Detailed information for compound 652764

Basic information

Technical information
  • TDR Targets ID: 652764
  • Name: methyl (2Z)-7-methyl-3-oxo-2-(2-oxo-1-prop-2- enylindol-3-ylidene)-5-thiophen-2-yl-5H-[1,3] thiazolo[3,2-a]pyrimidine-6-carboxylate
  • MW: 477.555 | Formula: C24H19N3O4S2
  • H donors: 0 H acceptors: 3 LogP: 3.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN1C(=O)/C(=c\2/sc3=NC(=C(C(n3c2=O)c2cccs2)C(=O)OC)C)/c2c1cccc2
  • InChi: 1S/C24H19N3O4S2/c1-4-11-26-15-9-6-5-8-14(15)18(21(26)28)20-22(29)27-19(16-10-7-12-32-16)17(23(30)31-3)13(2)25-24(27)33-20/h4-10,12,19H,1,11H2,2-3H3/b20-18-
  • InChiKey: NGBNYEPCCQWNCS-ZZEZOPTASA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl (2Z)-2-(1-allyl-2-oxo-indolin-3-ylidene)-7-methyl-3-oxo-5-(2-thienyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate
  • (2Z)-2-(1-allyl-2-oxo-3-indolinylidene)-7-methyl-3-oxo-5-(2-thienyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid methyl ester
  • (2Z)-2-(1-allyl-2-keto-indolin-3-ylidene)-3-keto-7-methyl-5-(2-thienyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid methyl ester
  • methyl (2Z)-7-methyl-3-oxo-2-(2-oxo-1-prop-2-enyl-indol-3-ylidene)-5-thiophen-2-yl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
  • STOCK3S-40491
  • AG-690/37079184
  • BAS 00665229

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0169 0.037 0.2666
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.001 0.0684
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Brugia malayi RNA, U transporter 1 0.0082 0.0157 0.1285
Echinococcus granulosus nibrin 0.004 0.0054 0.0335
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0265 0.0604 0.6521
Echinococcus granulosus Niemann Pick C1 protein 0.0564 0.1337 0.9791
Plasmodium vivax patched family protein, putative 0.0024 0.0015 0.1023
Schistosoma mansoni lamin 0.0031 0.0033 0.0185
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0014 0.0088
Schistosoma mansoni ran 0.0021 0.0009 0.0001
Schistosoma mansoni intermediate filament proteins 0.0031 0.0033 0.0185
Echinococcus multilocularis microtubule associated protein 2 0.0576 0.1365 0.1358
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0109 0.0743
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0109 0.0101
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0014 0.0372
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0493 0.1163 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.0604 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0126
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0015 0.0429
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0015 0.0429
Plasmodium falciparum replication factor C subunit 1, putative 0.004 0.0054 0.3592
Entamoeba histolytica hypothetical protein 0.004 0.0054 0.0496
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.001 0.0121
Onchocerca volvulus 0.0024 0.0015 0.0017
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Schistosoma mansoni hypothetical protein 0.0163 0.0356 0.2564
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0258
Echinococcus multilocularis expressed conserved protein 0.0371 0.0864 0.0856
Brugia malayi Matrixin family protein 0.009 0.0178 0.1468
Plasmodium falciparum lipid/sterol:H+ symporter 0.0024 0.0015 0.1023
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0164 0.602
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0043 0.0258
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0329 0.0761 0.5544
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0109 0.094
Echinococcus multilocularis replication factor c subunit 1 0.004 0.0054 0.0046
Loa Loa (eye worm) Smad1 0.0021 0.0008 0.0072
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0015 0.0535
Echinococcus multilocularis sterol regulatory element binding protein 0.0169 0.0371 0.0363
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.001 0.0376
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0015 0.0054
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0395 0.0922 1
Onchocerca volvulus Matrilysin homolog 0.009 0.0178 0.3775
Schistosoma mansoni hypothetical protein 0.0163 0.0356 0.2564
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0109 0.094
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0761
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0129 0.0273 1
Loa Loa (eye worm) transcription factor SMAD2 0.031 0.0715 0.6145
Echinococcus granulosus importin subunit beta 1 0.0029 0.0027 0.0138
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0015 0.0054
Brugia malayi MH2 domain containing protein 0.031 0.0715 0.6117
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0033 0.0288
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0015 0.0535
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0054 0.3205
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0401 0.0937 0.6847
Mycobacterium leprae PROBABLE HYDROLASE 0.011 0.0226 0.8178
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0054 0.3205
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0188 0.1322
Loa Loa (eye worm) MH1 domain-containing protein 0.0021 0.0008 0.0072
Brugia malayi hypothetical protein 0.004 0.0054 0.0394
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0033 0.0288
Schistosoma mansoni hypothetical protein 0.0163 0.0356 0.2564
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.001 0.0121
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Brugia malayi intermediate filament protein 0.0031 0.0033 0.0217
Plasmodium vivax glutathione reductase, putative 0.0037 0.0048 0.3189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Onchocerca volvulus Protein patched homolog 0.0024 0.0015 0.0017
Schistosoma mansoni chromosome transmission fidelity factor 0.004 0.0054 0.0335
Echinococcus multilocularis musashi 0.0031 0.0033 0.0025
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Brugia malayi Matrixin family protein 0.0218 0.0491 0.4184
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.0708 0.6085
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0054 0.0761
Echinococcus multilocularis protein dispatched 1 0.0193 0.043 0.0422
Onchocerca volvulus 0.0024 0.0015 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0761
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0371 0.6085
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.001 0.0029
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0463
Schistosoma mansoni polycystin 1-related 0.0094 0.0188 0.1321
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Plasmodium vivax replication factor C subunit 1, putative 0.004 0.0054 0.3592
Toxoplasma gondii patched family protein 0.0024 0.0015 0.0481
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.015 1
Schistosoma mansoni patched 1 0.0169 0.0371 0.2674
Brugia malayi Patched related family protein 4 0.0024 0.0015 0.006
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.015 1
Brugia malayi protein C24B5.3 0.0024 0.0015 0.006
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0048 0.3189
Schistosoma mansoni ap endonuclease 0.0022 0.001 0.0014
Onchocerca volvulus 0.0096 0.0192 0.4102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.0604 1
Brugia malayi Patched protein homolog 1 0.0024 0.0015 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0188 0.1322
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Brugia malayi hypothetical protein 0.0024 0.0015 0.006
Plasmodium vivax importin-beta 2, putative 0.0029 0.0027 0.1808
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0075 0.0139 0.0966
Echinococcus granulosus expressed conserved protein 0.0371 0.0864 0.6305
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0192 0.1591
Loa Loa (eye worm) matrix metalloproteinase 0.009 0.0178 0.153
Onchocerca volvulus 0.0128 0.027 0.5911
Giardia lamblia Fructose-bisphosphate aldolase 0.0265 0.0604 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.015 0.129
Entamoeba histolytica hypothetical protein 0.003 0.003 0.0237
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Loa Loa (eye worm) hypothetical protein 0.011 0.0226 0.1944
Entamoeba histolytica hypothetical protein 0.0023 0.0014 0.0058
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.011 0.0226 0.8276
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0015 0.0535
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.015 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0015 0.0535
Echinococcus multilocularis protein patched 0.0169 0.0371 0.0363
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0265 0.0604 0.6521
Echinococcus multilocularis survival motor neuron protein 1 0.0471 0.111 0.1103
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0761
Plasmodium falciparum importin beta, putative 0.0029 0.0027 0.1808
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Brugia malayi glutathione reductase 0.0037 0.0048 0.0341
Onchocerca volvulus 0.0024 0.0015 0.0017
Brugia malayi Matrixin family protein 0.009 0.0178 0.1468
Chlamydia trachomatis DNA ligase 0.004 0.0054 1
Schistosoma mansoni topbp1 0.004 0.0054 0.0335
Schistosoma mansoni survival motor neuron protein 0.0096 0.0192 0.1354
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0015 0.0066
Onchocerca volvulus 0.0024 0.0015 0.0017
Onchocerca volvulus 0.0024 0.0015 0.0017
Mycobacterium tuberculosis Probable reductase 0.0085 0.0164 0.602
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Echinococcus granulosus tar DNA binding protein 0.0062 0.0109 0.0743
Schistosoma mansoni transcription factor LCR-F1 0.003 0.003 0.0161
Entamoeba histolytica hypothetical protein 0.003 0.003 0.0237
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.001 0.0019
Toxoplasma gondii hypothetical protein 0.0024 0.0015 0.0481
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.004 0.0054 0.017
Schistosoma mansoni DNA ligase IV 0.004 0.0054 0.0335
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0054 0.3205
Toxoplasma gondii patched family protein 0.0024 0.0015 0.0481
Brugia malayi hypothetical protein 0.0051 0.0082 0.0633
Echinococcus granulosus survival motor neuron protein 1 0.0471 0.111 0.8121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0015 0.0535
Loa Loa (eye worm) patched family protein 0.0024 0.0015 0.0132
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0043 0.0035
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0027 0.1313
Leishmania major trypanothione reductase 0.0037 0.0048 0.2777
Echinococcus multilocularis Niemann Pick C1 protein 0.0564 0.1337 0.1329
Schistosoma mansoni hypothetical protein 0.0096 0.0192 0.1354
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0463
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0015 0.0066
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0126
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.015 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0015 0.0535
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.001 0.0014
Echinococcus granulosus snurportin 1 0.0307 0.0708 0.5153
Schistosoma mansoni hypothetical protein 0.003 0.003 0.0161
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0463
Treponema pallidum DNA ligase (lig) 0.004 0.0054 0.0734
Trichomonas vaginalis replication factor C large subunit, putative 0.004 0.0054 0.0761
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0761
Brugia malayi Patched related family protein 12 0.0024 0.0015 0.006
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0463
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.057
Schistosoma mansoni ap endonuclease 0.0022 0.001 0.0014
Echinococcus multilocularis snurportin 1 0.0307 0.0708 0.07
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0048 0.2777
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0188 0.6691
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.015 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0761
Loa Loa (eye worm) patched family protein 0.0024 0.0015 0.0132
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0169 0.0371 0.3192
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0054 0.0761
Echinococcus granulosus sterol regulatory element binding protein 0.0169 0.0371 0.2674
Onchocerca volvulus 0.009 0.0178 0.3775
Trypanosoma cruzi FHA domain containing protein, putative 0.004 0.0054 0.3205
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.001 0.0121
Onchocerca volvulus 0.004 0.0054 0.0908
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.0074
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0027 0.1313
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Entamoeba histolytica hypothetical protein 0.003 0.003 0.0237
Loa Loa (eye worm) MH2 domain-containing protein 0.0021 0.0008 0.0072
Brugia malayi RNA binding protein 0.0062 0.0109 0.0873
Brugia malayi Myosin head containing protein 0.0024 0.0015 0.006
Trypanosoma brucei trypanothione reductase 0.0037 0.0048 0.2777
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0164 0.602
Loa Loa (eye worm) patched family protein 0.0024 0.0015 0.0132
Loa Loa (eye worm) hypothetical protein 0.009 0.0178 0.153
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0329 0.0761 0.0753
Brugia malayi TAR-binding protein 0.0062 0.0109 0.0873
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0015 0.0535
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.001 0.0029
Loa Loa (eye worm) hypothetical protein 0.0207 0.0464 0.3994
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0288
Onchocerca volvulus Matrix metalloproteinase homolog 0.02 0.0447 1
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.1074 0.2583 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.004 0.0054 0.0496
Echinococcus granulosus lamin 0.0031 0.0033 0.0185
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.011 0.0226 0.1886
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0109 0.0743
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0463
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0049 0.0299
Leishmania major hypothetical protein, conserved 0.0079 0.015 1
Toxoplasma gondii patched family protein 0.0024 0.0015 0.0481
Loa Loa (eye worm) RNA binding protein 0.0062 0.0109 0.094
Loa Loa (eye worm) MH2 domain-containing protein 0.031 0.0715 0.6145
Brugia malayi hypothetical protein 0.0024 0.0015 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.0604 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0493 0.1163 0.8508
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0188 0.0179
Echinococcus granulosus lamin dm0 0.0031 0.0033 0.0185
Loa Loa (eye worm) patched family protein 0.0024 0.0015 0.0132
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0015 0.0535
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Plasmodium falciparum thioredoxin reductase 0.0037 0.0048 0.3189
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0233
Brugia malayi protein C24B5.3 0.0024 0.0015 0.006
Loa Loa (eye worm) hypothetical protein 0.009 0.0178 0.153
Toxoplasma gondii thioredoxin reductase 0.0037 0.0048 0.2777
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0109 0.0743
Echinococcus multilocularis lamin dm0 0.0031 0.0033 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0015 0.0066
Onchocerca volvulus 0.0031 0.0033 0.0436
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0027 0.0019
Brugia malayi topoisomerase 0.004 0.0054 0.0394
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0188 0.1322
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0015 0.0429
Echinococcus granulosus Niemann Pick C1 protein 0.0395 0.0922 0.6737
Brugia malayi CHE-14 protein 0.0169 0.0371 0.3143
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.001 0.0376
Brugia malayi hypothetical protein 0.004 0.0054 0.0394
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0276
Brugia malayi Pax transcription activation domain interacting protein 0.004 0.0054 0.0394
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0126
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0054 0.0761
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0129 0.0273 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.0604 1
Schistosoma mansoni hypothetical protein 0.0128 0.027 0.193
Brugia malayi Importin beta-1 subunit 0.0029 0.0027 0.0162
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0164 0.602
Toxoplasma gondii ATPase, AAA family protein 0.004 0.0054 0.3205
Brugia malayi hypothetical protein 0.003 0.003 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0054 0.3205
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0027 0.1313
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.001 0.0121
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0463
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.0604 1
Loa Loa (eye worm) hypothetical protein 0.0395 0.0922 0.7933
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.009 0.0178 0.1249
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.001 0.0029
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.0001
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0009 0.057
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0109 0.0743
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.015 1
Schistosoma mansoni topbp1 0.004 0.0054 0.0335
Brugia malayi DKFZp564C0469 protein 0.004 0.0054 0.0394
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0015 0.0054
Schistosoma mansoni importin beta-1 0.0029 0.0027 0.0138
Onchocerca volvulus 0.0031 0.0033 0.0436
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.0604 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.004 0.0054 0.1972
Brugia malayi hypothetical protein 0.0024 0.0015 0.006
Mycobacterium ulcerans hydrolase 0.011 0.0226 0.8276
Giardia lamblia Replication factor C, subunit 1 0.004 0.0054 0.0761
Loa Loa (eye worm) hypothetical protein 0.009 0.0178 0.153
Echinococcus multilocularis nibrin 0.004 0.0054 0.0045
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0048 0.1751
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0188 0.1322
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0188 0.1554
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0493 0.1163 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0395 0.0922 0.0915
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0014 0.0088
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.004 0.0054 0.3205
Schistosoma mansoni lamin 0.0031 0.0033 0.0185
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.004 0.0054 0.0394
Brugia malayi Patched related family protein 10 0.0024 0.0015 0.006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.003 0.0022
Brugia malayi hypothetical protein 0.0471 0.111 0.9545
Toxoplasma gondii patched family protein 0.0024 0.0015 0.0481
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0188 0.6868
Entamoeba histolytica hypothetical protein 0.003 0.003 0.0237
Leishmania major importin beta-1 subunit, putative 0.0023 0.0014 0.0372
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0493 0.1163 0.1155
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Toxoplasma gondii exonuclease III APE 0.0022 0.001 0.0121
Onchocerca volvulus Matrilysin homolog 0.02 0.0447 1
Schistosoma mansoni microtubule-associated protein tau 0.0576 0.1365 1
Brugia malayi Hemopexin family protein 0.0128 0.027 0.2268
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.004 0.0054 0.1519
Loa Loa (eye worm) glutathione reductase 0.0037 0.0048 0.0411
Onchocerca volvulus 0.0024 0.0015 0.0017
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0129 0.0273 1
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Onchocerca volvulus Protein patched homolog 0.0024 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.001 0.0684
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0054 0.0761
Loa Loa (eye worm) hypothetical protein 0.0169 0.0371 0.3192
Brugia malayi Matrixin family protein 0.009 0.0178 0.1468
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0109 0.0743
Brugia malayi hypothetical protein 0.0079 0.015 0.1227
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0015 0.0535
Loa Loa (eye worm) matrixin family protein 0.0218 0.0491 0.4226
Brugia malayi Matrixin family protein 0.009 0.0178 0.1468
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Loa Loa (eye worm) hypothetical protein 0.0471 0.111 0.9549
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0109 0.0873
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.001 0.0016
Onchocerca volvulus 0.0024 0.0015 0.0017
Echinococcus granulosus geminin 0.0169 0.037 0.2666
Schistosoma mansoni hypothetical protein 0.0169 0.037 0.2666
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0049 0.0041
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0164 0.5795
Brugia malayi Niemann-Pick C1 protein precursor 0.0395 0.0922 0.7918
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0164 0.602
Echinococcus multilocularis geminin 0.0169 0.037 0.0362
Loa Loa (eye worm) patched family protein 0.0024 0.0015 0.0132
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0009 0.0001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.001 0.0088
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Echinococcus granulosus microtubule associated protein 2 0.0576 0.1365 1
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0048 0.0411
Brugia malayi hypothetical protein 0.0024 0.0015 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.0604 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.003 0.0161
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0015 0.0535
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Treponema pallidum fructose-bisphosphate aldolase 0.0265 0.0604 1
Schistosoma mansoni ran 0.0021 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Loa Loa (eye worm) matrixin family protein 0.02 0.0447 0.3846
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0033 0.0217
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0188 0.1615
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Echinococcus granulosus intermediate filament protein 0.0031 0.0033 0.0185
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0014 0.0088
Brugia malayi Patched family protein 0.0024 0.0015 0.006
Brugia malayi Thioredoxin reductase 0.0037 0.0048 0.0341
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0188 0.6868
Echinococcus granulosus Protein patched homolog 1 0.0169 0.0371 0.2674
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0188 0.0179
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.001 0.0002
Plasmodium falciparum glutathione reductase 0.0037 0.0048 0.3189
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0493 0.1163 0.8508
Schistosoma mansoni hypothetical protein 0.0307 0.0708 0.5153
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.0604 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0132
Schistosoma mansoni hypothetical protein 0.0163 0.0356 0.2564
Echinococcus multilocularis lamin 0.0031 0.0033 0.0025
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.015 1
Echinococcus granulosus replication factor c subunit 1 0.004 0.0054 0.0335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0188 0.1322
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0188 0.6868
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0164 0.602

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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