Detailed information for compound 652977

Basic information

Technical information
  • TDR Targets ID: 652977
  • Name: 1-[(5,6-dimethyl-1H-benzimidazol-2-yl)sulfany l]-3,3-dimethylbutan-2-one
  • MW: 276.397 | Formula: C15H20N2OS
  • H donors: 1 H acceptors: 2 LogP: 4.04 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc2[nH]c(nc2cc1C)SCC(=O)C(C)(C)C
  • InChi: 1S/C15H20N2OS/c1-9-6-11-12(7-10(9)2)17-14(16-11)19-8-13(18)15(3,4)5/h6-7H,8H2,1-5H3,(H,16,17)
  • InChiKey: SFIISOWJHAYNEE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(5,6-dimethyl-1H-benzimidazol-2-yl)sulfanyl]-3,3-dimethyl-butan-2-one
  • 1-[(5,6-dimethyl-1H-benzimidazol-2-yl)thio]-3,3-dimethylbutan-2-one
  • 1-[(5,6-dimethyl-1H-benzimidazol-2-yl)thio]-3,3-dimethyl-butan-2-one
  • ZINC03164265
  • STK014077
  • Enamine_000374

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0037 0.0241 0.1793
Trypanosoma brucei DNA polymerase eta, putative 0.0052 0.0436 0.1035
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.0753 0.071
Trichomonas vaginalis protein kinase inhibitor, putative 0.0063 0.0572 0.1614
Loa Loa (eye worm) DnaJ domain-containing protein 0.0063 0.0572 0.1501
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0213 0.0443
Brugia malayi PHD-finger family protein 0.0029 0.0141 0.0337
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0136 0.0275
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0213 0.0168
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0336 0.077
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0055 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1131 0.3328
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1131 1
Schistosoma mansoni polycystin 1-related 0.0055 0.0471 0.1128
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0136 0.0275
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1131 0.288
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0714 0.5668
Echinococcus multilocularis muscleblind protein 1 0.0168 0.1913 0.1876
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0136 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0112 0.12 0.2062
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.054 0.1416
Onchocerca volvulus 0.0074 0.0714 0.1969
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.1131 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0074 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0231 0.2724 0.7108
Leishmania major importin beta-1 subunit, putative 0.0024 0.0074 0.0075
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0141 0.015
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0136 0.0275
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0231 0.2724 0.269
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.1131 0.5958
Brugia malayi ImpB/MucB/SamB family protein 0.0052 0.0436 0.1378
Onchocerca volvulus 0.0277 0.3306 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0141 0.1428
Entamoeba histolytica hypothetical protein 0.0037 0.0241 0.1793
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.1056 0.1815
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0055 0.0145
Loa Loa (eye worm) hypothetical protein 0.0161 0.183 0.48
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0046 0.1388
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Schistosoma mansoni hypothetical protein 0.0029 0.0141 0.0253
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0046 0.0121
Trypanosoma cruzi DNA polymerase eta, putative 0.0052 0.0436 0.1035
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0338 0.0459
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0714 0.205
Schistosoma mansoni hypothetical protein 0.0051 0.042 0.0992
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0231 0.2724 0.7143
Brugia malayi hypothetical protein 0.0037 0.0241 0.0687
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0079 0.0116
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0714 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0231 0.2724 0.9463
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0714 0.1774
Entamoeba histolytica hypothetical protein 0.0037 0.0241 0.1793
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1131 0.288
Brugia malayi beta-lactamase 0.0074 0.0714 0.2361
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0207
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0231 0.2724 0.4208
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1131 1
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0136 0.134
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.0415
Echinococcus granulosus dna polymerase eta 0.0052 0.0436 0.0613
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0714 0.1228
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0055 0.0009
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.1131 0.9385
Mycobacterium ulcerans hypothetical protein 0.0167 0.1898 1
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.022 0.0274
Echinococcus granulosus neuropeptide receptor A26 0.0519 0.641 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0473 0.5818 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0213 0.0443
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0079 0.0415
Echinococcus multilocularis snurportin 1 0.0316 0.3813 0.3785
Brugia malayi beta-lactamase family protein 0.0074 0.0714 0.2361
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0714 0.1774
Loa Loa (eye worm) hypothetical protein 0.0168 0.1913 0.5017
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0079 0.0087
Schistosoma mansoni DNA polymerase eta 0.0052 0.0436 0.1035
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.042 0.1321
Brugia malayi Latrophilin receptor protein 2 0.0051 0.042 0.1321
Giardia lamblia DINP protein human, muc B family 0.0023 0.0055 0.0978
Echinococcus multilocularis dna polymerase eta 0.0052 0.0436 0.0392
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0714 0.205
Trypanosoma brucei unspecified product 0.0023 0.0055 0.0025
Loa Loa (eye worm) hypothetical protein 0.0074 0.0714 0.1873
Leishmania major trypanothione reductase 0.0044 0.0332 0.076
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.1131 0.1944
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0714 0.205
Schistosoma mansoni hypothetical protein 0.0063 0.0572 0.1397
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1131 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0055 0.0095
Schistosoma mansoni hypothetical protein 0.0051 0.042 0.0992
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0316 0.3813 1
Leishmania major hypothetical protein, conserved 0.0074 0.0714 0.1774
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0146 0.0266
Schistosoma mansoni hypothetical protein 0.0037 0.0241 0.0516
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0055 0.0025
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0136 0.0825
Mycobacterium tuberculosis Conserved protein 0.0074 0.0714 0.1228
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0136 0.4082
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.034 0.0461
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Leishmania major DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.1056 0.1815
Echinococcus multilocularis neuropeptide s receptor 0.0519 0.641 0.6394
Plasmodium falciparum thioredoxin reductase 0.0044 0.0332 1
Toxoplasma gondii hypothetical protein 0.0051 0.042 0.5591
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.042 0.0376
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0197 0.0237
Echinococcus granulosus muscleblind protein 0.0168 0.1913 0.2934
Echinococcus multilocularis peregrin 0.0029 0.0141 0.0096
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.042 0.0376
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0993 0.1488
Brugia malayi glutathione reductase 0.0044 0.0332 0.1011
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0714 0.1228
Plasmodium falciparum phd finger protein, putative 0.0029 0.0141 0.4259
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.042 0.0587
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0055 0.0292
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0288 0.038
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0136 0.134
Loa Loa (eye worm) hypothetical protein 0.0074 0.0714 0.1873
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0136 0.0275
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0714 0.1228
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0079 0.0301
Echinococcus multilocularis importin subunit beta 1 0.003 0.0146 0.0101
Loa Loa (eye worm) hypothetical protein 0.003 0.0146 0.0383
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0079 0.0301
Brugia malayi Thioredoxin reductase 0.0044 0.0332 0.1011
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0336 0.077
Loa Loa (eye worm) hypothetical protein 0.0052 0.0436 0.1143
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.0415
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1131 0.2966
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0714 0.1228
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0136 0.134
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0055 0.0025
Schistosoma mansoni hypothetical protein 0.0051 0.042 0.0992
Echinococcus granulosus peregrin 0.0029 0.0141 0.015
Echinococcus multilocularis dnaJ subfamily C 6 0.0063 0.0572 0.0529
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.0753 0.1877
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0207
Brugia malayi Importin beta-1 subunit 0.003 0.0146 0.0354
Brugia malayi RNA, U transporter 1 0.0084 0.0845 0.2823
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0079 0.0415
Brugia malayi jmjC domain containing protein 0.0096 0.0993 0.3347
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0112 0.12 0.2062
Plasmodium vivax glutathione reductase, putative 0.0044 0.0332 0.4651
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0055 0.0025
Mycobacterium tuberculosis Conserved protein 0.0074 0.0714 0.1228
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0213 0.0559
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0714 0.1228
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0161 0.183 0.6305
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.1056 0.8717
Mycobacterium tuberculosis Conserved protein 0.0074 0.0714 0.1228
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0993 0.0951
Loa Loa (eye worm) hypothetical protein 0.0074 0.0714 0.1873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0231 0.2724 0.7108
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.3813 1
Loa Loa (eye worm) phosphofructokinase 0.0107 0.1131 0.2966
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0046 0.0645
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.1898 0.3263
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0714 0.205
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0136 0.9384
Giardia lamblia PHD finger protein 15 0.0029 0.0141 1
Mycobacterium tuberculosis Probable reductase 0.0101 0.1056 0.1815
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.1056 0.1815
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0055 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0714 0.205
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0714 0.3763
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0231 0.2724 0.4208
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0161 0.183 0.48
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0336 0.077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0079 0.0135
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0055 0.0292
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1682 0.4343
Plasmodium falciparum importin beta, putative 0.003 0.0146 0.44
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0213 0.0443
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0079 0.0301
Loa Loa (eye worm) glutathione reductase 0.0044 0.0332 0.0871
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0332 0.076
Mycobacterium ulcerans beta-lactamase 0.0074 0.0714 0.3763
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.042 0.1101
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.1056 0.1815
Echinococcus granulosus snurportin 1 0.0316 0.3813 0.592
Brugia malayi Pre-SET motif family protein 0.0243 0.2876 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.0753 0.2499
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.0753 0.1975
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0288 0.0243
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0714 0.1774
Loa Loa (eye worm) hypothetical protein 0.005 0.0409 0.1072
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0136 0.1898
Toxoplasma gondii thioredoxin reductase 0.0044 0.0332 0.4282
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0237 0.2859
Loa Loa (eye worm) hypothetical protein 0.0051 0.042 0.1101
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.1131 0.109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0231 0.2724 0.269
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0753 0.1877
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.046 0.11
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0241 0.0306
Schistosoma mansoni importin beta-1 0.003 0.0146 0.0266
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0141 0.0096
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0055 0.0086
Brugia malayi Bromodomain containing protein 0.0029 0.0141 0.0337
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.1131 0.1705
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1131 0.3328
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.1682 0.4343
Mycobacterium leprae Probable lipase LipE 0.0074 0.0714 0.5668
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0146 0.0266
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0338 0.0293
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0714 0.1774
Schistosoma mansoni hypothetical protein 0.0051 0.042 0.0992
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0146 0.1498
Echinococcus granulosus GPCR family 2 0.0051 0.042 0.0587
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0055 0.0025
Brugia malayi Muscleblind-like protein 0.0168 0.1913 0.6597
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0714 0.0671
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0207
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0136 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0136 1
Onchocerca volvulus 0.0035 0.0213 0.0416
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.0753 0.1111
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.3813 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1682 0.4343
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0332 0.0571
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0079 0.0087
Mycobacterium ulcerans lipase LipD 0.0074 0.0714 0.3763
Trypanosoma brucei trypanothione reductase 0.0044 0.0332 0.076
Plasmodium vivax importin-beta 2, putative 0.003 0.0146 0.2046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0055 0.0095
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0136 0.4082
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.022 0.0462
Loa Loa (eye worm) hypothetical protein 0.0074 0.0714 0.1873
Entamoeba histolytica hypothetical protein 0.0037 0.0241 0.1793
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Mycobacterium ulcerans hypothetical protein 0.0074 0.0714 0.3763
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0136 0.1898
Brugia malayi Pre-SET motif family protein 0.0035 0.0213 0.059
Echinococcus granulosus importin subunit beta 1 0.003 0.0146 0.0157
Brugia malayi DnaJ domain containing protein 0.0063 0.0572 0.186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0231 0.2724 0.7108
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0714 0.2361
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0136 0.0275
Toxoplasma gondii ABC1 family protein 0.0074 0.0714 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0079 0.0415
Onchocerca volvulus 0.0074 0.0714 0.1969
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0141 0.1428
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0213 0.0443
Loa Loa (eye worm) hypothetical protein 0.011 0.1178 0.3088
Plasmodium falciparum glutathione reductase 0.0044 0.0332 1
Loa Loa (eye worm) beta-lactamase 0.0074 0.0714 0.1873
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0336 0.077
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0714 0.1774
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.1056 0.1815
Leishmania major DNA polymerase eta, putative 0.0052 0.0436 0.1035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0213 0.2499
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0626 0.7776 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.1178 0.3998
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0055 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1131 0.3328
Leishmania major DNA polymerase eta, putative 0.0037 0.0237 0.0507
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0714 0.105
Plasmodium vivax SET domain protein, putative 0.0035 0.0213 0.2983
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.1131 0.288
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0055 0.0025
Mycobacterium tuberculosis Probable oxidoreductase 0.0112 0.12 0.2062
Echinococcus granulosus dna polymerase kappa 0.0023 0.0055 0.0015
Loa Loa (eye worm) hypothetical protein 0.0168 0.1913 0.5017
Leishmania major mitochondrial DNA polymerase beta 0.0316 0.3813 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0753 0.1877
Trichomonas vaginalis esterase, putative 0.0074 0.0714 0.205
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.0753 0.6518
Echinococcus granulosus dnaJ subfamily C 6 0.0063 0.0572 0.0827
Brugia malayi beta-lactamase family protein 0.0074 0.0714 0.2361
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Echinococcus multilocularis muscleblind protein 0.0168 0.1913 0.1876
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0241 0.0516
Echinococcus granulosus neuropeptide s receptor 0.0519 0.641 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0079 0.0415
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0079 0.0087
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0136 0.0275
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1131 0.288
Schistosoma mansoni hypothetical protein 0.011 0.1178 0.3003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0161 0.183 0.6305
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0079 0.0135
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0141 0.0371
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0079 0.0415
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.022 0.0578
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0237 0.0507
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0055 0.0029
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0213 0.0262
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.0753 0.1877
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0079 0.0116
Brugia malayi jmjC domain containing protein 0.0035 0.022 0.0615
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0741 0.1845
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1131 0.288
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.042 0.0587
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Entamoeba histolytica hypothetical protein 0.0024 0.0074 0.0262
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0055 0.0029
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0714 0.1228
Loa Loa (eye worm) hypothetical protein 0.0074 0.0714 0.1873
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0714 0.3763
Loa Loa (eye worm) hypothetical protein 0.0074 0.0714 0.1873
Trichomonas vaginalis set domain proteins, putative 0.0277 0.3306 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0055 0.0025
Onchocerca volvulus 0.0074 0.0714 0.1969
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0141 0.0253
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0112 0.12 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0714 0.1873
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.2876 0.7542
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0714 0.1228
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0332 0.4651
Brugia malayi phosphofructokinase 0.0107 0.1131 0.3834
Brugia malayi 6-phosphofructokinase 0.0107 0.1131 0.3834
Onchocerca volvulus Alhambra homolog 0.0029 0.0141 0.0194
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0074 0.0087
Schistosoma mansoni hypothetical protein 0.0316 0.3813 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.022 0.0462
Echinococcus multilocularis GPCR, family 2 0.0051 0.042 0.0376
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.0415
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.022 0.0175
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.034 0.0295
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0055 0.0025
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.3813 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0753 0.1877
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0213 0.0168
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0241 0.0195
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0332 0.0871
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1131 0.3328
Echinococcus multilocularis neuropeptide receptor A26 0.0519 0.641 0.6394
Brugia malayi 6-phosphofructokinase 0.0107 0.1131 0.3834
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0141 0.1981
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0079 0.0116
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1131 0.2966
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.0371

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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