TDR Targets

Basic information

Technical information

TDR Targets ID: 627343
Name: 2-methyl-N-[4-([1,3]thiazolo[5,4-b]pyridin-2- yl)phenyl]benzamide
MW: 345.418 | Formula: C20H15N3OS
H donors: 1 H acceptors: 3 LogP: 4.5 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1C)Nc1ccc(cc1)c1nc2c(s1)nccc2
InChi: 1S/C20H15N3OS/c1-13-5-2-3-6-16(13)18(24)22-15-10-8-14(9-11-15)19-23-17-7-4-12-21-20(17)25-19/h2-12H,1H3,(H,22,24)
InChiKey: WKHPRNRTOCZVGQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-methyl-N-(4-thiazolo[5,4-b]pyridin-2-ylphenyl)benzamide
2-methyl-N-[4-(2-thiazolo[5,4-b]pyridinyl)phenyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0324	0.4019	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.112	0.2753
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0587	0.0782
Loa Loa (eye worm)	hypothetical protein	0.002	0.0081	0.0202
Loa Loa (eye worm)	hypothetical protein	0.002	0.0081	0.0202
Brugia malayi	Pre-SET motif family protein	0.0032	0.0234	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0313	0.3885	0.9666
Schistosoma mansoni	hypothetical protein	0.0035	0.0277	0.0302
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.0081	0.0155
Echinococcus multilocularis	geminin	0.0519	0.6547	0.6547
Mycobacterium tuberculosis	Hypothetical protein	0.0154	0.182	0.4189
Brugia malayi	ecdysteroid receptor	0.002	0.0081	0.0155
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0081	0.0155
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0442	0.1057
Echinococcus granulosus	neuropeptide s receptor	0.0452	0.5683	0.868
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.2849	0.4351
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0235	0.0235
Schistosoma mansoni	hypothetical protein	0.0032	0.0235	0.0238
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0081	0.0202
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.112	0.2753
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0187	0.0164
Onchocerca volvulus		0.0048	0.0442	0.0916
Loa Loa (eye worm)	hypothetical protein	0.01	0.112	0.2788
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0081	0.0202
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.0081	0.0124
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0081	0.0124
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0236	0.0243
Entamoeba histolytica	hypothetical protein	0.0035	0.0277	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0277	0.0302
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0234	0.0234
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0032	0.0236	0.0243
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0081	0.0124
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.2849	0.2849
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0081	0.0124
Echinococcus multilocularis	musashi	0.0028	0.0187	0.0187
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0081	0.0202
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0081	0.0155
Onchocerca volvulus		0.0324	0.4019	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0081	0.0155
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0236	0.0243
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0587	0.1149
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0081	0.0202
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0324	0.4019	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0081	0.0081
Schistosoma mansoni	hypothetical protein	0.0032	0.0235	0.0238
Brugia malayi	hypothetical protein	0.0313	0.3885	0.9664
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0324	0.4019	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0181	0.045
Echinococcus multilocularis	isocitrate dehydrogenase	0.0032	0.0236	0.0236
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0236	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0235	0.0585
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0235	0.0235
Echinococcus multilocularis	neuropeptide receptor A26	0.0452	0.5683	0.5683
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0081	0.0155
Entamoeba histolytica	hypothetical protein	0.0035	0.0277	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0081	0.0202
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0324	0.4019	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0081	0.0155
Onchocerca volvulus		0.0313	0.3885	0.9659
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0081	0.0202
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0324	0.4019	1
Schistosoma mansoni	hypothetical protein	0.0519	0.6547	1
Echinococcus granulosus	lamin	0.0028	0.0187	0.0286
Loa Loa (eye worm)	thymidylate synthase	0.0324	0.4019	1
Echinococcus granulosus	thymidylate synthase	0.0324	0.4019	0.6139
Echinococcus granulosus	lamin dm0	0.0028	0.0187	0.0286
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0277	0.0422
Brugia malayi	Cytochrome P450 family protein	0.0068	0.0711	0.1729
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0187	0.0421
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0324	0.4019	0.609
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0711	0.1768
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0236	0.0236
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1323	0.3292
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0711	0.1728
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0032	0.0236	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0187	0.0466
Loa Loa (eye worm)	hypothetical protein	0.002	0.0081	0.0202
Plasmodium vivax	SET domain protein, putative	0.0032	0.0234	0.0238
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0081	0.0124
Echinococcus multilocularis	thymidylate synthase	0.0324	0.4019	0.4019
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0234	0.0357
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0234	0.0238
Entamoeba histolytica	hypothetical protein	0.0035	0.0277	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0141	0.0352
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0587	0.0897
Loa Loa (eye worm)	hypothetical protein	0.002	0.0081	0.0202
Brugia malayi	follicle stimulating hormone receptor	0.0229	0.2797	0.6944
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0081	0.0155
Schistosoma mansoni	hypothetical protein	0.0519	0.6547	1
Echinococcus multilocularis	lamin dm0	0.0028	0.0187	0.0187
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0081	0.0081
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0081	0.0155
Echinococcus multilocularis	neuropeptide s receptor	0.0452	0.5683	0.5683
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0587	0.0929
Brugia malayi	Isocitrate dehydrogenase	0.0032	0.0236	0.0541
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0154	0.182	0.433
Brugia malayi	nuclear hormone receptor	0.002	0.0081	0.0155
Brugia malayi	nuclear receptor NHR-88	0.002	0.0081	0.0155
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0324	0.4019	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.0081	0.0124
Schistosoma mansoni	hypothetical protein	0.0068	0.0711	0.0973
Schistosoma mansoni	lamin	0.0028	0.0187	0.0164
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0081	0.0081
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0235	0.0585
Entamoeba histolytica	hypothetical protein	0.0035	0.0277	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0081	0.0202
Echinococcus multilocularis	lamin	0.0028	0.0187	0.0187
Loa Loa (eye worm)	cytochrome P450 family protein	0.0068	0.0711	0.1768
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0081	0.0155
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0081	0.0202
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0081	0.0081
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0032	0.0236	0.0239
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0032	0.0236	0.0243
Trichomonas vaginalis	set domain proteins, putative	0.025	0.3068	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0032	0.0236	0.0236
Brugia malayi	thymidylate synthase	0.0324	0.4019	1
Echinococcus granulosus	geminin	0.0519	0.6547	1
Brugia malayi	hypothetical protein	0.0154	0.182	0.4503
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0032	0.0236	0.036
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.0081	0.0081
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0236	0.0236
Schistosoma mansoni	hypothetical protein	0.0032	0.0235	0.0238
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0219	0.0334
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0032	0.0236	0.0243
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0234	0.0236
Brugia malayi	Pre-SET motif family protein	0.022	0.2674	0.6638
Brugia malayi	hypothetical protein	0.0024	0.0141	0.0306
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0234	0.0236
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0019	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0234	0.0582
Echinococcus granulosus	neuropeptide receptor A26	0.0452	0.5683	0.868
Onchocerca volvulus		0.025	0.3068	0.7585
Loa Loa (eye worm)	hypothetical protein	0.002	0.0081	0.0202
Brugia malayi	hypothetical protein	0.0016	0.0029	0.0025
Loa Loa (eye worm)	hypothetical protein	0.002	0.0081	0.0202
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0081	0.0124
Brugia malayi	steroid hormone receptor	0.002	0.0081	0.0155
Loa Loa (eye worm)	hypothetical protein	0.002	0.0081	0.0202
Onchocerca volvulus		0.0032	0.0234	0.0388
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0081	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0233	0.2849	0.7089
Echinococcus granulosus	GPCR family 2	0.0032	0.0235	0.0359
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0187	0.0466
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.0081	0.0081
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0442	0.0558
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0081	0.0081
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0081	0.0124
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0324	0.4019	1
Brugia malayi	isocitrate dehydrogenase	0.0032	0.0236	0.0541
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0081	0.0155
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0235	0.0539
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0081	0.0155
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0229	0.2797	0.6958
Brugia malayi	MH2 domain containing protein	0.0116	0.1323	0.326
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0236	0.0243
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0234	0.0236
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0587	0.0587
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0187	0.0466
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0324	0.4019	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0081	0.0155
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.0081	0.0155
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.112	0.2788
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0236	0.0236
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0081	0.0155
Onchocerca volvulus		0.0028	0.0187	0.027
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.0081	0.0155
Echinococcus multilocularis	thyroid hormone receptor alpha	0.002	0.0081	0.0081
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0081	0.0124
Brugia malayi	hypothetical protein	0.0233	0.2849	0.7075
Brugia malayi	hypothetical protein	0.0035	0.0277	0.0643
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1323	0.3292
Schistosoma mansoni	lamin	0.0028	0.0187	0.0164
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0081	0.0202
Onchocerca volvulus		0.0028	0.0187	0.027
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0081	0.0081
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0234	0.0236
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.022	0.2674	0.6654
Schistosoma mansoni	hypothetical protein	0.0048	0.0442	0.0558
Brugia malayi	intermediate filament protein	0.0028	0.0187	0.0421
Echinococcus granulosus	intermediate filament protein	0.0028	0.0187	0.0286
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0032	0.0236	0.0586
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0236	0.0243
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0234	0.0234
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0587	0.1149
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0235	0.0359
Mycobacterium ulcerans	thymidylate synthase	0.0324	0.4019	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0277	0.0277
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0235	0.0359
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0587	0.0782
Schistosoma mansoni	hypothetical protein	0.0032	0.0235	0.0238
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0235	0.0539

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 627343