Detailed information for compound 662630

Basic information

Technical information
  • TDR Targets ID: 662630
  • Name: N-(2-ethoxyphenyl)-3-(5-methylfuran-2-yl)prop -2-enamide
  • MW: 271.311 | Formula: C16H17NO3
  • H donors: 1 H acceptors: 1 LogP: 3.02 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1NC(=O)C=Cc1ccc(o1)C
  • InChi: 1S/C16H17NO3/c1-3-19-15-7-5-4-6-14(15)17-16(18)11-10-13-9-8-12(2)20-13/h4-11H,3H2,1-2H3,(H,17,18)/b11-10+
  • InChiKey: LGDFJGPBNILKAH-ZHACJKMWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-N-(2-ethoxyphenyl)-3-(5-methylfuran-2-yl)prop-2-enamide
  • (E)-N-(2-ethoxyphenyl)-3-(5-methyl-2-furyl)prop-2-enamide
  • N-(2-ethoxyphenyl)-3-(5-methyl-2-furyl)prop-2-enamide
  • (E)-N-(2-ethoxyphenyl)-3-(5-methyl-2-furyl)acrylamide
  • N-(2-ethoxyphenyl)-3-(5-methyl-2-furyl)acrylamide
  • IVK/9053016
  • ZINC00476170
  • AK-968/15255671

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0772 0.155
Echinococcus multilocularis peptidase Clp (S14 family) 0.0048 0.1119 0.1119
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0112 0.3127 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0099 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Schistosoma mansoni hypothetical protein 0.0015 0.0081 0.0081
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0772 0.155
Loa Loa (eye worm) hypothetical protein 0.0035 0.0723 0.1452
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0723 0.0723
Loa Loa (eye worm) beta-lactamase 0.0035 0.0723 0.1452
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0081 0.0081
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0073 0.1907 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.2376 0.4771
Brugia malayi Probable ClpP-like protease 0.0073 0.1907 0.3829
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0772 0.3721
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0099 0.0199
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0726 0.0954
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.667 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0104 0.0104
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0133 0.0267
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1561 0.1561
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0048 0.1119 0.2616
Brugia malayi hypothetical protein 0.0148 0.4251 0.8536
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0133 0.0133
Onchocerca volvulus 0.0088 0.2376 0.5447
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.1289 0.1289
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0133 0.0267
Loa Loa (eye worm) hypothetical protein 0.0047 0.1078 0.2164
Brugia malayi Cathepsin L-like precursor 0.0016 0.0133 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1561 0.1561
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1561 0.1561
Plasmodium falciparum thioredoxin reductase 0.0044 0.1003 0.5258
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0073 0.1907 0.1907
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0723 0.3792
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.1405 0.2822
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0772 0.155
Onchocerca volvulus 0.0035 0.0723 0.1433
Onchocerca volvulus 0.0035 0.0723 0.1433
Brugia malayi hypothetical protein 0.0016 0.0118 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Echinococcus granulosus peptidase Clp S14 family 0.0048 0.1119 0.1119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1575 0.3163
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0723 0.095
Trypanosoma brucei CAAX amino terminal protease, putative 0.0172 0.498 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0772 0.3721
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0133 0.0697
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0133 0.0133
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0723 0.0723
Mycobacterium tuberculosis Probable oxidoreductase 0.0112 0.3127 0.4608
Trichomonas vaginalis esterase, putative 0.0035 0.0723 0.1452
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.2774 0.4072
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0723 0.1452
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0391 0.0786
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1575 0.3163
Mycobacterium leprae Probable lipase LipE 0.0035 0.0723 0.116
Mycobacterium tuberculosis Conserved protein 0.0035 0.0723 0.095
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0088 0.2376 0.2376
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0099 0.0199
Leishmania major cathepsin L-like protease 0.0016 0.0133 0.0267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0133 0.0267
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0047 0.1078 0.2164
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1561 0.3135
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.1289 0.2589
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0025 0.0408 0.2138
Leishmania major cathepsin L-like protease 0.0016 0.0133 0.0267
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0723 0.1452
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0723 0.095
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0104 0.0209
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0099 0.0519
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0723 0.095
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0081 0.0163
Brugia malayi Cathepsin L-like precursor 0.0016 0.0133 0.0267
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.1003 0.1375
Brugia malayi beta-lactamase 0.0035 0.0723 0.1452
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0772 0.155
Echinococcus multilocularis cysteine protease 0.0016 0.0133 0.0133
Plasmodium falciparum glutathione reductase 0.0015 0.0099 0.0519
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0772 0.155
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0099 0.0199
Loa Loa (eye worm) hypothetical protein 0.0016 0.0133 0.0267
Mycobacterium tuberculosis Conserved protein 0.0035 0.0723 0.095
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0133 0.0267
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0133 0.0267
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0099 0.0199
Leishmania major cathepsin L-like protease 0.0016 0.0133 0.0267
Brugia malayi beta-lactamase family protein 0.0035 0.0723 0.1452
Loa Loa (eye worm) fibroinase 0.0016 0.0133 0.0267
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0099 0.0099
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0087 0.2326 0.467
Echinococcus granulosus tar DNA binding protein 0.0062 0.1561 0.1561
Loa Loa (eye worm) hypothetical protein 0.0172 0.498 1
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0172 0.498 0.498
Mycobacterium tuberculosis Probable integral membrane protein 0.0035 0.0726 0.0954
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.1289 0.2589
Toxoplasma gondii cathepsin CPL 0.0016 0.0133 0.0697
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0723 0.1452
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0035 0.0726 0.0954
Brugia malayi isocitrate dehydrogenase 0.0016 0.0104 0.0209
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1575 0.3163
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0723 0.0723
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1561 0.1561
Brugia malayi hypothetical protein 0.0025 0.0391 0.0786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0104 0.0545
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0099 0.0099
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0616 0.1238
Brugia malayi MAP kinase sur-1 0.0053 0.1289 0.2589
Echinococcus multilocularis cysteine protease 0.0016 0.0133 0.0133
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0081 0.0163
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.2774 0.4072
Loa Loa (eye worm) RNA binding protein 0.0062 0.1561 0.3135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Trypanosoma brucei trypanothione reductase 0.0044 0.1003 0.2014
Brugia malayi Cathepsin L-like precursor 0.0016 0.0133 0.0267
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0391 0.2052
Plasmodium vivax glutathione reductase, putative 0.0044 0.1003 0.5258
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0047 0.1078 0.2164
Toxoplasma gondii thioredoxin reductase 0.0044 0.1003 0.5258
Entamoeba histolytica cysteine protease, putative 0.0016 0.0133 0.0267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1575 0.3163
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0772 0.3721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Brugia malayi Cathepsin L-like precursor 0.0016 0.0133 0.0267
Loa Loa (eye worm) hypothetical protein 0.0088 0.2376 0.4771
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0073 0.1907 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0099 0.0199
Brugia malayi Calcitonin receptor-like protein seb-1 0.0047 0.1078 0.2164
Brugia malayi glutathione reductase 0.0044 0.1003 0.2014
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.1156 0.2322
Mycobacterium tuberculosis Conserved protein 0.0035 0.0723 0.095
Echinococcus granulosus GPCR family 2 0.0015 0.0081 0.0081
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0172 0.498 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0099 0.0519
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0772 0.155
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0172 0.498 0.498
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0163
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0391 0.0786
Schistosoma mansoni hypothetical protein 0.0015 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0148 0.4251 0.8536
Loa Loa (eye worm) hypothetical protein 0.0025 0.0391 0.0786
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1575 0.3163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1575 0.3163
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1575 0.3163
Loa Loa (eye worm) hypothetical protein 0.0032 0.0616 0.1238
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.1575 0.3163
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.1003 0.2014
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.2774 0.4072
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.1289 0.1289
Mycobacterium tuberculosis Probable reductase 0.0101 0.2774 0.4072
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0104 0.0104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0723 0.0723
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0723 0.116
Schistosoma mansoni ap endonuclease 0.0037 0.0772 0.0772
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0099 0.0199
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0099 0.0519
Plasmodium falciparum thioredoxin reductase 0.0015 0.0099 0.0519
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1561 0.3135
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0104 0.0209
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0073 0.1907 0.1907
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1575 0.3163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1575 0.3163
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0723 0.095
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0073 0.1907 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0073 0.1907 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0772 0.4047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0772 0.155
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0081 0.0081
Brugia malayi beta-lactamase family protein 0.0035 0.0723 0.1452
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0104 0.0209
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0133 0.0267
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0723 0.1452
Toxoplasma gondii hypothetical protein 0.0025 0.0408 0.2138
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0772 0.4047
Leishmania major cathepsin L-like protease 0.0063 0.1575 0.3163
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0723 0.1452
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0087 0.2326 0.467
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.2774 0.4072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0723 0.1452
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Brugia malayi CAAX amino terminal protease family protein 0.0172 0.498 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0726 0.3467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0112 0.3127 0.4608
Loa Loa (eye worm) hypothetical protein 0.0035 0.0723 0.1452
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0073 0.1907 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0133 0.0267
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0099 0.0199
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.1289 0.2589
Loa Loa (eye worm) hypothetical protein 0.0035 0.0723 0.1452
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0172 0.498 1
Toxoplasma gondii hypothetical protein 0.0035 0.0726 0.3806
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0172 0.498 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.1289 0.1289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0723 0.095
Schistosoma mansoni hypothetical protein 0.0015 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Leishmania major cathepsin L-like protease 0.0063 0.1575 0.3163
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0048 0.1119 0.1552
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1289 0.2589
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0073 0.1907 1
Leishmania major cathepsin L-like protease 0.0016 0.0133 0.0267
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0133 0.0697
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0104 0.0209
Plasmodium falciparum glutathione reductase 0.0044 0.1003 0.5258
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0199
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0723 0.095
Entamoeba histolytica CAAX amino terminal protease family 0.0035 0.0726 0.1457
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0099 0.0199
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0723 0.1452
Mycobacterium ulcerans hypothetical protein 0.0035 0.0726 0.3467
Leishmania major cathepsin L-like protease 0.0063 0.1575 0.3163
Echinococcus multilocularis geminin 0.0332 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1575 0.3163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Schistosoma mansoni hypothetical protein 0.0032 0.0616 0.0616
Echinococcus multilocularis GPCR, family 2 0.0015 0.0081 0.0081
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.1003 0.1003
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0133 0.0267
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0199
Mycobacterium ulcerans beta-lactamase 0.0035 0.0723 0.3452
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0112 0.3127 0.4608
Brugia malayi Cathepsin L-like precursor 0.0016 0.0133 0.0267
Toxoplasma gondii CAAX amino terminal protease family protein 0.0035 0.0726 0.3806
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0391 0.2052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1575 0.3163
Loa Loa (eye worm) hypothetical protein 0.0035 0.0723 0.1452
Leishmania major hypothetical protein, conserved 0.0035 0.0723 0.1452
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1289 0.2589
Toxoplasma gondii exonuclease III APE 0.0037 0.0772 0.4047
Brugia malayi Thioredoxin reductase 0.0044 0.1003 0.2014
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0133 0.0697
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0133 0.0133
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0772 0.155
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0099 0.0199
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0099 0.0199
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1289 0.2589
Plasmodium falciparum protease, putative 0.0035 0.0726 0.3806
Toxoplasma gondii ABC1 family protein 0.0035 0.0723 0.3792
Toxoplasma gondii hypothetical protein 0.0035 0.0726 0.3806
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0772 0.0772
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.1003 0.2014
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.1289 0.2589
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.2774 0.8705
Plasmodium vivax protease, putative 0.0035 0.0726 0.3806
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0391 0.0786
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0133 0.0267
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0104 0.0104
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0772 0.0772
Echinococcus granulosus CAAX prenyl protease 2 0.0172 0.498 0.498
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0133 0.0267
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.1003 0.1003
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0723 0.1452
Giardia lamblia Hypothetical protein 0.0172 0.498 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1289 0.1289
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0172 0.498 1
Schistosoma mansoni hypothetical protein 0.0332 1 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1561 0.3135
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1561 0.1561
Entamoeba histolytica CAAX amino terminal protease family 0.0035 0.0726 0.1457
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0035 0.0726 0.0954
Brugia malayi TAR-binding protein 0.0062 0.1561 0.3135
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0133 0.0133
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0772 0.155
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1561 0.1561
Echinococcus granulosus cathepsin l1 0.0016 0.0133 0.0133
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0723 0.095
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1289 0.2589
Loa Loa (eye worm) hypothetical protein 0.0035 0.0723 0.1452
Loa Loa (eye worm) cysteine protease 0.0016 0.0133 0.0267
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0104 0.0008
Plasmodium vivax vivapain-2 0.0016 0.0133 0.0697
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0104 0.0104
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0073 0.1907 0.5514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.1289 0.2589
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0081 0.0081
Plasmodium vivax vivapain-2 0.0016 0.0133 0.0697
Loa Loa (eye worm) ctsf protein 0.0016 0.0133 0.0267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0133 0.0267
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0199
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0099 0.0519
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0133 0.0267
Onchocerca volvulus 0.0148 0.4251 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.1289 0.2589
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0723 0.1452
Leishmania major cathepsin L-like protease 0.0016 0.0133 0.0267
Mycobacterium ulcerans hypothetical protein 0.0035 0.0723 0.3452
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.1289 0.676
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0133 0.0267
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0104 0.0209
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0723 0.3452
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0133 0.0267
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0073 0.1907 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0133 0.0267
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0081 0.0163
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0099 0.0199
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.1003 0.5258
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0073 0.1907 0.3829
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0199
Onchocerca volvulus 0.0035 0.0723 0.1433
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0723 0.1452
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0099 0.0199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0133 0.0267
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1289 0.2589
Brugia malayi RNA binding protein 0.0062 0.1561 0.3135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0133 0.0267
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1289 0.2589
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0772 0.1024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0199
Schistosoma mansoni peptidase Clp (S14 family) 0.0073 0.1907 0.1907
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0104 0.0545
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0104 0.0209
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0104 0.0545
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0772 0.155
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0099 0.0199
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.2774 0.4072
Mycobacterium ulcerans lipase LipD 0.0035 0.0723 0.3452
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0723 0.3452
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0104 0.0545
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0133 0.0267
Leishmania major hypothetical protein, conserved 0.0025 0.0391 0.0786
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0723 0.1452
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0073 0.1907 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0391 0.2052
Mycobacterium ulcerans integral membrane protein 0.0035 0.0726 0.3467
Brugia malayi Cathepsin L-like precursor 0.0016 0.0133 0.0267
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0099 0.0199
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0025 0.0408 0.2138
Loa Loa (eye worm) glutathione reductase 0.0044 0.1003 0.2014
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0133 0.0133
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0133 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1575 0.3163
Loa Loa (eye worm) hypothetical protein 0.0087 0.2326 0.467
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0104 0.0104
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0081 0.0081
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.1289 0.2589
Leishmania major trypanothione reductase 0.0044 0.1003 0.2014
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0048 0.1119 0.1552
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0073 0.1907 1
Schistosoma mansoni hypothetical protein 0.0015 0.0081 0.0081
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0133 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1575 0.3163
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0099 0.0519
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0391 0.2052
Trypanosoma brucei protein kinase, putative 0.0053 0.1289 0.2589
Schistosoma mansoni hypothetical protein 0.0332 1 1
Echinococcus multilocularis CAAX prenyl protease 2 0.0172 0.498 0.498
Brugia malayi Trypsin family protein 0.0088 0.2376 0.4771
Chlamydia trachomatis hypothetical protein 0.0035 0.0726 0.3467
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0104 0.0104
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0099 0.0519
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1575 0.3163
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0025 0.0408 0.1708
Schistosoma mansoni ap endonuclease 0.0037 0.0772 0.0772
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0133 0.0267
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0088 0.2376 0.2376
Onchocerca volvulus 0.0083 0.2196 0.5011
Entamoeba histolytica CAAX prenyl protease family 0.0172 0.498 1
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.1289 0.1289
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0073 0.1907 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0104 0.0209
Treponema pallidum hypothetical protein 0.0035 0.0726 0.3467

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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