004
Schistosoma mansoni intermediate filament proteins 0.0021 0.0047 0.0059
Leishmania major cathepsin L-like protease 0.0094 0.0753 0.17
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0079 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0272 0.0342
Chlamydia trachomatis sulfate transporter 0.0028 0.0111 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0105 0.0855 0.2628
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0219
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0174 0.0508
Onchocerca volvulus 0.0035 0.018 0.1165
Brugia malayi Cathepsin L-like precursor 0.0025 0.0079 0.0886
Toxoplasma gondii cathepsin CPL 0.0025 0.0079 0.0289
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0302
Schistosoma mansoni carbonic anhydrase-related 0.0024 0.0071 0.009
Loa Loa (eye worm) intermediate filament protein 0.0021 0.0047 0.0521
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0079 0.01
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0174 0.1938
Brugia malayi beta-lactamase family protein 0.0035 0.018 0.2006
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0078 0.0229
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0794
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0079 0.0514
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.018 0.018
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0025 0.0079 0.0097
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0079 0.0514
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0289 0.0715
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0025 0.0079 0.6248
Echinococcus granulosus carbonic anhydrase 0.0024 0.0071 0.0208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0079 0.0079
Trypanosoma brucei carbonic anhydrase-like protein 0.0105 0.0855 0.2628
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0794
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0091 0.0224
Mycobacterium ulcerans integral membrane transporter 0.0028 0.0111 0.0084
Plasmodium vivax hypothetical protein, conserved 0.0035 0.018 1
Echinococcus granulosus intermediate filament protein 0.0021 0.0047 0.0137
Onchocerca volvulus 0.0026 0.0091 0.0587
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0753 0.2282
Mycobacterium ulcerans hypothetical protein 0.0026 0.0091 0.0064
Mycobacterium tuberculosis Conserved protein 0.0035 0.018 0.0205
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0078 0.6045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0753 0.2282
Plasmodium vivax sulfate transporter, putative 0.0028 0.0111 0.5479
Plasmodium vivax vivapain-2 0.0025 0.0079 0.3423
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0753 0.2282
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.018 0.0153
Schistosoma mansoni hypothetical protein 0.0074 0.0561 0.0708
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.018 0.0345
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.018 0.0205
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0222 0.1996 0.2496
Brugia malayi Cathepsin L-like precursor 0.0025 0.0079 0.0886
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0156 0.1353 0.4309
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0021 0.0047 0.0521
Plasmodium vivax vivapain-2 0.0025 0.0079 0.3423
Trichomonas vaginalis esterase, putative 0.0035 0.018 0.018
Onchocerca volvulus 0.0021 0.0047 0.0303
Brugia malayi Cathepsin L-like precursor 0.0025 0.0079 0.0886
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0895 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0753 0.2282
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.018 0.018
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.1353 0.4309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Plasmodium falciparum carbonic anhydrase 0.0024 0.0071 0.5266
Leishmania major cathepsin L-like protease 0.0025 0.0079 0.0004
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0028 0.0111 0.1392
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0753 0.2282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0753 0.2282
Toxoplasma gondii hypothetical protein 0.0053 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0753 0.2282
Mycobacterium leprae Probable lipase LipE 0.0035 0.018 0.0225
Brugia malayi Cathepsin L-like precursor 0.0025 0.0079 0.0886
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0174 0.1938
Leishmania major cathepsin L-like protease 0.0025 0.0079 0.0004
Entamoeba histolytica cysteine protease, putative 0.0025 0.0079 0.0196
Brugia malayi Cathepsin L-like precursor 0.0025 0.0079 0.0886
Mycobacterium ulcerans carbonic anhydrase 0.0434 0.405 0.4034
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0152 0.1311 0.1653
Entamoeba histolytica carbonic anhydrase, putative 0.0434 0.405 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0078 0.6045
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0091 0.0064
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.018 0.018
Leishmania major cathepsin L-like protease 0.0025 0.0079 0.0004
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0203 0.1805 0.2256
Trypanosoma cruzi cruzipain precursor, putative 0.0094 0.0753 0.2282
Leishmania major cathepsin L-like protease 0.0094 0.0753 0.17
Schistosoma mansoni carbonic anhydrase-related 0.0024 0.0071 0.009
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.1353 0.3211
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.018 0.0226
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0479
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0079 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0272 0.0795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0028 0.0111 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0025 0.0079 0.0097
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0028 0.0111 0.0112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0895 1
Leishmania major carbonic anhydrase family protein, putative 0.0434 0.405 1
Loa Loa (eye worm) cysteine protease 0.0025 0.0079 0.0886
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0078 0.3312
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0024 0.0071 0.0794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Onchocerca volvulus 0.0176 0.1541 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0895 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0753 0.2282
Trypanosoma brucei mitochondrial DNA polymerase beta 0.033 0.3037 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0272 0.0342
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0272 0.0667
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0091 0.0064
Brugia malayi Cathepsin L-like precursor 0.0025 0.0079 0.0886
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0521
Echinococcus granulosus carbonic anhydrase II 0.0105 0.0855 0.2503
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0079 0.0886
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0091 0.1011
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.2006
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0025 0.0079 0.0886
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.018 0.0345
Leishmania major mitochondrial DNA polymerase beta 0.033 0.3037 0.7451
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.018 0.0153
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.018 0.0394
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0174 0.1938
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0561 0.6269
Schistosoma mansoni carbonic anhydrase 0.0434 0.405 0.5107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0289 0.0715
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0289 0.0715
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.018 0.0205
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.018 0.0525
Trichomonas vaginalis conserved hypothetical protein 0.1048 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0091 0.0064
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0028 0.0111 0.0084
Schistosoma mansoni lamin 0.0021 0.0047 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.018 0.018
Echinococcus multilocularis carbonic anhydrase 0.0024 0.0071 0.0072
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2012 0.2516
Echinococcus multilocularis cathepsin L cysteine protease 0.0025 0.0079 0.0097
Leishmania major cathepsin L-like protease 0.0025 0.0079 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0302
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.2006
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0363 0.0458
Onchocerca volvulus 0.0035 0.018 0.1165
Mycobacterium ulcerans hypothetical protein 0.0174 0.1524 0.1501
Echinococcus granulosus carbonic anhydrase 0.0024 0.0071 0.0208
Loa Loa (eye worm) hypothetical protein 0.0109 0.0895 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0027 0.0013
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0174 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Mycobacterium leprae Probable transmembrane transport protein 0.0203 0.1805 0.4331
Onchocerca volvulus 0.0025 0.0079 0.0514
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0079 0.0886
Echinococcus multilocularis GPCR, family 2 0.0034 0.0174 0.0376
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0086 0.0674 0.2014
Onchocerca volvulus 0.0025 0.0079 0.0514
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.2006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0079 0.0079
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.018 0.0205
Echinococcus granulosus lamin dm0 0.0021 0.0047 0.0137
Onchocerca volvulus 0.0025 0.0079 0.0514
Leishmania major cathepsin L-like protease 0.0025 0.0079 0.0004
Loa Loa (eye worm) ctsf protein 0.0025 0.0079 0.0886
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0091 0.0033
Onchocerca volvulus 0.0025 0.0079 0.0514
Echinococcus multilocularis tumor protein p63 0.0369 0.3417 1
Leishmania major hypothetical protein, conserved 0.0035 0.018 0.0257
Echinococcus multilocularis cathepsin L cysteine protease 0.0025 0.0079 0.0097
Mycobacterium tuberculosis Conserved protein 0.0035 0.018 0.0205
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.018 0.0226
Onchocerca volvulus 0.0021 0.0047 0.0303
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.2006
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.1938
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.2006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0753 0.2282
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.3037 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0024 0.0071 0.0794
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0434 0.405 1
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0079 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0174 0.0508
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.018 0.2006
Schistosoma mansoni carbonic anhydrase-related 0.0024 0.0071 0.009
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0289 0.0715
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0415 0.3859 0.4846
Loa Loa (eye worm) carbonic anhydrase 3 0.0105 0.0855 0.9554
Loa Loa (eye worm) hypothetical protein 0.0074 0.0561 0.6269
Onchocerca volvulus Putative sulfate transporter 0.0176 0.1541 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0024 0.0071 0.0794
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0091 0.1011
Brugia malayi beta-lactamase family protein 0.0035 0.018 0.2006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.018 0.0205
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.018 0.0205
Echinococcus granulosus cathepsin L cysteine proteinase 0.0025 0.0079 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0079 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0079 0.0079
Echinococcus multilocularis carbonic anhydrase 0.0024 0.0071 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0272 0.0667
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.1524 0.1901
Echinococcus multilocularis cysteine protease 0.0025 0.0079 0.0097
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0091 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0091 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0079 0.0079
Trypanosoma cruzi major cysteine proteinase, putative 0.0074 0.0557 0.1622
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0025 0.0079 0.0079
Echinococcus granulosus cathepsin l cysteine peptidase 0.0025 0.0079 0.0232
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0105 0.0855 0.9554
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0886
Leishmania major cathepsin L-like protease 0.0094 0.0753 0.17
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0091 0.0224
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0091 0.0064

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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