Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0107 | 0.0823 | 0.0891 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0093 | 0.0645 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0144 | 0.1336 | 0.1336 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0373 | 0.443 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.1 | 0.3559 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0301 | 0.107 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1336 | 0.4754 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 0.3962 | 0.4286 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0185 | 0.1888 | 0.2042 |
Echinococcus multilocularis | geminin | 0.0338 | 0.3962 | 0.3962 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0029 | 0.0102 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0093 | 0.0645 | 0.2296 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0107 | 0.0823 | 0.0891 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0301 | 0.0325 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0045 | 0.0049 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0373 | 0.443 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0728 | 0.9244 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0107 | 0.0823 | 0.5 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0093 | 0.0645 | 0.0645 |
Brugia malayi | Muscleblind-like protein | 0.0144 | 0.1336 | 0.4754 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.2564 | 0.9126 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0235 | 0.2564 | 0.2773 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.0823 | 0.0891 |
Entamoeba histolytica | hypothetical protein | 0.0107 | 0.0823 | 0.5 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0093 | 0.0645 | 0.0698 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0029 | 0.0031 |
Onchocerca volvulus | 0.0049 | 0.0045 | 1 | |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0102 | 0.0758 | 0.1306 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0253 | 0.2809 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0373 | 0.443 | 0.5 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0102 | 0.0758 | 0.0298 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0235 | 0.2564 | 0.2564 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0029 | 0.0031 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0373 | 0.443 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0144 | 0.1336 | 0.1445 |
Echinococcus multilocularis | tumor protein p63 | 0.0336 | 0.393 | 0.393 |
Brugia malayi | hypothetical protein | 0.0107 | 0.0823 | 0.293 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.2809 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.0727 | 0.2589 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.1 | 0.3559 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0093 | 0.0645 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.0727 | 0.2589 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0185 | 0.1888 | 0.1888 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0373 | 0.443 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0336 | 0.393 | 0.4251 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0093 | 0.0645 | 0.2296 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.0645 | 0.0698 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.0645 | 0.104 |
Echinococcus granulosus | geminin | 0.0338 | 0.3962 | 0.4286 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0373 | 0.443 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0144 | 0.1336 | 0.1336 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 0.3962 | 0.4286 |
Trichomonas vaginalis | hypothetical protein | 0.0373 | 0.443 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0301 | 0.107 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.0645 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0373 | 0.443 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0728 | 0.9244 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1336 | 0.4754 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.0645 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0107 | 0.0823 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0728 | 0.9244 | 0.9244 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.1 | 0.3559 |
Brugia malayi | hypothetical protein | 0.0235 | 0.2564 | 0.9126 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0107 | 0.0823 | 0.0823 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0373 | 0.443 | 1 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0102 | 0.0758 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0045 | 0.016 |
Entamoeba histolytica | hypothetical protein | 0.0107 | 0.0823 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.