Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0026 | 0.4773 | 0.6376 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0657 | 0.0657 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0657 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0657 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.002 | 0.3157 | 0.4188 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0025 | 0.4383 | 0.5856 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0657 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0024 | 0.4191 | 0.5599 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0657 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0014 | 0.1676 | 0.224 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0657 | 0.0657 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.4383 | 0.5834 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.3971 | 0.4147 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0016 | 0.2258 | 0.2981 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0657 | 0.0657 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0657 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0657 | 0.0657 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.4383 | 0.5834 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0657 | 0.0657 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0016 | 0.2258 | 0.2981 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.4383 | 0.5834 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0657 | 0.0657 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0657 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1625 | 0.1211 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.002 | 0.324 | 0.4329 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0024 | 0.4191 | 0.5599 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0026 | 0.4773 | 0.6337 |
Onchocerca volvulus | 0.0023 | 0.3971 | 0.3783 | |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0021 | 0.3337 | 0.4459 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0657 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.9028 | 0.9555 | |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0657 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.001 | 0.0647 | 0.0864 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0009 | 0.0267 | 0.0356 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0657 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0018 | 0.2576 | 0.3708 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0657 | 0.0657 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0037 | 0.7486 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0657 | 0.5 |
Loa Loa (eye worm) | acyl carrier protein | 0.0011 | 0.0995 | 0.0423 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0039 | 0.0039 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.002 | 0.3157 | 0.4155 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0026 | 0.4773 | 0.6337 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0657 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0025 | 0.4383 | 0.5856 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.8648 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0657 | 0.0657 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.002 | 0.3157 | 0.4188 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0657 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0018 | 0.2616 | 0.3495 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0657 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.3971 | 0.3971 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0657 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0657 | 0.0657 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.4773 | 0.6376 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.4773 | 0.6357 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0657 | 0.0657 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0026 | 0.4773 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.4383 | 0.5856 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0657 | 0.0657 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0657 | 0.0657 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0045 | 0.9418 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0021 | 0.3337 | 0.443 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.218 | 0.2574 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0025 | 0.4383 | 0.581 |
Mycobacterium ulcerans | thioesterase | 0.0021 | 0.3337 | 0.443 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0657 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0025 | 0.4383 | 0.581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.4383 | 0.5834 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0657 | 0.0657 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.4773 | 0.6357 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0657 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0657 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0657 | 0.0657 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0657 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0008 | 0.0081 | 0.0108 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0657 | 0.5 |
Giardia lamblia | Methyltransferase like 2 | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0657 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0657 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0657 | 1 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | fatty acid synthase | 0.0024 | 0.43 | 0.4558 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0025 | 0.4383 | 0.4383 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0037 | 0.7486 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0026 | 0.4773 | 0.6376 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0037 | 0.7486 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0037 | 0.7486 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.4773 | 0.6357 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0657 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0657 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0657 | 0.0657 |
Leishmania major | hypothetical protein, conserved | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0008 | 0.0081 | 0.0056 |
Mycobacterium ulcerans | polyketide synthase | 0.0025 | 0.4383 | 0.5834 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0021 | 0.3337 | 0.4398 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0657 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0657 | 0.0657 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0657 | 0.0657 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0657 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0657 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0016 | 0.2258 | 0.2941 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0026 | 0.4773 | 0.6337 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0657 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0657 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0008 | 0.0039 | 0.0052 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0657 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0657 | 0.5 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.3971 | 0.5305 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0657 | 0.0657 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.