Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0145 | 0.1891 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0232 | 0.0533 |
Plasmodium vivax | cytochrome b | 0.0312 | 0.3861 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.006 | 0.0043 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0007 | 0.0024 | 0.0028 |
Onchocerca volvulus | 0.0023 | 0.0232 | 1 | |
Trypanosoma brucei | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0312 | 0.3861 | 0.5 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.006 | 0.0037 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0096 | 0.1049 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0007 | 0.0024 | 0.003 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0157 | 0.2061 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0007 | 0.0024 | 0.0032 |
Trypanosoma cruzi | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.001 | 0.006 | 0.0127 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0232 | 0.3115 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0462 | 0.109 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.0024 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0232 | 0.0533 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.1178 | 0.1386 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.0024 | 0.017 |
Onchocerca volvulus | 0.0007 | 0.0024 | 0.0559 | |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0157 | 0.0379 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.0235 | 0.0542 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.0024 | 0.017 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0466 | 0.6379 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0145 | 0.1891 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0097 | 0.1159 | 0.2778 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1437 | 0.345 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0232 | 1 |
Plasmodium falciparum | cytochrome b | 0.0312 | 0.3861 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0232 | 0.3115 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.006 | 0.0156 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0232 | 1 |
Echinococcus granulosus | cytochrome B | 0.0312 | 0.3861 | 0.4527 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0232 | 0.0533 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0232 | 0.1998 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0462 | 0.0517 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.0024 | 0.017 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0462 | 0.6312 |
Toxoplasma gondii | patched family protein | 0.0006 | 0.0011 | 0.003 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0235 | 0.3049 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.006 | 0.0037 |
Schistosoma mansoni | cytochrome b | 0.0312 | 0.3861 | 0.4542 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.0466 | 0.1182 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0145 | 0.1891 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0157 | 0.6421 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0097 | 0.1159 | 0.1138 |
Toxoplasma gondii | patched family protein | 0.0006 | 0.0011 | 0.003 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0007 | 0.0024 | 0.003 |
Toxoplasma gondii | patched family protein | 0.0006 | 0.0011 | 0.003 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase | 0.0062 | 0.0717 | 0.0844 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.0235 | 0.025 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.006 | 0.0156 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0024 | 0.017 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0157 | 0.0379 |
Onchocerca volvulus | 0.0007 | 0.0024 | 0.0559 | |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0232 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.0235 | 0.3049 |
Trichomonas vaginalis | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 1 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0024 | 0.017 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0024 | 0.017 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0232 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0232 | 1 |
Schistosoma mansoni | cytochrome b | 0.0312 | 0.3861 | 0.4542 |
Brugia malayi | Pre-B cell enhancing factor precursor | 0.0334 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0232 | 0.0533 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0024 | 0.017 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.0466 | 0.1208 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0232 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0091 | 0.1085 | 0.1252 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0007 | 0.0024 | 0.003 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0145 | 0.1891 |
Onchocerca volvulus | 0.0007 | 0.0024 | 0.0559 | |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0462 | 0.0543 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0466 | 0.6379 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.0235 | 0.0212 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.006 | 0.0043 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.006 | 0.0118 |
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | 0.0334 | 0.4143 | 0.4129 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0007 | 0.0024 | 0.0061 |
Onchocerca volvulus | 0.0007 | 0.0024 | 0.0559 | |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0096 | 0.1049 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0443 | 0.0521 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0462 | 0.0439 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0443 | 0.0521 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0462 | 0.109 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0443 | 0.0521 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0536 | 0.0513 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.0422 | 0.3642 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0139 | 0.1683 | 0.1664 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Loa Loa (eye worm) | acetyltransferase | 0.0143 | 0.1736 | 0.4174 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.058 | 0.1375 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0462 | 0.0439 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0681 | 0.8501 | 1 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0007 | 0.0024 | 0.0061 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.0422 | 0.1067 |
Entamoeba histolytica | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 0.619 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0024 | 0.017 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0143 | 0.1736 | 0.1716 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0143 | 0.1736 | 0.2042 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB2 | 0.0062 | 0.0717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0157 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1159 | 0.2778 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0232 | 0.1998 |
Treponema pallidum | nicotinate phosphoribosyltransferase | 0.0062 | 0.0717 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0232 | 0.2996 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.0235 | 0.0542 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.0422 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0232 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0013 | 0.0096 | 0.1049 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.006 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0096 | 0.0832 |
Echinococcus multilocularis | expressed conserved protein | 0.0091 | 0.1085 | 0.1064 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0681 | 0.8501 | 1 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | 0.0334 | 0.4143 | 0.486 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0007 | 0.0024 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0462 | 0.109 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0334 | 0.4143 | 0.4874 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0016 | 0.0139 | 0.0331 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0007 | 0.0024 | 0.0205 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.006 | 0.0071 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0096 | 0.1049 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0173 | 0.0203 |
Toxoplasma gondii | apocytochrome b, putative | 0.0312 | 0.3861 | 1 |
Loa Loa (eye worm) | cytochrome b | 0.0312 | 0.3861 | 0.9317 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0024 | 0.003 |
Loa Loa (eye worm) | pre-B cell enhancing factor | 0.0334 | 0.4143 | 1 |
Plasmodium falciparum | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 0.1834 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB1 | 0.0062 | 0.0717 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0232 | 0.2996 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0443 | 0.0521 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0199 | 0.0487 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.0466 | 0.1208 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0024 | 0.003 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0232 | 0.1998 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0097 | 0.1159 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0006 | 0.0011 | 0.003 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0232 | 0.2996 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0062 | 0.0717 | 0.0844 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0139 | 0.1685 | 0.196 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0681 | 0.8501 | 0.8497 |
Leishmania major | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0143 | 0.1736 | 0.4174 |
Toxoplasma gondii | propionate-CoA ligase | 0.0007 | 0.0024 | 0.0061 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0232 | 0.0533 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.006 | 0.0118 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0466 | 0.0522 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.006 | 0.0118 |
Toxoplasma gondii | cytochrome b | 0.0312 | 0.3861 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0097 | 0.1159 | 0.1339 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Brugia malayi | cytochrome b | 0.0312 | 0.3861 | 0.9317 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.0024 | 0.017 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.0024 | 0.017 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0462 | 0.0517 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0139 | 0.1683 | 0.1958 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0232 | 0.0533 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.006 | 0.0118 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0136 | 0.0353 |
Toxoplasma gondii | patched family protein | 0.0006 | 0.0011 | 0.003 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 6.06 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 6.32 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 10.69 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 19 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 77 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 20 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 19 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 77 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 100 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.18 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.65554 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.