Detailed information for compound 663583

Basic information

Technical information
  • TDR Targets ID: 663583
  • Name: 4-[(2-chlorophenyl)methyl-methylsulfonylamino ]-N-(2-methoxy-5-methylphenyl)benzamide
  • MW: 458.958 | Formula: C23H23ClN2O4S
  • H donors: 1 H acceptors: 3 LogP: 4.36 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)c1ccc(cc1)N(S(=O)(=O)C)Cc1ccccc1Cl)C
  • InChi: 1S/C23H23ClN2O4S/c1-16-8-13-22(30-2)21(14-16)25-23(27)17-9-11-19(12-10-17)26(31(3,28)29)15-18-6-4-5-7-20(18)24/h4-14H,15H2,1-3H3,(H,25,27)
  • InChiKey: NWABLPOXXPMLAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(2-chlorophenyl)methyl-methylsulfonyl-amino]-N-(2-methoxy-5-methyl-phenyl)benzamide
  • 4-[(2-chlorobenzyl)-mesyl-amino]-N-(2-methoxy-5-methyl-phenyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0048 0.0064
Echinococcus granulosus g protein coupled receptor 0.0058 0.044 0.0586
Loa Loa (eye worm) hypothetical protein 0.0066 0.054 0.0642
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Brugia malayi hypothetical protein 0.0058 0.044 0.1367
Echinococcus multilocularis orexin receptor type 2 0.0058 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0132 0.0157
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0379 0.6596
Brugia malayi hypothetical protein 0.0058 0.044 0.1367
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Onchocerca volvulus Pyruvate kinase homolog 0.0025 0.0066 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0132 0.0409
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0022 0.0027 0.0036
Mycobacterium tuberculosis Conserved protein 0.0036 0.0193 0.0443
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0154 0.0205
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0083 0.0728 0.0866
Loa Loa (eye worm) hypothetical protein 0.0052 0.0379 0.045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0323 0.1002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 0.044 0.0586
Onchocerca volvulus 0.0058 0.044 0.2274
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0132 0.0475
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0132 0.0409
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Onchocerca volvulus 0.0058 0.044 0.2274
Brugia malayi G protein-coupled receptor 0.0058 0.044 0.1367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0132 0.0157
Mycobacterium ulcerans pyruvate kinase 0.0025 0.0066 0.0066
Brugia malayi hypothetical protein 0.0052 0.0379 0.1176
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0132 0.0175
Schistosoma mansoni alpha-1 adrenergic receptor 0.0058 0.044 0.1585
Onchocerca volvulus 0.0058 0.044 0.2274
Echinococcus granulosus g-protein coupled receptor 0.0058 0.044 0.0586
Echinococcus multilocularis sex peptide receptor 0.0058 0.044 0.044
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0058 0.044 0.0586
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.044 0.1585
Chlamydia trachomatis glutamine binding protein 0.0055 0.0413 0.104
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0154 0.0154
Echinococcus multilocularis neuropeptides capa receptor 0.0058 0.044 0.044
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 0.044 0.0586
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0379 0.7014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.044 0.044
Loa Loa (eye worm) melatonin receptor type 1A 0.0058 0.044 0.0524
Schistosoma mansoni neuropeptide f receptor 76f 0.0058 0.044 0.1585
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0132 0.0132
Plasmodium vivax glutathione reductase, putative 0.0041 0.0244 0.4526
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0193 0.0599
Echinococcus granulosus neuropeptide receptor 0.0058 0.044 0.0586
Schistosoma mansoni hypothetical protein 0.0188 0.1935 0.6967
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0212 0.2205 0.2624
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0066 0.054 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0103 0.0957 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0058 0.044 0.2274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0132 0.0157
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.044 0.0524
Echinococcus multilocularis pyruvate kinase 0.0025 0.0066 0.0066
Echinococcus multilocularis neuropeptide receptor 0.0058 0.044 0.044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.0839 0.2366
Loa Loa (eye worm) hypothetical protein 0.0083 0.0728 0.0866
Echinococcus granulosus glutamate NMDA receptor subunit 0.0022 0.0027 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0132 0.0157
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0026 0.008 0.0106
Loa Loa (eye worm) glutamate receptor 2 0.0022 0.0027 0.0032
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0058 0.044 0.2274
Brugia malayi Pyruvate kinase, muscle isozyme 0.0025 0.0066 0.0206
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0132 0.0475
Echinococcus granulosus allatostatin A receptor 0.0058 0.044 0.0586
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0058 0.044 0.044
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0193 0.1629
Onchocerca volvulus 0.0058 0.044 0.2274
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0058 0.044 0.1367
Onchocerca volvulus 0.0036 0.0193 0.0882
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.2418 0.7068
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0193 0.2676
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.2205 0.794
Mycobacterium tuberculosis Probable reductase 0.0092 0.0839 0.2366
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0058 0.044 0.1585
Chlamydia trachomatis phenylalanine--tRNA ligase subunit alpha 0.0316 0.3403 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0026 0.008 0.008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0323 0.0323
Echinococcus granulosus nmda type glutamate receptor 0.024 0.253 0.3368
Echinococcus granulosus tachykinin peptides receptor 99D 0.0675 0.7512 1
Onchocerca volvulus 0.0058 0.044 0.2274
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0379 0.6596
Plasmodium vivax pyruvate kinase, putative 0.0025 0.0066 0.1227
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0132 0.0475
Schistosoma mansoni histamine h1 receptor 0.0058 0.044 0.1585
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0193 0.0193
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0058 0.044 0.1585
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0058 0.044 0.0524
Schistosoma mansoni hypothetical protein 0.0022 0.0027 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.044 0.1585
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0154 0.0205
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0033 0.0154 0.0205
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0066 0.054 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.044 0.0586
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0244 0.0596
Loa Loa (eye worm) pyruvate kinase 0.0025 0.0066 0.0079
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 0.044 0.1585
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0132 0.0175
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0066 0.054 1
Echinococcus multilocularis GPCR, family 2 0.0026 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0023 0.0048 0.0174
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus multilocularis fmrfamide receptor 0.0058 0.044 0.044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.044 0.044
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0193 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0132 0.0157
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0022 0.0027 0.0036
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0027 0.0036
Trichomonas vaginalis set domain proteins, putative 0.0177 0.1813 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Schistosoma mansoni glutamate receptor NMDA 0.0022 0.0027 0.0097
Brugia malayi G-protein coupled receptor 0.0058 0.044 0.1367
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0193 0.2676
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.0839 0.2366
Loa Loa (eye worm) hypothetical protein 0.0031 0.0132 0.0157
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0058 0.044 0.044
Schistosoma mansoni coup transcription factor 0.0031 0.0132 0.0475
Brugia malayi hypothetical protein 0.0168 0.1702 0.5286
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0132 0.0475
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0026 0.008 0.0106
Loa Loa (eye worm) latrophilin receptor protein 2 0.0026 0.008 0.0095
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0079
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0066 0.054 1
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0047 0.032 0.3017
Toxoplasma gondii pyruvate kinase PyK1 0.0025 0.0066 0.1227
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0048 0.0048
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.111 0.1321
Echinococcus granulosus neuropeptide receptor 0.0058 0.044 0.0586
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.044 0.1585
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0316 0.3403 1
Onchocerca volvulus 0.0058 0.044 0.2274
Schistosoma mansoni hypothetical protein 0.0057 0.0428 0.1541
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.044 0.0586
Loa Loa (eye worm) TYRA-2 protein 0.0058 0.044 0.0524
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0132 0.0175
Echinococcus multilocularis neuropeptide receptor 0.0058 0.044 0.044
Echinococcus multilocularis g-protein coupled receptor 0.0058 0.044 0.044
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0066 0.054 1
Brugia malayi larval opioid receptor 0.0058 0.044 0.1367
Leishmania major hypothetical protein, conserved 0.0052 0.0379 0.6748
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0132 0.0409
Brugia malayi Pyruvate kinase, M2 isozyme 0.0025 0.0066 0.0206
Echinococcus granulosus histone lysine methyltransferase setb 0.0022 0.0036 0.0048
Schistosoma mansoni hypothetical protein 0.0058 0.044 0.1585
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0132 0.0175
Schistosoma mansoni amine GPCR 0.0058 0.044 0.1585
Echinococcus multilocularis g protein coupled receptor 0.0058 0.044 0.044
Loa Loa (eye worm) pyruvate kinase 0.0025 0.0066 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0132 0.0157
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0193 0.0443
Schistosoma mansoni glutamate receptor kainate 0.0022 0.0027 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0132 0.0132
Onchocerca volvulus 0.0168 0.1702 0.9374
Schistosoma mansoni glutamate receptor kainate 0.0022 0.0027 0.0097
Brugia malayi hypothetical protein 0.0058 0.044 0.1367
Loa Loa (eye worm) hypothetical protein 0.0036 0.0193 0.023
Brugia malayi Dopamine receptor protein 2 0.0058 0.044 0.1367
Loa Loa (eye worm) hypothetical protein 0.0031 0.0132 0.0157
Echinococcus granulosus 7TM GPCR rhodopsin 0.0058 0.044 0.0586
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0132 0.0475
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.0316 0.3403 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.044 0.1585
Loa Loa (eye worm) glutamate receptor 1 0.0022 0.0027 0.0032
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.044 0.0524
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0058 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0095
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.044 0.0586
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 0.044 0.1585
Echinococcus granulosus dro:myosuppressin receptor 0.0058 0.044 0.0586
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.0316 0.3403 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0022 0.0036 0.0036
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0132 0.0475
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0193 0.3575
Onchocerca volvulus 0.0058 0.044 0.2274
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus granulosus neuropeptides capa receptor 0.0058 0.044 0.0586
Trypanosoma brucei trypanothione reductase 0.0041 0.0244 0.376
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus granulosus neuropeptide receptor A26 0.0058 0.044 0.0586
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.044 0.1585
Mycobacterium ulcerans lipase LipD 0.0036 0.0193 0.0443
Schistosoma mansoni glutamate receptor AMPA 0.0022 0.0027 0.0097
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0204 0.0272
Schistosoma mansoni hypothetical protein 0.0026 0.008 0.0288
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0132 0.0132
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0092 0.0839 0.8706
Brugia malayi hypothetical protein 0.0058 0.044 0.1367
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 0.044 0.044
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0058 0.044 0.1367
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0379 0.6596
Echinococcus multilocularis pyruvate kinase 0.0025 0.0066 0.0066
Brugia malayi GnHR receptor homolog 0.0058 0.044 0.1367
Entamoeba histolytica hypothetical protein 0.0037 0.0204 0.3227
Schistosoma mansoni amine GPCR 0.0058 0.044 0.1585
Loa Loa (eye worm) hypothetical protein 0.0752 0.8403 1
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0193 0.0443
Trichomonas vaginalis pyruvate kinase, putative 0.0025 0.0066 0.0365
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.044 0.1585
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0193 0.0443
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0053
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.044 0.1585
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus multilocularis nmda type glutamate receptor 0.0306 0.3284 0.3284
Brugia malayi hypothetical protein 0.0034 0.0166 0.0517
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Brugia malayi sulfakinin receptor protein 0.0058 0.044 0.1367
Brugia malayi nuclear receptor NHR-88 0.0031 0.0132 0.0409
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0025 0.0066 0.0066
Plasmodium falciparum pyruvate kinase 0.0025 0.0066 0.1227
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0058 0.044 0.044
Plasmodium vivax SET domain protein, putative 0.0022 0.0036 0.067
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0132 0.0475
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.111 0.1321
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0132 0.0475
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.0957 0.2718
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.044 0.044
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0022 0.0036 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.03 0.3219 0.3831
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0022 0.0027 0.0027
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0132 0.0538
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Schistosoma mansoni biogenic amine receptor 0.0058 0.044 0.1585
Brugia malayi small heat shock protein 0.03 0.3219 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0058 0.044 0.1367
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0244 0.4526
Echinococcus multilocularis neuropeptide Y receptor 0.0058 0.044 0.044
Brugia malayi hypothetical protein 0.0058 0.044 0.1367
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0055 0.0413 0.104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0036 0.013
Leishmania major pyruvate kinase 0.0025 0.0066 0.0445
Echinococcus granulosus g protein coupled receptor 0.0058 0.044 0.0586
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0044 0.0137
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus granulosus glutamate receptor NMDA 0.0229 0.2403 0.3199
Echinococcus granulosus neuropeptide Y receptor 0.0058 0.044 0.0586
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0022 0.0036 0.067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.044 0.1585
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0022 0.0036 0.013
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0193 0.2676
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0193 0.0443
Brugia malayi G-protein coupled receptor 0.0058 0.044 0.1367
Loa Loa (eye worm) hypothetical protein 0.0168 0.1702 0.2025
Echinococcus multilocularis serotonin receptor 0.0058 0.044 0.044
Onchocerca volvulus 0.0023 0.0044 0.0045
Brugia malayi Stress-activated protein kinase jnk-1 0.0212 0.2205 0.685
Onchocerca volvulus 0.0058 0.044 0.2274
Mycobacterium ulcerans beta-lactamase 0.0036 0.0193 0.0443
Trichomonas vaginalis pyruvate kinase, putative 0.0025 0.0066 0.0365
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.0839 0.2366
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.044 0.1585
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0058 0.044 0.1585
Brugia malayi hypothetical protein 0.0058 0.044 0.1367
Echinococcus granulosus neuropeptide s receptor 0.0058 0.044 0.0586
Schistosoma mansoni ATP-binding cassette transporter 0.0022 0.0027 0.0097
Echinococcus granulosus nmda type glutamate receptor 0.0306 0.3284 0.4371
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.044 0.0586
Echinococcus multilocularis nmda type glutamate receptor 0.024 0.253 0.253
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0058 0.044 0.1585
Loa Loa (eye worm) hypothetical protein 0.0031 0.0132 0.0157
Mycobacterium leprae Probable lipase LipE 0.0036 0.0193 0.1629
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0204 0.0204
Brugia malayi ecdysteroid receptor 0.0031 0.0132 0.0409
Loa Loa (eye worm) hypothetical protein 0.0036 0.0193 0.023
Echinococcus multilocularis neuropeptide s receptor 0.0058 0.044 0.044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.044 0.044
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0026 0.008 0.0248
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0212 0.2205 0.2205
Schistosoma mansoni hypothetical protein 0.0026 0.008 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0132 0.0409
Onchocerca volvulus 0.0058 0.044 0.2274
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0058 0.044 0.0586
Brugia malayi beta-lactamase family protein 0.0036 0.0193 0.0599
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.044 0.0586
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.044 0.0586
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0379 0.7014
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.025 0.0333
Onchocerca volvulus 0.0177 0.1813 1
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0066 0.054 0.1677
Schistosoma mansoni biogenic amine receptor 0.0058 0.044 0.1585
Echinococcus multilocularis serotonin receptor 0.0058 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0132 0.0409
Schistosoma mansoni hypothetical protein 0.0058 0.044 0.1585
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0193 0.0443
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.044 0.044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0193 0.0695
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0132 0.0409
Brugia malayi putative neuropeptide receptor 0.0058 0.044 0.1367
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0193 0.1064
Echinococcus granulosus glutamate receptor subunit protein glur 0.0022 0.0027 0.0036
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0055 0.0413 0.1099
Schistosoma mansoni adenoreceptor 0.0058 0.044 0.1585
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0058 0.044 0.1585
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0323 0.1162
Brugia malayi ORL1-like opioid receptor 0.0058 0.044 0.1367
Echinococcus multilocularis g protein coupled receptor 0.0058 0.044 0.044
Brugia malayi beta-lactamase 0.0036 0.0193 0.0599
Trichomonas vaginalis esterase, putative 0.0036 0.0193 0.1064
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0132 0.0538
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0244 0.0291
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0058 0.044 0.0524
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0053
Schistosoma mansoni pyruvate kinase 0.0025 0.0066 0.0239
Echinococcus multilocularis fmrfamide receptor 0.0058 0.044 0.044
Brugia malayi Latrophilin receptor protein 2 0.0026 0.008 0.0248
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.044 0.0586
Brugia malayi Calcitonin receptor-like protein seb-1 0.0083 0.0728 0.2261
Schistosoma mansoni biogenic amine receptor 0.0058 0.044 0.1585
Onchocerca volvulus 0.0058 0.044 0.2274
Toxoplasma gondii thioredoxin reductase 0.0041 0.0244 0.4526
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0132 0.0409
Brugia malayi glutathione reductase 0.0041 0.0244 0.0759
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Brugia malayi neuropeptide F receptor 0.0058 0.044 0.1367
Schistosoma mansoni hypothetical protein 0.0058 0.044 0.1585
Loa Loa (eye worm) hypothetical protein 0.0057 0.0428 0.0509
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0036 0.013
Brugia malayi Serotonin receptor 0.0058 0.044 0.1367
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0193 0.1064
Loa Loa (eye worm) pyruvate kinase 0.0025 0.0066 0.0079
Loa Loa (eye worm) hypothetical protein 0.0752 0.8403 1
Echinococcus granulosus pyruvate kinase 0.0025 0.0066 0.0088
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0058 0.044 0.1367
Onchocerca volvulus 0.0031 0.0132 0.0538
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Brugia malayi hypothetical protein 0.0037 0.0204 0.0634
Onchocerca volvulus 0.0058 0.044 0.2274
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0066 0.054 0.0718
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0022 0.0027 0.0027
Schistosoma mansoni pyruvate kinase 0.0025 0.0066 0.0239
Echinococcus granulosus GPCR family 2 0.0026 0.008 0.0106
Echinococcus granulosus g protein coupled receptor 0.0058 0.044 0.0586
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0193 0.0443
Loa Loa (eye worm) hypothetical protein 0.0036 0.0193 0.023
Echinococcus granulosus somatostatin receptor 0.0058 0.044 0.0586
Schistosoma mansoni neuropeptide receptor 0.0058 0.044 0.1585
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.044 0.1585
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0055 0.0413 0.1099
Echinococcus granulosus hypothetical protein 0.0058 0.044 0.0586
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0058 0.044 0.044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0132 0.0409
Loa Loa (eye worm) hypothetical protein 0.0036 0.0193 0.023
Schistosoma mansoni myosin xvIII 0.0058 0.044 0.1585
Schistosoma mansoni neuropeptide receptor 0.0058 0.044 0.1585
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0058 0.044 0.0524
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0132 0.0538
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0132 0.0132
Brugia malayi latrophilin 2 splice variant baaae 0.0057 0.0428 0.1329
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Entamoeba histolytica hypothetical protein 0.0037 0.0204 0.3227
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Brugia malayi putative neuropeptide receptor NPR1 0.0058 0.044 0.1367
Echinococcus multilocularis g protein coupled receptor 0.0058 0.044 0.044
Schistosoma mansoni amine GPCR 0.0058 0.044 0.1585
Schistosoma mansoni hypothetical protein 0.0188 0.1935 0.6967
Echinococcus granulosus biogenic amine 5HT receptor 0.0058 0.044 0.0586
Brugia malayi Serotonin receptor 0.0058 0.044 0.1367
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0132 0.0132
Schistosoma mansoni glutamate receptor kainate 0.0022 0.0027 0.0097
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0058 0.044 0.1367
Schistosoma mansoni hypothetical protein 0.0037 0.0204 0.0735
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0132 0.0475
Onchocerca volvulus 0.0036 0.0193 0.0882
Loa Loa (eye worm) hypothetical protein 0.0036 0.0193 0.023
Brugia malayi beta-lactamase family protein 0.0036 0.0193 0.0599
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.0839 0.2366
Brugia malayi nuclear hormone receptor 0.0031 0.0132 0.0409
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0058 0.044 0.1585
Echinococcus granulosus alpha 1A adrenergic receptor 0.0058 0.044 0.0586
Schistosoma mansoni hypothetical protein 0.0026 0.008 0.0288
Entamoeba histolytica hypothetical protein 0.0037 0.0204 0.3227
Schistosoma mansoni opsin-like receptor 0.0058 0.044 0.1585
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0379 0.7014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.044 0.044
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0675 0.7512 0.7512
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0154 0.0154
Brugia malayi follicle stimulating hormone receptor 0.0058 0.044 0.1367
Brugia malayi Glutamate receptor 1 precursor 0.0022 0.0027 0.0084
Echinococcus multilocularis neuropeptide receptor A26 0.0058 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Onchocerca volvulus 0.0058 0.044 0.2274
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus granulosus pyruvate kinase 0.0025 0.0066 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0132 0.0157
Schistosoma mansoni growth hormone secretagogue receptor 0.0058 0.044 0.1585
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0058 0.044 0.1585
Echinococcus multilocularis geminin 0.0188 0.1935 0.1935
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0193 0.0443
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.044 0.1585
Brugia malayi Pre-SET motif family protein 0.0022 0.0036 0.0112
Loa Loa (eye worm) glutathione reductase 0.0041 0.0244 0.0291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0323 0.1162
Echinococcus granulosus sex peptide receptor 0.0058 0.044 0.0586
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0193 0.1064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Brugia malayi AKH receptor 0.0058 0.044 0.1367
Leishmania major pyruvate kinase 0.0025 0.0066 0.0445
Schistosoma mansoni opsin-like receptor 0.0058 0.044 0.1585
Echinococcus multilocularis dro:myosuppressin receptor 0.0058 0.044 0.044
Plasmodium falciparum glutathione reductase 0.0041 0.0244 0.4526
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0066 0.054 0.054
Brugia malayi hypothetical protein 0.0058 0.044 0.1367
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0066 0.054 1
Brugia malayi Melatonin receptor type 1A 0.0058 0.044 0.1367
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0193 0.0695
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0132 0.0409
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Onchocerca volvulus 0.0058 0.044 0.2274
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0193 0.1064
Brugia malayi Pre-SET motif family protein 0.0156 0.1566 0.4865
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0036 0.013
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.044 0.0586
Brugia malayi Glutamate receptor 2 precursor 0.0022 0.0027 0.0084
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.044 0.1585
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0132 0.0409
Brugia malayi MH2 domain containing protein 0.0116 0.111 0.345
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus granulosus glutamate receptor 2 0.0033 0.0154 0.0205
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0132 0.0475
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0132 0.0409
Brugia malayi G protein-coupled receptor F59B2.13 0.0058 0.044 0.1367
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Mycobacterium leprae Probable pyruvate kinase PykA 0.0025 0.0066 0.0242
Brugia malayi Dopamine receptor protein 1 0.0058 0.044 0.1367
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0193 0.0443
Leishmania major hypothetical protein, conserved 0.0036 0.0193 0.3002
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0058 0.044 0.0524
Echinococcus granulosus neuropeptide FF receptor 2 0.0058 0.044 0.0586
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0066 0.054 0.2977
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Plasmodium falciparum thioredoxin reductase 0.0041 0.0244 0.4526
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.044 0.044
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0204 0.0735
Onchocerca volvulus Pyruvate kinase homolog 0.0025 0.0066 0.0169
Schistosoma mansoni hypothetical protein 0.0026 0.008 0.0288
Brugia malayi Thioredoxin reductase 0.0041 0.0244 0.0759
Onchocerca volvulus 0.0058 0.044 0.2274
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0044 0.0137
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0132 0.0409
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Loa Loa (eye worm) hypothetical protein 0.0031 0.0132 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0132 0.0409
Echinococcus multilocularis G protein coupled receptor 139 0.0058 0.044 0.044
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.044 0.0586
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0103 0.0957 0.2718
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0022 0.0027 0.0027
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.044 0.044
Leishmania major trypanothione reductase 0.0041 0.0244 0.4038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0083 0.0728 0.2261
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0132 0.0475
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0132 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0132 0.0409
Brugia malayi neuropeptide F receptor 0.0058 0.044 0.1367
Brugia malayi hypothetical protein 0.0058 0.044 0.1367
Echinococcus granulosus neuropeptide Y receptor 0.0058 0.044 0.0586
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.044 0.1585
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0058 0.044 0.044
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0154 0.0154
Entamoeba histolytica hypothetical protein 0.0037 0.0204 0.3227
Onchocerca volvulus 0.0058 0.044 0.2274
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0379 0.7014
Brugia malayi steroid hormone receptor 0.0031 0.0132 0.0409
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0033 0.0154 0.0154
Brugia malayi hypothetical protein 0.0058 0.044 0.1367
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0044 0.0137
Loa Loa (eye worm) beta-lactamase 0.0036 0.0193 0.023
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 0.044 0.044
Schistosoma mansoni opsin-like receptor 0.0058 0.044 0.1585
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0066 0.054 1
Schistosoma mansoni neuropeptide receptor 0.0058 0.044 0.1585
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0132 0.0175
Brugia malayi Tachykinin-like peptides receptor 99D 0.0058 0.044 0.1367
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.025 0.025
Echinococcus granulosus geminin 0.0188 0.1935 0.2576
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0058 0.044 0.1585
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0323 0.0429
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0132 0.0175
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.044 0.1585
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0132 0.0132
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0132 0.0175
Echinococcus multilocularis neuropeptides capa receptor 0.0058 0.044 0.044
Echinococcus multilocularis NMDA receptor 0.0022 0.0027 0.0027
Echinococcus granulosus orexin receptor type 2 0.0058 0.044 0.0586
Echinococcus granulosus neuropeptides capa receptor 0.0058 0.044 0.0586
Mycobacterium ulcerans hypothetical protein 0.0036 0.0193 0.0443
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0022 0.0027 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0132 0.0132
Brugia malayi Dopamine receptor 0.0058 0.044 0.1367
Loa Loa (eye worm) hypothetical protein 0.0031 0.0132 0.0157
Echinococcus multilocularis glutamate receptor 2 0.0022 0.0027 0.0027
Echinococcus granulosus G protein coupled receptor 139 0.0058 0.044 0.0586
Onchocerca volvulus 0.0058 0.044 0.2274
Echinococcus multilocularis glutamate receptor NMDA 0.0229 0.2403 0.2403
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0244 0.376
Echinococcus granulosus peptide allatostatin:somatostatin 0.0058 0.044 0.0586
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0058 0.044 0.0524
Schistosoma mansoni hypothetical protein 0.0058 0.044 0.1585
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0058 0.044 0.0586
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0193 0.0257
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0058 0.044 0.044
Echinococcus multilocularis allatostatin A receptor 0.0058 0.044 0.044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0026 0.008 0.008
Echinococcus multilocularis neuropeptide FF receptor 2 0.0058 0.044 0.044
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.044 0.0524
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0132 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0323 0.1162
Echinococcus multilocularis G-protein coupled receptor, putative 0.0058 0.044 0.044
Echinococcus multilocularis somatostatin receptor 0.0058 0.044 0.044
Echinococcus multilocularis pyruvate kinase 0.002 0.0006 0.0006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0323 0.0384
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.044 0.044
Brugia malayi RE15519p 0.0058 0.044 0.1367
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0066 0.054 0.1944
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0132 0.0157
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.044 0.1585
Schistosoma mansoni glutamate receptor AMPA 0.0022 0.0027 0.0097
Echinococcus granulosus fmrfamide receptor 0.0058 0.044 0.0586
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0022 0.0027 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0132 0.0175
Schistosoma mansoni neuropeptide receptor 0.0058 0.044 0.1585
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0156 0.1566 0.1864
Mycobacterium tuberculosis Conserved protein 0.0036 0.0193 0.0443
Brugia malayi hypothetical protein 0.0058 0.044 0.1367
Echinococcus granulosus c-Jun N-terminal kinases 0.0212 0.2205 0.2935
Echinococcus granulosus 7tm_1 domain containing protein 0.0058 0.044 0.0586
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0132 0.0175
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0058 0.044 0.0586
Echinococcus granulosus biogenic amine 5HT receptor 0.0058 0.044 0.0586
Loa Loa (eye worm) hypothetical protein 0.0031 0.0132 0.0157
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0154 0.0205
Schistosoma mansoni amine GPCR 0.0058 0.044 0.1585
Mycobacterium tuberculosis Conserved protein 0.0036 0.0193 0.0443
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0036 0.0193 0.023
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0066 0.054 1
Toxoplasma gondii ABC1 family protein 0.0036 0.0193 0.3575
Echinococcus granulosus serotonin receptor 0.0058 0.044 0.0586
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.044 0.0586
Onchocerca volvulus Pyruvate kinase homolog 0.0025 0.0066 0.0169
Onchocerca volvulus 0.0036 0.0193 0.0882
Loa Loa (eye worm) hypothetical protein 0.0031 0.0132 0.0157
Loa Loa (eye worm) hypothetical protein 0.0058 0.044 0.0524
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0077 0.066 0.066
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0103 0.0957 0.2718
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.044 0.1585
Schistosoma mansoni amine GPCR 0.0058 0.044 0.1585
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0132 0.0475
Schistosoma mansoni glutamate receptor NMDA 0.0262 0.2777 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0043
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.044 0.0524
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.0839 0.2366
Echinococcus multilocularis neuropeptide Y receptor 0.0058 0.044 0.044
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0066 0.054 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0193 0.0443
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0132 0.0157
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0132 0.0409
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0193 0.1064
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0058 0.044 0.044
Onchocerca volvulus 0.0058 0.044 0.2274
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0323 0.0429

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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