Detailed information for compound 583919

Basic information

Technical information
  • TDR Targets ID: 583919
  • Name: (5S,6R,7E,9E,11E,14E)-6-(2-acetamido-3-hydrox y-3-oxo-propyl)sulfanyl-5-hydroxy-icosa-7,9,1 1,14-tetraenoic acid
  • MW: 481.645 | Formula: C25H39NO6S
  • H donors: 4 H acceptors: 6 LogP: 4.61 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCC=CCC=CC=CC=C[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)O)NC(=O)C
  • InChi: 1S/C25H39NO6S/c1-3-4-5-6-7-8-9-10-11-12-13-14-17-23(22(28)16-15-18-24(29)30)33-19-21(25(31)32)26-20(2)27/h7-8,10-14,17,21-23,28H,3-6,9,15-16,18-19H2,1-2H3,(H,26,27)(H,29,30)(H,31,32)/b8-7+,11-10+,13-12+,17-14+/t21?,22-,23+/m0/s1
  • InChiKey: BGGYAYMMFYBWEX-YSUFHIAUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5S,6R,7E,9E,11E,14E)-6-[(2-acetamido-3-hydroxy-3-oxopropyl)thio]-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • (5S,6R,7E,9E,11E,14E)-6-[(2-acetamido-3-hydroxy-3-keto-propyl)thio]-5-hydroxy-icosa-7,9,11,14-tetraenoic acid
  • (5S,6R,7E,9E,11E,14E)-6-(2-acetamido-3-hydroxy-3-oxopropyl)sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • N-acetylleukotriene E4
  • (5S,6R)-6-(2-acetamido-3-hydroxy-3-oxopropyl)sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • (5S,6R)-6-(2-acetamido-3-hydroxy-3-oxo-propyl)sulfanyl-5-hydroxy-icosa-7,9,11,14-tetraenoic acid
  • (5S,6R)-6-[(2-acetamido-3-hydroxy-3-oxopropyl)thio]-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • (5S,6R)-6-[(2-acetamido-3-hydroxy-3-keto-propyl)thio]-5-hydroxy-icosa-7,9,11,14-tetraenoic acid
  • 7,9,11,14-Eicosatetraenoic acid, 6-((2-(acetylamino)-2-carboxyethyl)thio)-5-hydroxy-, (5S-(5R*,6S*(S*),7E,9E,11Z,14Z))-
  • Bio1_000191
  • 5-Hydroxy-6-S-(2-acetamido-3-thiopropionyl)-7,9,11,14-eicosatetraenoic acid
  • KBioGR_000162
  • Bio1_000680
  • NA-Lte4
  • CBiol_001905
  • Bio2_000642
  • KBio2_000162
  • KBio2_002730
  • KBio2_005298
  • KBio3_000323
  • KBioSS_000162
  • Bio1_001169
  • KBio3_000324
  • Bio2_000162

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0044 0.0164
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0943 0.0913
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0044 0.0164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0044 0.0164
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.2525
Schistosoma mansoni hypothetical protein 0.0101 0.055 0.1265
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0044 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0135
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0084 0.0323
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0037 0.0135
Trichomonas vaginalis set domain proteins, putative 0.0473 0.2863 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0146 0.0499
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0044 0.0143
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0164
Schistosoma mansoni lamin 0.0027 0.0084 0.0125
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0044 0.0015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0146 0.057
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.055 0.2185
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0044 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0044 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0044 0.0164
Brugia malayi ecdysteroid receptor 0.002 0.0044 0.0164
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0211 0.0178
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0146 0.4801
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0276 0.0317
Trichomonas vaginalis ran, putative 0.0021 0.0048 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.2525
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0146 0.0499
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.03 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0146 0.0147
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0044 0.0015
Echinococcus multilocularis lamin 0.0027 0.0084 0.0051
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0289 0.0257
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0005
Echinococcus granulosus intermediate filament protein 0.0027 0.0084 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0044 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0146 1
Schistosoma mansoni ran 0.0021 0.0048 0.0037
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0135
Brugia malayi intermediate filament protein 0.0027 0.0084 0.0323
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0033 0.5
Onchocerca volvulus 0.006 0.0289 0.1001
Echinococcus multilocularis snurportin 1 0.0301 0.1796 0.1769
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.03 0.0348
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0033 0.2089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0199 0.0167
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0199 0.0217
Echinococcus granulosus lamin 0.0027 0.0084 0.0067
Echinococcus multilocularis dna polymerase eta 0.0019 0.0037 0.0004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0199 0.0784
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0094 0.6463
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.03 1
Schistosoma mansoni alpha-glucosidase 0.0142 0.08 0.1878
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0311
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0146 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0061 0.1949
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.015
Echinococcus granulosus lamin dm0 0.0027 0.0084 0.0067
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0044 0.0011
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0146 0.057
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0037 0.0118
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0044 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.237
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0044 0.0143
Trypanosoma brucei unspecified product 0.0019 0.0037 0.2525
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0044 0.0164
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0094 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0044 0.0164
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0044 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0044 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.2525
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.2525
Loa Loa (eye worm) hypothetical protein 0.0124 0.0689 0.2741
Onchocerca volvulus Huntingtin homolog 0.0124 0.0689 0.2398
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.2525
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0033 0.0104
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0199 0.0167
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0048 0.0558
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0164
Schistosoma mansoni hypothetical protein 0.0047 0.0211 0.0435
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0199 0.0407
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.0943 0.3757
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0044 0.0164
Giardia lamblia DINP protein human, muc B family 0.0019 0.0037 0.2688
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0044 0.0143
Leishmania major GTP-binding protein, putative 0.0021 0.0048 0.1505
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.2525
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.015
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0033 0.0119
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0211 0.083
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0044 0.0027
Schistosoma mansoni coup transcription factor 0.002 0.0044 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0044 0.0164
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0044 0.0027
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0146 0.4222
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0048 0.0019
Loa Loa (eye worm) hypothetical protein 0.006 0.0289 0.1144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0289 0.0628
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0033 0.0119
Brugia malayi nuclear receptor NHR-88 0.002 0.0044 0.0164
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.0179
Loa Loa (eye worm) hypothetical protein 0.0101 0.055 0.2185
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0037 0.237
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0289 0.0628
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.03 0.0268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0044 0.0164
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0007 0.0016
Onchocerca volvulus 0.0027 0.0084 0.0283
Schistosoma mansoni hypothetical protein 0.0047 0.0211 0.0435
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.2434
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.1796 0.7164
Entamoeba histolytica hypothetical protein 0.0023 0.0061 0.4058
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.412 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0037 0.1138
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.2525
Onchocerca volvulus 0.0473 0.2863 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0037 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0044 0.0164
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.03 0.0654
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0146 0.0113
Loa Loa (eye worm) hypothetical protein 0.0148 0.0842 0.3353
Loa Loa (eye worm) hypothetical protein 0.0047 0.0211 0.083
Echinococcus granulosus dna polymerase eta 0.0019 0.0037 0.0005
Onchocerca volvulus Huntingtin homolog 0.0124 0.0689 0.2398
Entamoeba histolytica Ran family GTPase 0.0021 0.0048 0.3135
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0044 0.0164
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0044 0.0011
Brugia malayi steroid hormone receptor 0.002 0.0044 0.0164
Brugia malayi Importin beta-1 subunit 0.0028 0.0094 0.0364
Plasmodium vivax importin-beta 2, putative 0.0028 0.0094 0.2392
Schistosoma mansoni alpha-glucosidase 0.0142 0.08 0.1878
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0211 0.083
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0003 0.0203
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.03 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0289 0.9595
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0033 0.225
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.2525
Echinococcus granulosus microtubule associated protein 2 0.0674 0.412 0.5326
Schistosoma mansoni thyroid hormone receptor 0.002 0.0044 0.0027
Brugia malayi RNA, U transporter 1 0.008 0.0418 0.166
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0033 0.1003
Echinococcus multilocularis GPCR, family 2 0.0047 0.0211 0.0178
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0033 0.2089
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0146 0.0499
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0044 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0044 0.0164
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0146 0.0499
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0037 0.1138
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0146 0.0499
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0044 0.0015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0211 0.0178
Echinococcus multilocularis lamin dm0 0.0027 0.0084 0.0051
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0146 0.0499
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0048 0.3135
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0146 0.0499
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0084 0.0323
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0211 0.083
Schistosoma mansoni thyroid hormone receptor 0.002 0.0044 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0289 0.0628
Echinococcus granulosus snurportin 1 0.0301 0.1796 0.2297
Onchocerca volvulus 0.0095 0.0511 0.1776
Brugia malayi Pre-SET motif family protein 0.0415 0.2506 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.2525
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0146 0.0499
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0037 0.015
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0943 0.0913
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0044 0.0164
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0044 0.0164
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0164
Schistosoma mansoni DNA polymerase eta 0.0019 0.0037 0.001
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0033 0.0104
Schistosoma mansoni hypothetical protein 0.0047 0.0211 0.0435
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0044 0.0027
Echinococcus granulosus FTZ F1 alpha 0.002 0.0044 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0199 0.0407
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.412 0.4101
Plasmodium vivax SET domain protein, putative 0.006 0.0289 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0084 0.0323
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0061 0.0203
Plasmodium falciparum importin beta, putative 0.0028 0.0094 1
Echinococcus granulosus GPCR family 2 0.0047 0.0211 0.0232
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0164
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0842 0.3353
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0094 0.2295
Onchocerca volvulus 0.0027 0.0084 0.0283
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0289 0.0257
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0211 0.0232
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0044 0.0164
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.237
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0048 0.0582
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.0943 0.3757
Echinococcus granulosus dna polymerase kappa 0.0019 0.0037 0.0005
Brugia malayi Pre-SET motif family protein 0.006 0.0289 0.1144
Schistosoma mansoni importin beta-1 0.0028 0.0094 0.015
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0199 0.0784
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.2525
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0048 0.3135
Schistosoma mansoni hypothetical protein 0.0047 0.0211 0.0435
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.03 0.0654
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0044 0.0011
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0135
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0044 0.0015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0211 0.0232
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0164
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0842 0.3353
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0164
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0146 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0044 0.0011
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0037 0.0004
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0037 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0044 0.0164
Leishmania major DNA polymerase kappa, putative 0.0019 0.0037 0.1138
Brugia malayi nuclear hormone receptor 0.002 0.0044 0.0164
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0037 0.2525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0044 0.0164
Echinococcus multilocularis musashi 0.0027 0.0084 0.0051
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0044 0.0011
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0037 0.015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.03 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0044 0.0011
Schistosoma mansoni nuclear hormone receptor 0.002 0.0044 0.0027
Schistosoma mansoni lamin 0.0027 0.0084 0.0125
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0044 0.0164
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0048 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.03 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0842 0.3353
Echinococcus granulosus importin subunit beta 1 0.0028 0.0094 0.008
Schistosoma mansoni alpha glucosidase 0.0036 0.0146 0.0276
Schistosoma mansoni hypothetical protein 0.0301 0.1796 0.4314
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.0943 0.1186
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0146 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0146 0.0499
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0044 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0044 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0199 0.0407
Loa Loa (eye worm) hypothetical protein 0.0124 0.0689 0.2741
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.237
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0061 0.4058
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0094 0.6463
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0037 0.237
Loa Loa (eye worm) hypothetical protein 0.0027 0.0084 0.0323
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0007 0.0016
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0044 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.2525
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0037 0.001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0048 0.3275
Schistosoma mansoni ran 0.0021 0.0048 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.2525
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0061 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0044 0.0164
Schistosoma mansoni intermediate filament proteins 0.0027 0.0084 0.0125
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0044 0.0027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0199 0.0217
Echinococcus granulosus Solute carrier family 22 5 0.125 0.7708 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0044 0.0027
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0044 0.0164
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0289 0.0334
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0044 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0289 0.0628
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0033 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.237
Trypanosoma brucei glucosidase, putative 0.0036 0.0146 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0044 0.0164
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0415 0.2506 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.03 1
Brugia malayi hypothetical protein 0.0124 0.0689 0.2741
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 1
Onchocerca volvulus 0.002 0.0044 0.0143
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0061 0.0203
Loa Loa (eye worm) hypothetical protein 0.0028 0.0094 0.0364
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0044 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.2525
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0044 0.0027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0033 0.2089

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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