Detailed information for compound 594720

Basic information

Technical information
  • TDR Targets ID: 594720
  • Name: N-(5-chloro-2-methoxyphenyl)-2-[1-(2,4-dimeth oxyphenyl)imidazol-2-yl]sulfanylacetamide
  • MW: 433.909 | Formula: C20H20ClN3O4S
  • H donors: 1 H acceptors: 2 LogP: 3.96 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)OC)n1ccnc1SCC(=O)Nc1cc(Cl)ccc1OC
  • InChi: 1S/C20H20ClN3O4S/c1-26-14-5-6-16(18(11-14)28-3)24-9-8-22-20(24)29-12-19(25)23-15-10-13(21)4-7-17(15)27-2/h4-11H,12H2,1-3H3,(H,23,25)
  • InChiKey: OYQIGTYBGVMOTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-chloro-2-methoxy-phenyl)-2-[1-(2,4-dimethoxyphenyl)imidazol-2-yl]sulfanyl-acetamide
  • N-(5-chloro-2-methoxyphenyl)-2-[[1-(2,4-dimethoxyphenyl)-2-imidazolyl]thio]acetamide
  • N-(5-chloro-2-methoxy-phenyl)-2-[[1-(2,4-dimethoxyphenyl)imidazol-2-yl]thio]acetamide
  • N-(5-chloro-2-methoxy-phenyl)-2-[1-(2,4-dimethoxyphenyl)imidazol-2-yl]sulfanyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ankyrin repeat protein 0.016 0.2202 0.2202
Echinococcus granulosus RUN 0.0019 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0373 0.0412
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0031 0.0031
Trichomonas vaginalis esterase, putative 0.0039 0.0373 0.1049
Trichomonas vaginalis set domain proteins, putative 0.0232 0.3294 1
Schistosoma mansoni lipoxygenase 0.0054 0.0606 0.0576
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.023 0.023
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1385 0.3876
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.023 0.2781
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0406 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0031 0.0031
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0031 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.023 0.02
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0373 0.1049
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0606 0.0606
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0488 0.1309
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0695 0.926
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.008 0.008
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0031 0.0028
Plasmodium falciparum glutathione reductase 0.0046 0.0488 1
Schistosoma mansoni rab6-interacting 0.0019 0.008 0.0049
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0748 1
Echinococcus multilocularis musashi 0.0029 0.0227 0.0227
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0462 0.9422
Loa Loa (eye worm) hypothetical protein 0.0039 0.0373 0.0412
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0198 0.3648
Mycobacterium ulcerans hypothetical protein 0.0039 0.0373 0.4774
Echinococcus granulosus lamin dm0 0.0029 0.0227 0.0227
Toxoplasma gondii ABC1 family protein 0.0039 0.0373 0.4774
Toxoplasma gondii kinesin motor domain-containing protein 0.0026 0.0183 0.2114
Brugia malayi Pre-SET motif family protein 0.0029 0.023 0.0728
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0748 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0488 0.0539
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0227 0.025
Leishmania major hypothetical protein, conserved 0.0039 0.0373 0.4774
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0462 0.132
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0373 0.1049
Echinococcus multilocularis lamin 0.0029 0.0227 0.0227
Schistosoma mansoni loxhd1 0.0019 0.008 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0576 0.1943
Brugia malayi intermediate filament protein 0.0029 0.0227 0.0715
Plasmodium vivax kinesin-5 0.0026 0.0183 0.3314
Plasmodium falciparum thioredoxin reductase 0.0046 0.0488 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0373 0.098
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0695 0.0666
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.023 0.023
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.016 0.2202 0.2178
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.008 0.1078
Loa Loa (eye worm) hypothetical protein 0.0039 0.0373 0.0412
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0198 0.3648
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0038 0.0038
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1385 0.3876
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1385 0.3876
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0373 0.0373
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0007
Loa Loa (eye worm) hypothetical protein 0.0039 0.0373 0.0412
Echinococcus granulosus transient receptor potential cation channel 0.0164 0.2276 0.2276
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1563 0.4386
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0373 0.123
Onchocerca volvulus 0.0039 0.0373 0.091
Loa Loa (eye worm) kinesin-like protein KLP2 0.0026 0.0183 0.0202
Loa Loa (eye worm) doublecortin family protein 0.0019 0.008 0.0089
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0406 0.8195
Mycobacterium ulcerans lipase LipD 0.0039 0.0373 0.4774
Schistosoma mansoni hypothetical protein 0.0174 0.2427 0.2404
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0373 0.7482
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0488 0.0488
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0373 0.7482
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0254
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0007
Echinococcus multilocularis RUN 0.0019 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0019 0.008 0.0049
Leishmania major trypanothione reductase 0.0046 0.0488 0.638
Plasmodium falciparum kinesin-5 0.0026 0.0183 0.3314
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.008 0.008
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0023 0.0026
Echinococcus granulosus intermediate filament protein 0.0029 0.0227 0.0227
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.058 0.064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0373 0.0343
Schistosoma mansoni rab6-interacting 0.0019 0.008 0.0049
Brugia malayi Doublecortin family protein 0.0019 0.008 0.0201
Echinococcus multilocularis kinesin family 1 0.02 0.2821 0.2821
Schistosoma mansoni hypothetical protein 0.0036 0.0327 0.0297
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0373 0.1049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.023 0.02
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0373 0.098
Echinococcus granulosus lamin 0.0029 0.0227 0.0227
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0373 0.7482
Loa Loa (eye worm) hypothetical protein 0.0029 0.0227 0.025
Brugia malayi beta-lactamase family protein 0.0039 0.0373 0.123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0748 1
Brugia malayi beta-lactamase family protein 0.0039 0.0373 0.123
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0042
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0198 0.3648
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1385 0.8503
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.023 0.02
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0462 0.6011
Mycobacterium tuberculosis Conserved protein 0.0039 0.0373 0.098
Loa Loa (eye worm) beta-lactamase 0.0039 0.0373 0.0412
Brugia malayi hypothetical protein 0.0019 0.008 0.0201
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0373 0.098
Echinococcus multilocularis transient receptor potential cation channel 0.0165 0.228 0.228
Schistosoma mansoni kinesin eg-5 0.0026 0.0183 0.0152
Brugia malayi hypothetical protein 0.0027 0.0198 0.0614
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0748 0.0719
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0373 0.7482
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0695 0.0695
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0241
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0214 0.0214
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1563 0.4386
Schistosoma mansoni polycystin 1-related 0.0019 0.008 0.0049
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0373 0.0373
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0089
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0089
Leishmania major hypothetical protein, conserved 0.0027 0.0198 0.2327
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0373 0.098
Mycobacterium tuberculosis Conserved protein 0.0039 0.0373 0.098
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0031 0.5
Schistosoma mansoni lipoxygenase 0.0019 0.008 0.0049
Schistosoma mansoni lamin 0.0029 0.0227 0.0196
Mycobacterium ulcerans beta-lactamase 0.0039 0.0373 0.4774
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.2078 0.7222
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0462 0.132
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0695 0.236
Loa Loa (eye worm) hypothetical protein 0.0036 0.0327 0.0361
Onchocerca volvulus 0.0029 0.0227 0.0454
Brugia malayi hypothetical protein 0.0017 0.0053 0.0104
Echinococcus granulosus kinesin family 1 0.02 0.2821 0.2821
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1385 0.3876
Loa Loa (eye worm) acetyltransferase 0.0151 0.2078 0.2292
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0198 0.2327
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.3523 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0748 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0695 0.19
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0373 0.0412
Brugia malayi hypothetical protein 0.0019 0.008 0.0201
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0373 0.1049
Toxoplasma gondii thioredoxin reductase 0.0046 0.0488 0.638
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.023 0.02
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0576 0.0636
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1385 0.3876
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0198 0.3648
Brugia malayi beta-lactamase 0.0039 0.0373 0.123
Loa Loa (eye worm) hypothetical protein 0.0613 0.9065 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0373 0.4774
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1563 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0748 0.0748
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0695 0.0695
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2868 0.3164
Schistosoma mansoni microtubule-associated protein tau 0.0675 1 1
Loa Loa (eye worm) hypothetical protein 0.0613 0.9065 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0488 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0198 0.3648
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0031 0.5
Echinococcus granulosus GPCR family 2 0.0016 0.0038 0.0038
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0373 0.098
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.023 0.023
Onchocerca volvulus 0.0029 0.0227 0.0454
Mycobacterium tuberculosis Conserved protein 0.0039 0.0373 0.098
Brugia malayi Pre-SET motif family protein 0.0204 0.2868 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0373 0.0412
Treponema pallidum NADH oxidase 0.0016 0.0031 0.5
Echinococcus granulosus ankyrin repeat protein 0.016 0.2202 0.2202
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0198 0.3648
Brugia malayi glutathione reductase 0.0046 0.0488 0.1635
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0038 0.0051
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0462 0.6011
Onchocerca volvulus 0.0039 0.0373 0.091
Schistosoma mansoni lamin 0.0029 0.0227 0.0196
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.008 0.1078
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0327 0.1067
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0373 0.1049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0373 0.0343
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0748 0.2052
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0373 0.098
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0373 0.098
Brugia malayi Kinesin motor domain containing protein 0.0026 0.0183 0.056
Mycobacterium tuberculosis Probable reductase 0.0106 0.1385 0.3876
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0406 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0748 0.0719
Loa Loa (eye worm) hypothetical protein 0.0039 0.0373 0.0412
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0462 0.0462
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.008 0.008
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.008 0.008
Loa Loa (eye worm) glutathione reductase 0.0046 0.0488 0.0539
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0695 0.926
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1563 0.4386
Brugia malayi Thioredoxin reductase 0.0046 0.0488 0.1635
Loa Loa (eye worm) hypothetical protein 0.0027 0.0198 0.0218
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0695 0.926
Echinococcus multilocularis GPCR, family 2 0.0016 0.0038 0.0038
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.2078 0.2053
Plasmodium vivax SET domain protein, putative 0.0029 0.023 0.4358
Loa Loa (eye worm) hypothetical protein 0.0052 0.0576 0.0636
Schistosoma mansoni intermediate filament proteins 0.0029 0.0227 0.0196
Echinococcus multilocularis microtubule associated protein 2 0.0675 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0748 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0038 0.0051
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0488 0.0488
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.2014 0.2014
Echinococcus multilocularis lamin dm0 0.0029 0.0227 0.0227
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0038 0.0042
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.2078 0.2078
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0748 0.0748
Onchocerca volvulus 0.0029 0.023 0.0466
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0373 0.4774
Onchocerca volvulus 0.0232 0.3298 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0227 0.0715
Giardia lamblia Kinesin-5 0.0026 0.0183 0.4044
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0227 0.025
Onchocerca volvulus 0.0039 0.0373 0.091
Plasmodium vivax glutathione reductase, putative 0.0046 0.0488 1
Trypanosoma brucei trypanothione reductase 0.0046 0.0488 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0488 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0038 0.0038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0576 0.1943

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -0.3 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 2.64 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4.9 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 92 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 96 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 2.74 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -8 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = -3 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 92 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 96 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.13 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.73366 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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