TDR Targets

Basic information

Technical information

TDR Targets ID: 676144
Name: 3-cyclohexyl-N-(3,4-dimethylphenyl)propanamid e
MW: 259.386 | Formula: C17H25NO
H donors: 1 H acceptors: 1 LogP: 4.86 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(c(c1)C)C)CCC1CCCCC1
InChi: 1S/C17H25NO/c1-13-8-10-16(12-14(13)2)18-17(19)11-9-15-6-4-3-5-7-15/h8,10,12,15H,3-7,9,11H2,1-2H3,(H,18,19)
InChiKey: BKJXNDYVKALUDG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-cyclohexyl-N-(3,4-dimethylphenyl)propionamide
AN-652/41845782

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0043	0.0497	0.8365
Echinococcus multilocularis	geminin	0.0164	0.2043	0.2043
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0616	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0066	0.0324
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.3491	0.9536
Leishmania major	protein kinase, putative	0.0015	0.0137	0.0001
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0497	0.1023
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0051	0.0597	0.0597
Entamoeba histolytica	hypothetical protein	0.0034	0.0375	0.5
Echinococcus granulosus	transcription factor btf3	0.0034	0.0375	0.1834
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0297	0.1192
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0066	0.0066
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0066	0.0266
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0066	0.0324
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0066	0.0266
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0919	0.4496
Treponema pallidum	hypothetical protein	0.0291	0.3654	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0519	0.0519
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0497	0.1023
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0066	0.0324
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0066	0.0266
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0497	0.2431
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0029	0.0144
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0497	0.1023
Brugia malayi	latrophilin 2 splice variant baaae	0.0136	0.1685	0.6761
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0266
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0497	0.1023
Loa Loa (eye worm)	hypothetical protein	0.02	0.2492	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0266
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0137	0.0001
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0497	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0266
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0066	0.0324
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0497	0.1023
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0066	0.0266
Schistosoma mansoni	aryl hydrocarbon receptor nuclear translocator homolog (darnt)	0.0036	0.0401	0.1962
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0519	0.0519
Brugia malayi	hypothetical protein	0.0036	0.0401	0.1609
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0497	0.1993
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0497	0.1993
Toxoplasma gondii	ABC1 family protein	0.0043	0.0497	0.751
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0007	0.0035
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0291	0.3654	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0137	0.2428
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0497	0.1993
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0007	0.0035
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0137	0.0137
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0497	0.1023
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0266
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0497	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0748	0.3002
Schistosoma mansoni	coup transcription factor	0.001	0.0066	0.0324
Onchocerca volvulus		0.0043	0.0497	0.8365
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0266
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0137	0.0001
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0015	0.0137	0.2428
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0028
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0497	0.1023
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0015	0.0137	0.2428
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0066	0.0066
Brugia malayi	nuclear hormone receptor	0.001	0.0066	0.0266
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0497	0.1023
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0063	0.0748	0.3662
Brugia malayi	steroid hormone receptor	0.001	0.0066	0.0266
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0137	0.0549
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.005	0.0199
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0007	0.0028
Leishmania major	hypothetical protein, conserved	0.0043	0.0497	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0919	0.4496
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0398	0.1595
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0066	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0497	0.1993
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0919	0.4496
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0066	0.0324
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0066	0.0266
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0066	0.0324
Onchocerca volvulus		0.0051	0.0594	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0497	0.1023
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0036	0.0401	0.1609
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0497	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0137	0.0549
Echinococcus granulosus	aryl hydrocarbon receptor	0.0051	0.0597	0.2922
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0297	0.1192
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0066	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0137	0.2428
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0137	0.2428
Schistosoma mansoni	hypothetical protein	0.0063	0.0748	0.3662
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0291	0.3654	1
Schistosoma mansoni	hypothetical protein	0.0063	0.0748	0.3662
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0066	0.0266
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0066	0.0266
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0066	0.0324
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0066	0.0324
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0036	0.0398	0.1595
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0497	0.2431
Brugia malayi	beta-lactamase	0.0043	0.0497	0.1993
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0697	0.341
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0066	0.1116
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0136	0.1685	0.8247
Plasmodium falciparum	basic transcription factor 3b, putative	0.0034	0.0375	0.0676
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0066	0.0324
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0266
Brugia malayi	hypothetical protein	0.0005	0.0007	0.0028
Brugia malayi	PAS domain containing protein	0.0015	0.0137	0.0549
Brugia malayi	nuclear receptor RXR	0.0005	0.0007	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0066	0.0266
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0066	0.0324
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0919	0.4496
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0028
Schistosoma mansoni	cpg binding protein	0.0028	0.0297	0.1454
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0066	0.0266
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0497	0.1993
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0497	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0066	0.0266
Echinococcus multilocularis	transcription factor btf3	0.0034	0.0375	0.0375
Onchocerca volvulus		0.0043	0.0497	0.8365
Brugia malayi	nuclear receptor NHR-88	0.001	0.0066	0.0266
Schistosoma mansoni	hypothetical protein	0.0164	0.2043	1
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0137	0.0001
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0375	0.7432
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0029	0.0029
Schistosoma mansoni	hypothetical protein	0.0063	0.0748	0.3662
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0015	0.0137	0.2428
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0066	0.0324
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0919	0.4496
Echinococcus multilocularis	GPCR, family 2	0.0063	0.0748	0.0748
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0375	0.7432
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0137	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0497	0.1993
Brugia malayi	hypothetical protein	0.0051	0.0594	0.2382
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0051	0.025
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0497	0.1023
Schistosoma mansoni	single-minded	0.0015	0.0137	0.067
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0066	0.0266
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0016	0.014	0.0686
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0919	0.0919
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0029	0.0029
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0497	0.1023
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0015	0.0137	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0066	0.0066
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0375	0.6609
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0066	0.0324
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0066	0.0324
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0066	0.0266
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0063	0.0748	0.0748
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0137	0.0137
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0066	0.0266
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.02	0.2492	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0066	0.0266
Loa Loa (eye worm)	ICD-1 protein	0.0034	0.0375	0.1503
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0066	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0028
Trichomonas vaginalis	adenylate cyclase, putative	0.0015	0.0137	0.2428
Brugia malayi	hypothetical protein	0.0005	0.0007	0.0028
Brugia malayi	Calcitonin receptor-like protein seb-1	0.02	0.2492	1
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0291	0.3654	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0015	0.0137	0.0001
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0007	0.0028
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0919	0.3686
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0016	0.014	0.014
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0519	0.2541
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0015	0.0137	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0066	0.0266
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0015	0.0137	0.0001
Echinococcus granulosus	cpg binding protein	0.0029	0.0317	0.1554
Plasmodium vivax	basic transcription factor 3b, putative	0.0034	0.0375	0.0676
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.02	0.2492	1
Leishmania major	protein kinase, putative	0.0015	0.0137	0.0001
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0066	0.0066
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0063	0.0748	0.3662
Onchocerca volvulus	Protein cycle homolog	0.0036	0.0401	0.6752
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1685	0.6761
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0398	0.1595
Echinococcus granulosus	GPCR family 2	0.0063	0.0748	0.3662
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0375	0.6609
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0137	0.0549
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0137	0.067
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0266
Trichomonas vaginalis	guanylate cyclase, putative	0.0015	0.0137	0.2428
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0519	0.2083
Schistosoma mansoni	cpg binding protein	0.0029	0.0317	0.1554
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0519	0.2541
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0066	0.0266
Schistosoma mansoni	cpg binding protein	0.0029	0.0317	0.1554
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0063	0.0748	0.3002
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0066	0.0324
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0137	0.067
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0519	0.2541
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0519	0.2541
Onchocerca volvulus		0.0028	0.0297	0.5005
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0266
Onchocerca volvulus		0.001	0.0066	0.1116
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0137	0.0137
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0066	0.0066
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0066	0.0266
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0066	0.1116
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0028
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0007	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0066	0.0266
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0919	0.3686
Leishmania major	basic transcription factor 3a, putative	0.0034	0.0375	0.6609
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0066	0.0266
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0137	0.0137
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0066	0.0266
Schistosoma mansoni	transcription factor btf3	0.0034	0.0375	0.1834
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0063	0.0748	0.0748
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0036	0.0401	0.1609
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0063	0.0748	0.3002
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0029	0.0144
Entamoeba histolytica	transcription factor BTF3, putative	0.0034	0.0375	0.5
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0137	0.0549
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0497	0.1993
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0497	0.1993
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0066	0.0324
Brugia malayi	hypothetical protein	0.0036	0.0398	0.1595
Trichomonas vaginalis	guanylate cyclase, putative	0.0015	0.0137	0.2428
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0497	0.2431
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0066	0.0324
Brugia malayi	beta-lactamase family protein	0.0043	0.0497	0.1993
Brugia malayi	TAR-binding protein	0.0076	0.0919	0.3686
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0919	0.3686
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0066	0.0324
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0015	0.0137	0.2428
Brugia malayi	RNA binding protein	0.0076	0.0919	0.3686
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0066	0.0324
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0919	0.3686
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0497	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0919	0.4496
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0375	0.7432
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0066	0.1116
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0036	0.0401	0.1609
Schistosoma mansoni	hypothetical protein	0.0164	0.2043	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0066	0.0324
Brugia malayi	beta-lactamase family protein	0.0043	0.0497	0.1993
Schistosoma mansoni	aryl hydrocarbon receptor	0.0016	0.014	0.0686
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0519	0.2083
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0051	0.0205
Echinococcus granulosus	geminin	0.0164	0.2043	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0497	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0497	1
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0291	0.3654	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0497	0.1993
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0497	0.0497
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0497	0.1023
Trichomonas vaginalis	esterase, putative	0.0043	0.0497	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0028
Trypanosoma brucei	transcription factor BTF3, putative	0.0034	0.0375	0.6609
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0066	0.0324
Toxoplasma gondii	NAC domain-containing protein	0.0034	0.0375	0.4963
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0051	0.0597	0.2395
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0029	0.0144
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0051	0.0051
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0497	1
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0291	0.3654	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0398	0.1595
Schistosoma mansoni	hypothetical protein	0.0063	0.0748	0.3662
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0497	0.1023
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0007	0.0035
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0066	0.0066
Brugia malayi	beta-NAC-like protein	0.0034	0.0375	0.1503
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0015	0.0137	0.2428
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0066	0.0266
Echinococcus multilocularis	cpg binding protein	0.0029	0.0317	0.0317
Brugia malayi	ecdysteroid receptor	0.001	0.0066	0.0266
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0066	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0594	0.2382
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0398	0.1595
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0519	0.2541
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0015	0.0137	0.0001
Brugia malayi	Latrophilin receptor protein 2	0.0063	0.0748	0.3002
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0066	0.0066

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 676144