Detailed information for compound 667391

Basic information

Technical information
  • TDR Targets ID: 667391
  • Name: 4-(4-chlorophenoxy)-N-methyl-N-(phenylmethyl) butan-1-amine
  • MW: 303.826 | Formula: C18H22ClNO
  • H donors: 0 H acceptors: 0 LogP: 4.77 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cc1ccccc1)CCCCOc1ccc(cc1)Cl
  • InChi: 1S/C18H22ClNO/c1-20(15-16-7-3-2-4-8-16)13-5-6-14-21-18-11-9-17(19)10-12-18/h2-4,7-12H,5-6,13-15H2,1H3
  • InChiKey: HFZMDKXLWIGDPG-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • benzyl-[4-(4-chlorophenoxy)butyl]-methyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutathione reductase 0.0095 0.134 0.1305
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0233 0.3881 1
Plasmodium falciparum thioredoxin reductase 0.0033 0.0202 0.027
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0233 0.3881 1
Mycobacterium tuberculosis Probable integral membrane protein 0.0092 0.1294 0.2696
Toxoplasma gondii melibiase subfamily protein 0.0104 0.1506 0.3718
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0286 0.0241
Plasmodium falciparum thioredoxin reductase 0.0095 0.134 0.328
Echinococcus multilocularis geminin 0.0166 0.2642 0.3293
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0202 0.0132
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0202 0.027
Echinococcus multilocularis caax prenyl protease 1 0.0066 0.0815 0.0927
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0233 0.3881 1
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1762 0.1729
Giardia lamblia Hypothetical protein 0.0448 0.7819 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0202 0.0151
Mycobacterium tuberculosis Conserved protein 0.004 0.0327 0.0309
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0893 0.0857
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.4237 0.4237
Brugia malayi Probable ClpP-like protease 0.0233 0.3881 0.3857
Loa Loa (eye worm) hypothetical protein 0.004 0.0327 0.0288
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.4237 0.4237
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0448 0.7819 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2806 0.2806
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0286 0.0241
Loa Loa (eye worm) hypothetical protein 0.0033 0.0197 0.0158
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.1506 0.1462
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2642 0.2642
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0202 0.0132
Schistosoma mansoni inositol monophosphatase 0.0037 0.0286 0.0236
Mycobacterium ulcerans glutaminase 0.0567 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0202 0.027
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0118 0.1767 0.216
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0327 0.0327
Schistosoma mansoni peptidase Clp (S14 family) 0.0233 0.3881 0.385
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0066 0.0815 0.0815
Schistosoma mansoni hypothetical protein 0.0033 0.0197 0.0147
Toxoplasma gondii CAAX metallo endopeptidase 0.0066 0.0815 0.1892
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.1506 0.1462
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0448 0.7819 0.7808
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0233 0.3881 0.9648
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0202 0.0202
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0202 0.0202
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0118 0.1767 0.3863
Trypanosoma brucei metallo- peptidase, Clan M- Family M48 0.0066 0.0815 0.0927
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0202 0.027
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0197 0.0158
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0202 0.0132
Brugia malayi Melibiase family protein 0.0069 0.087 0.0834
Entamoeba histolytica CAAX prenyl protease, putative 0.0066 0.0815 0.0927
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.4237 0.4237
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0414 0.0407
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0202 0.0132
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0202 0.0132
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0286 0.0241
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0233 0.3881 1
Trichomonas vaginalis esterase, putative 0.004 0.0327 0.0327
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0286 0.0241
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0202 0.0132
Echinococcus multilocularis peptidase Clp (S14 family) 0.0153 0.2406 0.2987
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0104 0.1506 0.1821
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0233 0.3881 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.1506 0.1462
Trypanosoma cruzi metallo- peptidase, Clan M- Family M48 0.0066 0.0815 0.0927
Chlamydia trachomatis hypothetical protein 0.0092 0.1294 0.297
Plasmodium falciparum glutathione reductase 0.0033 0.0202 0.027
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0233 0.3881 0.4899
Loa Loa (eye worm) hypothetical protein 0.004 0.0327 0.0288
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0327 0.0327
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0286 0.0286
Echinococcus granulosus caax prenyl protease 1 0.0066 0.0815 0.0927
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0041 0.0002
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0202 0.0132
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0104 0.1506 0.1821
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0327 0.0294
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0327 0.0288
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0107 0.1554 0.152
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.4237 0.4214
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0327 0.0128
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.1074 0.2576
Mycobacterium ulcerans hypothetical protein 0.0092 0.1294 0.1115
Leishmania major trypanothione reductase 0.0095 0.134 0.1607
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0202 0.0132
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1493 0.1459
Toxoplasma gondii hypothetical protein 0.0092 0.1294 0.316
Schistosoma mansoni farnesylated-protein converting enzyme 1 (M48 family) 0.0066 0.0815 0.0768
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0214 0.003
Schistosoma mansoni inositol monophosphatase 0.0037 0.0286 0.0236
Loa Loa (eye worm) hypothetical protein 0.004 0.0327 0.0288
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0216 0.3571 0.8315
Leishmania major CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 0.0066 0.0815 0.0927
Brugia malayi Trypsin family protein 0.0276 0.4671 0.4649
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0197 0.0158
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0327 0.0294
Loa Loa (eye worm) hypothetical protein 0.004 0.0327 0.0288
Loa Loa (eye worm) hypothetical protein 0.0161 0.255 0.252
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0099 0.0099
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.1074 0.237
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1493 0.1459
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0202 0.0132
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0327 0.0309
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0066 0.0815 0.0815
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.1767 0.216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0414 0.0364
Echinococcus granulosus peptidase Clp S14 family 0.0153 0.2406 0.2987
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0448 0.7819 0.7819
Trypanosoma brucei CAAX amino terminal protease, putative 0.0448 0.7819 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1762 0.1729
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0414 0.0364
Trichomonas vaginalis glutaminase, putative 0.0567 1 1
Echinococcus multilocularis muscleblind protein 1 0.0161 0.255 0.3174
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0448 0.7819 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0202 0.0162
Plasmodium falciparum protease, putative 0.0092 0.1294 0.316
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0202 0.0132
Mycobacterium ulcerans integral membrane protein 0.0092 0.1294 0.1115
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0448 0.7819 1
Mycobacterium leprae Probable lipase LipE 0.004 0.0327 0.0297
Echinococcus multilocularis CAAX prenyl protease 2 0.0448 0.7819 1
Trypanosoma cruzi CAAX prenyl protease 1, putative 0.0066 0.0815 0.0927
Loa Loa (eye worm) hypothetical protein 0.004 0.0327 0.0288
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.1767 0.1598
Brugia malayi Flap endonuclease-1 0.0027 0.0099 0.006
Loa Loa (eye worm) hypothetical protein 0.0233 0.3881 0.3857
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1493 0.1459
Brugia malayi Peptidase family M48 containing protein 0.0066 0.0815 0.0778
Entamoeba histolytica CAAX prenyl protease family 0.0448 0.7819 1
Loa Loa (eye worm) hypothetical protein 0.0276 0.4671 0.4649
Loa Loa (eye worm) peptidase family M48 containing protein 0.0066 0.0815 0.0778
Loa Loa (eye worm) hypothetical protein 0.0071 0.0893 0.0857
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0286 0.0286
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.4237 0.4237
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0414 0.0407
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2642 0.2642
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0414 0.0375
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0233 0.3881 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2642 0.2642
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0092 0.1294 0.2696
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0327 0.0294
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0327 0.0309
Loa Loa (eye worm) glutaminase 0.0567 1 1
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.2642 0.533
Mycobacterium ulcerans beta-lactamase 0.004 0.0327 0.0128
Brugia malayi beta-lactamase family protein 0.004 0.0327 0.0288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0414 0.0407
Trypanosoma brucei trypanothione reductase 0.0095 0.134 0.1607
Schistosoma mansoni hypothetical protein 0.0166 0.2642 0.2604
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.1506 0.1462
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0216 0.3571 0.8315
Toxoplasma gondii thioredoxin reductase 0.0095 0.134 0.328
Schistosoma mansoni hypothetical protein 0.0033 0.0197 0.0147
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0099 0.006
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.1767 0.1598
Schistosoma mansoni hypothetical protein 0.0033 0.0197 0.0147
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0327 0.0309
Mycobacterium tuberculosis Conserved protein 0.004 0.0327 0.0309
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.4237 0.4237
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0286 0.0241
Entamoeba histolytica CAAX amino terminal protease family 0.0092 0.1294 0.1548
Onchocerca volvulus 0.0258 0.434 0.9239
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2642 0.2642
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2642 0.2642
Echinococcus granulosus geminin 0.0166 0.2642 0.3293
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0286 0.0493
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0216 0.3571 0.8315
Mycobacterium tuberculosis Conserved hypothetical protein 0.0092 0.1294 0.2696
Schistosoma mansoni glutaminase 0.0567 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0276 0.4671 0.4643
Loa Loa (eye worm) hypothetical protein 0.0448 0.7819 0.7811
Brugia malayi Inositol-1 0.0037 0.0286 0.0247
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.087 0.0823
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0327 0.0327
Schistosoma mansoni hypothetical protein 0.0071 0.0893 0.0846
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0197 0.0127
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0414 0.0375
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0216 0.3571 0.8833
Brugia malayi beta-lactamase family protein 0.004 0.0327 0.0288
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0233 0.3881 0.4899
Mycobacterium tuberculosis Probable dehydrogenase 0.0216 0.3571 0.8315
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0202 0.0132
Mycobacterium tuberculosis Probable reductase 0.0216 0.3571 0.8315
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0216 0.3571 0.8315
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0153 0.2406 0.5438
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.008 0.1074 0.2262
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0202 0.0132
Brugia malayi MH2 domain containing protein 0.0118 0.1762 0.1729
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0286 0.0086
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0202 0.027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0202 0.0132
Toxoplasma gondii ABC1 family protein 0.004 0.0327 0.0601
Schistosoma mansoni hypothetical protein 0.0166 0.2642 0.2604
Loa Loa (eye worm) inositol-1 0.0037 0.0286 0.0247
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0041 0.0002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0153 0.2406 0.5438
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0202 0.0132
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0327 0.0309
Mycobacterium ulcerans lipase LipD 0.004 0.0327 0.0128
Echinococcus granulosus muscleblind protein 0.0161 0.255 0.3174
Loa Loa (eye worm) hypothetical protein 0.0103 0.1493 0.1459
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0448 0.7819 0.7808
Echinococcus granulosus CAAX prenyl protease 2 0.0448 0.7819 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0327 0.0277
Brugia malayi Thioredoxin reductase 0.0095 0.134 0.1305
Plasmodium vivax glutathione reductase, putative 0.0095 0.134 0.328
Plasmodium vivax protease, putative 0.0092 0.1294 0.316
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0327 0.0327
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0233 0.3881 0.3755
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0241 0.4015 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0197 0.0127
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2806 0.2806
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.134 0.328
Plasmodium falciparum glutathione reductase 0.0095 0.134 0.328
Toxoplasma gondii hypothetical protein 0.0092 0.1294 0.316
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0153 0.2406 0.5766
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.4237 0.4214
Loa Loa (eye worm) glutathione reductase 0.0095 0.134 0.1305
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0286 0.0241
Treponema pallidum hypothetical protein 0.0092 0.1294 0.297
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0202 0.0132
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0327 0.0309
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0202 0.027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0414 0.0364
Mycobacterium tuberculosis Probable oxidoreductase 0.0241 0.4015 0.9409
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0202 0.0132
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0286 0.0229
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0104 0.1506 0.1821
Brugia malayi Muscleblind-like protein 0.0161 0.255 0.252
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.134 0.1305
Loa Loa (eye worm) beta-lactamase 0.004 0.0327 0.0288
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.4254 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0414 0.0407
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0276 0.4671 0.4643
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0327 0.0288
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0286 0.0241
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2642 0.2642
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0327 0.0128
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.087 0.0823
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2642 0.2642
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0327 0.0294
Brugia malayi CAAX amino terminal protease family protein 0.0448 0.7819 0.7811
Echinococcus granulosus GPCR family 2 0.0033 0.0197 0.0127
Leishmania major hypothetical protein, conserved 0.004 0.0327 0.0294
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0202 0.0132
Schistosoma mansoni hypothetical protein 0.0033 0.0197 0.0147
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0241 0.4015 0.9409
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0197 0.0158
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0327 0.0309
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0202 0.0132
Mycobacterium tuberculosis Conserved protein 0.004 0.0327 0.0309
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0092 0.1294 0.2696
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0202 0.0132
Toxoplasma gondii CAAX amino terminal protease family protein 0.0092 0.1294 0.316
Entamoeba histolytica CAAX amino terminal protease family 0.0092 0.1294 0.1548
Mycobacterium leprae conserved hypothetical protein 0.004 0.0327 0.0297
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0197 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0327 0.0294
Toxoplasma gondii hypothetical protein 0.008 0.1074 0.2576
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.4237 0.4237
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0233 0.3881 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0327 0.0277
Loa Loa (eye worm) glutaminase 2 0.0567 1 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.1074 0.2576
Mycobacterium ulcerans hypothetical protein 0.004 0.0327 0.0128
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0327 0.0327
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0233 0.3881 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0327 0.0309
Onchocerca volvulus 0.0276 0.4671 1
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.087 0.087
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.134 0.2809
Loa Loa (eye worm) hypothetical protein 0.0069 0.087 0.0834
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0118 0.1767 0.1725
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.134 0.1607
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0197 0.0127
Loa Loa (eye worm) hypothetical protein 0.004 0.0327 0.0288
Brugia malayi beta-lactamase 0.004 0.0327 0.0288
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0202 0.0132
Loa Loa (eye worm) hypothetical protein 0.0161 0.255 0.252
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.134 0.1607
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.1767 0.216
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0233 0.3881 0.3755
Plasmodium vivax hypothetical protein, conserved 0.004 0.0327 0.0601
Mycobacterium ulcerans hypothetical protein 0.0092 0.1294 0.1115
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0286 0.0286
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0241 0.4015 0.9409
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0118 0.1767 0.1734
Echinococcus multilocularis muscleblind protein 0.0161 0.255 0.3174
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.134 0.1607
Echinococcus multilocularis GPCR, family 2 0.0033 0.0197 0.0127
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0202 0.027
Loa Loa (eye worm) hypothetical protein 0.0276 0.4671 0.4649

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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