Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | pyruvate kinase | 0.0066 | 0.0955 | 0.7738 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0107 | 0.0066 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0374 | 0.0389 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0081 | 0.1218 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0107 | 0.0114 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.2438 | 0.2931 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.2438 | 0.2931 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0145 | 0.237 | 0.4531 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0374 | 0.0389 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.237 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0088 | 0.135 | 0.8181 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0107 | 0.0106 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.1683 | 0.1638 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0374 | 0.0389 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.237 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0608 | 0.0674 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.1683 | 0.1638 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.0034 | 0.0374 | 0.2471 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0608 | 0.0674 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.8287 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.0608 | 0.072 |
Mycobacterium ulcerans | molybdopterin-guanine dinucleotide biosynthesis protein A | 0.0104 | 0.1639 | 0.1594 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Mycobacterium ulcerans | hypothetical protein | 0.0104 | 0.1639 | 0.1594 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0583 | 0.0689 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0096 | 0.15 | 0.1798 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0016 | 0.0053 | 0.0559 |
Giardia lamblia | Pyruvate kinase | 0.0066 | 0.0955 | 0.7738 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0088 | 0.135 | 0.3303 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0299 | 0.5165 | 0.6226 |
Onchocerca volvulus | 0.0096 | 0.15 | 0.3274 | |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.1683 | 0.1638 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0088 | 0.135 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0274 | 0.0268 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0583 | 0.0643 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0583 | 0.1036 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0107 | 0.0066 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0293 | 0.1513 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0107 | 0.0114 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0088 | 0.135 | 0.3303 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0016 | 0.0053 | 0.0559 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0299 | 0.5165 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0293 | 0.0469 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.1897 | 0.1854 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0066 | 0.0955 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0107 | 0.0114 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0472 | 0.8287 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.1591 | 0.1907 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0604 | 0.6107 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0583 | 0.0643 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.1897 | 0.1042 |
Chlamydia trachomatis | pyruvate kinase | 0.0066 | 0.0955 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0583 | 0.0643 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1591 | 0.3009 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0293 | 0.0291 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0066 | 0.0955 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.1683 | 0.1638 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0608 | 0.1086 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0567 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0066 | 0.0955 | 0.0906 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0604 | 0.4725 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0107 | 0.0054 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0066 | 0.0955 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.06 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0472 | 0.8287 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.237 | 0.4531 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0107 | 0.1125 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0066 | 0.0955 | 0.1138 |
Echinococcus granulosus | pyruvate kinase | 0.0066 | 0.0955 | 0.1095 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.06 |
Plasmodium vivax | pyruvate kinase, putative | 0.0066 | 0.0955 | 0.6948 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0088 | 0.135 | 0.1575 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0107 | 0.0138 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0016 | 0.0053 | 0.0559 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.1683 | 0.1638 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0608 | 0.0674 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.3469 | 0.4176 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 0.3981 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0046 | 0.0594 | 0.2149 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0107 | 0.0066 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0053 | 0.0049 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0604 | 0.0553 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0107 | 0.06 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0293 | 0.0469 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0034 | 0.0374 | 0.2022 |
Brugia malayi | hypothetical protein | 0.0145 | 0.237 | 0.2848 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0046 | 0.0594 | 0.0702 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0016 | 0.0053 | 0.0559 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.3469 | 0.4176 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0107 | 0.0066 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.06 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.1897 | 0.1854 |
Echinococcus multilocularis | pyruvate kinase | 0.0066 | 0.0955 | 0.1095 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0107 | 0.0464 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0107 | 0.0106 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0604 | 0.0714 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0081 | 0.1218 | 0.491 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0604 | 0.0668 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0604 | 0.6324 |
Leishmania major | pyruvate kinase | 0.0066 | 0.0955 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1591 | 0.1907 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0107 | 0.1125 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0608 | 0.1086 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0608 | 0.1086 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0107 | 0.0054 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.0374 | 0.0627 |
Echinococcus multilocularis | pyruvate kinase | 0.0066 | 0.0955 | 0.1095 |
Loa Loa (eye worm) | pyruvate kinase | 0.0066 | 0.0955 | 0.1138 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.06 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0604 | 0.0714 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0107 | 0.1125 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.2438 | 0.2931 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0583 | 0.1036 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0604 | 0.0714 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0374 | 0.0389 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0107 | 0.0066 |
Echinococcus granulosus | pyruvate kinase | 0.0066 | 0.0955 | 0.1095 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0604 | 0.4243 |
Loa Loa (eye worm) | pyruvate kinase | 0.0066 | 0.0955 | 0.1138 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0107 | 0.0114 |
Plasmodium falciparum | pyruvate kinase 2 | 0.0034 | 0.0374 | 0.2752 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0583 | 0.0689 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.06 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0066 | 0.0955 | 0.1138 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0107 | 0.0054 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0066 | 0.0955 | 0.1794 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0608 | 0.1086 |
Loa Loa (eye worm) | pyruvate kinase | 0.0066 | 0.0955 | 0.1138 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.0608 | 0.0674 |
Giardia lamblia | Pyruvate kinase | 0.0034 | 0.0374 | 0.2752 |
Treponema pallidum | licC protein (licC) | 0.0104 | 0.1639 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0293 | 0.0469 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.1683 | 0.1638 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0604 | 0.6107 |
Schistosoma mansoni | pyruvate kinase | 0.0066 | 0.0955 | 0.1763 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0604 | 0.0668 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0293 | 0.0339 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0604 | 0.3471 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0081 | 0.1218 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0299 | 0.5165 | 0.6208 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0293 | 0.0291 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.237 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0052 | 0.0703 | 0.0789 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.15 | 0.2831 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0107 | 0.0066 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0293 | 0.0291 |
Schistosoma mansoni | survival motor neuron protein | 0.0096 | 0.15 | 0.2831 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0604 | 0.4243 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0107 | 0.1125 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0145 | 0.237 | 0.2813 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0374 | 0.0389 |
Loa Loa (eye worm) | acetyltransferase | 0.0299 | 0.5165 | 0.6226 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0583 | 0.0643 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0604 | 0.0714 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0066 | 0.0955 | 0.5684 |
Onchocerca volvulus | 0.0234 | 0.3981 | 1 | |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0107 | 0.0106 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0066 | 0.0955 | 0.0906 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0107 | 0.0138 |
Brugia malayi | hypothetical protein | 0.0472 | 0.8287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0608 | 0.072 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0293 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0293 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0955 | 0.1138 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0066 | 0.0955 | 0.1794 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.002 | 0.0122 | 0.0133 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0293 | 0.1849 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.0608 | 0.0674 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.2438 | 0.2931 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0066 | 0.0955 | 0.2295 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.1897 | 0.1854 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0608 | 0.0674 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.0608 | 0.072 |
Schistosoma mansoni | pyruvate kinase | 0.0066 | 0.0955 | 0.1763 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0374 | 0.0389 |
Leishmania major | pyruvate kinase | 0.0066 | 0.0955 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0604 | 0.4725 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0066 | 0.0955 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0107 | 0.1125 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.237 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0104 | 0.1639 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0107 | 0.0054 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0088 | 0.135 | 0.8181 |
Mycobacterium ulcerans | hypothetical protein | 0.0104 | 0.1639 | 0.1594 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0145 | 0.237 | 0.2813 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.1683 | 0.0805 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0583 | 0.1036 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.0608 | 0.072 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0104 | 0.1639 | 0.1594 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0104 | 0.1639 | 0.1594 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0107 | 0.1125 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0291 | 0.5013 | 0.6024 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0107 | 0.06 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0594 | 0.0702 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0107 | 0.06 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0567 | 1 | 1 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0567 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0066 | 0.0955 | 0.2295 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0066 | 0.0955 | 0.1794 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.