Detailed information for compound 654999

Basic information

Technical information
  • TDR Targets ID: 654999
  • Name: 4-bromo-N-(3-methoxyphenyl)-1-methylpyrazole- 3-carboxamide
  • MW: 310.147 | Formula: C12H12BrN3O2
  • H donors: 1 H acceptors: 2 LogP: 2.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NC(=O)c1nn(cc1Br)C
  • InChi: 1S/C12H12BrN3O2/c1-16-7-10(13)11(15-16)12(17)14-8-4-3-5-9(6-8)18-2/h3-7H,1-2H3,(H,14,17)
  • InChiKey: NAVYJKQZNPZIKY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-bromo-N-(3-methoxyphenyl)-1-methyl-pyrazole-3-carboxamide
  • 4-bromo-N-(3-methoxyphenyl)-1-methyl-3-pyrazolecarboxamide
  • CBDivE_012296
  • Oprea1_575880
  • SMR000117118
  • AG-690/33350003
  • ZINC00096543
  • 4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid (3-methoxy-phenyl)-amide
  • BAS 00614204
  • MLS000526644
  • Oprea1_417653
  • EU-0007445
  • ST031039

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1439 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0033 0.0058 0.0054
Schistosoma mansoni hypothetical protein 0.0029 0.0044 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.011
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0102 0.0099
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0044 0.0714
Schistosoma mansoni aldehyde dehydrogenase 0.0058 0.0162 0.0159
Brugia malayi Thioredoxin reductase 0.0032 0.0056 0.0929
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0003 0.0496
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.004 0.5688
Plasmodium falciparum importin beta, putative 0.0035 0.0067 1
Brugia malayi latrophilin 2 splice variant baaae 0.0063 0.0181 0.3153
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0044 0.004
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0067 0.9858
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.0568 0.0565
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0068 1
Schistosoma mansoni lamin 0.005 0.0128 0.0125
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0173 0.0169
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0003 0.0496
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0173 0.0169
Brugia malayi Muscleblind-like protein 0.0143 0.0509 0.8956
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0068 0.0064
Echinococcus granulosus tar DNA binding protein 0.0061 0.0173 0.0169
Echinococcus multilocularis muscleblind protein 0.0143 0.0509 0.0506
Mycobacterium tuberculosis Probable oxidoreductase 0.0081 0.0257 1
Brugia malayi RNA binding protein 0.0061 0.0173 0.2998
Loa Loa (eye worm) glutathione reductase 0.0032 0.0056 0.0366
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0058 0.0162 0.0159
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0058 0.0162 0.6277
Echinococcus granulosus acetylcholinesterase 0.0069 0.0208 0.0204
Echinococcus granulosus tumor protein p63 0.0342 0.1318 0.1315
Echinococcus granulosus neuropeptide s receptor 0.041 0.1597 0.1594
Loa Loa (eye worm) hypothetical protein 0.0069 0.0208 0.1424
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0068 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.005 0.0128 0.0868
Schistosoma mansoni alpha-glucosidase 0.0136 0.0479 0.0475
Plasmodium vivax importin-beta 2, putative 0.0035 0.0067 1
Onchocerca volvulus 0.005 0.0129 0.0055
Schistosoma mansoni hypothetical protein 0.0029 0.0044 0.004
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0073 0.0223 0.8686
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0029 0.4037
Toxoplasma gondii thioredoxin reductase 0.0032 0.0056 0.1991
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.011
Brugia malayi Intermediate filament tail domain containing protein 0.005 0.0128 0.2205
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 1
Onchocerca volvulus 0.0091 0.0297 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0068 1
Entamoeba histolytica hypothetical protein 0.0043 0.0102 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0568 0.0565
Echinococcus multilocularis GPCR, family 2 0.0029 0.0044 0.004
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0081 0.0257 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0068 0.6528
Trichomonas vaginalis importin beta-1, putative 0.0028 0.004 0.5902
Brugia malayi TAR-binding protein 0.0061 0.0173 0.2998
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.009 0.0087
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.0044 0.004
Entamoeba histolytica Ran family GTPase 0.0026 0.0029 0.2635
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.3126 0.3124
Echinococcus granulosus geminin 0.0445 0.1736 0.1733
Mycobacterium tuberculosis Probable dehydrogenase 0.0073 0.0223 0.8686
Loa Loa (eye worm) hypothetical protein 0.0035 0.0067 0.0442
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 1
Brugia malayi cytoplasmic intermediate filament protein 0.0027 0.0034 0.0537
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.009 0.0087
Echinococcus granulosus neuropeptide receptor A26 0.041 0.1597 0.1594
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.004 0.5902
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0173 0.118
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0068 0.0064
Echinococcus multilocularis microtubule associated protein 2 0.2474 1 1
Plasmodium vivax thioredoxin reductase, putative 0.0032 0.0056 0.7079
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0073 0.0223 0.8686
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0029 0.046
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0068 0.6528
Brugia malayi Importin beta-1 subunit 0.0035 0.0067 0.1123
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.009 0.0606
Echinococcus multilocularis carboxylesterase 5A 0.0069 0.0208 0.0204
Schistosoma mansoni importin beta-1 0.0035 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.0143 0.0509 0.3524
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0068 1
Echinococcus multilocularis musashi 0.005 0.0128 0.0125
Schistosoma mansoni hypothetical protein 0.0043 0.0102 0.0099
Loa Loa (eye worm) hypothetical protein 0.0092 0.03 0.2067
Echinococcus granulosus muscleblind protein 0.0143 0.0509 0.0506
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0102 0.0099
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0029 0.4037
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0068 0.2881
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.0044 0.004
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0024 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Entamoeba histolytica hypothetical protein 0.0043 0.0102 1
Leishmania major GTP-binding protein, putative 0.0026 0.0029 0.1632
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.0568 1
Entamoeba histolytica hypothetical protein 0.0043 0.0102 1
Loa Loa (eye worm) RNA binding protein 0.0061 0.0173 0.118
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.0568 0.3934
Schistosoma mansoni lamin 0.005 0.0128 0.0125
Loa Loa (eye worm) hypothetical protein 0.0069 0.0208 0.1424
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0068 0.0448
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0081 0.0257 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0068 0.1139
Echinococcus multilocularis muscleblind protein 1 0.0143 0.0509 0.0506
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0058 0.0162 0.0159
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0281
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0081 0.0257 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0033 0.0058 0.0054
Schistosoma mansoni hypothetical protein 0.0445 0.1736 0.1733
Echinococcus granulosus GPCR family 2 0.0029 0.0044 0.004
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0029 0.4037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.009 0.0087
Echinococcus multilocularis geminin 0.0445 0.1736 0.1733
Mycobacterium ulcerans aldehyde dehydrogenase 0.0058 0.0162 1
Schistosoma mansoni intermediate filament proteins 0.005 0.0128 0.0125
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0029 1
Plasmodium vivax glutathione reductase, putative 0.0032 0.0056 0.7079
Trypanosoma brucei trypanothione reductase 0.0032 0.0056 0.8157
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0874
Schistosoma mansoni alpha-glucosidase 0.0136 0.0479 0.0475
Schistosoma mansoni ran 0.0026 0.0029 0.0026
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.1172 0.4698 0.5
Brugia malayi RNA, U transporter 1 0.0099 0.0328 0.5752
Echinococcus multilocularis snurportin 1 0.0372 0.1439 0.1436
Echinococcus granulosus carboxylesterase 5A 0.0069 0.0208 0.0204
Echinococcus granulosus importin subunit beta 1 0.0035 0.0067 0.0063
Brugia malayi Calcitonin receptor-like protein seb-1 0.0092 0.03 0.5255
Loa Loa (eye worm) carboxylesterase 0.0069 0.0208 0.1424
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0024 0.0023 0.002
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0129 0.0126
Schistosoma mansoni hypothetical protein 0.0063 0.0181 0.0178
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0173 0.0169
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0073 0.0223 0.8686
Schistosoma mansoni alpha glucosidase 0.0035 0.0068 0.0064
Loa Loa (eye worm) acetylcholinesterase 1 0.0069 0.0208 0.1424
Echinococcus multilocularis neuropeptide s receptor 0.041 0.1597 0.1594
Schistosoma mansoni polycystin 1-related 0.0103 0.0344 0.0341
Echinococcus multilocularis lamin dm0 0.005 0.0128 0.0125
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0102 0.0099
Echinococcus multilocularis lamin 0.005 0.0128 0.0125
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0068 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0068 1
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0056 0.8157
Loa Loa (eye worm) hypothetical protein 0.0143 0.0509 0.3524
Plasmodium falciparum glutathione reductase 0.0032 0.0056 0.7079
Loa Loa (eye worm) thioredoxin reductase 0.0032 0.0056 0.0366
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0068 0.4043
Loa Loa (eye worm) hypothetical protein 0.0063 0.0181 0.124
Plasmodium falciparum thioredoxin reductase 0.0032 0.0056 0.7079
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0068 1
Echinococcus granulosus lamin 0.005 0.0128 0.0125
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0029 0.0026
Loa Loa (eye worm) hypothetical protein 0.005 0.0128 0.0868
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0029 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.009 0.0087
Entamoeba histolytica hypothetical protein 0.0028 0.004 0.3713
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0029 0.0026
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0173 0.0169
Echinococcus granulosus lamin dm0 0.005 0.0128 0.0125
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0173 0.2998
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0092 0.03 0.2067
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0568 0.0565
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0068 1
Schistosoma mansoni aldehyde dehydrogenase 0.0058 0.0162 0.0159
Schistosoma mansoni microtubule-associated protein tau 0.2474 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0208 0.0204
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0067 0.9858
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0092 0.03 0.5255
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0208 0.0204
Echinococcus multilocularis neuropeptide receptor A26 0.041 0.1597 0.1594
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0173 0.0169
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0173 0.118
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0173 0.0169
Echinococcus granulosus acetylcholinesterase 0.0069 0.0208 0.0204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.009 0.0087
Schistosoma mansoni hypothetical protein 0.0372 0.1439 0.1436
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0044 0.0714
Trypanosoma brucei glucosidase, putative 0.0035 0.0068 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0058 0.0162 1
Schistosoma mansoni hypothetical protein 0.0029 0.0044 0.004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0044 0.0281
Toxoplasma gondii aldehyde dehydrogenase 0.0058 0.0162 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0073 0.0223 0.8686
Mycobacterium ulcerans aldehyde dehydrogenase 0.0058 0.0162 1
Schistosoma mansoni hypothetical protein 0.0445 0.1736 0.1733
Trichomonas vaginalis ran, putative 0.0026 0.0029 0.4332
Brugia malayi intermediate filament protein 0.005 0.0128 0.2205
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.009 0.0087
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0067 0.2813
Echinococcus granulosus snurportin 1 0.0372 0.1439 0.1436
Mycobacterium tuberculosis Probable reductase 0.0073 0.0223 0.8686
Echinococcus granulosus intermediate filament protein 0.005 0.0128 0.0125
Schistosoma mansoni hypothetical protein 0.0029 0.0044 0.004
Echinococcus multilocularis tumor protein p63 0.0342 0.1318 0.1315
Entamoeba histolytica hypothetical protein 0.0043 0.0102 1
Brugia malayi glutathione reductase 0.0032 0.0056 0.0929
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.009 0.0087
Leishmania major importin beta-1 subunit, putative 0.0028 0.004 0.23
Brugia malayi Carboxylesterase family protein 0.0069 0.0208 0.3619
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0208 0.0204
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0027 0.0034 0.0211
Brugia malayi Carboxylesterase family protein 0.0069 0.0208 0.3619
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0058 0.0162 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0044 0.004
Leishmania major trypanothione reductase 0.0032 0.0056 0.3298
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.004 0.5902
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0032 0.0056 0.207
Schistosoma mansoni ran 0.0026 0.0029 0.0026
Loa Loa (eye worm) hypothetical protein 0.0049 0.0124 0.0842
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.009 0.154
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0068 1
Loa Loa (eye worm) intermediate filament protein 0.005 0.0128 0.0868
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0067 0.0063
Brugia malayi hypothetical protein 0.0043 0.0102 0.1745

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1458 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 11.9955 uM PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Secondary FLuc Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.