Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.033 | 0.1667 | 0.1667 |
Echinococcus granulosus | serotonin transporter | 0.1943 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.033 | 0.1667 | 0.1667 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.033 | 0.1667 | 0.1667 |
Echinococcus multilocularis | voltage gated potassium channel | 0.001 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0772 | 0.3951 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.1943 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.001 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.3857 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.0234 | 0.0234 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0052 | 0.0234 | 0.5 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.033 | 0.1667 | 0.1667 |
Onchocerca volvulus | 0.033 | 0.1667 | 0.1468 | |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.033 | 0.1667 | 0.1667 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0772 | 0.3951 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.1943 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0052 | 0.0234 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0772 | 0.3951 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.3857 |
Onchocerca volvulus | 0.033 | 0.1667 | 0.1468 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.0148 | 0.0148 |
Trypanosoma brucei | pteridine reductase 1 | 0.0052 | 0.0234 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.033 | 0.1667 | 0.1667 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0772 | 0.3951 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.0148 | 0.0148 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.033 | 0.1667 | 0.1667 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.0148 | 0.0148 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.001 | 0.0017 | 0.0017 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0052 | 0.0234 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0052 | 0.0234 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | serotonin transporter b | 0.1943 | 1 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.033 | 0.1667 | 0.1667 |
Brugia malayi | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.033 | 0.1667 | 0.1667 |
Leishmania major | oxidoreductase-like protein | 0.0052 | 0.0234 | 0.5 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Loa Loa (eye worm) | oxidoreductase | 0.0052 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.0148 | 0.0148 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0234 | 0.0234 |
Toxoplasma gondii | hypothetical protein | 0.033 | 0.1667 | 0.3857 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.033 | 0.1667 | 0.1667 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0052 | 0.0234 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1943 | 1 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0052 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0123 | 0.0123 |
Plasmodium falciparum | amino acid transporter, putative | 0.033 | 0.1667 | 0.3857 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.033 | 0.1667 | 0.1667 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0052 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.1943 | 1 | 1 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.033 | 0.1667 | 0.1667 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | dihydropteridine reductase | 0.0052 | 0.0234 | 0.0234 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0052 | 0.0234 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Echinococcus granulosus | voltage gated potassium channel | 0.001 | 0.0017 | 0.0017 |
Onchocerca volvulus | 0.1943 | 1 | 1 | |
Toxoplasma gondii | hypothetical protein | 0.033 | 0.1667 | 0.3857 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.1943 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.1943 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.033 | 0.1667 | 0.1667 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0052 | 0.0234 | 0.0234 |
Plasmodium falciparum | transporter, putative | 0.033 | 0.1667 | 0.3857 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.001 | 0.0017 | 0.0017 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0772 | 0.3951 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.1943 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0772 | 0.3951 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.001 | 0.0017 | 0.0017 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Plasmodium vivax | amine transporter, putative | 0.033 | 0.1667 | 0.3857 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0772 | 0.3951 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0033 | 0.0136 | 0.0343 |
Onchocerca volvulus | 0.033 | 0.1667 | 0.1468 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0033 | 0.0136 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.1943 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0165 | 0.0165 |
Plasmodium vivax | hypothetical protein, conserved | 0.033 | 0.1667 | 0.3857 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.033 | 0.1667 | 0.3857 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0052 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0017 | 0.0017 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0052 | 0.0234 | 0.0234 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.3857 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.033 | 0.1667 | 0.1667 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0052 | 0.0234 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0052 | 0.0234 | 0.0234 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0772 | 0.3951 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0052 | 0.0234 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.1943 | 1 | 0.5 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.033 | 0.1667 | 0.1667 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0052 | 0.0234 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0772 | 0.3951 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.001 | 0.0017 | 0.0017 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0052 | 0.0234 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.000000005 M | Inhibition of NADH dehydrogenase in blowfly flight-muscle submitochondrial preparation | ChEMBL. | No reference |
Relative activity (binding) | = 30 % | Relative activity against blowfly flight muscle submitochondrial NADH dehydrogenase compared to rotenone | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.