Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | alcohol dehydrogenase 1A (class I), alpha polypeptide | Starlite/ChEMBL | References |
Equus caballus | Alcohol dehydrogenase | Starlite/ChEMBL | References |
Homo sapiens | alcohol dehydrogenase 1B (class I), beta polypeptide | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | likely Zinc-binding dehydrogenase, one of two genes similar to S. cerevisiae YAL060W and BDH1 (YAL060W) butanediol dehydrogenase | Alcohol dehydrogenase | 374 aa | 366 aa | 24.6 % |
Onchocerca volvulus | Putative ATP-dependent RNA helicase DDX52 | Alcohol dehydrogenase | 374 aa | 337 aa | 21.4 % |
Mycobacterium tuberculosis | Possible dehydrogenase | alcohol dehydrogenase 1A (class I), alpha polypeptide | 375 aa | 356 aa | 27.0 % |
Onchocerca volvulus | Alcohol dehydrogenase | 374 aa | 376 aa | 48.9 % | |
Mycobacterium tuberculosis | Possible dehydrogenase | alcohol dehydrogenase 1B (class I), beta polypeptide | 375 aa | 352 aa | 26.4 % |
Toxoplasma gondii | quinone oxidoreductase, putative | Alcohol dehydrogenase | 374 aa | 323 aa | 23.8 % |
Mycobacterium tuberculosis | Possible dehydrogenase | Alcohol dehydrogenase | 374 aa | 350 aa | 26.0 % |
Trypanosoma cruzi | oxidoreductase, putative | Alcohol dehydrogenase | 374 aa | 318 aa | 20.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acyl carrier protein | 0.0021 | 0.0031 | 0.0031 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0021 | 0.0031 | 0.0031 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0032 | 0.0511 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0032 | 0.0511 | 0.0481 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0265 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0511 | 0.0511 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0265 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase FadB5 | 0.0032 | 0.0511 | 0.0481 |
Trypanosoma brucei | oxidoreductase, putative | 0.0032 | 0.0511 | 1 |
Mycobacterium ulcerans | Zn-dependent alcohol dehydrogenase, AdhX | 0.0032 | 0.0511 | 0.0481 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0032 | 0.0511 | 0.0481 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0032 | 0.0511 | 1 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0265 | 1 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0032 | 0.0511 | 0.0481 |
Leishmania major | oxidoreductase-like protein | 0.0032 | 0.0511 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0032 | 0.0511 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0032 | 0.0511 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0032 | 0.0511 | 1 |
Leishmania major | quinone oxidoreductase, putative | 0.0032 | 0.0511 | 1 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0265 | 1 | 1 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0233 | 0.8682 | 0.8612 |
Mycobacterium ulcerans | NADPH quinone oxidoreductase FadB4 | 0.0032 | 0.0511 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0511 | 0.0511 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0032 | 0.0511 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0021 | 0.0031 | 0.0031 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0265 | 1 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0032 | 0.0511 | 1 |
Onchocerca volvulus | 0.0021 | 0.0031 | 0.0031 | |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0032 | 0.0511 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0032 | 0.0511 | 0.5 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0233 | 0.8682 | 0.8612 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase Adh | 0.0032 | 0.0511 | 0.0481 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0032 | 0.0511 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0511 | 0.0511 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0032 | 0.0511 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0032 | 0.0511 | 0.0511 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0032 | 0.0511 | 1 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0265 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0031 | 0.0031 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0265 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 0.0511 | 0.0511 | |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0032 | 0.0511 | 1 |
Schistosoma mansoni | zinc binding dehydrogenase | 0.0032 | 0.0511 | 0.0511 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0032 | 0.0511 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0265 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0032 | 0.0511 | 0.5 |
Mycobacterium ulcerans | quinone reductase Qor | 0.0032 | 0.0511 | 0.0481 |
Mycobacterium ulcerans | short-chain dehydrogenase | 0.0032 | 0.0511 | 0.0481 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0032 | 0.0511 | 0.0511 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0032 | 0.0511 | 0.0481 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0032 | 0.0511 | 0.5 |
Mycobacterium ulcerans | dehydrogenase | 0.0032 | 0.0511 | 0.0481 |
Leishmania major | d-xylulose reductase, putative | 0.0032 | 0.0511 | 1 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0265 | 1 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0032 | 0.0511 | 0.5 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0032 | 0.0511 | 0.0481 |
Trypanosoma brucei | oxidoreductase, putative | 0.0032 | 0.0511 | 1 |
Leishmania major | oxidoreductase, putative | 0.0032 | 0.0511 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0265 | 1 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0032 | 0.0511 | 0.0481 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase AdhC | 0.0032 | 0.0511 | 0.0481 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0265 | 1 | 1 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0032 | 0.0511 | 1 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0021 | 0.0031 | 0.0031 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0032 | 0.0511 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 7.2 uM | Inhibition of human alcohol dehydrogenase alpha activity | ChEMBL. | 9572895 |
Ki (binding) | = 7.2 uM | Inhibition of human alcohol dehydrogenase alpha activity | ChEMBL. | 9572895 |
Ki (binding) | = 11 uM | Inhibition of human alcohol dehydrogenase beta 1 activity | ChEMBL. | 9572895 |
Ki (binding) | = 11 uM | Inhibition of human alcohol dehydrogenase beta 1 activity | ChEMBL. | 9572895 |
Ki (binding) | = 16 uM | Inhibition of horse liver alcohol dehydrogenase activity | ChEMBL. | 9572895 |
Ki (binding) | = 16 uM | Inhibition of horse liver alcohol dehydrogenase activity | ChEMBL. | 9572895 |
Ki (binding) | = 30 uM | Inhibition of human alcohol dehydrogenase sigma activity | ChEMBL. | 9572895 |
Ki (binding) | = 30 uM | Inhibition of human alcohol dehydrogenase sigma activity | ChEMBL. | 9572895 |
Ki (binding) | = 100 uM | Inhibition of human alcohol dehydrogenase gamma2 activity | ChEMBL. | 9572895 |
Ki (binding) | = 100 uM | Inhibition of human alcohol dehydrogenase gamma2 activity | ChEMBL. | 9572895 |
Ki (binding) | = 110 uM | Inhibition of human alcohol dehydrogenase pi activity | ChEMBL. | 9572895 |
Ki (binding) | = 110 uM | Inhibition of human alcohol dehydrogenase pi activity | ChEMBL. | 9572895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.