Detailed information for compound 60826

Basic information

Technical information
  • TDR Targets ID: 60826
  • Name: 1,8-dihydroxy-3-methoxy-6-methylanthracene-9, 10-dione
  • MW: 284.263 | Formula: C16H12O5
  • H donors: 2 H acceptors: 4 LogP: 3.04 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(O)c2c(c1)C(=O)c1c(C2=O)c(O)cc(c1)C
  • InChi: 1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3
  • InChiKey: FFWOKTFYGVYKIR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1,8-dihydroxy-3-methoxy-6-methyl-anthracene-9,10-dione
  • 1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone
  • physcione
  • 521-61-9
  • SpecPlus_000471
  • 1,8-Dihydroxy-3-methoxy-6-methyl-anthraquinone
  • AIDS-014879
  • AIDS014879
  • Methoxyemodin
  • ZINC03978794
  • Spectrum4_000909
  • 17797_FLUKA
  • Emodin-3-methyl ether
  • Spectrum5_001742
  • SPECTRUM1504070
  • SPBio_000425
  • KBio1_001511
  • SDCCGMLS-0066772.P001
  • Spectrum3_001829
  • KBio3_002981
  • CHEBI:38167
  • BSPBio_003477
  • 9,10-Anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl-
  • Anthraquinone, 1,8-dihydroxy-3-methoxy-6-methyl-
  • Emodin 3-methyl ether
  • NSC251670
  • Parietin
  • Physcion
  • Rheochrysidin
  • Spectrum_001782
  • KBioSS_002265
  • DivK1c_006567
  • Spectrum2_000503
  • KBioGR_001378
  • 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione
  • 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone
  • 1,8-Dihydroxy-3-methyl-6-methoxy-9,10-anthraquinone
  • 9,10-Anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl- (9CI)
  • BRN 1915778
  • CCRIS 4399
  • EINECS 208-315-7
  • NSC 251670
  • NCI60_002011
  • KBio2_002264
  • KBio2_004832
  • NCGC00096075-01
  • KBio2_007400
  • MEGxm0_000018

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens purinergic receptor P2Y, G-protein coupled, 12 Starlite/ChEMBL References
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) Curated by TDR Targets References
Homo sapiens elastase, neutrophil expressed Starlite/ChEMBL References
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans mycothiol conjugate amidase Mca Get druggable targets OG5_178532 All targets in OG5_178532
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) Get druggable targets OG5_178532 All targets in OG5_178532
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) Get druggable targets OG5_178532 All targets in OG5_178532
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 290 aa 315 aa 31.1 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Echinococcus granulosus transmembrane protease serine 3 elastase, neutrophil expressed 267 aa 236 aa 27.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0006 0.0143
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0018 0.0053
Toxoplasma gondii ABC1 family protein 0.0071 0.0249 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121
Schistosoma mansoni hypothetical protein 0.0032 0.0091 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0049 0.1814
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0049 0.1814
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0006 0.0016
Schistosoma mansoni hypothetical protein 0.0024 0.006 0.0055
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0055 0.0186 0.0816
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0249 1
Brugia malayi G-protein coupled receptor 0.001 0.0006 0.0155
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0049 0.0044
Echinococcus multilocularis lamin 0.0027 0.0074 0.0224
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0006 0.0001
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0006 0.0016
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0055 0.0186 0.5
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.0001
Schistosoma mansoni amine GPCR 0.001 0.0006 0.0001
Echinococcus granulosus g protein coupled receptor 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0006 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0049 0.1351
Schistosoma mansoni rab6-interacting 0.0024 0.006 0.0055
Echinococcus multilocularis fmrfamide receptor 0.001 0.0006 0.0016
Mycobacterium tuberculosis Conserved protein 0.0071 0.0249 0.01
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0005 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0249 0.0245
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0049 0.0148
Brugia malayi ORL1-like opioid receptor 0.001 0.0006 0.0155
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.1341
Schistosoma mansoni loxhd1 0.0024 0.006 0.0055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0049 0.0044
Echinococcus granulosus intermediate filament protein 0.0027 0.0074 0.0224
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0005 0.0013
Onchocerca volvulus 0.0021 0.0049 0.1814
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0006 0.0155
Onchocerca volvulus 0.001 0.0006 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0005 0.0013
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0249 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0251
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0006 0.0143
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.001 0.0028
Onchocerca volvulus 0.001 0.0006 0.0033
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0221 0.067
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0049 0.0044
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0006 0.0001
Brugia malayi ecdysone receptor 0.001 0.0005 0.0133
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0049 0.0148
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0006 0.0155
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.1341
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0016
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0006 0.0016
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0049 0.0148
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0016
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.006 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0049 0.1351
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0364 1
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Schistosoma mansoni biogenic amine receptor 0.001 0.0006 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0049 0.1341
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0221 0.6068
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121
Schistosoma mansoni neuropeptide receptor 0.001 0.0006 0.0001
Mycobacterium leprae Probable lipase LipE 0.0071 0.0249 0.0097
Schistosoma mansoni biogenic amine receptor 0.001 0.0006 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Onchocerca volvulus 0.0071 0.0249 1
Schistosoma mansoni histamine h1 receptor 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.2025
Onchocerca volvulus 0.001 0.0006 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0016
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0249 0.0097
Echinococcus granulosus tar DNA binding protein 0.0064 0.0221 0.067
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0006 0.0016
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0006 0.0016
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0091 0.0276
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0071 0.0249 0.6847
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0249 0.0756
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0006 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0049 0.0148
Onchocerca volvulus 0.001 0.0006 0.0033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0091 0.0276
Trichomonas vaginalis esterase, putative 0.0071 0.0249 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0006 0.0155
Brugia malayi putative neuropeptide receptor 0.001 0.0006 0.0155
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0049 0.1351
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0006 0.0155
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0006 0.0001
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0006 0.0001
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0006 0.0143
Brugia malayi G protein-coupled receptor 0.001 0.0006 0.0155
Loa Loa (eye worm) hypothetical protein 0.0068 0.0238 0.6529
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121
Brugia malayi Dopamine receptor protein 1 0.001 0.0006 0.0155
Loa Loa (eye worm) DR-78 0.001 0.0005 0.0121
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0006 0.0016
Schistosoma mansoni opsin-like receptor 0.001 0.0006 0.0001
Brugia malayi neuropeptide F receptor 0.001 0.0006 0.0155
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.006 0.0182
Brugia malayi Dopamine receptor protein 2 0.001 0.0006 0.0155
Schistosoma mansoni lipoxygenase 0.0024 0.006 0.0055
Echinococcus granulosus g-protein coupled receptor 0.001 0.0006 0.0016
Loa Loa (eye worm) beta-lactamase 0.0071 0.0249 0.6847
Brugia malayi Nuclear hormone receptor E75 0.001 0.0005 0.0133
Schistosoma mansoni hypothetical protein 0.0068 0.0238 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0049 0.1351
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus multilocularis sex peptide receptor 0.001 0.0006 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0049 0.0148
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0005 0.0133
Echinococcus granulosus hypothetical protein 0.001 0.0006 0.0016
Schistosoma mansoni intermediate filament proteins 0.0027 0.0074 0.0069
Brugia malayi hypothetical protein 0.001 0.0006 0.0155
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.001 0.0263
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0049 0.0148
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Schistosoma mansoni myosin xvIII 0.001 0.0006 0.0001
Schistosoma mansoni lipoxygenase 0.0067 0.0231 0.0227
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0001
Brugia malayi larval opioid receptor 0.001 0.0006 0.0155
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0006 0.0001
Schistosoma mansoni adenoreceptor 0.001 0.0006 0.0001
Echinococcus multilocularis serotonin receptor 0.001 0.0006 0.0016
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0049 0.0044
Brugia malayi CXXC zinc finger family protein 0.0029 0.0079 0.2172
Brugia malayi hypothetical protein 0.0011 0.001 0.0263
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Mycobacterium tuberculosis Conserved protein 0.0071 0.0249 0.01
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0091 0.2511
Schistosoma mansoni lamin 0.0027 0.0074 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0049 0.1351
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0006 0.0001
Brugia malayi nuclear receptor NHR-67 0.001 0.0005 0.0133
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0006 0.0016
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1624 0.6449 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.1341
Brugia malayi hypothetical protein 0.0024 0.006 0.1656
Echinococcus multilocularis g protein coupled receptor 0.001 0.0006 0.0016
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.006 0.0182
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0013
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0006 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0364 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0006 0.0155
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0249 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0049 0.1341
Brugia malayi TAR-binding protein 0.0064 0.0221 0.6068
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0049 0.0148
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0249 1
Brugia malayi ecdysteroid receptor 0.0021 0.0049 0.1351
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0006 0.0016
Onchocerca volvulus 0.001 0.0006 0.0033
Schistosoma mansoni hypothetical protein 0.0406 0.1587 0.1582
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0049 0.1351
Onchocerca volvulus 0.0024 0.006 0.2267
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0006 0.0001
Schistosoma mansoni hypothetical protein 0.0032 0.0091 0.0087
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0006 0.0143
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0016
Brugia malayi GnHR receptor homolog 0.001 0.0006 0.0155
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.168 0.667 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0221 0.0216
Echinococcus granulosus dnaJ subfamily B 0.0406 0.1587 0.4819
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0049 0.1341
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0055 0.0186 0.6673
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.1587 0.4819
Brugia malayi Serotonin receptor 0.001 0.0006 0.0155
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0074 0.2025
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0006 0.0001
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0006 0.0143
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.1341
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0221 0.6063
Onchocerca volvulus 0.001 0.0006 0.0033
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121
Schistosoma mansoni amine GPCR 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.1341
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.006 0.0182
Onchocerca volvulus 0.001 0.0006 0.0033
Loa Loa (eye worm) hypothetical protein 0.0032 0.0091 0.2502
Echinococcus granulosus lamin dm0 0.0027 0.0074 0.0224
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0005 0.0121
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0049 0.0044
Loa Loa (eye worm) hypothetical protein 0.0071 0.0249 0.6847
Brugia malayi hypothetical protein 0.0024 0.006 0.1656
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0249 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0143 0.0138
Onchocerca volvulus 0.0027 0.0074 0.2831
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.197
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0143 0.0432
Brugia malayi hypothetical protein 0.001 0.0006 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0049 0.1341
Schistosoma mansoni coup transcription factor 0.0021 0.0049 0.0044
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0006 0.0016
Echinococcus granulosus allatostatin A receptor 0.001 0.0006 0.0016
Brugia malayi RE15519p 0.001 0.0006 0.0155
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0249 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.1341
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0006 0.0016
Leishmania major hypothetical protein, conserved 0.0071 0.0249 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0005 0.0013
Schistosoma mansoni polycystin 1-related 0.0024 0.006 0.0055
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0049 0.0044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.1341
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0006 0.0016
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0249 0.01
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0091 0.2511
Brugia malayi hypothetical protein 0.001 0.0006 0.0155
Brugia malayi hypothetical protein 0.001 0.0005 0.0133
Brugia malayi hypothetical protein 0.001 0.0005 0.0133
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121
Onchocerca volvulus 0.001 0.0006 0.0033
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0251
Echinococcus granulosus serotonin receptor 0.001 0.0006 0.0016
Brugia malayi Serotonin receptor 0.001 0.0006 0.0155
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.1646
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Brugia malayi nuclear receptor RXR 0.001 0.0005 0.0133
Onchocerca volvulus 0.001 0.0006 0.0033
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.006 0.0182
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121
Echinococcus multilocularis somatostatin receptor 0.001 0.0006 0.0016
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0055 0.0186 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0049 0.0148
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Brugia malayi tailless protein 0.001 0.0005 0.0133
Echinococcus multilocularis RUN 0.0024 0.006 0.0182
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0143 0.391
Echinococcus multilocularis fmrfamide receptor 0.001 0.0006 0.0016
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0006 0.0143
Brugia malayi hypothetical protein 0.001 0.0006 0.0155
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0421
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0049 0.0044
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0049 0.0148
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0249 0.01
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0016
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 0.168 0.667 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0049 0.1341
Loa Loa (eye worm) hypothetical protein 0.01 0.0364 1
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0055 0.0186 0.5123
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0249 0.01
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus granulosus neuropeptide receptor 0.001 0.0006 0.0016
Brugia malayi nuclear receptor RXR 0.0011 0.001 0.0263
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0049 0.1341
Brugia malayi Melatonin receptor type 1A 0.001 0.0006 0.0155
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0006 0.0016
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0005 0.0013
Echinococcus multilocularis GPCR, family 2 0.0032 0.0091 0.0276
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0005 0.0013
Echinococcus granulosus fmrfamide receptor 0.001 0.0006 0.0016
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0006 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus multilocularis musashi 0.0027 0.0074 0.0224
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0006 0.0016
Mycobacterium ulcerans hypothetical protein 0.0071 0.0249 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0143 0.0138
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0071 0.0249 0.6847
Loa Loa (eye worm) RNA binding protein 0.0064 0.0221 0.6063
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0006 0.0001
Echinococcus granulosus GPCR family 2 0.0032 0.0091 0.0276
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0251
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.001 0.0251
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0016
Brugia malayi hypothetical protein 0.001 0.0006 0.0155
Brugia malayi Dopamine receptor 0.001 0.0006 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0221 0.0216
Echinococcus granulosus cpg binding protein 0.003 0.0086 0.0259
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0006 0.0016
Mycobacterium ulcerans beta-lactamase 0.0071 0.0249 0.0097
Loa Loa (eye worm) doublecortin family protein 0.0024 0.006 0.1646
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0091 0.2502
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0001
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0005 0.0013
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0005 0.0133
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0005 0.0133
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3292 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0249 0.6847
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121
Brugia malayi conserved hypotetical protein 0.001 0.0005 0.0133
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0006 0.0143
Brugia malayi Nuclear hormone receptor E75 0.001 0.0005 0.0133
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0006 0.0016
Echinococcus multilocularis lamin dm0 0.0027 0.0074 0.0224
Onchocerca volvulus 0.001 0.0006 0.0033
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.0001
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0074 0.2035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0049 0.1351
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0006 0.0143
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0006 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0049 0.1341
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0006 0.0016
Echinococcus granulosus neuropeptide s receptor 0.001 0.0006 0.0016
Brugia malayi steroid hormone receptor 0.0021 0.0049 0.1351
Brugia malayi follicle stimulating hormone receptor 0.001 0.0006 0.0155
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0006 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0049 0.1351
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0049 0.1814
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0006 0.0155
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0249 1
Mycobacterium ulcerans lipase LipD 0.0071 0.0249 0.0097
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Onchocerca volvulus 0.001 0.0006 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0221 0.0216
Schistosoma mansoni neuropeptide receptor 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.1341
Brugia malayi hypothetical protein 0.0011 0.001 0.0263
Echinococcus multilocularis g protein coupled receptor 0.001 0.0006 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0049 0.0148
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0143 0.3917
Schistosoma mansoni opsin-like receptor 0.001 0.0006 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0091 0.0276
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.001 0.0006 0.0033
Brugia malayi hypothetical protein 0.001 0.0006 0.0155
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0006 0.0143
Brugia malayi intermediate filament protein 0.0027 0.0074 0.2035
Echinococcus multilocularis serotonin receptor 0.001 0.0006 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0001
Schistosoma mansoni cpg binding protein 0.003 0.0086 0.0081
Schistosoma mansoni cpg binding protein 0.003 0.0086 0.0081
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0079 0.2162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0049 0.1351
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0049 0.0148
Echinococcus multilocularis cpg binding protein 0.003 0.0086 0.0259
Schistosoma mansoni lamin 0.0027 0.0074 0.0069
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0421
Brugia malayi nuclear receptor NHR-88 0.0021 0.0049 0.1351
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0249 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0049 0.1351
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0221 0.6063
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0005 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0143 0.0432
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0006 0.0143
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0006 0.0155
Brugia malayi hypothetical protein 0.001 0.0006 0.0155
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0024 0.0647
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0207 0.0202
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0006 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0049 0.1351
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121
Mycobacterium tuberculosis Conserved protein 0.0071 0.0249 0.01
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0249 0.0245
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0055 0.0186 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0005 0.0133
Schistosoma mansoni opsin-like receptor 0.001 0.0006 0.0001
Echinococcus multilocularis g protein coupled receptor 0.001 0.0006 0.0016
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Brugia malayi nuclear hormone receptor 0.001 0.0005 0.0133
Onchocerca volvulus 0.0024 0.006 0.2267
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.001 0.0263
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0049 0.0148
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0006 0.0016
Echinococcus multilocularis orexin receptor type 2 0.001 0.0006 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0049 0.1351
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0006 0.0016
Onchocerca volvulus 0.0071 0.0249 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0249 0.01
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0049 0.0148
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0249 0.0756
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0006 0.0001
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0006 0.0016
Onchocerca volvulus 0.0071 0.0249 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3292 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3292 0.3289
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0049 0.1351
Brugia malayi beta-lactamase family protein 0.0071 0.0249 0.6851
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0055 0.0186 0.5
Echinococcus granulosus lamin 0.0027 0.0074 0.0224
Schistosoma mansoni neuropeptide receptor 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0071 0.0249 0.6847
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0049 0.0044
Echinococcus granulosus sex peptide receptor 0.001 0.0006 0.0016
Brugia malayi hypothetical protein 0.001 0.0006 0.0155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0006 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0049 0.1351
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0006 0.0016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0006 0.0016
Echinococcus multilocularis neuropeptide receptor 0.001 0.0006 0.0016
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0238 0.6534
Schistosoma mansoni hypothetical protein 0.0032 0.0091 0.0087
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0016
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0231 0.0702
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0221 0.0216
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0049 0.0044
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0249 0.01
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0016
Brugia malayi neuropeptide F receptor 0.001 0.0006 0.0155
Brugia malayi Doublecortin family protein 0.0024 0.006 0.1656
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0049 0.0044
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0055 0.0186 0.5117
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0006 0.0016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0364 1
Schistosoma mansoni amine GPCR 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0071 0.0249 0.6847
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0006 0.0001
Echinococcus granulosus orexin receptor type 2 0.001 0.0006 0.0016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0013
Onchocerca volvulus 0.001 0.0006 0.0033
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0005 0.0013
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0457 0.179 0.1786
Schistosoma mansoni amine GPCR 0.001 0.0006 0.0001
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0018 0.0053
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0074 0.2025
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0091 0.0276
Onchocerca volvulus 0.001 0.0006 0.0033
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.006 0.0182
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0055 0.0186 0.0565
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.1646
Echinococcus granulosus somatostatin receptor 0.001 0.0006 0.0016
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0055 0.0186 0.0565
Schistosoma mansoni amine GPCR 0.001 0.0006 0.0001
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0476
Schistosoma mansoni cpg binding protein 0.0029 0.0079 0.0074
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0049 0.1341
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0049 0.0148
Brugia malayi nuclear hormone receptor 0.0021 0.0049 0.1351
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0251
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0016
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0006 0.0016
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0006 0.0016
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0005 0.0121
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0006 0.0001
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0024 0.0635
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0049 0.0044
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0006 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0249 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0049 0.0148
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0005 0.0133
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0006 0.0143
Schistosoma mansoni neuropeptide receptor 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0049 0.1351
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0006 0.0016
Onchocerca volvulus 0.0027 0.0074 0.2831
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0005 0.0121
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0049 0.0148
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0049 0.0148
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0049 0.0148
Onchocerca volvulus 0.001 0.0006 0.0033
Brugia malayi AKH receptor 0.001 0.0006 0.0155
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0249 0.6851
Onchocerca volvulus 0.001 0.0006 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Schistosoma mansoni rab6-interacting 0.0024 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Schistosoma mansoni biogenic amine receptor 0.001 0.0006 0.0001
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0055 0.0186 0.0182
Schistosoma mansoni hypothetical protein 0.0032 0.0091 0.0087
Echinococcus multilocularis neuropeptide receptor 0.001 0.0006 0.0016
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.0001
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0006 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0143 0.0138
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0071 0.0249 0.6847
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Onchocerca volvulus Neuropeptide F receptor homolog 0.001 0.0006 0.0033
Brugia malayi hypothetical protein 0.001 0.0006 0.0155
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.001 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0249 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus granulosus g protein coupled receptor 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0249 0.0097
Echinococcus multilocularis allatostatin A receptor 0.001 0.0006 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0016
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0249 0.01
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0006 0.0016
Onchocerca volvulus 0.001 0.0006 0.0033
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.1781 0.2546
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0006 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0143 0.0432
Brugia malayi G-protein coupled receptor 0.001 0.0006 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0231 0.0702
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0049 0.1351
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.001 0.0028
Brugia malayi beta-lactamase 0.0071 0.0249 0.6851
Echinococcus granulosus neuropeptide receptor 0.001 0.0006 0.0016
Brugia malayi hypothetical protein 0.001 0.0006 0.0155
Brugia malayi sulfakinin receptor protein 0.001 0.0006 0.0155
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0249 0.01
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0006 0.0001
Onchocerca volvulus 0.001 0.0006 0.0033
Echinococcus granulosus RUN 0.0024 0.006 0.0182
Brugia malayi RNA binding protein 0.0064 0.0221 0.6068
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0006 0.0016
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0251
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0049 0.0044
Onchocerca volvulus 0.0029 0.0079 0.3035
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0143
Brugia malayi beta-lactamase family protein 0.0071 0.0249 0.6851
Echinococcus granulosus g protein coupled receptor 0.001 0.0006 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0143 0.0432
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0121

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibitory activity on PDGF-induced ERK phosphorylation in NIH3T3 cells at 20 uM ChEMBL. 16275083
Activity (functional) Antituberculosis activity against Mycobacterium tuberculosis at 12.5 ug/mL ChEMBL. 9917291
Activity (binding) 0 Inhibitory activity on PDGF-induced ERK phosphorylation in NIH3T3 cells at 20 uM ChEMBL. 16275083
Activity (ADMET) = 60 % Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio ChEMBL. 18556196
Control (functional) = 94 % Compound was tested for enhancement of proliferation of MCF-7 cell line at a concentration 3 microM ChEMBL. 11459643
Control (functional) = 94 % Compound was tested for enhancement of proliferation of MCF-7 cell line at a concentration 3 microM ChEMBL. 11459643
Control (functional) = 99.2 % Compound was tested for enhancement of proliferation of MCF-7 cell line at a concentration 10 microM ChEMBL. 11459643
Control (functional) = 99.2 % Compound was tested for enhancement of proliferation of MCF-7 cell line at a concentration 10 microM ChEMBL. 11459643
Control (functional) = 104.2 % Compound was tested for enhancement of proliferation of MCF-7 cell line at a concentration 1 microM ChEMBL. 11459643
Control (functional) = 104.2 % Compound was tested for enhancement of proliferation of MCF-7 cell line at a concentration 1 microM ChEMBL. 11459643
ED50 (functional) = 1.55 ug ml-1 Cytotoxicity against human KB cells ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 8 10'2 ug/ml Inhibition of p56 lck ChEMBL. 1479375
IC50 (functional) = 12.7 ug ml-1 Antiamoebic activity against Entamoeba histolytica ChEMBL. No reference
IC50 (functional) > 100 ug ml-1 Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay ChEMBL. 26995526
IC50 (binding) uM Inhibitory activity against papain using HPLC assay; Not tested ChEMBL. 11720861
IC50 (binding) 0 uM Inhibitory activity against papain using HPLC assay; Not tested ChEMBL. 11720861
IC50 (binding) = 6.2 uM Compound was tested for the enzyme inhibitory activity against Human Leukocyte Elastase (HLE) at 65 microM concentration ChEMBL. 1578486
IC50 (binding) = 6.2 uM Compound was tested for the enzyme inhibitory activity against Human Leukocyte Elastase (HLE) at 65 microM concentration ChEMBL. 1578486
IC50 (functional) = 19 uM Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay ChEMBL. 17949858
IC50 (functional) = 77.3 uM Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay ChEMBL. 17949858
IC50 (binding) = 132 uM Inhibition of rat liver mitochondrial TrxR2 by spectrophotometry ChEMBL. 21106380
IC50 (binding) > 150 uM Inhibitory activity against HRV 3Cpro using HPLC assay ChEMBL. 11720861
IC50 (binding) > 150 uM Inhibitory activity against HRV 3Cpro using HPLC assay ChEMBL. 11720861
IC50 (binding) = 185 uM Inhibition of rat liver cytosolic TrxR1 by spectrophotometry ChEMBL. 21106380
Inhibition (binding) Inhibitory activity of the compound against rat alpha-glucosidase; mild activity observed ChEMBL. 15203173
Inhibition (binding) Inhibitory activity of the compound against yeast alpha-glucosidase; mild activity observed ChEMBL. 15203173
Inhibition (binding) 0 Inhibitory activity of the compound against yeast alpha-glucosidase; mild activity observed ChEMBL. 15203173
Inhibition (binding) 0 Inhibitory activity of the compound against rat alpha-glucosidase; mild activity observed ChEMBL. 15203173
Inhibition (binding) = % Inhibitory activity of the compound against Chymotrypsinogen at 65 microM concentration; Active ChEMBL. 1578486
Inhibition (binding) % Inhibitory activity of the compound against Porcine Pancreatic Elastase (PPE) at 65 microM concentration; NI = no inhibition ChEMBL. 1578486
Inhibition (binding) 0 % Inhibitory activity of the compound against Porcine Pancreatic Elastase (PPE) at 65 microM concentration; NI = no inhibition ChEMBL. 1578486
Inhibition (binding) = 0 % Inhibitory activity of the compound against Chymotrypsinogen at 65 microM concentration; Active ChEMBL. 1578486
Inhibition (functional) = 0 % Antifungal activity against Fusarium oxysporum at 0.5 mg/ml ChEMBL. 16275083
Inhibition (binding) = 7 % Displacement of [3H]PSB0413 from human platelet P2Y12 receptor at 10 uM ChEMBL. 19463000
Inhibition (functional) = 10.12 % Antifungal activity against Gibberella zeae at 0.5 mg/ml ChEMBL. 16275083
Inhibition (functional) = 19.05 % Antifungal activity against Phytopthora infestans at 0.5 mg/ml ChEMBL. 16275083
Inhibition (binding) = 27.1 % Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate ChEMBL. 26483136
Inhibition (binding) = 39 % Inhibitory activity of the compound against Cathepsin G (CatG) at 65 microM concentration ChEMBL. 1578486
Inhibition (binding) = 39 % Inhibitory activity of the compound against Cathepsin G (CatG) at 65 microM concentration ChEMBL. 1578486
Inhibition (functional) = 73.2 % Antiproliferative activity against prostate cancer PC3 cell line at 20 uM by MTT method ChEMBL. 16275083
Inhibition (functional) = 73.2 % Antiproliferative activity against prostate cancer PC3 cell line at 20 uM by MTT method ChEMBL. 16275083
Inhibition (functional) = 80.5 % Antiproliferative activity against human epidermal carcinoma A431 cell line at 20 uM by MTT method ChEMBL. 16275083
Inhibition (functional) = 80.5 % Antiproliferative activity against human epidermal carcinoma A431 cell line at 20 uM by MTT method ChEMBL. 16275083
Inhibition (binding) = 100 % Inhibitory activity of the compound against Human Leukocyte Elastase (HLE) at 65 microM concentration ChEMBL. 1578486
Inhibition (binding) = 100 % Inhibitory activity of the compound against Human Leukocyte Elastase (HLE) at 65 microM concentration ChEMBL. 1578486
Inhibition (ADMET) = 111.9327965 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 112.8232269 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (functional) = 119.9 % Effect on Streptococcus mutans LMG 14558 assessed as inhibition of biofilm formation in modified Robbin's device at 5 ug/ml relative to BHIS control ChEMBL. 17220400
Ki (binding) > 10 uM Displacement of [3H]PSB0413 from human platelet P2Y12 receptor ChEMBL. 19463000
Log Pow = 3.65 Partition coefficient of compound in octanol and water by Fragmental method of Leo/Hansch ChEMBL. 12639543
MIC (functional) > 250 ug ml-1 Activity against planktonic Streptococcus mutans LMG 14558 ChEMBL. 17220400
Potency (binding) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Entamoeba histolytica ChEMBL23
Homo sapiens ChEMBL23 17949858

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 257019  
Annotator: crowther@u.washington.edu Comment: 2007-12-26 References: 11388862 12538025
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium smegmatis 257019  
Annotator: crowther@u.washington.edu Comment: 2007-12-26 References: 12538025

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

13 literature references were collected for this gene.

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