Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Aph-1 protein, putative | 0.0095 | 0.0077 | 0.025 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0101 | 0.0088 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0276 | 0.0724 |
Leishmania major | N-myristoyl transferase, putative | 0.1977 | 0.31 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0124 | 0.0125 | 0.039 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0243 | 0.0315 | 0.1005 |
Plasmodium falciparum | plasmepsin I | 0.0751 | 0.1131 | 0.364 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.023 | 0.0295 | 0.0295 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0255 | 0.0335 | 0.0335 |
Echinococcus multilocularis | cathepsin b | 0.0141 | 0.0151 | 0.0475 |
Plasmodium falciparum | plasmepsin II | 0.0751 | 0.1131 | 0.364 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.0295 | 0.0775 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0146 | 0.0159 | 0.0159 |
Brugia malayi | hypothetical protein | 0.023 | 0.0295 | 0.0764 |
Plasmodium falciparum | plasmepsin X | 0.0475 | 0.0688 | 0.2208 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0017 | 0.0045 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0255 | 0.0335 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0124 | 0.0125 | 0.0778 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0288 | 0.0389 | 0.101 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1048 | 0.1609 | 0.5189 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0155 | 0.0407 |
Toxoplasma gondii | aspartyl protease | 0.023 | 0.0295 | 0.1834 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0046 | 0.0046 |
Trypanosoma cruzi | oligopeptidase b | 0.0101 | 0.0088 | 0.0285 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.023 | 0.0295 | 0.0295 |
Trypanosoma brucei | N-myristoyltransferase | 0.1977 | 0.31 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0276 | 0.0724 |
Plasmodium vivax | aspartyl proteinase, putative | 0.023 | 0.0295 | 0.0939 |
Echinococcus granulosus | cathepsin b | 0.0141 | 0.0151 | 0.0475 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0288 | 0.0389 | 0.0389 |
Onchocerca volvulus | 0.0143 | 0.0155 | 0.4613 | |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0101 | 0.0088 | 0.0285 |
Trypanosoma brucei | oligopeptidase b | 0.0101 | 0.0088 | 0.0285 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.007 | 0.0038 | 0.0038 |
Plasmodium vivax | aspartyl protease, putative | 0.0475 | 0.0688 | 0.2208 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0146 | 0.0159 | 0.0159 |
Onchocerca volvulus | 0.023 | 0.0295 | 0.8803 | |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.007 | 0.0038 | 0.0038 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0077 | 0.0049 | 0.0143 |
Trypanosoma cruzi | oligopeptidase b | 0.0101 | 0.0088 | 0.0285 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0046 | 0.0046 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0288 | 0.0389 | 0.1975 |
Leishmania major | oligopeptidase b | 0.0101 | 0.0088 | 0.0285 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0243 | 0.0315 | 0.1005 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.1977 | 0.31 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0255 | 0.0335 | 0.1081 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0421 | 0.0601 | 0.1939 |
Plasmodium falciparum | plasmepsin VII | 0.023 | 0.0295 | 0.0939 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1048 | 0.1609 | 0.1609 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0057 | 0.0017 | 0.0491 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1048 | 0.1609 | 1 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0243 | 0.0315 | 0.0817 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.1977 | 0.31 | 1 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.023 | 0.0295 | 0.0764 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.023 | 0.0295 | 0.0775 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0268 | 0.0703 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.1977 | 0.31 | 0.8138 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0751 | 0.1131 | 0.297 |
Plasmodium vivax | aspartyl protease, putative | 0.023 | 0.0295 | 0.0939 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.023 | 0.0295 | 0.0775 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0046 | 0.0046 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.007 | 0.0038 | 0.0038 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0124 | 0.0125 | 0.039 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1048 | 0.1609 | 0.5 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0146 | 0.0159 | 0.0159 |
Plasmodium falciparum | plasmepsin IX | 0.0475 | 0.0688 | 0.2208 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0124 | 0.0125 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.0389 | 0.102 |
Toxoplasma gondii | peptidase family M13 protein | 0.0288 | 0.0389 | 0.2416 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0276 | 0.0724 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0268 | 0.0703 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0049 | 0.0004 | 0.0014 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0101 | 0.0088 | 0.0285 |
Plasmodium falciparum | plasmepsin V | 0.023 | 0.0295 | 0.0939 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.0256 | 0.0671 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0288 | 0.0389 | 0.1975 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0255 | 0.0335 | 0.0335 |
Brugia malayi | Thioredoxin reductase | 0.0124 | 0.0125 | 0.0317 |
Plasmodium falciparum | thioredoxin reductase | 0.0124 | 0.0125 | 0.039 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1048 | 0.1609 | 0.5189 |
Brugia malayi | Peptidase family M13 containing protein | 0.0288 | 0.0389 | 0.101 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.023 | 0.0295 | 0.0295 |
Echinococcus multilocularis | cathepsin b | 0.0141 | 0.0151 | 0.0475 |
Plasmodium falciparum | glutathione reductase | 0.0124 | 0.0125 | 0.039 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0255 | 0.0335 | 0.1081 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.0389 | 0.102 |
Plasmodium vivax | plasmepsin IV, putative | 0.0751 | 0.1131 | 0.364 |
Brugia malayi | glutathione transferase | 0.0206 | 0.0256 | 0.066 |
Toxoplasma gondii | prolyl endopeptidase | 0.0255 | 0.0335 | 0.2083 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0049 | 0.0004 | 0.0014 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0049 | 0.0004 | 0.0014 |
Leishmania major | dihydroorotate dehydrogenase | 0.1048 | 0.1609 | 0.5189 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0141 | 0.0151 | 0.0386 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.023 | 0.0295 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0268 | 0.0703 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0046 | 0.0046 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0751 | 0.1131 | 0.364 |
Plasmodium vivax | aspartyl protease, putative | 0.0475 | 0.0688 | 0.2208 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.0389 | 0.102 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.007 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.0295 | 0.0775 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.007 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | matrixin family protein | 0.0047 | 0.0001 | 0.0002 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.1977 | 0.31 | 1 |
Schistosoma mansoni | N-myristoyltransferase | 0.1977 | 0.31 | 0.31 |
Echinococcus multilocularis | caspase 2 | 0.0057 | 0.0017 | 0.0041 |
Onchocerca volvulus | 0.023 | 0.0295 | 0.8803 | |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0049 | 0.0004 | 0.0004 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0049 | 0.0004 | 0.0027 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0146 | 0.0159 | 0.0159 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0475 | 0.0688 | 0.4277 |
Mycobacterium tuberculosis | Probable peptidase | 0.0101 | 0.0088 | 0.0523 |
Brugia malayi | hypothetical protein | 0.023 | 0.0295 | 0.0764 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0409 | 0.0583 | 0.188 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0057 | 0.0017 | 0.0017 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0409 | 0.0583 | 0.188 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0421 | 0.0601 | 0.1927 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0421 | 0.0601 | 0.1927 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0228 | 0.0292 | 0.1793 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0213 | 0.0268 | 0.0703 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.1977 | 0.31 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0141 | 0.0151 | 0.0151 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0101 | 0.0088 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0268 | 0.0703 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0421 | 0.0601 | 0.1939 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.2419 | 0.3809 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0141 | 0.0151 | 0.0488 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0409 | 0.0583 | 0.152 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0049 | 0.0004 | 0.0004 |
Plasmodium falciparum | plasmepsin IV | 0.0751 | 0.1131 | 0.364 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.1141 | 0.1757 | 0.1757 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0146 | 0.0159 | 0.0159 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.1049 | 0.161 | 0.161 |
Loa Loa (eye worm) | matrixin family protein | 0.0051 | 0.0007 | 0.0019 |
Plasmodium falciparum | plasmepsin VI | 0.0751 | 0.1131 | 0.364 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0049 | 0.0004 | 0.0014 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0409 | 0.0583 | 0.188 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0409 | 0.0583 | 0.188 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0751 | 0.1131 | 0.7033 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1048 | 0.1609 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0049 | 0.0004 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0151 | 0.0397 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.1977 | 0.31 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0751 | 0.1131 | 0.297 |
Leishmania major | trypanothione reductase | 0.0124 | 0.0125 | 0.0404 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0751 | 0.1131 | 0.364 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0243 | 0.0315 | 0.0828 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0095 | 0.0077 | 0.025 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0046 | 0.0046 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0288 | 0.0389 | 0.1241 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.023 | 0.0295 | 0.0939 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0004 | 0.0012 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0049 | 0.0004 | 0.0014 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.023 | 0.0295 | 0.1834 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0101 | 0.0088 | 0.0523 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1048 | 0.1609 | 0.5189 |
Echinococcus granulosus | prolyl endopeptidase | 0.0255 | 0.0335 | 0.1068 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.023 | 0.0295 | 0.0295 |
Plasmodium vivax | plasmepsin V, putative | 0.023 | 0.0295 | 0.0939 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1048 | 0.1609 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0049 | 0.0004 | 0.0014 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0409 | 0.0583 | 0.188 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0288 | 0.0389 | 0.2395 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0141 | 0.0151 | 0.0151 |
Brugia malayi | Pepsin A precursor | 0.023 | 0.0295 | 0.0764 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0276 | 0.0724 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0049 | 0.0004 | 0.0014 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.007 | 0.0038 | 0.0038 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.023 | 0.0295 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0276 | 0.0724 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.023 | 0.0295 | 0.0295 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.1977 | 0.31 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0124 | 0.0125 | 0.0328 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0049 | 0.0004 | 0.0113 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.1977 | 0.31 | 1 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.2419 | 0.3809 | 1 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.1977 | 0.31 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0124 | 0.0125 | 0.0328 |
Brugia malayi | Cell death protein 3 precursor | 0.0057 | 0.0017 | 0.0033 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0421 | 0.0601 | 0.1927 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.2082 | 0.3269 | 0.3269 |
Echinococcus granulosus | caspase 2 | 0.0057 | 0.0017 | 0.0041 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0141 | 0.0151 | 0.0151 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.023 | 0.0295 | 0.0764 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0421 | 0.0601 | 0.1927 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0141 | 0.0151 | 0.0151 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0255 | 0.0335 | 0.1068 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1048 | 0.1609 | 0.5189 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0124 | 0.0125 | 0.039 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1048 | 0.1609 | 0.5182 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0255 | 0.0335 | 0.0869 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1048 | 0.1609 | 0.4216 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.2082 | 0.3269 | 0.3269 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0751 | 0.1131 | 0.7033 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1048 | 0.1609 | 1 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.1977 | 0.31 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0751 | 0.1131 | 0.364 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0335 | 0.088 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0095 | 0.0077 | 0.025 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0421 | 0.0601 | 0.1927 |
Plasmodium falciparum | plasmepsin III | 0.023 | 0.0295 | 0.0939 |
Brugia malayi | peptidase family M13 containing protein | 0.007 | 0.0038 | 0.0089 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0213 | 0.0268 | 0.0703 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1048 | 0.1609 | 0.5182 |
Giardia lamblia | CDC72 | 0.1977 | 0.31 | 1 |
Brugia malayi | N-myristoyltransferase 2 | 0.1977 | 0.31 | 0.8136 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0124 | 0.0125 | 0.0753 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.1299 | 0.2011 | 0.6488 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0255 | 0.0335 | 0.1081 |
Echinococcus granulosus | cathepsin b | 0.0141 | 0.0151 | 0.0475 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0276 | 0.0724 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0751 | 0.1131 | 0.1131 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0288 | 0.0389 | 0.1241 |
Brugia malayi | Matrixin family protein | 0.0051 | 0.0007 | 0.0008 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0075 | 0.0046 | 0.0046 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.023 | 0.0295 | 0.0764 |
Brugia malayi | glutathione reductase | 0.0124 | 0.0125 | 0.0317 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.023 | 0.0295 | 0.0295 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0049 | 0.0004 | 0.5 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0101 | 0.0088 | 0.0285 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0124 | 0.0125 | 0.039 |
Trypanosoma brucei | trypanothione reductase | 0.0124 | 0.0125 | 0.0404 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0751 | 0.1131 | 0.3649 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0049 | 0.0004 | 0.0014 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1048 | 0.1609 | 0.4216 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0077 | 0.0049 | 0.0143 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0243 | 0.0315 | 0.0315 |
Schistosoma mansoni | neprilysin | 0.0075 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.007 | 0.0038 | 0.01 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.06 mg kg-1 | Tested for oral activity against S. aureus smith infection in mice after single subcutaneous dose(SSC) | ChEMBL. | No reference |
ED50 (functional) | = 0.06 mg kg-1 | Tested for oral activity against S. aureus smith infection in mice after single subcutaneous dose(SSC) | ChEMBL. | No reference |
ED50 (functional) | = 0.28 mg kg-1 | Tested for oral activity against S. aureus smith infection in mice after single oral dose(SOD) | ChEMBL. | No reference |
ED50 (functional) | = 0.28 mg kg-1 | Tested for oral activity against S. aureus smith infection in mice after single oral dose(SOD) | ChEMBL. | No reference |
ED50 (functional) | = 0.48 mg kg-1 | Tested for oral activity against E. coli #311 infection in mice after single subcutaneous dose(SSC) | ChEMBL. | No reference |
ED50 (functional) | = 0.48 mg kg-1 | Tested for oral activity against E. coli #311 infection in mice after single subcutaneous dose(SSC) | ChEMBL. | No reference |
ED50 (functional) | = 1.2 mg kg-1 | Tested for oral activity against E. coli #311 infection in mice after single oral dose(SOD) | ChEMBL. | No reference |
ED50 (functional) | = 1.2 mg kg-1 | Tested for oral activity against E. coli #311 infection in mice after single oral dose(SOD) | ChEMBL. | No reference |
MIC (functional) | = 0.03 ug ml-1 | In vitro antimicrobial activity against E. coli GC 2205 strain | ChEMBL. | No reference |
MIC (functional) | = 0.03 ug ml-1 | In vitro antimicrobial activity against E. coli GC 2205 strain | ChEMBL. | No reference |
MIC (functional) | = 0.25 ug ml-1 | In vitro antimicrobial activity against E. coli ATCC 25922 strain | ChEMBL. | No reference |
MIC (functional) | = 0.25 ug ml-1 | In vitro antimicrobial activity against S. aureus ATCC 29213 strain | ChEMBL. | No reference |
MIC (functional) | = 0.25 ug ml-1 | In vitro antimicrobial activity against E. coli ATCC 25922 strain | ChEMBL. | No reference |
MIC (functional) | = 0.5 ug ml-1 | In vitro antimicrobial activity against E. coli GC 1792 strain | ChEMBL. | No reference |
MIC (functional) | = 0.5 ug ml-1 | In vitro antimicrobial activity against E. coli GC 1792 strain | ChEMBL. | No reference |
MIC (functional) | = 1 ug ml-1 | In vitro antimicrobial activity against E. faecalis GC 842 strain | ChEMBL. | No reference |
MIC (functional) | = 4 ug ml-1 | In vitro antimicrobial activity against E. cloacae GC 2209 strain | ChEMBL. | No reference |
MIC (functional) | = 4 ug ml-1 | In vitro antimicrobial activity against M. morganii GC 2213 strain | ChEMBL. | No reference |
MIC (functional) | = 4 ug ml-1 | In vitro antimicrobial activity against S. aureus GC 2220 strain | ChEMBL. | No reference |
MIC (functional) | = 8 ug ml-1 | In vitro antimicrobial activity against C. freundii GC 2211 strain | ChEMBL. | No reference |
MIC (functional) | = 64 ug ml-1 | In vitro antimicrobial activity against A. calcoaceticus GC 756 strain | ChEMBL. | No reference |
MIC (functional) | = 64 ug ml-1 | In vitro antimicrobial activity against P. aeruginosa ATCC 27853 strain | ChEMBL. | No reference |
MIC (functional) | = 128 ug ml-1 | In vitro antimicrobial activity against P. aeruginosa GC 1544 strain | ChEMBL. | No reference |
MIC (functional) | > 128 ug ml-1 | In vitro antimicrobial activity against X. maltophilia GC 562 strain | ChEMBL. | No reference |
MIC (functional) | = 128 ug ml-1 | In vitro antimicrobial activity against E. faecium GC 1182 strain | ChEMBL. | No reference |
Ratio (functional) | = 2.5 | Ratio of ED50 of single oral dose to ED50 of single subcutaneous dose against E. coli #311 infection in mice | ChEMBL. | No reference |
Ratio (functional) | = 4.7 | Ratio of ED50 of single oral dose to ED50 of single subcutaneous dose against S. aureus smith infection in mice | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.