Detailed information for compound 663284

Basic information

Technical information
  • TDR Targets ID: 663284
  • Name: 5-[(3-chloro-5-ethoxy-4-prop-2-enoxyphenyl)me thylidene]-3-(2-oxo-2-phenylethyl)-1,3-thiazo lidine-2,4-dione
  • MW: 457.927 | Formula: C23H20ClNO5S
  • H donors: 0 H acceptors: 3 LogP: 5.37 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1c(Cl)cc(cc1OCC)C=C1SC(=O)N(C1=O)CC(=O)c1ccccc1
  • InChi: 1S/C23H20ClNO5S/c1-3-10-30-21-17(24)11-15(12-19(21)29-4-2)13-20-22(27)25(23(28)31-20)14-18(26)16-8-6-5-7-9-16/h3,5-9,11-13H,1,4,10,14H2,2H3/b20-13-
  • InChiKey: DRHACFYRAVTNOC-MOSHPQCFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5Z)-5-[(3-chloro-5-ethoxy-4-prop-2-enoxyphenyl)methylidene]-3-(2-oxo-2-phenylethyl)-1,3-thiazolidine-2,4-dione
  • 5-[(4-allyloxy-3-chloro-5-ethoxy-phenyl)methylene]-3-(2-oxo-2-phenyl-ethyl)thiazolidine-2,4-dione
  • (5Z)-5-[(4-allyloxy-3-chloro-5-ethoxy-phenyl)methylene]-3-(2-oxo-2-phenyl-ethyl)thiazolidine-2,4-dione
  • 5-[(4-allyloxy-3-chloro-5-ethoxyphenyl)methylene]-3-(2-oxo-2-phenylethyl)thiazolidine-2,4-dione
  • (5Z)-5-[(4-allyloxy-3-chloro-5-ethoxyphenyl)methylene]-3-(2-oxo-2-phenylethyl)thiazolidine-2,4-dione
  • (5Z)-5-(4-allyloxy-3-chloro-5-ethoxy-benzylidene)-3-(2-keto-2-phenyl-ethyl)thiazolidine-2,4-quinone
  • 5-(4-allyloxy-3-chloro-5-ethoxy-benzylidene)-3-(2-keto-2-phenyl-ethyl)thiazolidine-2,4-quinone
  • (5Z)-5-[(3-chloro-5-ethoxy-4-prop-2-enoxy-phenyl)methylidene]-3-(2-oxo-2-phenyl-ethyl)-1,3-thiazolidine-2,4-dione
  • 5-[(3-chloro-5-ethoxy-4-prop-2-enoxy-phenyl)methylidene]-3-(2-oxo-2-phenyl-ethyl)-1,3-thiazolidine-2,4-dione
  • ZINC02946157

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.029 0.7053
Loa Loa (eye worm) hypothetical protein 0.0514 0.4913 0.928
Trichomonas vaginalis ran, putative 0.0024 0.0146 0.0197
Loa Loa (eye worm) Smad1 0.0017 0.0074 0.0139
Leishmania major DNA polymerase kappa, putative 0.0039 0.029 0.7053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0356 0.0368
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.005 0.04 1
Schistosoma mansoni DNA polymerase eta 0.0039 0.029 0.0319
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.029 0.7053
Brugia malayi Isocitrate dehydrogenase 0.005 0.04 0.0755
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0146 0.0111
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.029 0.0319
Plasmodium vivax importin-beta 2, putative 0.0033 0.023 0.545
Schistosoma mansoni ran 0.0024 0.0146 0.0144
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.04 0.0421
Echinococcus multilocularis dna polymerase kappa 0.0039 0.029 0.0287
Schistosoma mansoni cpg binding protein 0.006 0.0496 0.0569
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.029 0.0264
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.029 0.7053
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.029 0.0548
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0074 0.0023
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.029 0.7053
Loa Loa (eye worm) histone methyltransferase 0.0019 0.009 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.029 0.7053
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0163 0.1492 0.1751
Schistosoma mansoni smad1 5 8 and 0.0017 0.0074 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0356 0.0368
Loa Loa (eye worm) hypothetical protein 0.0033 0.023 0.0435
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0496 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.029 0.7053
Trypanosoma brucei unspecified product 0.0027 0.0172 0.3879
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0356 0.04
Echinococcus granulosus tumor protein p63 0.0333 0.3153 0.3775
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.017 0.0243
Schistosoma mansoni glutaminase 0.0553 0.5294 0.6395
Trypanosoma brucei unspecified product 0.0027 0.0172 0.3879
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0163 0.1492 0.1751
Schistosoma mansoni ran 0.0024 0.0146 0.0144
Echinococcus multilocularis tumor protein p63 0.0333 0.3153 0.3775
Brugia malayi MH1 domain containing protein 0.0017 0.0074 0.0139
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.029 0.0264
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.1153 0.1367
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.04 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.009 0.0044
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.005 0.04 1
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0088 0.0166
Trypanosoma brucei isocitrate dehydrogenase, putative 0.005 0.04 1
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.029 0.7053
Schistosoma mansoni hypothetical protein 0.0163 0.1492 0.1779
Plasmodium falciparum importin beta, putative 0.0033 0.023 0.545
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.029 0.7053
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.029 0.0473
Echinococcus multilocularis isocitrate dehydrogenase 0.005 0.04 0.0421
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.019 0.1759 0.1737
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.017 0.3819
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0356 0.0673
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.04 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.04 0.0421
Loa Loa (eye worm) hypothetical protein 0.0039 0.029 0.0548
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0514 0.4913 0.928
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.017 0.0243
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0146 0.0111
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.04 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.023 0.545
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.029 0.7053
Treponema pallidum licC protein (licC) 0.019 0.1759 0.5
Giardia lamblia DINP protein human, muc B family 0.0039 0.029 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0356 0.04
Loa Loa (eye worm) glutaminase 0.0553 0.5294 1
Leishmania major DNA polymerase eta, putative 0.0039 0.029 0.7053
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.023 0.1173
Schistosoma mansoni hypothetical protein 0.052 0.4979 0.6013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.04 0.0421
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.029 0.7053
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.029 0.0473
Echinococcus multilocularis dnaJ subfamily B 0.0857 0.8263 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.005 0.04 0.0113
Echinococcus multilocularis Smad4 0.0017 0.0074 0.0023
Echinococcus multilocularis smad 0.0017 0.0074 0.0023
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0146 0.0275
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.005 0.04 0.0421
Entamoeba histolytica hypothetical protein 0.0027 0.017 0.1665
Leishmania major importin beta-1 subunit, putative 0.0027 0.017 0.3819
Brugia malayi glutaminase DH11.1 0.0553 0.5294 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0146 0.3173
Schistosoma mansoni hypothetical protein 0.0163 0.1492 0.1779
Schistosoma mansoni hypothetical protein 0.0163 0.1492 0.1779
Echinococcus multilocularis dna polymerase eta 0.0039 0.029 0.0287
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.029 0.7053
Brugia malayi Smad1 0.0017 0.0074 0.0139
Schistosoma mansoni smad1 5 8 and 0.0017 0.0074 0.0056
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.005 0.04 0.0421
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0356 0.0673
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.1036 1 0.5
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.1036 1 1
Onchocerca volvulus 0.006 0.0496 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.029 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0146 0.3173
Echinococcus granulosus Smad4 0.0017 0.0074 0.0023
Brugia malayi latrophilin 2 splice variant baaae 0.0351 0.333 0.6289
Brugia malayi Latrophilin receptor protein 2 0.0163 0.1492 0.2819
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.029 0.0319
Mycobacterium ulcerans hypothetical protein 0.019 0.1759 0.1737
Schistosoma mansoni hypothetical protein 0.0352 0.334 0.4022
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0146 0.3173
Echinococcus multilocularis GPCR, family 2 0.0163 0.1492 0.1751
Brugia malayi RNA, U transporter 1 0.0094 0.0823 0.1554
Echinococcus granulosus importin subunit beta 1 0.0033 0.023 0.0214
Loa Loa (eye worm) latrophilin receptor protein 2 0.0163 0.1492 0.2819
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0146 0.0275
Echinococcus granulosus cpg binding protein 0.0064 0.0529 0.0578
Mycobacterium ulcerans hypothetical protein 0.019 0.1759 0.1737
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.029 0.0287
Echinococcus granulosus snurportin 1 0.0352 0.334 0.4003
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.029 0.7053
Mycobacterium ulcerans glutaminase 0.0553 0.5294 0.5281
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.029 0.0548
Schistosoma mansoni importin beta-1 0.0033 0.023 0.0247
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0163 0.1492 0.2819
Schistosoma mansoni Smad4 0.0017 0.0074 0.0056
Schistosoma mansoni hypothetical protein 0.0163 0.1492 0.1779
Echinococcus multilocularis importin subunit beta 1 0.0033 0.023 0.0214
Brugia malayi MH2 domain containing protein 0.0017 0.0074 0.0139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0356 0.04
Loa Loa (eye worm) hypothetical protein 0.0351 0.333 0.6289
Echinococcus granulosus dna polymerase eta 0.0039 0.029 0.0287
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0514 0.4913 0.928
Brugia malayi Calcitonin receptor-like protein seb-1 0.0514 0.4913 0.928
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0074 0.0023
Brugia malayi CXXC zinc finger family protein 0.006 0.0496 0.0936
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0352 0.334 0.6309
Loa Loa (eye worm) glutaminase 2 0.0553 0.5294 1
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.04 0.2152
Brugia malayi MH2 domain containing protein 0.0248 0.2324 0.439
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0172 0.3879
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.029 0.0287
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0163 0.1492 0.1751
Schistosoma mansoni hypothetical protein 0.0857 0.8263 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0074 0.0056
Trichomonas vaginalis glutaminase, putative 0.0553 0.5294 1
Schistosoma mansoni cpg binding protein 0.0064 0.0529 0.0609
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0384 0.0433
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0163 0.1492 0.1751
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.029 0.7053
Mycobacterium tuberculosis Conserved hypothetical protein 0.019 0.1759 0.1513
Loa Loa (eye worm) hypothetical protein 0.0163 0.1492 0.2819
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.029 0.7053
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.029 0.7053
Schistosoma mansoni smad 0.0017 0.0074 0.0056
Trichomonas vaginalis importin beta-1, putative 0.0027 0.017 0.0243
Echinococcus multilocularis cpg binding protein 0.0064 0.0529 0.0578
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0172 0.3879
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0146 0.3173
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.102 0.5733
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0074 0.0139
Leishmania major GTP-binding protein, putative 0.0024 0.0146 0.3173
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.029 0.7053
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.04 0.2152
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.1036 1 1
Schistosoma mansoni hypothetical protein 0.0351 0.333 0.401
Echinococcus granulosus dnaJ subfamily B 0.0857 0.8263 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.009 0.0044
Loa Loa (eye worm) hypothetical protein 0.0049 0.0384 0.0725
Brugia malayi MH1 domain containing protein 0.0017 0.0074 0.0139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0356 0.0368
Loa Loa (eye worm) transcription factor SMAD2 0.0248 0.2324 0.439
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.029 0.7053
Echinococcus granulosus GPCR family 2 0.0163 0.1492 0.1751
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.029 0.7053
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0146 0.4499
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0074 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0172 0.3879
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.029 0.7053
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.019 0.1759 1
Brugia malayi isocitrate dehydrogenase 0.005 0.04 0.0755
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0055 0.0033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0052
Echinococcus granulosus dna polymerase kappa 0.0039 0.029 0.0287
Echinococcus granulosus geminin 0.052 0.4979 0.6
Brugia malayi MH2 domain containing protein 0.0017 0.0074 0.0139
Loa Loa (eye worm) isocitrate dehydrogenase 0.005 0.04 0.0755
Loa Loa (eye worm) MH2 domain-containing protein 0.0248 0.2324 0.439
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0146 0.0683
Echinococcus granulosus smad 0.0017 0.0074 0.0023
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.005 0.04 0.0453
Brugia malayi polk-prov protein 0.0012 0.0027 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0356 0.0368
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.005 0.04 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0074 0.0023
Schistosoma mansoni smad1 5 8 and 0.0017 0.0074 0.0056
Schistosoma mansoni cpg binding protein 0.0064 0.0529 0.0609
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0146 0.3173
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.029 0.7053
Schistosoma mansoni hypothetical protein 0.052 0.4979 0.6013
Trypanosoma brucei unspecified product 0.0039 0.029 0.7053
Echinococcus multilocularis geminin 0.052 0.4979 0.6
Mycobacterium tuberculosis Conserved hypothetical protein 0.019 0.1759 0.1513
Echinococcus multilocularis snurportin 1 0.0352 0.334 0.4003
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0074 0.0023
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.023 0.545
Brugia malayi Importin beta-1 subunit 0.0033 0.023 0.0435
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.029 0.0548

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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