Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0933 | 0.1005 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0439 | 0.0472 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4605 | 0.4958 |
Echinococcus granulosus | lamin | 0.0027 | 0.2173 | 0.2583 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.8046 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.2173 | 0.2583 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.2173 | 0.234 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.1647 | 0.1647 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.2173 | 0.2173 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.2173 | 0.2173 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.7449 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0757 | 0.0592 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.0044 | 0.5 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.0044 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0336 | 0.0362 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3485 | 0.4427 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.2173 | 0.2583 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0933 | 0.1112 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2173 | 0.234 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.2173 | 0.234 |
Schistosoma mansoni | lamin | 0.0027 | 0.2173 | 0.2661 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.0044 | 0.5 |
Echinococcus multilocularis | musashi | 0.0027 | 0.2173 | 0.2583 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.2173 | 0.2583 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0336 | 0.0366 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.7449 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.2173 | 0.2661 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0336 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.3891 | 0.419 |
Onchocerca volvulus | 0.0027 | 0.2173 | 0.5 | |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0336 | 0.0366 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.1252 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4286 | 0.4615 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.9287 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3485 | 0.4427 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.1252 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2088 | 0.2248 |
Onchocerca volvulus | 0.0027 | 0.2173 | 0.5 | |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0336 | 0.0366 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.388 | 0.388 |
Schistosoma mansoni | lamin | 0.0027 | 0.2173 | 0.2661 |
Trypanosoma brucei | ISWI complex protein | 0.0015 | 0.0044 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.2173 | 0.2583 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.1252 | 0.151 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0757 | 0.0891 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0757 | 0.0592 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1.53 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.09 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.53 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 48 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 59 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 96 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 9.52 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -5 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 48 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 59 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 96 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.12 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.75494 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.