Detailed information for compound 673463

Basic information

Technical information
  • TDR Targets ID: 673463
  • Name: 3-(3,4-dichlorophenyl)-1-(2-propoxyphenyl)ure a
  • MW: 339.216 | Formula: C16H16Cl2N2O2
  • H donors: 2 H acceptors: 1 LogP: 4.61 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccccc1NC(=O)Nc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C16H16Cl2N2O2/c1-2-9-22-15-6-4-3-5-14(15)20-16(21)19-11-7-8-12(17)13(18)10-11/h3-8,10H,2,9H2,1H3,(H2,19,20,21)
  • InChiKey: BUGJUJMQTJMYOA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ZINC01917336

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Methionine aminopeptidase protein type I 0.0738 0.3935 1
Plasmodium vivax hypothetical protein, conserved 0.027 0.1263 0.3111
Schistosoma mansoni peptidase 0.0059 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.03 0.1431 0.1431
Onchocerca volvulus Dipeptidase C homolog 0.0059 0.0056 0.2216
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0468 0.2391 1
Echinococcus multilocularis microtubule associated protein 2 0.18 1 1
Trypanosoma brucei methionine aminopeptidase, putative 0.0738 0.3935 1
Entamoeba histolytica peptidase, putative 0.0059 0.0056 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.0641 0.0641
Leishmania major hypothetical protein, conserved 0.027 0.1263 0.3111
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0059 0.0056 0.0056
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Giardia lamblia Xaa-Pro dipeptidase 0.0059 0.0056 0.5
Schistosoma mansoni alpha-glucosidase 0.0139 0.0513 0.0513
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0242 0.0615
Echinococcus granulosus xaa Pro dipeptidase 0.0059 0.0056 0.0056
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0468 0.2391 0.2391
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0056 0.0039 0.0099
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Toxoplasma gondii hypothetical protein 0.027 0.1263 0.3111
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0738 0.3935 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0056 0.0142
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0468 0.2391 1
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0468 0.2391 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0039 0.0039
Brugia malayi metallopeptidase family M24 containing protein 0.0059 0.0056 0.0142
Giardia lamblia Methionine aminopeptidase 0.0059 0.0056 0.5
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0059 0.0056 0.0056
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0468 0.2391 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0242 0.0615
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0738 0.3935 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0039 0.0039
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0059 0.0056 0.0056
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0468 0.2391 0.6018
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0738 0.3935 1
Entamoeba histolytica aminopeptidase, putative 0.0059 0.0056 0.5
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0468 0.2391 1
Brugia malayi initiation factor 2-associated protein. 0.0059 0.0056 0.0142
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0641 0.0641
Echinococcus multilocularis xaa pro aminopeptidase 0.0059 0.0056 0.0056
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0059 0.0056 0.0142
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0059 0.0056 0.0056
Loa Loa (eye worm) initiation factor 2-associated protein 0.0059 0.0056 0.0142
Onchocerca volvulus 0.0093 0.0252 1
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0059 0.0056 0.0056
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0039 0.0039
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0468 0.2391 0.2391
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0738 0.3935 1
Toxoplasma gondii methionine aminopeptidase 0.0468 0.2391 0.6018
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0468 0.2391 0.2391
Loa Loa (eye worm) methionine aminopeptidase type I 0.0738 0.3935 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0039 0.0039
Echinococcus granulosus xaa pro aminopeptidase 0.0059 0.0056 0.0056
Echinococcus multilocularis FACT complex subunit SPT16 0.0059 0.0056 0.0056
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.0641 0.163
Giardia lamblia Xaa-Pro dipeptidase 0.0059 0.0056 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Schistosoma mansoni alpha-glucosidase 0.0139 0.0513 0.0513
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0468 0.2391 0.6018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0242 0.0242
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0738 0.3935 0.3935
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.0828 0.0828
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0059 0.0056 0.5
Echinococcus granulosus FACT complex subunit SPT16 0.0059 0.0056 0.0056
Brugia malayi metallopeptidase family M24 containing protein 0.0059 0.0056 0.0142
Mycobacterium ulcerans methionine aminopeptidase 0.0468 0.2391 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Echinococcus multilocularis Proliferation associated protein 2G4 0.0059 0.0056 0.0056
Entamoeba histolytica methionine aminopeptidase, putative 0.0059 0.0056 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.027 0.1263 0.3111
Treponema pallidum methionine aminopeptidase (map) 0.0468 0.2391 1
Onchocerca volvulus 0.0059 0.0056 0.2216
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0059 0.0056 0.0056
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0468 0.2391 1
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0059 0.0056 0.0142
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0059 0.0056 0.0056
Loa Loa (eye worm) MBCTL1 0.0056 0.0039 0.0099
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0738 0.3935 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0242 0.0242
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0738 0.3935 1
Echinococcus multilocularis xaa Pro dipeptidase 0.0059 0.0056 0.0056
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.0828 0.0828
Entamoeba histolytica hypothetical protein, conserved 0.0059 0.0056 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.0056 0.0142
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0242 0.0242
Plasmodium falciparum HP12 protein homolog, putative 0.027 0.1263 0.3111
Echinococcus granulosus methionine aminopeptidase type I 0.0059 0.0056 0.0056
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0059 0.0056 0.2216
Brugia malayi metallopeptidase family M24 containing protein 0.0059 0.0056 0.0142
Chlamydia trachomatis methionine aminopeptidase 0.0468 0.2391 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0039 0.0099
Schistosoma mansoni microtubule-associated protein tau 0.18 1 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0059 0.0056 0.0142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0242 0.0242
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0738 0.3935 0.3935
Echinococcus granulosus methionyl aminopeptidase 2 0.0059 0.0056 0.0056
Echinococcus multilocularis methionine aminopeptidase, type I 0.0059 0.0056 0.0056
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0059 0.0056 0.0056
Echinococcus multilocularis xaa Pro dipeptidase 0.0059 0.0056 0.0056
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0242 0.0242
Echinococcus granulosus xaa Pro dipeptidase 0.0059 0.0056 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0242 0.0242
Echinococcus multilocularis methionyl aminopeptidase 2 0.0059 0.0056 0.0056
Loa Loa (eye worm) DNA-binding protein 0.0059 0.0056 0.0142
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0738 0.3935 1
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0059 0.0056 0.0056
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.0641 0.163
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0468 0.2391 0.6018
Toxoplasma gondii methionine aminopeptidase 0.0738 0.3935 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.027 0.1263 0.3111
Trypanosoma brucei hypothetical protein, conserved 0.027 0.1263 0.3111
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0059 0.0056 0.5
Echinococcus granulosus Proliferation associated protein 2G4 0.0059 0.0056 0.0056
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0059 0.0056 0.2216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0242 0.0242

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.