Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | p2X purinoceptor 4 | 0.0205 | 0.1316 | 0.4056 |
Loa Loa (eye worm) | oxidoreductase | 0.0092 | 0.0469 | 0.3092 |
Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0092 | 0.0469 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0194 | 0.1279 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0092 | 0.0469 | 0.0432 |
Onchocerca volvulus | 0.0056 | 0.0194 | 0.3614 | |
Leishmania major | serine/threonine protein phosphatase 2B catalytic subunit A2, putative | 0.0042 | 0.0094 | 0.1305 |
Brugia malayi | Serine/threonine protein phosphatase 2B catalytic subunit 2 | 0.0042 | 0.0094 | 0.0623 |
Onchocerca volvulus | 0.0056 | 0.0194 | 0.3614 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0038 | 0.006 |
Plasmodium vivax | serine/threonine protein phosphatase 2B catalytic subunit A, putative | 0.0042 | 0.0094 | 0.0056 |
Trypanosoma cruzi | serine/threonine protein phosphatase, putative | 0.0042 | 0.0094 | 0.1305 |
Schistosoma mansoni | P2X receptor subunit | 0.0205 | 0.1316 | 0.5565 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.1362 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0092 | 0.0469 | 0.0432 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0038 | 0.006 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0092 | 0.0469 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0186 | 0.1228 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0092 | 0.0469 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0092 | 0.0469 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0092 | 0.0469 | 1 |
Brugia malayi | TAR-binding protein | 0.0189 | 0.1197 | 0.79 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0255 | 0.0996 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0092 | 0.0469 | 0.0432 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0189 | 0.1197 | 0.79 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0205 | 0.1316 | 0.4056 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.1362 | 1 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0455 | 0.3189 | 0.5136 |
Leishmania major | pteridine reductase 1 | 0.0092 | 0.0469 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0092 | 0.0469 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0127 | 0.0444 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0148 | 0.0535 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0779 | 0.5139 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0038 | 0.0252 |
Mycobacterium tuberculosis | Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) | 0.0092 | 0.0469 | 0.0432 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0645 | 0.4253 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0092 | 0.0469 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0092 | 0.0469 | 0.0432 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0038 | 0.0252 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0024 | 0.016 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 0.2345 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0092 | 0.0469 | 0.0432 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0092 | 0.0469 | 0.0432 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Mycobacterium ulcerans | 20-beta-hydroxysteroid dehydrogenase FabG3 | 0.0092 | 0.0469 | 0.0432 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0645 | 0.4253 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.0255 | 0.0218 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.0092 | 0.0469 | 0.0378 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0092 | 0.0469 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0038 | 0.0252 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.1197 | 0.5055 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0092 | 0.0469 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.0255 | 0.0689 |
Loa Loa (eye worm) | intermediate filament protein | 0.0056 | 0.0194 | 0.1279 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0092 | 0.0469 | 0.0432 |
Loa Loa (eye worm) | TAR-binding protein | 0.0189 | 0.1197 | 0.79 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0255 | 0.0218 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0139 | 0.0917 |
Trypanosoma brucei | protein phosphatase 2B, putative | 0.0042 | 0.0094 | 0.1305 |
Schistosoma mansoni | P2X receptor subunit | 0.0205 | 0.1316 | 0.5565 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0038 | 0.0252 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0092 | 0.0469 | 0.0432 |
Schistosoma mansoni | lamin | 0.0056 | 0.0194 | 0.0731 |
Echinococcus multilocularis | tar DNA binding protein | 0.0189 | 0.1197 | 0.189 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.0255 | 0.0354 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0038 | 0.0252 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0056 | 0.0194 | 0.1279 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0852 | 0.6172 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0148 | 0.035 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0092 | 0.0469 | 0.0432 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0092 | 0.0469 | 0.1366 |
Schistosoma mansoni | dihydropteridine reductase | 0.0092 | 0.0469 | 0.1915 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.1197 | 0.5055 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0092 | 0.0469 | 0.0432 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0229 | 0.1496 | 0.2377 |
Echinococcus granulosus | lamin dm0 | 0.0056 | 0.0194 | 0.0494 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0092 | 0.0469 | 0.0432 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0205 | 0.1316 | 0.2083 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0092 | 0.0469 | 0.0432 |
Echinococcus granulosus | lamin | 0.0056 | 0.0194 | 0.0494 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Schistosoma mansoni | lamin | 0.0056 | 0.0194 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0038 | 0.0252 |
Echinococcus granulosus | serine:threonine protein phosphatase 2B | 0.0042 | 0.0094 | 0.0178 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0092 | 0.0469 | 0.3092 |
Onchocerca volvulus | 0.0092 | 0.0469 | 1 | |
Echinococcus granulosus | neuropeptide s receptor | 0.0455 | 0.3189 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0139 | 0.0917 |
Echinococcus multilocularis | serine:threonine protein phosphatase 2B | 0.0042 | 0.0094 | 0.0092 |
Trypanosoma cruzi | serine/threonine protein phosphatase 2B catalytic subunit A2, putative | 0.0042 | 0.0094 | 0.1305 |
Echinococcus granulosus | serine:threonine protein phosphatase 2B | 0.0042 | 0.0094 | 0.0178 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0232 | 0.1516 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0148 | 0.0535 |
Schistosoma mansoni | P2X receptor subunit | 0.0205 | 0.1316 | 0.5565 |
Echinococcus multilocularis | serine:threonine protein phosphatase 2B | 0.0042 | 0.0094 | 0.0092 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0092 | 0.0469 | 0.1915 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0092 | 0.0469 | 0.0432 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0092 | 0.0469 | 0.0432 |
Mycobacterium leprae | POSSIBLE OXIDOREDUCTASE | 0.0092 | 0.0469 | 0.0432 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0092 | 0.0469 | 0.0432 |
Onchocerca volvulus | 0.0092 | 0.0469 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0038 | 0.0252 |
Brugia malayi | intermediate filament protein | 0.0056 | 0.0194 | 0.1279 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0148 | 0.018 |
Trypanosoma cruzi | serine/threonine protein phosphatase, putative | 0.0042 | 0.0094 | 0.1305 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Loa Loa (eye worm) | RNA binding protein | 0.0189 | 0.1197 | 0.79 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0148 | 0.098 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.1197 | 0.5055 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0255 | 0.0996 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0038 | 0.0252 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0092 | 0.0469 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0092 | 0.0469 | 0.0432 |
Trichomonas vaginalis | hypothetical protein | 0.1362 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0205 | 0.1316 | 0.2083 |
Echinococcus multilocularis | lamin dm0 | 0.0056 | 0.0194 | 0.0254 |
Schistosoma mansoni | intermediate filament proteins | 0.0056 | 0.0194 | 0.0731 |
Echinococcus granulosus | tar DNA binding protein | 0.0189 | 0.1197 | 0.3679 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1362 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0205 | 0.1316 | 0.4056 |
Mycobacterium ulcerans | oxidoreductase | 0.0092 | 0.0469 | 0.0432 |
Schistosoma mansoni | protein phosphatase-2b | 0.0042 | 0.0094 | 0.0302 |
Echinococcus multilocularis | serotonin receptor | 0.0134 | 0.0779 | 0.1208 |
Onchocerca volvulus | 0.0047 | 0.0127 | 0.2066 | |
Toxoplasma gondii | protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein | 0.0042 | 0.0094 | 0.0056 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0092 | 0.0469 | 0.0432 |
Echinococcus multilocularis | geminin | 0.0342 | 0.2345 | 0.3761 |
Brugia malayi | RNA binding protein | 0.0189 | 0.1197 | 0.79 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0139 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.009 | 0.0593 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0134 | 0.0779 | 0.2351 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0255 | 0.0218 |
Echinococcus multilocularis | lamin | 0.0056 | 0.0194 | 0.0254 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.1197 | 0.5055 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0148 | 0.035 |
Echinococcus granulosus | intermediate filament protein | 0.0056 | 0.0194 | 0.0494 |
Brugia malayi | hypothetical protein | 0.0229 | 0.1496 | 0.9871 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1362 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0094 | 0.0623 |
Leishmania major | serine/threonine protein phosphatase, putative | 0.0042 | 0.0094 | 0.1305 |
Mycobacterium leprae | 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI | 0.0092 | 0.0469 | 0.0432 |
Echinococcus multilocularis | musashi | 0.0056 | 0.0194 | 0.0254 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.1362 | 1 | 1 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0092 | 0.0469 | 0.0432 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0645 | 0.4253 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0205 | 0.1316 | 0.2083 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0127 | 0.0444 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0092 | 0.0469 | 0.0432 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0092 | 0.0469 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.0255 | 0.0218 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0134 | 0.0779 | 0.3252 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0038 | 0.0252 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0455 | 0.3189 | 1 |
Schistosoma mansoni | protein phosphatase-2b | 0.0042 | 0.0094 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0038 | 0.0252 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0092 | 0.0469 | 0.0432 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0092 | 0.0469 | 0.0432 |
Trypanosoma brucei | pteridine reductase 1 | 0.0092 | 0.0469 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0127 | 0.0839 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0092 | 0.0469 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 0.2345 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0189 | 0.1197 | 0.79 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0092 | 0.0469 | 0.0432 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.1197 | 0.5055 |
Echinococcus multilocularis | serotonin receptor | 0.0134 | 0.0779 | 0.1208 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0255 | 0.0218 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0092 | 0.0469 | 0.0702 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0779 | 0.5139 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0092 | 0.0469 | 0.3092 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0139 | 0.0917 |
Schistosoma mansoni | P2X receptor subunit | 0.0205 | 0.1316 | 0.5565 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0229 | 0.1496 | 0.4628 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1362 | 1 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0038 | 0.0252 |
Mycobacterium tuberculosis | Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) | 0.0092 | 0.0469 | 0.0432 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0455 | 0.3189 | 0.5136 |
Brugia malayi | follicle stimulating hormone receptor | 0.0232 | 0.1516 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0148 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0024 | 0.016 |
Echinococcus granulosus | geminin | 0.0342 | 0.2345 | 0.7323 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0148 | 0.098 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.1362 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0148 | 0.0535 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0092 | 0.0469 | 0.3092 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0092 | 0.0469 | 0.3092 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0092 | 0.0469 | 0.0432 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0038 | 0.0252 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.0469 | 0.0432 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0056 | 0.0194 | 0.1279 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0092 | 0.0469 | 0.0432 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.1449 | 0.1417 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1496 | 0.9871 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0469 | 0.3092 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.0255 | 0.5042 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.