Detailed information for compound 649015

Basic information

Technical information
  • TDR Targets ID: 649015
  • Name: 1-[(4-ethylphenyl)methyl]-4-naphthalen-2-ylsu lfonylpiperazine
  • MW: 394.53 | Formula: C23H26N2O2S
  • H donors: 0 H acceptors: 2 LogP: 4.42 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)CN1CCN(CC1)S(=O)(=O)c1ccc2c(c1)cccc2
  • InChi: 1S/C23H26N2O2S/c1-2-19-7-9-20(10-8-19)18-24-13-15-25(16-14-24)28(26,27)23-12-11-21-5-3-4-6-22(21)17-23/h3-12,17H,2,13-16,18H2,1H3
  • InChiKey: AZOJQIMVLNXVJI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(4-ethylphenyl)methyl]-4-(2-naphthylsulfonyl)piperazine
  • 1-(4-ethylbenzyl)-4-(2-naphthylsulfonyl)piperazine
  • 1-[(4-ethylphenyl)methyl]-4-naphthalen-2-ylsulfonyl-piperazine
  • STK147096
  • Oprea1_357917

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein, putative 0.003 0.0264 0.1501
Plasmodium falciparum cyclin 0.0058 0.069 0.2823
Trypanosoma cruzi CYC2-like cyclin, putative 0.0112 0.1507 1
Brugia malayi Pre-SET motif family protein 0.0205 0.2904 0.6288
Trypanosoma brucei heat shock protein, putative 0.0045 0.0491 0.3142
Schistosoma mansoni pyruvate kinase 0.0017 0.0068 0.0042
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0014 0.0026 0.0057
Echinococcus multilocularis muscleblind protein 1 0.0318 0.4604 0.46
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0524 0.1507
Giardia lamblia Cyclin A 0.0058 0.069 0.4486
Brugia malayi Cyclin, N-terminal domain containing protein 0.0112 0.1507 0.3234
Echinococcus multilocularis cyclin dependent kinase 1 0.0047 0.0524 0.0517
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0673 0.1413
Echinococcus granulosus intermediate filament protein 0.0026 0.0213 0.0206
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0047 0.0524 0.0517
Schistosoma mansoni endoplasmin 0.0045 0.0491 0.0466
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0394 0.2482
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0306 0.0846
Mycobacterium ulcerans heat shock protein 90 0.0042 0.045 0.2668
Echinococcus multilocularis lamin dm0 0.0026 0.0213 0.0206
Plasmodium falciparum heat shock protein 90, putative 0.017 0.2378 1
Loa Loa (eye worm) hypothetical protein 0.0318 0.4604 1
Giardia lamblia G2/mitotic-specific cyclin B 0.0112 0.1507 1
Onchocerca volvulus 0.0026 0.0213 0.0565
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0264 0.072
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0087 0.0132
Giardia lamblia Grp94/Hsp90 0.0042 0.045 0.2861
Echinococcus multilocularis cyclins 0.0058 0.069 0.0684
Brugia malayi hypothetical protein 0.0036 0.0355 0.0719
Echinococcus multilocularis cyclin t1 0.0014 0.0026 0.0019
Echinococcus multilocularis pyruvate kinase 0.0026 0.0204 0.0197
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0087 0.0079
Echinococcus multilocularis cyclin b3 0.0058 0.069 0.0684
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0027 0.0058
Schistosoma mansoni pyruvate kinase 0.0033 0.0308 0.0282
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0087 0.0079
Leishmania major cytochrome p450-like protein 0.0014 0.0027 0.0003
Echinococcus multilocularis cyclins 0.0058 0.069 0.0684
Echinococcus granulosus cyclin k 0.0014 0.0026 0.0019
Brugia malayi Cyclin, N-terminal domain containing protein 0.018 0.2519 0.5446
Echinococcus multilocularis heat shock protein 90 0.0038 0.0394 0.0387
Entamoeba histolytica cyclin family protein 0.0058 0.069 0.4486
Echinococcus multilocularis cyclin k 0.0014 0.0026 0.0019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0087 0.0079
Echinococcus multilocularis Cyclin L1 0.0014 0.0026 0.0019
Echinococcus granulosus cyclin A3 4 0.0014 0.0026 0.0019
Onchocerca volvulus 0.0234 0.3331 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0047 0.0524 0.2117
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0308 0.0668
Echinococcus granulosus cyclin y 0.0014 0.0026 0.0019
Echinococcus granulosus lamin dm0 0.0026 0.0213 0.0206
Trichomonas vaginalis cyclins, putative 0.0068 0.0843 0.247
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0413 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.069 0.2009
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0394 0.0387
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Giardia lamblia Hypothetical protein 0.0058 0.069 0.4486
Plasmodium vivax heat shock protein 90, putative 0.003 0.0264 0.1012
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0112 0.1507 0.9331
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0208 0.0774
Trichomonas vaginalis cyclin B3, putative 0.0058 0.069 0.2009
Entamoeba histolytica cyclin, putative 0.0058 0.069 0.4486
Entamoeba histolytica cyclin family protein 0.0058 0.069 0.4486
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0258 0.0251
Echinococcus multilocularis cyclin B3 1 0.0058 0.069 0.0684
Loa Loa (eye worm) hypothetical protein 0.0026 0.0213 0.0463
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0308 0.1899
Echinococcus granulosus muscleblind protein 0.0318 0.4604 0.46
Echinococcus granulosus cyclin y 0.0014 0.0026 0.0019
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0491 0.1977
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0491 0.3142
Echinococcus multilocularis pyruvate kinase 0.0033 0.0308 0.03
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0691 0.2941
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Giardia lamblia Pyruvate kinase 0.0017 0.0068 0.028
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0014 0.0026 0.0019
Toxoplasma gondii exonuclease III APE 0.0058 0.0691 0.2828
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0413 0.0846
Echinococcus multilocularis cyclin A3 4 0.0014 0.0026 0.0019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0691 0.4493
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0213 0.0463
Echinococcus multilocularis cyclin B 0.0112 0.1507 0.15
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0016
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Echinococcus granulosus Cyclin L1 0.0014 0.0026 0.0019
Echinococcus multilocularis cyclins 0.0058 0.069 0.0684
Echinococcus granulosus heat shock protein 90 0.0045 0.0491 0.0485
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0258 0.0233
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Echinococcus multilocularis pyruvate kinase 0.0033 0.0308 0.03
Loa Loa (eye worm) endoplasmin 0.0045 0.0491 0.1068
Loa Loa (eye worm) cyclin domain-containing protein 0.0014 0.0026 0.0057
Onchocerca volvulus 0.0029 0.0258 0.0702
Echinococcus granulosus cyclin dependent kinase 1 0.0047 0.0524 0.0517
Echinococcus multilocularis cyclins 0.0058 0.069 0.0684
Schistosoma mansoni hypothetical protein 0.0018 0.0087 0.006
Echinococcus multilocularis heat shock protein 90 0.0045 0.0491 0.0485
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0068 0.0177
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.045 0.267
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0159 0.0344
Loa Loa (eye worm) hypothetical protein 0.0112 0.1507 0.3273
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.1613 0.159
Chlamydia trachomatis pyruvate kinase 0.0033 0.0308 0.5
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.0668
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0308 0.0851
Echinococcus granulosus cyclins 0.0058 0.069 0.0684
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0014 0.0026 0.0019
Schistosoma mansoni cyclin B3 0.018 0.2519 0.2499
Trichomonas vaginalis cyclin B, putative 0.0058 0.069 0.2009
Schistosoma mansoni hypothetical protein 0.0039 0.0402 0.0376
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0691 1
Schistosoma mansoni hypothetical protein 0.0167 0.233 0.231
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Schistosoma mansoni hypothetical protein 0.0018 0.0087 0.006
Schistosoma mansoni pyruvate kinase 0.0033 0.0308 0.0282
Trypanosoma cruzi cyclin 6, putative 0.0112 0.1507 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.0491 0.3142
Trichomonas vaginalis cyclin D, putative 0.0058 0.069 0.2009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0691 1
Echinococcus granulosus cyclin B3 1 0.0058 0.069 0.0684
Echinococcus multilocularis cyclin 0.0014 0.0026 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0258 0.0233
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0527 0.1094
Echinococcus granulosus lamin 0.0026 0.0213 0.0206
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0027 0.0004
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0047 0.0524 0.3139
Trypanosoma cruzi cyclin, putative 0.0112 0.1507 1
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0014 0.0026 0.0019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0402 0.0873
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0047 0.0524 0.1139
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0491 0.3142
Brugia malayi Hsp90 protein 0.003 0.0264 0.052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1613 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0028 0.0062
Echinococcus multilocularis microtubule associated protein 2 0.0677 1 1
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0264 0.1608
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.1613 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0413 0.0846
Loa Loa (eye worm) cyclin domain-containing protein 0.0014 0.0026 0.0057
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0394 0.2482
Echinococcus granulosus cyclin G2 0.0014 0.0026 0.0019
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0413 0.1646
Trichomonas vaginalis heat shock protein, putative 0.0042 0.045 0.1282
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0057
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0691 0.0685
Echinococcus multilocularis cyclins 0.0058 0.069 0.0684
Schistosoma mansoni ap endonuclease 0.0058 0.0691 0.0667
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0087 0.0188
Trichomonas vaginalis cyclins, putative 0.0112 0.1507 0.4479
Schistosoma mansoni hypothetical protein 0.0018 0.0087 0.006
Loa Loa (eye worm) cyclin domain-containing protein 0.0014 0.0026 0.0057
Trypanosoma brucei heat shock protein, putative 0.0045 0.0491 0.3142
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0306 0.0846
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0524 0.0499
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2904 0.6309
Echinococcus multilocularis endoplasmin 0.0042 0.045 0.0443
Brugia malayi heat shock protein 90 0.0045 0.0491 0.1016
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0308 0.0851
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0258 0.0986
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0308 0.1899
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0491 0.3142
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.018 0.2519 0.2514
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0344
Plasmodium falciparum pyruvate kinase 0.0033 0.0308 0.1195
Schistosoma mansoni heat shock protein 0.003 0.0264 0.0239
Echinococcus multilocularis GPCR, family 2 0.0018 0.0087 0.0079
Giardia lamblia Kinase, CMGC CDK 0.0047 0.0524 0.3364
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0014 0.0026 0.0019
Schistosoma mansoni lamin 0.0026 0.0213 0.0187
Echinococcus granulosus heat shock protein 90 0.0038 0.0394 0.0387
Trichomonas vaginalis cyclins, putative 0.0112 0.1507 0.4479
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0691 0.1502
Trypanosoma cruzi cdc2-related kinase 1 0.0047 0.0524 0.3364
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.045 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0691 0.4493
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.045 0.1091
Loa Loa (eye worm) hypothetical protein 0.0232 0.3305 0.718
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0491 0.3142
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0308 0.1195
Plasmodium falciparum protein kinase 5 0.0047 0.0524 0.2117
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.1613 0.1607
Plasmodium falciparum heat shock protein 90 0.0045 0.0491 0.1977
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0213 0.0408
Trypanosoma brucei heat shock protein, putative 0.0045 0.0491 0.3142
Echinococcus multilocularis pyruvate kinase 0.0017 0.0068 0.0061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1613 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.1613 1
Trypanosoma cruzi cdc2-related kinase 3 0.0047 0.0524 0.3364
Schistosoma mansoni intermediate filament proteins 0.0026 0.0213 0.0187
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0691 0.0685
Trichomonas vaginalis cyclins, putative 0.0112 0.1507 0.4479
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0308 0.0668
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0691 0.4493
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Trypanosoma brucei heat shock protein, putative 0.0045 0.0491 0.3142
Echinococcus granulosus cyclin dependent kinase 0.0047 0.0524 0.0517
Echinococcus granulosus geminin 0.0167 0.233 0.2325
Echinococcus granulosus cyclins 0.0058 0.069 0.0684
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0308 0.0851
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0308 0.0851
Loa Loa (eye worm) hypothetical protein 0.0029 0.0258 0.0561
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0068 0.0177
Schistosoma mansoni heat shock protein 0.0045 0.0491 0.0466
Brugia malayi intermediate filament protein 0.0026 0.0213 0.0408
Trypanosoma cruzi cdc2-related kinase 1 0.0047 0.0524 0.3364
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0491 0.3142
Brugia malayi hypothetical protein 0.0036 0.0355 0.0719
Plasmodium vivax SET domain protein, putative 0.0029 0.0258 0.0986
Echinococcus granulosus cyclins 0.0014 0.0026 0.0019
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0394 0.2482
Trypanosoma cruzi cyclin, putative 0.0112 0.1507 1
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0491 0.1068
Trichomonas vaginalis heat shock protein, putative 0.0042 0.045 0.1282
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.3305 0.33
Loa Loa (eye worm) heat shock protein 75 0.003 0.0264 0.0575
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0394 0.1112
Trypanosoma cruzi cdc2-related kinase 3 0.0047 0.0524 0.3364
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Echinococcus granulosus pyruvate kinase 0.0033 0.0308 0.03
Leishmania major pyruvate kinase 0.0033 0.0308 0.1772
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0491 0.3142
Trichomonas vaginalis set domain proteins, putative 0.0234 0.3331 1
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Trypanosoma cruzi heat shock protein, putative 0.003 0.0264 0.1608
Schistosoma mansoni microtubule-associated protein tau 0.0677 1 1
Leishmania major pyruvate kinase 0.0033 0.0308 0.1772
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.1613 0.1607
Echinococcus granulosus cyclin dependent kinase 5 0.0047 0.0524 0.0517
Trypanosoma brucei mitotic cyclin 6 0.0112 0.1507 1
Echinococcus multilocularis cyclin dependent kinase 0.0047 0.0524 0.0517
Loa Loa (eye worm) cyclin C 0.0014 0.0026 0.0057
Echinococcus granulosus endoplasmin 0.0042 0.045 0.0443
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0047 0.0524 0.1139
Trypanosoma brucei cdc2-related kinase 3 0.0047 0.0524 0.3364
Echinococcus multilocularis cyclin dependent kinase 5 0.0047 0.0524 0.0517
Brugia malayi Muscleblind-like protein 0.0318 0.4604 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0258 0.0233
Plasmodium vivax protein kinase Crk2 0.0047 0.0524 0.2117
Echinococcus granulosus pyruvate kinase 0.0017 0.0068 0.0061
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0057
Echinococcus multilocularis cyclin G2 0.0014 0.0026 0.0019
Echinococcus multilocularis heat shock protein 0.0045 0.0491 0.0485
Loa Loa (eye worm) hypothetical protein 0.0057 0.0673 0.1462
Loa Loa (eye worm) hypothetical protein 0.0112 0.1507 0.3273
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0691 0.2012
Echinococcus granulosus G2:mitotic specific cyclin B3 0.018 0.2519 0.2514
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0258 0.0251
Schistosoma mansoni cyclin B 0.0112 0.1507 0.1484
Echinococcus multilocularis G1:S specific cyclin D1 0.0014 0.0026 0.0019
Schistosoma mansoni survival motor neuron protein 0.0047 0.0527 0.0502
Schistosoma mansoni hypothetical protein 0.0047 0.0527 0.0502
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0491 0.3142
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Brugia malayi Cyclin, N-terminal domain containing protein 0.0112 0.1507 0.3234
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0047 0.0524 0.3139
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0491 0.3142
Trichomonas vaginalis cyclins, putative 0.0112 0.1507 0.4479
Echinococcus granulosus cyclin 0.0014 0.0026 0.0019
Entamoeba histolytica cell division protein kinase 2, putative 0.0047 0.0524 0.3364
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.1613 0.6745
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0242 0.0235
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0264 0.1608
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0413 0.1646
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0028 0.0004
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0264 0.0257
Trichomonas vaginalis cyclin B, putative 0.0112 0.1507 0.4479
Plasmodium vivax endoplasmin, putative 0.0045 0.0491 0.1977
Echinococcus multilocularis pyruvate kinase 0.0017 0.0068 0.0061
Entamoeba histolytica cyclin, putative 0.0112 0.1507 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0047 0.0524 0.3364
Echinococcus multilocularis cyclin G2 0.0014 0.0026 0.0019
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0491 0.1407
Schistosoma mansoni endoplasmin 0.0045 0.0491 0.0466
Echinococcus multilocularis cyclin y 0.0014 0.0026 0.0019
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0491 0.1977
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0491 0.3142
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0491 0.1977
Schistosoma mansoni heat shock protein 0.0045 0.0491 0.0466
Echinococcus granulosus pyruvate kinase 0.0033 0.0308 0.03
Giardia lamblia Pyruvate kinase 0.0033 0.0308 0.1899
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0308 0.1195
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0208 0.0551
Toxoplasma gondii Hsp90 domain-containing protein 0.017 0.2378 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0258 0.0251
Echinococcus multilocularis pyruvate kinase 0.0017 0.0068 0.0061
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0027 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0258 0.0233
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0673 0.1413
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0402 0.082
Brugia malayi Pre-SET motif family protein 0.0029 0.0258 0.0507
Echinococcus granulosus heat shock protein 0.0045 0.0491 0.0485
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0087 0.0132
Schistosoma mansoni hypothetical protein 0.004 0.0413 0.0388
Loa Loa (eye worm) cyclin domain-containing protein 0.0014 0.0026 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0524 0.0499
Loa Loa (eye worm) cyclin domain-containing protein 0.0014 0.0026 0.0057
Onchocerca volvulus 0.0112 0.1507 0.4479
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0673 0.1462
Trichomonas vaginalis cyclin B, putative 0.0112 0.1507 0.4479
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0308 0.0851
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0027 0.0058
Loa Loa (eye worm) hypothetical protein 0.0054 0.0631 0.1372
Loa Loa (eye worm) cyclin domain-containing protein 0.0014 0.0026 0.0057
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0047 0.0524 0.1139
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0491 0.3142
Onchocerca volvulus 0.0026 0.0213 0.0565
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0691 0.2012
Echinococcus multilocularis cyclins 0.0058 0.069 0.0684
Echinococcus multilocularis lamin 0.0026 0.0213 0.0206
Loa Loa (eye worm) hypothetical protein 0.0026 0.0206 0.0447
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0027 0.0004
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0308 0.0614
Trichomonas vaginalis cyclins, putative 0.0058 0.069 0.2009
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932
Echinococcus multilocularis cyclin y 0.0014 0.0026 0.0019
Schistosoma mansoni hypothetical protein 0.0018 0.0087 0.006
Echinococcus granulosus cyclins 0.0058 0.069 0.0684
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0491 0.3142
Echinococcus granulosus pyruvate kinase 0.0017 0.0068 0.0061
Trichomonas vaginalis cyclin D, putative 0.0058 0.069 0.2009
Echinococcus granulosus cyclin G2 0.0014 0.0026 0.0019
Loa Loa (eye worm) cyclin domain-containing protein 0.018 0.2519 0.5472
Schistosoma mansoni lamin 0.0026 0.0213 0.0187
Echinococcus multilocularis geminin 0.0167 0.233 0.2325
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0213 0.0463
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0087 0.0079
Trypanosoma brucei heat shock protein, putative 0.0045 0.0491 0.3142
Loa Loa (eye worm) hypothetical protein 0.0047 0.0517 0.1123
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0308 0.0668
Schistosoma mansoni hypothetical protein 0.0167 0.233 0.231
Brugia malayi Cytochrome P450 family protein 0.0014 0.0027 0.0001
Echinococcus granulosus G1:S specific cyclin D1 0.0014 0.0026 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1613 1
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0691 0.1453
Plasmodium vivax heat shock protein, putative 0.017 0.2378 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0068 0.0061
Trypanosoma brucei heat shock protein, putative 0.0045 0.0491 0.3142
Onchocerca volvulus 0.0047 0.0527 0.1515
Echinococcus multilocularis cyclins 0.0058 0.069 0.0684
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.3305 0.33
Toxoplasma gondii hypothetical protein 0.0044 0.0479 0.1925
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0691 0.2828
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0264 0.0257
Brugia malayi Cytochrome P450 family protein 0.0014 0.0027 0.0001
Echinococcus granulosus GPCR family 2 0.0018 0.0087 0.0079
Giardia lamblia Kinase, CMGC CDK 0.0047 0.0524 0.3364
Leishmania major cyclin 0.0112 0.1507 0.9331
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0308 0.0614
Echinococcus multilocularis musashi 0.0026 0.0213 0.0206
Brugia malayi hypothetical protein 0.0232 0.3305 0.7164
Loa Loa (eye worm) CYL-1 protein 0.0014 0.0026 0.0057
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0027 0.0004
Schistosoma mansoni cyclins 0.0058 0.069 0.0666
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0098 0.0486
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0691 0.4192
Echinococcus multilocularis muscleblind protein 0.0318 0.4604 0.46
Echinococcus granulosus cyclins 0.0058 0.069 0.0684
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0691 0.4493
Schistosoma mansoni ap endonuclease 0.0058 0.0691 0.0667
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0691 0.2828
Plasmodium falciparum endoplasmin, putative 0.0033 0.0306 0.1189
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0524 0.1507
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0524 0.1507
Loa Loa (eye worm) hypothetical protein 0.004 0.0413 0.0898
Trichomonas vaginalis cyclin A, putative 0.0112 0.1507 0.4479
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0308 0.1899
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0308 0.177
Echinococcus granulosus cyclins 0.0058 0.069 0.0684
Echinococcus granulosus cyclin B 0.0112 0.1507 0.15
Loa Loa (eye worm) hypothetical protein 0.0318 0.4604 1
Echinococcus granulosus cyclin b3 0.0058 0.069 0.0684
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0691 0.419
Echinococcus granulosus cyclin t1 0.0014 0.0026 0.0019
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0308 0.1899
Brugia malayi Endoplasmin precursor 0.0045 0.0491 0.1016
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0159 0.0893
Echinococcus multilocularis cyclin dependent kinase 1 0.0047 0.0524 0.0517
Brugia malayi cell division control protein 2 homolog 0.0047 0.0524 0.1088
Trypanosoma brucei cdc2-related kinase 1 0.0047 0.0524 0.3364
Trypanosoma brucei heat shock protein, putative 0.0045 0.0491 0.3142
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0413 0.1646
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0068 0.0177
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0413 0.0846
Trichomonas vaginalis cyclin B, putative 0.0112 0.1507 0.4479
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0691 0.4493
Trichomonas vaginalis cyclin B, putative 0.0112 0.1507 0.4479
Brugia malayi Protein kinase domain containing protein 0.0047 0.0524 0.1088
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.1613 0.159
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0264 0.1012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0087 0.0188
Leishmania major heat shock protein 83-1 0.0045 0.0491 0.2932

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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