Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0107 | 0.0066 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0291 | 0.5013 | 0.6024 |
Leishmania major | pyruvate kinase | 0.0066 | 0.0955 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0107 | 0.06 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.237 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0066 | 0.0955 | 0.1794 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0107 | 0.0114 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0107 | 0.0106 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0293 | 0.1849 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0107 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1591 | 0.1907 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0107 | 0.0114 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0604 | 0.0553 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0604 | 0.4243 |
Plasmodium falciparum | pyruvate kinase 2 | 0.0034 | 0.0374 | 0.2752 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 0.3981 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0046 | 0.0594 | 0.0702 |
Plasmodium vivax | pyruvate kinase, putative | 0.0066 | 0.0955 | 0.6948 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0608 | 0.1086 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0583 | 0.0689 |
Echinococcus granulosus | pyruvate kinase | 0.0066 | 0.0955 | 0.1095 |
Echinococcus multilocularis | pyruvate kinase | 0.0066 | 0.0955 | 0.1095 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0107 | 0.0054 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0604 | 0.4243 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.06 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.3469 | 0.4176 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0145 | 0.237 | 0.2813 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0293 | 0.0291 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0081 | 0.1218 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0583 | 0.0643 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0293 | 0.0291 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0299 | 0.5165 | 0.6226 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0066 | 0.0955 | 0.1138 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.237 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.0608 | 0.0674 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0046 | 0.0594 | 0.2149 |
Mycobacterium ulcerans | hypothetical protein | 0.0104 | 0.1639 | 0.1594 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.15 | 0.2831 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0604 | 0.0714 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0293 | 0.0339 |
Giardia lamblia | Pyruvate kinase | 0.0066 | 0.0955 | 0.7738 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0066 | 0.0955 | 0.5684 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0107 | 0.0106 |
Echinococcus multilocularis | pyruvate kinase | 0.0052 | 0.0703 | 0.0789 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0088 | 0.135 | 0.1575 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1591 | 0.3009 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0604 | 0.0668 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0066 | 0.0955 | 0.1794 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0016 | 0.0053 | 0.0559 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.1683 | 0.1638 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.1683 | 0.1638 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0299 | 0.5165 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0374 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0293 | 0.0339 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0088 | 0.135 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0583 | 0.1036 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0293 | 0.0469 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.06 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.8287 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0604 | 0.0668 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.0374 | 0.0627 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0081 | 0.1218 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.1683 | 0.0805 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.237 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0293 | 0.1513 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0088 | 0.135 | 0.8181 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0107 | 0.06 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0299 | 0.5165 | 0.6208 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0608 | 0.0674 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0107 | 0.0138 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.06 |
Brugia malayi | hypothetical protein | 0.0472 | 0.8287 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0583 | 0.1036 |
Loa Loa (eye worm) | acetyltransferase | 0.0299 | 0.5165 | 0.6226 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0604 | 0.6107 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.002 | 0.0122 | 0.0133 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0066 | 0.0955 | 0.2295 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0104 | 0.1639 | 0.1594 |
Loa Loa (eye worm) | pyruvate kinase | 0.0066 | 0.0955 | 0.1138 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0107 | 0.0066 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.1591 | 0.1907 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0374 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0955 | 0.1138 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0608 | 0.1086 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0066 | 0.0955 | 0.0906 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0604 | 0.4725 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.2438 | 0.2931 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0016 | 0.0053 | 0.0559 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0104 | 0.1639 | 0.1594 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0374 | 0.0389 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0088 | 0.135 | 0.3303 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.06 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0472 | 0.8287 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0066 | 0.0955 | 0.0906 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0608 | 0.0674 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0293 | 0.0469 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.237 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0107 | 0.0066 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0608 | 0.0674 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.0608 | 0.072 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.1897 | 0.1854 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0066 | 0.0955 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0604 | 0.0714 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0608 | 0.1086 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.1897 | 0.1854 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0053 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.237 | 0.4531 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0594 | 0.0702 |
Schistosoma mansoni | pyruvate kinase | 0.0066 | 0.0955 | 0.1763 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.1683 | 0.1638 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.1683 | 0.1638 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0107 | 0.0464 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0096 | 0.15 | 0.1798 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.06 |
Loa Loa (eye worm) | pyruvate kinase | 0.0066 | 0.0955 | 0.1138 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0107 | 0.0066 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0066 | 0.0955 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0608 | 0.072 |
Echinococcus multilocularis | pyruvate kinase | 0.0066 | 0.0955 | 0.1095 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0583 | 0.0643 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0274 | 0.0268 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0604 | 0.0714 |
Schistosoma mansoni | pyruvate kinase | 0.0066 | 0.0955 | 0.1763 |
Mycobacterium ulcerans | molybdopterin-guanine dinucleotide biosynthesis protein A | 0.0104 | 0.1639 | 0.1594 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.0608 | 0.0674 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0107 | 0.0114 |
Leishmania major | pyruvate kinase | 0.0066 | 0.0955 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0107 | 0.0066 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0107 | 0.0066 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0604 | 0.4725 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.2438 | 0.2931 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0107 | 0.1125 |
Onchocerca volvulus | 0.0096 | 0.15 | 0.3274 | |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0107 | 0.1125 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Mycobacterium ulcerans | hypothetical protein | 0.0104 | 0.1639 | 0.1594 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0604 | 0.6324 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0088 | 0.135 | 0.3303 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0107 | 0.1125 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0583 | 0.0689 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0583 | 0.0643 |
Schistosoma mansoni | survival motor neuron protein | 0.0096 | 0.15 | 0.2831 |
Chlamydia trachomatis | pyruvate kinase | 0.0066 | 0.0955 | 1 |
Onchocerca volvulus | 0.0234 | 0.3981 | 1 | |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.1897 | 0.1854 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.0608 | 0.072 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.1897 | 0.1042 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0066 | 0.0955 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0066 | 0.0955 | 0.1138 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0374 | 0.0389 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0107 | 0.06 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0567 | 1 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0066 | 0.0955 | 0.1138 |
Echinococcus granulosus | pyruvate kinase | 0.0066 | 0.0955 | 0.1095 |
Brugia malayi | hypothetical protein | 0.0145 | 0.237 | 0.2848 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0567 | 1 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0016 | 0.0053 | 0.0559 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.3469 | 0.4176 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0107 | 0.0106 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0604 | 0.3471 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0107 | 0.0114 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.1683 | 0.1638 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0583 | 0.0643 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0145 | 0.237 | 0.4531 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.0034 | 0.0374 | 0.2471 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0604 | 0.6107 |
Treponema pallidum | licC protein (licC) | 0.0104 | 0.1639 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0107 | 0.1125 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0604 | 0.0714 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0608 | 0.0674 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.2438 | 0.2931 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0293 | 0.0469 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0107 | 0.0054 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0374 | 0.0389 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0567 | 1 | 1 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0034 | 0.0374 | 0.2022 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0472 | 0.8287 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0034 | 0.0374 | 0.2752 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0374 | 0.0389 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0066 | 0.0955 | 0.2295 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0293 | 0.0291 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0107 | 0.1125 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.0608 | 0.072 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.2438 | 0.2931 |
Plasmodium falciparum | pyruvate kinase | 0.0066 | 0.0955 | 0.7738 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0104 | 0.1639 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0107 | 0.0138 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0081 | 0.1218 | 0.491 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0583 | 0.1036 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0145 | 0.237 | 0.2813 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0293 | 0.0469 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0016 | 0.0053 | 0.0559 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.1683 | 0.1638 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0107 | 0.0054 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0066 | 0.0955 | 0.1794 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0608 | 0.1086 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0088 | 0.135 | 0.8181 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0066 | 0.0955 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.