Detailed information for compound 583529

Basic information

Technical information
  • TDR Targets ID: 583529
  • Name: 5-(2-amino-1-hydroxy-ethyl)-2-chloro-benzenes ulfonamide
  • MW: 250.703 | Formula: C8H11ClN2O3S
  • H donors: 3 H acceptors: 3 LogP: -0.68 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC(c1ccc(c(c1)S(=O)(=O)N)Cl)O
  • InChi: 1S/C8H11ClN2O3S/c9-6-2-1-5(7(12)4-10)3-8(6)15(11,13)14/h1-3,7,12H,4,10H2,(H2,11,13,14)
  • InChiKey: BIRMKLDLCBUZEU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(2-amino-1-hydroxyethyl)-2-chlorobenzenesulfonamide
  • 5-(2-azanyl-1-hydroxy-ethyl)-2-chloro-benzenesulfonamide
  • SK&F 29029
  • 79406-75-0
  • Benzenesulfonamide, 5-(2-amino-1-hydroxyethyl)-2-chloro-
  • SK&F-29029
  • Skf 29029
  • 4-Chloro-3-sulfamyl-alpha-aminomethylbenzyl alcohol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans transmembrane alkane 1-monooxygenase AlkB 0.0016 0.001 0.5
Brugia malayi Delta5 fatty acid desaturase 0.0016 0.001 0.0011
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.1285 0.0889
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.7125 1
Schistosoma mansoni hypothetical protein 0.0034 0.101 0.1417
Brugia malayi hypothetical protein 0.0016 0.0028 0.003
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.1285 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.1481 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.7125 1
Loa Loa (eye worm) acetyltransferase 0.0144 0.7125 0.7812
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3 0.0016 0.001 0.5
Echinococcus granulosus Sphingolipid delta4 desaturase DES1 0.0016 0.001 0.0014
Loa Loa (eye worm) fatty acid desaturase 0.0016 0.001 0.0011
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.052 0.0511
Brugia malayi Fatty acid desaturase family protein 0.0016 0.001 0.0011
Brugia malayi acyl-CoA desaturase 0.018 0.912 1
Echinococcus multilocularis Fatty acid desaturase, type 1 0.0016 0.001 0.0014
Onchocerca volvulus 0.0196 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.052 0.0571
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3 0.0016 0.001 0.5
Leishmania major hypothetical protein, conserved 0.0025 0.052 0.0511
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.1481 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.052 0.347
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.188 0.2061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.188 0.2061
Schistosoma mansoni fatty acid desaturase 0.0016 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.005 0.188 0.2061
Plasmodium falciparum stearoyl-CoA desaturase 0.018 0.912 1
Mycobacterium ulcerans hypothetical protein 0.0016 0.001 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.5715 0.6267
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0016 0.001 0.5
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.1481 0.1117
Trypanosoma cruzi fatty acid desaturase, putative 0.018 0.912 0.9119
Brugia malayi MH2 domain containing protein 0.0119 0.5715 0.6267
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.188 0.2061
Brugia malayi hypothetical protein 0.0025 0.052 0.0571
Mycobacterium tuberculosis Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f 0.0016 0.001 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.101 0.1107
Mycobacterium ulcerans hypothetical protein 0.0016 0.001 0.5
Loa Loa (eye worm) FAT-3 protein 0.0016 0.001 0.0011
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3_2 0.0016 0.001 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.5715 0.6267
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.018 0.912 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.1481 0.5
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0016 0.001 0.0014
Loa Loa (eye worm) acyl-CoA desaturase 0.018 0.912 1
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.7125 0.7812
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0016 0.001 0.0014
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.6901 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.1481 1
Trypanosoma brucei fatty acid desaturase, putative 0.0196 1 1
Trypanosoma cruzi fatty acid desaturase, putative 0.018 0.912 0.9119
Echinococcus granulosus Fatty acid desaturase type 1 0.0016 0.001 0.0014
Loa Loa (eye worm) fatty acid desaturase 0.0016 0.001 0.0011
Onchocerca volvulus 0.0196 1 1
Brugia malayi Fatty acid desaturase family protein 0.0016 0.001 0.0011
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.1285 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.101 0.1107
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.1481 0.2146
Leishmania major fatty-acid desaturase, putative 0.0196 1 1
Mycobacterium tuberculosis Probable conserved membrane protein 0.0016 0.001 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.052 0.0511
Trypanosoma cruzi fatty acid desaturase, putative 0.0196 1 1
Mycobacterium ulcerans electron transfer protein FdxB 0.0016 0.001 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.052 0.0511
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0011

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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