Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0059 | 0.0241 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.048 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.048 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.048 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.048 | 0.1195 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0062 | 0.0358 | 0.0358 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0143 | 0.2931 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.048 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.048 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.3871 | 0.3871 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.048 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.4493 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.048 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.048 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.048 | 1 |
Onchocerca volvulus | 0.0143 | 0.2931 | 1 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.048 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.2931 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.048 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.4493 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0173 | 0.3871 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.048 | 0.1195 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0143 | 0.2931 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.