Detailed information for compound 590427

Basic information

Technical information
  • TDR Targets ID: 590427
  • Name: (2R,3R,4S,5R)-2-[4-[(1R)-1-hydroxyethyl]-5-me thyl-imidazol-1-yl]-5-(hydroxymethyl)tetrahyd rofuran-3,4-diol
  • MW: 258.271 | Formula: C11H18N2O5
  • H donors: 4 H acceptors: 5 LogP: -1.65 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc(c1C)[C@H](O)C
  • InChi: 1S/C11H18N2O5/c1-5-8(6(2)15)12-4-13(5)11-10(17)9(16)7(3-14)18-11/h4,6-7,9-11,14-17H,3H2,1-2H3/t6-,7-,9-,10-,11-/m1/s1
  • InChiKey: VMPSPVJCVIVEIK-JBSYKWBFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4S,5R)-2-[4-[(1R)-1-hydroxyethyl]-5-methyl-1-imidazolyl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-[4-[(1R)-1-hydroxyethyl]-5-methyl-imidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol
  • (2R,3R,4S,5R)-2-[4-[(1R)-1-hydroxyethyl]-5-methyl-imidazol-1-yl]-5-methylol-tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-[4-[(1R)-1-hydroxyethyl]-5-methylimidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol
  • (1-hydroxyethyl)-5-methyl-1-beta-ribofuranosylimidazole
  • (2R,3R,4S,5R)-2-[4-(1-hydroxyethyl)-5-methylimidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol
  • (2R,3R,4S,5R)-2-[4-(1-hydroxyethyl)-5-methyl-imidazol-1-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-[4-(1-hydroxyethyl)-5-methyl-1-imidazolyl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-[4-(1-hydroxyethyl)-5-methyl-imidazol-1-yl]-5-methylol-tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-[4-(1-hydroxyethyl)-5-methyl-imidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol
  • 98483-26-2
  • 1-Hemri

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis high affinity choline transporter 1 0.0359 0.3082 0.3081
Trichomonas vaginalis heat shock protein, putative 0.1121 1 1
Plasmodium vivax DNA topoisomerase II, putative 0.0257 0.2155 0.2154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0257 0.2155 0.2154
Schistosoma mansoni hypothetical protein 0.0175 0.141 0.141
Mycobacterium ulcerans two component regulator - sensor kinase 0.0257 0.2155 0.2785
Echinococcus multilocularis sodium:glucose cotransporter 2 0.004 0.0179 0.0177
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0257 0.2155 0.4905
Brugia malayi Protein kinase domain containing protein 0.0023 0.003 0.0028
Leishmania major heat shock protein 83-1 0.1121 1 1
Schistosoma mansoni endoplasmin 0.1121 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0864 0.7664 0.7663
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0137
Loa Loa (eye worm) AGC/NDR protein kinase 0.0023 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.019 0.1543 0.1542
Echinococcus multilocularis sodium:myo inositol cotransporter 0.004 0.0179 0.0177
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0257 0.2155 0.2154
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0095 0.0684 0.0682
Loa Loa (eye worm) hypothetical protein 0.0183 0.1482 0.148
Schistosoma mansoni topbp1 0.002 0.0002 0.0002
Loa Loa (eye worm) endoplasmin 0.1121 1 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0257 0.2155 0.2154
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0257 0.2155 0.4905
Echinococcus multilocularis heat shock protein 90 0.0864 0.7664 0.7663
Mycobacterium leprae Probable two component sensor kinase MprB 0.0257 0.2155 0.2785
Loa Loa (eye worm) hypothetical protein 0.0151 0.1192 0.1191
Echinococcus granulosus serine:threonine protein kinase N2 0.0023 0.003 0.0028
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0504 0.4392 0.4391
Leishmania major heat shock protein 83-1 0.1121 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0864 0.7664 0.7663
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.1993 0.1991
Echinococcus multilocularis serine:threonine protein kinase N2 0.0023 0.003 0.0028
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.1046 0.9313 0.9313
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0257 0.2155 0.2785
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0095 0.0684 0.0682
Loa Loa (eye worm) hypothetical protein 0.0167 0.1333 0.1331
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.004 0.0179 0.0177
Trypanosoma cruzi heat shock protein 85, putative 0.1121 1 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0257 0.2155 0.2785
Plasmodium vivax heat shock protein 86, putative 0.1121 1 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.1333 0.1331
Schistosoma mansoni endoplasmin 0.1121 1 1
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0257 0.2155 0.2785
Echinococcus granulosus sodium:glucose cotransporter 0.004 0.0179 0.0177
Echinococcus multilocularis protein dispatched 1 0.0049 0.0262 0.026
Chlamydia trachomatis DNA gyrase subunit B 0.0257 0.2155 1
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0257 0.2155 0.2785
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0095 0.0684 0.0682
Leishmania major heat shock protein 83-1 0.1121 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.015 0.0148
Schistosoma mansoni atypical protein kinase C 0.004 0.0179 0.0179
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0023 0.003 0.0028
Brugia malayi hypothetical protein 0.0239 0.1993 0.1991
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0459 0.3984 0.3983
Plasmodium falciparum heat shock protein 90, putative 0.0459 0.3984 0.3983
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0724 0.0722
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.0251 0.025
Entamoeba histolytica protein kinase, putative 0.0023 0.003 0.0028
Leishmania major heat shock protein 83-1 0.1121 1 1
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0257 0.2155 0.2785
Plasmodium falciparum DNA topoisomerase 2 0.0257 0.2155 0.2154
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0095 0.0684 0.0682
Leishmania major heat shock protein 83-1 0.1121 1 1
Echinococcus granulosus protein kinase c iota type 0.004 0.0179 0.0177
Loa Loa (eye worm) hypothetical protein 0.0167 0.1333 0.1331
Trypanosoma brucei heat shock protein 90, putative 0.1121 1 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0257 0.2155 0.2154
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0257 0.2155 0.2785
Loa Loa (eye worm) AGC/AKT protein kinase 0.0023 0.003 0.0028
Brugia malayi kinase, mitochondrial precursor 0.1046 0.9313 0.9313
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.0251 0.025
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0257 0.2155 0.2154
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0257 0.2155 0.2154
Echinococcus granulosus replication factor c subunit 1 0.002 0.0002 0.00000025563
Brugia malayi CHE-14 protein 0.0043 0.0208 0.0206
Mycobacterium ulcerans putative regultory protein 0.0257 0.2155 0.2785
Trypanosoma brucei heat shock protein, putative 0.1121 1 1
Echinococcus multilocularis endoplasmin 0.0872 0.7734 0.7733
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0504 0.4392 0.4391
Schistosoma mansoni high-affinity choline transporter 0.0359 0.3082 0.3082
Entamoeba histolytica heat shock protein 90, putative 0.1121 1 1
Toxoplasma gondii heat shock protein 75, putative 0.0504 0.4392 0.4391
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0248 0.0247
Schistosoma mansoni hypothetical protein 0.0095 0.0684 0.0684
Trichomonas vaginalis receptor histidine kinase, putative 0.0257 0.2155 0.2154
Leishmania major heat shock protein 83-1 0.1121 1 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0023 0.0025 0.0023
Brugia malayi Protein kinase domain containing protein 0.0023 0.003 0.0028
Echinococcus multilocularis heat shock protein 90 0.1121 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.1993 0.1991
Echinococcus granulosus solute carrier family 5 0.004 0.0179 0.0177
Schistosoma mansoni inositol transporter 0.004 0.0179 0.0179
Schistosoma mansoni hypothetical protein 0.0095 0.0684 0.0684
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0041 0.0193 0.0191
Echinococcus multilocularis serine:threonine protein kinase N2 0.0023 0.003 0.0028
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.004 0.0179 0.0177
Entamoeba histolytica hypothetical protein 0.0036 0.015 0.0148
Giardia lamblia Heat shock protein HSP 90-alpha 0.0864 0.7664 0.7663
Loa Loa (eye worm) hypothetical protein 0.0043 0.0208 0.0206
Mycobacterium ulcerans two component sensor kinase MprB 0.0257 0.2155 0.2785
Brugia malayi protein kinase C II. 0.0041 0.0193 0.0191
Brugia malayi Hr1 repeat family protein 0.0023 0.003 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.003 0.003
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0504 0.4392 1
Mycobacterium ulcerans DNA gyrase subunit B 0.0257 0.2155 0.2785
Trypanosoma brucei Heat shock protein 83, putative 0.1121 1 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0549 0.4805 0.4804
Entamoeba histolytica heat shock protein 90, putative 0.1121 1 1
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0257 0.2155 0.2785
Leishmania major heat shock protein 83-1 0.1121 1 1
Trichomonas vaginalis AGC family protein kinase 0.0023 0.003 0.0028
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0095 0.0684 0.0684
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0724 0.0722
Toxoplasma gondii AGC kinase 0.0023 0.003 0.0028
Brugia malayi Probable DNA topoisomerase II 0.0257 0.2155 0.2154
Leishmania major heat shock protein 83-1 0.1121 1 1
Plasmodium vivax DNA gyrase subunit B, putative 0.0257 0.2155 0.2154
Echinococcus multilocularis serine threonine protein kinase 0.0072 0.0476 0.0474
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0248 0.0248
Trypanosoma brucei heat shock protein, putative 0.1121 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.015 0.0148
Brugia malayi Muscleblind-like protein 0.0151 0.1192 0.1191
Trypanosoma cruzi Heat shock protein 83, putative 0.1121 1 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.1046 0.9313 0.9313
Loa Loa (eye worm) hypothetical protein 0.0257 0.2155 0.2154
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0257 0.2155 0.2785
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0872 0.7734 0.7111
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0287 0.0285
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.004 0.0179 0.0177
Brugia malayi Protein kinase c protein 2 0.0066 0.0419 0.0417
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0257 0.2155 0.2154
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0257 0.2155 0.2154
Brugia malayi GH02984p 0.0359 0.3082 0.3081
Echinococcus granulosus heat shock protein 0.1121 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0248 0.0247
Trichomonas vaginalis heat shock protein, putative 0.0864 0.7664 0.7663
Echinococcus granulosus heat shock protein 90 0.1121 1 1
Schistosoma mansoni hypothetical protein 0.0095 0.0684 0.0684
Echinococcus granulosus protein kinase C gamma type 0.0072 0.0476 0.0474
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0257 0.2155 0.2154
Echinococcus granulosus endoplasmin 0.0872 0.7734 0.7733
Leishmania major heat shock protein 83-1 0.1121 1 1
Plasmodium falciparum heat shock protein 90 0.1121 1 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0023 0.003 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0023 0.003 0.0028
Toxoplasma gondii heat shock protein 90, putative 0.1121 1 1
Trichomonas vaginalis sensor histidine kinase, putative 0.0257 0.2155 0.2154
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0023 0.003 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0193 0.0193
Loa Loa (eye worm) heat shock protein 75 0.0504 0.4392 0.4391
Leishmania major heat shock protein 83-1 0.1121 1 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0023 0.003 0.0028
Schistosoma mansoni DNA topoisomerase II 0.0257 0.2155 0.2155
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.003 0.003
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0292 0.2469 0.2467
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0023 0.003 0.0028
Echinococcus granulosus sodium:myo inositol cotransporter 0.004 0.0179 0.0177
Echinococcus granulosus heat shock protein 90 0.0864 0.7664 0.7663
Echinococcus multilocularis protein patched 0.0043 0.0208 0.0206
Schistosoma mansoni hypothetical protein 0.0175 0.141 0.141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0248 0.0248
Trypanosoma cruzi heat shock protein 90, putative 0.067 0.5904 0.5903
Trichomonas vaginalis heat shock protein, putative 0.0451 0.3915 0.3914
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0292 0.2469 0.2467
Echinococcus granulosus muscleblind protein 0.0151 0.1192 0.1191
Echinococcus multilocularis heat shock protein 0.1121 1 1
Entamoeba histolytica DNA topoisomerase II, putative 0.0257 0.2155 0.2154
Trypanosoma brucei DNA topoisomerase ii 0.0257 0.2155 0.2154
Chlamydia trachomatis DNA gyrase subunit B 0.0257 0.2155 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0257 0.2155 0.2154
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0287 0.0285
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0208 0.0206
Treponema pallidum heat shock protein 90 0.0872 0.7734 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.1046 0.9313 0.9124
Trypanosoma cruzi heat shock protein 90, putative 0.1121 1 1
Mycobacterium leprae Probable two-component sensor kinase 0.0257 0.2155 0.2785
Trypanosoma cruzi heat shock protein 85, putative 0.1121 1 1
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0023 0.003 0.0028
Trichomonas vaginalis receptor histidine kinase, putative 0.0257 0.2155 0.2154
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0257 0.2155 0.2154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0248 0.0247
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0177
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0002 0.0002
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0257 0.2155 0.2154
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0023 0.003 0.0028
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.005 0.027 0.0268
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0864 0.7664 0.7663
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0263 0.0261
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.015 0.0148
Brugia malayi Sodium:solute symporter family protein 0.004 0.0179 0.0177
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0738 0.0738
Brugia malayi hypothetical protein 0.0036 0.015 0.0148
Schistosoma mansoni inositol transporter 0.004 0.0179 0.0179
Trichomonas vaginalis AGC family protein kinase 0.0023 0.003 0.0028
Schistosoma mansoni sodium/solute symporter 0.004 0.0179 0.0179
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0257 0.2155 0.2785
Loa Loa (eye worm) hypothetical protein 0.0052 0.0295 0.0293
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0002 0.00000025563
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0257 0.2155 0.4905
Plasmodium vivax hypothetical protein, conserved 0.0257 0.2155 0.2154
Plasmodium falciparum heat shock protein 90, putative 0.0496 0.4322 0.4321
Loa Loa (eye worm) hypothetical protein 0.1046 0.9313 0.9313
Trypanosoma brucei heat shock protein 90, putative 0.1121 1 1
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0257 0.2155 0.2154
Loa Loa (eye worm) hypothetical protein 0.0151 0.1192 0.1191
Trichomonas vaginalis AGC family protein kinase 0.0023 0.003 0.0028
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0257 0.2155 0.2785
Schistosoma mansoni hypothetical protein 0.0041 0.0193 0.0193
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1113 0.1111
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0872 0.7734 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0095 0.0684 0.0682
Loa Loa (eye worm) hypothetical protein 0.0359 0.3082 0.3081
Giardia lamblia Heat shock protein HSP 90-alpha 0.1121 1 1
Trichomonas vaginalis endoplasmin, putative 0.0708 0.6251 0.625
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0292 0.2469 0.2467
Entamoeba histolytica protein kinase, putative 0.0023 0.003 0.0028
Echinococcus multilocularis solute carrier family 5 0.004 0.0179 0.0177
Trichomonas vaginalis heat shock protein, putative 0.0708 0.6251 0.625
Schistosoma mansoni hypothetical protein 0.0041 0.0193 0.0193
Brugia malayi Hsp90 protein 0.0504 0.4392 0.4391
Entamoeba histolytica protein kinase, putative 0.0023 0.003 0.0028
Toxoplasma gondii Hsp90 domain-containing protein 0.0459 0.3984 0.3983
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0002 0.00000025563
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.003 0.003
Loa Loa (eye worm) heat shock protein 90 0.1121 1 1
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0257 0.2155 0.2785
Loa Loa (eye worm) apoptosis regulator protein 0.0095 0.0684 0.0682
Leishmania major heat shock protein 83-1 0.1121 1 1
Loa Loa (eye worm) TOPoisomerase family member 0.0257 0.2155 0.2154
Trichomonas vaginalis AGC family protein kinase 0.0023 0.003 0.0028
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0208 0.0206
Trichomonas vaginalis heat shock protein, putative 0.0872 0.7734 0.7733
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0257 0.2155 0.2154
Leishmania major heat shock protein 83-1 0.1121 1 1
Echinococcus granulosus microtubule associated protein 2 0.0713 0.6297 0.6296
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0139 0.0137
Echinococcus multilocularis serine:threonine protein kinase 38 0.0023 0.003 0.0028
Schistosoma mansoni pyruvate dehydrogenase 0.0788 0.6977 0.6977
Echinococcus multilocularis geminin 0.0175 0.141 0.1408
Trichomonas vaginalis AGC family protein kinase 0.0023 0.003 0.0028
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0257 0.2155 0.2154
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0023 0.003 0.0028
Trypanosoma cruzi heat shock protein, putative 0.0504 0.4392 0.4391
Schistosoma mansoni survival motor neuron protein 0.0049 0.0263 0.0263
Echinococcus multilocularis protein kinase c iota type 0.004 0.0179 0.0177
Leishmania major heat shock protein 83-1 0.1121 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0713 0.6297 0.6297
Trichomonas vaginalis heat shock protein, putative 0.0872 0.7734 0.7733
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0002 0.00000025563
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0023 0.003 0.0028
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0208 0.0206
Giardia lamblia Pms1-like protein 0.0257 0.2155 0.2154
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0257 0.2155 0.2154
Schistosoma mansoni heat shock protein 0.1121 1 1
Trichomonas vaginalis AGC family protein kinase 0.0023 0.003 0.0028
Entamoeba histolytica protein kinase, putative 0.0023 0.003 0.0028
Onchocerca volvulus 0.004 0.0179 0.0403
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0872 0.7734 1
Trichomonas vaginalis AGC family protein kinase 0.0023 0.003 0.0028
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0002 0.00000025563
Schistosoma mansoni heat shock protein 0.1121 1 1
Schistosoma mansoni heat shock protein 0.0504 0.4392 0.4392
Loa Loa (eye worm) hypothetical protein 0.0048 0.0251 0.025
Plasmodium vivax endoplasmin, putative 0.1121 1 1
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0002 0.00000025563
Echinococcus granulosus Protein kinase C brain isozyme 0.0089 0.0625 0.0623
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.0251 0.025
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0257 0.2155 0.2154
Brugia malayi p70 ribosomal S6 kinase beta 0.0023 0.003 0.0028
Entamoeba histolytica hypothetical protein 0.0036 0.015 0.0148
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0257 0.2155 0.2785
Echinococcus granulosus NDR protein kinase 0.0023 0.003 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0023 0.003 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0023 0.003 0.0028
Echinococcus granulosus sodium:glucose cotransporter 2 0.004 0.0179 0.0177
Schistosoma mansoni patched 1 0.0043 0.0208 0.0208
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0248 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0208 0.0206
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0257 0.2155 0.2154
Giardia lamblia Grp94/Hsp90 0.0872 0.7734 0.7733
Onchocerca volvulus 0.0167 0.1333 0.3031
Trypanosoma brucei heat shock protein, putative 0.1121 1 1
Echinococcus granulosus high affinity choline transporter 1 0.0359 0.3082 0.3081
Trypanosoma brucei heat shock protein, putative 0.1121 1 1
Trypanosoma brucei heat shock protein, putative 0.1121 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0287 0.0285
Leishmania major heat shock protein 83-1 0.1121 1 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0872 0.7734 1
Schistosoma mansoni pyruvate dehydrogenase 0.1046 0.9313 0.9313
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0625 0.0625
Schistosoma mansoni hypothetical protein 0.0049 0.0263 0.0263
Schistosoma mansoni apoptosis regulator bax 0.0095 0.0684 0.0684
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0257 0.2155 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0023 0.003 0.0028
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0287 0.0285
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.1046 0.9313 0.9313
Toxoplasma gondii DNA topoisomerase 2, putative 0.0257 0.2155 0.2154
Brugia malayi heat shock protein 90 0.1121 1 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0089 0.0625 0.0623
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0248 0.0247
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0023 0.003 0.0028
Leishmania major heat shock protein, putative 0.0504 0.4392 0.2851
Trypanosoma brucei developmentally regulated phosphoprotein 0.1046 0.9313 0.9313
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.003 0.003
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.1046 0.9313 0.9313
Loa Loa (eye worm) hypothetical protein 0.0064 0.0401 0.0399
Echinococcus multilocularis expressed conserved protein 0.0094 0.0669 0.0667
Schistosoma mansoni serine/threonine kinase 0.0023 0.003 0.003
Leishmania major heat shock protein 83-1 0.1121 1 1
Brugia malayi Protein kinase domain containing protein 0.0023 0.003 0.0028
Schistosoma mansoni hypothetical protein 0.0041 0.0193 0.0193
Trypanosoma brucei heat shock protein, putative 0.1121 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.1121 1 1
Schistosoma mansoni topbp1 0.002 0.0002 0.0002
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0724 0.0722
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0821 0.7274 0.7274
Mycobacterium ulcerans heat shock protein 90 0.0872 0.7734 1
Onchocerca volvulus 0.0049 0.0263 0.0593
Loa Loa (eye worm) hypothetical protein 0.0239 0.1993 0.1991
Trichomonas vaginalis DNA topoisomerase II, putative 0.0257 0.2155 0.2154
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0257 0.2155 0.2785
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0257 0.2155 0.2154
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0257 0.2155 0.2154
Echinococcus granulosus expressed conserved protein 0.0094 0.0669 0.0667
Plasmodium vivax heat shock protein 90, putative 0.0504 0.4392 0.4391
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0625 0.0625
Loa Loa (eye worm) hypothetical protein 0.01 0.0724 0.0722
Trypanosoma brucei heat shock protein 84, putative 0.0504 0.4392 0.4391
Trypanosoma brucei heat shock protein, putative 0.1121 1 1
Leishmania major heat shock protein 83-1 0.1121 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.015 0.015
Echinococcus multilocularis muscleblind protein 1 0.0151 0.1192 0.1191
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0248 0.0247
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0002 0.00000025563
Schistosoma mansoni pyruvate dehydrogenase 0.0788 0.6977 0.6977
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1113 0.1111
Plasmodium vivax heat shock protein, putative 0.0459 0.3984 0.3983
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0257 0.2155 0.2785
Loa Loa (eye worm) AGC/PKN protein kinase 0.0023 0.003 0.0028
Trypanosoma brucei heat shock protein, putative 0.1121 1 1
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0724 0.0722
Trichomonas vaginalis AGC family protein kinase 0.0023 0.003 0.0028
Echinococcus granulosus geminin 0.0175 0.141 0.1408
Echinococcus granulosus protein kinase c epsilon type 0.0041 0.0193 0.0191
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0257 0.2155 0.2154
Leishmania major heat shock protein 83-1 0.1121 1 1
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0292 0.2469 0.04
Loa Loa (eye worm) hypothetical protein 0.0095 0.0684 0.0682
Echinococcus multilocularis protein kinase c epsilon type 0.0041 0.0193 0.0191
Schistosoma mansoni hypothetical protein 0.0035 0.0139 0.0139
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0208 0.0206
Echinococcus multilocularis muscleblind protein 0.0151 0.1192 0.1191
Schistosoma mansoni hypothetical protein 0.0041 0.0193 0.0193
Echinococcus multilocularis microtubule associated protein 2 0.0713 0.6297 0.6296
Plasmodium falciparum endoplasmin, putative 0.0708 0.6251 0.625
Plasmodium falciparum DNA gyrase subunit B 0.0257 0.2155 0.2154
Toxoplasma gondii heat shock protein HSP90 0.1121 1 1
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0257 0.2155 0.2785
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.015 0.015
Schistosoma mansoni DNA ligase IV 0.002 0.0002 0.0002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.015 0.0148

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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