Detailed information for compound 60406

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 472.562 | Formula: C25H24N6O2S
  • H donors: 1 H acceptors: 4 LogP: 3.85 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccc(cc1c1[nH]c(=O)c2c(n1)n(CC)nc2C)c1csc(n1)c1cccnc1
  • InChi: 1S/C25H24N6O2S/c1-4-11-33-20-9-8-16(19-14-34-25(27-19)17-7-6-10-26-13-17)12-18(20)22-28-23-21(24(32)29-22)15(3)30-31(23)5-2/h6-10,12-14H,4-5,11H2,1-3H3,(H,28,29,32)
  • InChiKey: SJCVBERFLJKEBJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Phosphodiesterase 5A Starlite/ChEMBL References
Homo sapiens phosphodiesterase 5A, cGMP-specific Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase Phosphodiesterase 5A   833 aa 691 aa 28.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major methionine aminopeptidase 2, putative 0.2204 1 1
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0274 0.0823 0.0823
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0137 0.0137
Echinococcus granulosus xaa Pro dipeptidase 0.0274 0.0823 0.0614
Entamoeba histolytica methionine aminopeptidase, putative 0.2204 1 1
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0274 0.0823 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0274 0.0823 0.0823
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0274 0.0823 0.0614
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Trypanosoma cruzi aminopeptidase P, putative 0.0274 0.0823 0.0823
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.2204 1 1
Treponema pallidum aminopeptidase P 0.0274 0.0823 0.5
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0274 0.0823 0.0614
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0274 0.0823 0.0614
Echinococcus granulosus FACT complex subunit SPT16 0.0274 0.0823 0.0614
Toxoplasma gondii methionine aminopeptidase 0.0274 0.0823 0.0696
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0274 0.0823 0.0696
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Mycobacterium ulcerans aminopeptidase 0.0274 0.0823 0.5
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0274 0.0823 0.0614
Treponema pallidum methionine aminopeptidase (map) 0.0274 0.0823 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.2204 1 1
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0274 0.0823 0.0614
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0274 0.0823 0.5
Leishmania major transcription factor-like protein 0.0274 0.0823 0.0614
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0147 0.0223 0.0223
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0147 0.0223 0.0223
Schistosoma mansoni peptidase 0.0274 0.0823 0.0614
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0274 0.0823 0.0614
Plasmodium vivax methionine aminopeptidase 2, putative 0.2204 1 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0274 0.0823 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0274 0.0823 0.0823
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0274 0.0823 0.0614
Trypanosoma brucei Metallopeptidase family M24, putative 0.0274 0.0823 0.0614
Toxoplasma gondii methionine aminopeptidase 2, putative 0.2204 1 1
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0274 0.0823 0.5
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0274 0.0823 0.0614
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.2204 1 1
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0274 0.0823 0.0823
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0274 0.0823 0.0823
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0274 0.0823 0.0823
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0274 0.0823 0.0823
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0274 0.0823 0.0823
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0274 0.0823 0.5
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0274 0.0823 0.0823
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0274 0.0823 0.0823
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0274 0.0823 0.0614
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0274 0.0823 0.0823
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0274 0.0823 0.0823
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0274 0.0823 0.0614
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.2204 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0147 0.0223 0.0223
Mycobacterium tuberculosis Dipeptidase PepE 0.0274 0.0823 0.5
Leishmania major hypothetical protein, conserved 0.0274 0.0823 0.0614
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0274 0.0823 0.0823
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0274 0.0823 0.0614
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0223 0.0223
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0274 0.0823 0.0614
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0274 0.0823 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Echinococcus multilocularis methionyl aminopeptidase 2 0.2204 1 1
Chlamydia trachomatis methionine aminopeptidase 0.0274 0.0823 0.5
Mycobacterium ulcerans methionine aminopeptidase 0.0274 0.0823 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0147 0.0223 0.0223
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.2204 1 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0274 0.0823 0.0614
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0274 0.0823 0.0614
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0274 0.0823 0.0614
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0274 0.0823 0.0823
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0147 0.0223 0.0223
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0274 0.0823 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0137 0.0137
Echinococcus granulosus Proliferation associated protein 2G4 0.0274 0.0823 0.0614
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0274 0.0823 0.0614
Trypanosoma cruzi aminopeptidase P1, putative 0.0274 0.0823 0.0823
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0274 0.0823 0.0614
Echinococcus granulosus methionine aminopeptidase type I 0.0274 0.0823 0.0614
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.2204 1 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0274 0.0823 0.0614
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0147 0.0223 0.0223
Toxoplasma gondii creatinase domain-containing protein 0.0274 0.0823 0.0696
Toxoplasma gondii peptidase D, putative 0.0274 0.0823 0.0696
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0274 0.0823 0.0614
Echinococcus multilocularis xaa pro aminopeptidase 0.0274 0.0823 0.0614
Trypanosoma brucei methionine aminopeptidase, putative 0.0274 0.0823 0.0614
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Echinococcus multilocularis FACT complex subunit SPT16 0.0274 0.0823 0.0614
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0274 0.0823 0.0823
Echinococcus granulosus xaa Pro dipeptidase 0.0274 0.0823 0.0614
Echinococcus multilocularis methionine aminopeptidase, type I 0.0274 0.0823 0.0614
Toxoplasma gondii methionine aminopeptidase 0.0274 0.0823 0.0696
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.2204 1 1
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.2204 1 1
Chlamydia trachomatis aminopeptidase P 0.0274 0.0823 0.5
Toxoplasma gondii transcriptional elongation factor FACT140 0.0274 0.0823 0.0696
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0274 0.0823 0.0614
Echinococcus multilocularis xaa Pro dipeptidase 0.0274 0.0823 0.0614
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0147 0.0223 0.0223
Mycobacterium ulcerans dipeptidase 0.0274 0.0823 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0147 0.0223 0.0223
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0274 0.0823 0.0614
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0274 0.0823 0.0614
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0274 0.0823 0.5
Giardia lamblia Methionine aminopeptidase 0.2204 1 1
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0274 0.0823 0.5
Loa Loa (eye worm) initiation factor 2-associated protein 0.2204 1 1
Plasmodium falciparum methionine aminopeptidase 2 0.2204 1 1
Mycobacterium ulcerans dipeptidase PepE 0.0274 0.0823 0.5
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.2204 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0147 0.0223 0.0223
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0147 0.0223 0.0223
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0274 0.0823 0.0823
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0147 0.0223 0.0223
Echinococcus granulosus xaa pro aminopeptidase 0.0274 0.0823 0.0614
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0147 0.0223 0.0223
Echinococcus multilocularis xaa Pro dipeptidase 0.0274 0.0823 0.0614
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0274 0.0823 0.0696
Echinococcus multilocularis Proliferation associated protein 2G4 0.0274 0.0823 0.0614
Trypanosoma brucei methionine aminopeptidase 2, putative 0.2204 1 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0147 0.0223 0.0223
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0274 0.0823 0.0823
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0147 0.0223 0.0223
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0274 0.0823 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0137 0.0137
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0274 0.0823 0.0823
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0274 0.0823 0.5
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0274 0.0823 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0147 0.0223 0.0223
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0274 0.0823 0.0614
Echinococcus granulosus methionyl aminopeptidase 2 0.2204 1 1

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 145 mmHg hr-1 The compound was testred for the area of the change in MABP versus time curve at dose 5 mg/kg (po) in conscious spontaneously hypertensive rat ChEMBL. 8648603
EC50 (functional) < 0.1 uM Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC) ChEMBL. 8648603
EC50 (functional) < 0.1 uM Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC) ChEMBL. 8648603
IC50 (binding) = 2 nM Inhibition of Phosphodiesterase 5 from human ChEMBL. 8648603
IC50 (binding) = 2 nM Inhibition of Phosphodiesterase 5 from human ChEMBL. 8648603

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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