TDR Targets

Basic information

Technical information

TDR Targets ID: 670384
Name: N-(3-acetylphenyl)-4-(4-nitrophenoxy)benzamid e
MW: 376.362 | Formula: C21H16N2O5
H donors: 1 H acceptors: 4 LogP: 3.8 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)Oc1ccc(cc1)[N+](=O)[O-])Nc1cccc(c1)C(=O)C
InChi: 1S/C21H16N2O5/c1-14(24)16-3-2-4-17(13-16)22-21(25)15-5-9-19(10-6-15)28-20-11-7-18(8-12-20)23(26)27/h2-13H,1H3,(H,22,25)
InChiKey: QLVDEZPNDJUKAP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-ethanoylphenyl)-4-(4-nitrophenoxy)benzamide
STK047789
ZINC00894463
BAS 00287468
N-(3-Acetyl-phenyl)-4-(4-nitro-phenoxy)-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Brugia malayi	Heterochromatin protein 1	0.0062	0.0457	0.085
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0172	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0065	0.0093
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0037	0.0183	0.0915
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0203	0.2993
Plasmodium falciparum	phosphoglycerate kinase	0.0077	0.0632	0.2299
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0125	0.1165	0.1147
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0028	0.0085	0.1056
Brugia malayi	MH2 domain containing protein	0.0033	0.0134	0.0223
Echinococcus granulosus	dna polymerase eta	0.0071	0.056	0.0542
Trypanosoma cruzi	3-phosphoglycerate kinase, glycosomal	0.0028	0.0085	0.1056
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1304	0.2502
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0041	0.0037
Schistosoma mansoni	chromobox protein	0.0062	0.0457	0.0441
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0077	0.0632	0.1085
Leishmania major	DNA polymerase kappa, putative	0.0054	0.0369	0.5692
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0171	0.1684	0.3241
Trypanosoma cruzi	DNA polymerase eta, putative	0.0038	0.0192	0.2808
Trypanosoma brucei	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0028	0.0085	0.1056
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0154	0.0237
Plasmodium vivax	phosphoglycerate kinase, putative	0.0077	0.0632	0.2299
Trypanosoma brucei	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0077	0.0632	0.1085
Giardia lamblia	Phosphoglycerate kinase	0.0077	0.0632	1
Trichomonas vaginalis	chromobox protein, putative	0.0037	0.0183	0.0289
Echinococcus granulosus	chromobox protein 1	0.0062	0.0457	0.0438
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0125	0.1165	0.1147
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0033	0.0134	0.0118
Trypanosoma brucei	DNA polymerase IV, putative	0.0072	0.0572	0.9012
Echinococcus granulosus	phosphoglycerate kinase 1	0.0077	0.0632	0.0614
Brugia malayi	hypothetical protein	0.0027	0.0065	0.0087
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0035	0.0154	0.0677
Echinococcus granulosus	chromobox protein 1	0.0062	0.0457	0.0438
Loa Loa (eye worm)	transcription factor SMAD2	0.0482	0.516	1
Loa Loa (eye worm)	TAR-binding protein	0.0171	0.1684	0.3241
Trypanosoma brucei	DNA polymerase IV, putative	0.0066	0.0505	0.7917
Schistosoma mansoni	smad	0.0033	0.0134	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0071	0.056	0.1057
Loa Loa (eye worm)	Smad1	0.0033	0.0134	0.0229
Trichomonas vaginalis	chromobox protein, putative	0.0062	0.0457	0.0774
Trypanosoma brucei	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Schistosoma mansoni	hypothetical protein	0.0036	0.0172	0.0155
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0107	0.0969	0.0951
Trypanosoma brucei	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0041	0.0037
Echinococcus multilocularis	tar DNA binding protein	0.0171	0.1684	0.1667
Schistosoma mansoni	Smad4	0.0033	0.0134	0.0118
Trypanosoma brucei	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Trypanosoma brucei	unspecified product	0.0033	0.0136	0.1888
Schistosoma mansoni	phosphoglycerate kinase	0.0077	0.0632	0.0616
Trypanosoma brucei	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0048	0.0301	0.0499
Brugia malayi	chromobox protein homolog 3	0.0035	0.0154	0.026
Loa Loa (eye worm)	heterochromatin protein 1	0.0062	0.0457	0.0855
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0125	0.1165	0.2232
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0033	0.0134	0.0115
Brugia malayi	ImpB/MucB/SamB family protein	0.0048	0.0301	0.0548
Echinococcus granulosus	Smad4	0.0033	0.0134	0.0115
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0203	0.2983
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.026	0.2683	1
Echinococcus multilocularis	chromobox protein 1	0.0062	0.0457	0.0438
Leishmania major	hypothetical protein, conserved	0.0027	0.0065	0.0729
Toxoplasma gondii	Dullard family phosphatase domain-containing protein	0.0023	0.002	0.0317
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0054	0.0369	0.5692
Schistosoma mansoni	DNA polymerase eta	0.0071	0.056	0.0545
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0107	0.0969	0.1851
Brugia malayi	MH2 domain containing protein	0.0033	0.0134	0.0223
Treponema pallidum	hypothetical protein	0.026	0.2683	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0203	0.0362
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0028	0.0085	0.1056
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0065	0.0729
Trichomonas vaginalis	DNA polymerase eta, putative	0.0072	0.0572	0.0978
Trypanosoma brucei	DNA polymerase kappa, putative	0.0054	0.0369	0.5692
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0077	0.0632	0.0614
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Echinococcus multilocularis	dna polymerase eta	0.0071	0.056	0.0542
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.026	0.2683	1
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0028	0.0085	0.1056
Trypanosoma brucei	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0023	0.002	0.0003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0203	0.2983
Trypanosoma brucei	unspecified product	0.0066	0.0505	0.7917
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.026	0.2683	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0071	0.056	0.1051
Echinococcus granulosus	tar DNA binding protein	0.0171	0.1684	0.1667
Giardia lamblia	DINP protein human, muc B family	0.0054	0.0369	0.5692
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0125	0.1165	0.115
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0077	0.0632	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0065	0.0168
Brugia malayi	Phosphoglycerate kinase	0.0028	0.0085	0.0126
Loa Loa (eye worm)	MH2 domain-containing protein	0.0033	0.0134	0.0229
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0072	0.0572	0.0978
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0065	0.0168
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0065	0.0729
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0054	0.0369	0.0282
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0154	0.0237
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0107	0.0969	0.0951
Schistosoma mansoni	hypothetical protein	0.0914	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0171	0.1684	0.167
Echinococcus multilocularis	dna polymerase kappa	0.0072	0.0572	0.0553
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0125	0.1165	0.115
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0125	0.1165	0.1147
Brugia malayi	MH1 domain containing protein	0.0033	0.0134	0.0223
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Echinococcus multilocularis	Smad4	0.0033	0.0134	0.0115
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0077	0.0632	1
Echinococcus multilocularis	chromobox protein 1	0.0062	0.0457	0.0438
Mycobacterium ulcerans	phosphoglycerate kinase	0.0077	0.0632	0.0286
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0065	0.0729
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0125	0.1165	0.115
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0107	0.0969	0.0954
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.0526	0.5662	1
Schistosoma mansoni	tar DNA-binding protein	0.0171	0.1684	0.167
Echinococcus granulosus	mothers against decapentaplegic 5	0.0033	0.0134	0.0115
Schistosoma mansoni	chromobox protein	0.0062	0.0457	0.0441
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.026	0.2683	1
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0038	0.0192	0.3035
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0048	0.0301	0.0285
Brugia malayi	Smad1	0.0033	0.0134	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0359	0.0665
Trypanosoma brucei	unspecified product	0.0033	0.0136	0.1888
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0526	0.5662	1
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0077	0.0632	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0482	0.516	1
Echinococcus multilocularis	geminin	0.0914	1	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0065	0.1023
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0359	0.0665
Trypanosoma brucei	phosphoglycerate kinase	0.0028	0.0085	0.1056
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0048	0.0301	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0023	0.002	0.0006
Trypanosoma brucei	DNA polymerase eta, putative	0.0071	0.056	0.8827
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0065	0.0168
Schistosoma mansoni	tar DNA-binding protein	0.0171	0.1684	0.167
Chlamydia trachomatis	phosphoglycerate kinase	0.0077	0.0632	0.5
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0033	0.0134	0.0115
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0134	0.0118
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0134	0.0118
Brugia malayi	RNA recognition motif domain containing protein	0.0171	0.1684	0.3237
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.026	0.2683	1
Onchocerca volvulus		0.0137	0.1304	1
Trichomonas vaginalis	chromobox protein, putative	0.0037	0.0183	0.0289
Entamoeba histolytica	phosphoglycerate kinase, putative	0.0077	0.0632	0.1085
Trypanosoma brucei	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Brugia malayi	polk-prov protein	0.0039	0.0203	0.0357
Echinococcus multilocularis	smad	0.0033	0.0134	0.0115
Trypanosoma cruzi	DNA polymerase eta, putative	0.0071	0.056	0.8827
Schistosoma mansoni	tar DNA-binding protein	0.0171	0.1684	0.167
Schistosoma mansoni	tar DNA-binding protein	0.0171	0.1684	0.167
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0107	0.0969	0.0951
Brugia malayi	RNA binding protein	0.0171	0.1684	0.3237
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0154	0.0266
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0125	0.1165	0.1147
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0077	0.0632	0.1389
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0134	0.0118
Schistosoma mansoni	hypothetical protein	0.0914	1	1
Brugia malayi	Phosphoglycerate kinase	0.0077	0.0632	0.1191
Loa Loa (eye worm)	MH1 domain-containing protein	0.0033	0.0134	0.0229
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0107	0.0969	0.0951
Loa Loa (eye worm)	RNA binding protein	0.0171	0.1684	0.3241
Brugia malayi	MH1 domain containing protein	0.0033	0.0134	0.0223
Brugia malayi	TAR-binding protein	0.0171	0.1684	0.3237
Schistosoma mansoni	phosphoglycerate kinase	0.0077	0.0632	0.0616
Trypanosoma brucei	phosphoglycerate kinase	0.0077	0.0632	1
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0077	0.0632	0.5
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0077	0.0632	1
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0077	0.0632	1
Trypanosoma brucei	phosphoglycerate kinase	0.0077	0.0632	1
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0077	0.0632	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0048	0.0301	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0172	0.0301
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0028	0.0085	0.1056
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0033	0.0134	0.0115
Brugia malayi	MH2 domain containing protein	0.0482	0.516	1
Leishmania major	DNA polymerase eta, putative	0.0038	0.0192	0.2808
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0203	0.2993
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0125	0.1165	0.2227
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0048	0.0301	0.0553
Trichomonas vaginalis	chromobox protein, putative	0.0062	0.0457	0.0774
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0203	0.2983
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0048	0.0301	0.0282
Echinococcus granulosus	smad	0.0033	0.0134	0.0115
Echinococcus granulosus	dna polymerase kappa	0.0072	0.0572	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0632	0.1197
Trypanosoma brucei	DNA polymerase IV, putative	0.0072	0.0572	0.9012
Loa Loa (eye worm)	hypothetical protein	0.0027	0.007	0.0103
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0023	0.002	0.0003
Leishmania major	DNA polymerase eta, putative	0.0071	0.056	0.8827
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0107	0.0969	0.1846
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0072	0.0572	0.9012
Brugia malayi	hypothetical protein	0.0137	0.1304	0.2497
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0359	0.0659
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0028	0.0085	0.1056
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0359	0.0659

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 670384