Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.033 | 0.1667 | 0.3857 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.0148 | 0.0148 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Loa Loa (eye worm) | oxidoreductase | 0.0052 | 0.0234 | 0.0234 |
Leishmania major | oxidoreductase-like protein | 0.0052 | 0.0234 | 0.5 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.033 | 0.1667 | 0.1667 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.033 | 0.1667 | 0.1667 |
Brugia malayi | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | serotonin transporter b | 0.1943 | 1 | 1 |
Leishmania major | pteridine reductase 1 | 0.0052 | 0.0234 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0052 | 0.0234 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.001 | 0.0017 | 0.0017 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.0148 | 0.0148 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.033 | 0.1667 | 0.1667 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0772 | 0.3951 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.0148 | 0.0148 |
Trypanosoma brucei | pteridine reductase 1 | 0.0052 | 0.0234 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.033 | 0.1667 | 0.1667 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.0148 | 0.0148 |
Onchocerca volvulus | 0.033 | 0.1667 | 0.1468 | |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.3857 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0772 | 0.3951 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0052 | 0.0234 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.1943 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0772 | 0.3951 | 1 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.033 | 0.1667 | 0.1667 |
Onchocerca volvulus | 0.033 | 0.1667 | 0.1468 | |
Trypanosoma brucei | oxidoreductase-like protein | 0.0052 | 0.0234 | 0.5 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.3857 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.1667 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.001 | 0.0017 | 0.0017 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.1943 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.1667 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0772 | 0.3951 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Echinococcus multilocularis | voltage gated potassium channel | 0.001 | 0.0017 | 0.0017 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.033 | 0.1667 | 0.1667 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Echinococcus granulosus | serotonin transporter | 0.1943 | 1 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.033 | 0.1667 | 0.1667 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0052 | 0.0234 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0772 | 0.3951 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0052 | 0.0234 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.001 | 0.0017 | 0.0017 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.1943 | 1 | 0.5 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0052 | 0.0234 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0772 | 0.3951 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0052 | 0.0234 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0052 | 0.0234 | 0.0234 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.033 | 0.1667 | 0.1667 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0052 | 0.0234 | 0.0234 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.3857 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0017 | 0.0017 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0052 | 0.0234 | 0.0234 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.033 | 0.1667 | 0.3857 |
Plasmodium vivax | hypothetical protein, conserved | 0.033 | 0.1667 | 0.3857 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.1943 | 1 | 1 |
Onchocerca volvulus | 0.033 | 0.1667 | 0.1468 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0033 | 0.0136 | 0.0343 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0033 | 0.0136 | 0.0343 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0772 | 0.3951 | 1 |
Plasmodium vivax | amine transporter, putative | 0.033 | 0.1667 | 0.3857 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | voltage-gated potassium channel | 0.001 | 0.0017 | 0.0017 |
Trichomonas vaginalis | hypothetical protein | 0.0772 | 0.3951 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0772 | 0.3951 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.001 | 0.0017 | 0.0017 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.1943 | 1 | 1 |
Plasmodium falciparum | transporter, putative | 0.033 | 0.1667 | 0.3857 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0052 | 0.0234 | 0.0234 |
Echinococcus multilocularis | serotonin transporter | 0.1943 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.033 | 0.1667 | 0.1667 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.1943 | 1 | 1 |
Onchocerca volvulus | 0.1943 | 1 | 1 | |
Toxoplasma gondii | hypothetical protein | 0.033 | 0.1667 | 0.3857 |
Echinococcus granulosus | voltage gated potassium channel | 0.001 | 0.0017 | 0.0017 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0052 | 0.0234 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | dihydropteridine reductase | 0.0052 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.1943 | 1 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0052 | 0.0234 | 0.0234 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.033 | 0.1667 | 0.1667 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.1667 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.033 | 0.1667 | 0.1667 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1667 | 0.1667 |
Plasmodium falciparum | amino acid transporter, putative | 0.033 | 0.1667 | 0.3857 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0123 | 0.0123 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0052 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.033 | 0.1667 | 0.1667 |
Loa Loa (eye worm) | hypothetical protein | 0.1943 | 1 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0052 | 0.0234 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.033 | 0.1667 | 0.1667 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.000000002 M | Inhibition of NADH dehydrogenase in blowfly flight-muscle submitochondrial preparation | ChEMBL. | No reference |
Relative activity (binding) | = 75 % | Relative activity against blowfly flight muscle submitochondrial NADH dehydrogenase compared to rotenone | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.