Detailed information for compound 676597

Basic information

Technical information
  • TDR Targets ID: 676597
  • Name: N-[2-[(2-chlorophenyl)methylsulfanyl]ethyl]-2 -[(4-chlorophenyl)-methylsulfonylamino]acetam ide
  • MW: 447.399 | Formula: C18H20Cl2N2O3S2
  • H donors: 1 H acceptors: 3 LogP: 3.81 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)C)c1ccc(cc1)Cl)NCCSCc1ccccc1Cl
  • InChi: 1S/C18H20Cl2N2O3S2/c1-27(24,25)22(16-8-6-15(19)7-9-16)12-18(23)21-10-11-26-13-14-4-2-3-5-17(14)20/h2-9H,10-13H2,1H3,(H,21,23)
  • InChiKey: IRGDHXCKKRDFOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[(2-chlorophenyl)methylsulfanyl]ethyl]-2-[(4-chlorophenyl)-methylsulfonyl-amino]acetamide
  • 2-[(4-chlorophenyl)-methylsulfonylamino]-N-[2-[(2-chlorophenyl)methylthio]ethyl]acetamide
  • N-[2-[(2-chlorobenzyl)thio]ethyl]-2-[(4-chlorophenyl)-mesyl-amino]acetamide
  • N-[2-[(2-chlorophenyl)methylsulfanyl]ethyl]-2-[(4-chlorophenyl)-methylsulfonyl-amino]ethanamide
  • ZINC03004155

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0412 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0215 0.0188
Loa Loa (eye worm) hypothetical protein 0.0011 0.0098 0.0058
Echinococcus multilocularis cpg binding protein 0.0029 0.0578 0.0578
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0074 0.0036
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0074 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0251 0.0211
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0412 0.0402
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0074 0.0074
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0023 0.0412 0.0399
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0182 0.015
Schistosoma mansoni coup transcription factor 0.001 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0655 1
Loa Loa (eye worm) ctsf protein 0.0032 0.0655 0.0661
Echinococcus multilocularis dnaJ subfamily B 0.0396 1 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0263 0.2975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0033
Loa Loa (eye worm) hypothetical protein 0.0022 0.0379 0.0363
Loa Loa (eye worm) hypothetical protein 0.0017 0.0263 0.0238
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0074 0.0074
Brugia malayi Cathepsin L-like precursor 0.0022 0.0379 0.0366
Echinococcus granulosus cathepsin L cysteine proteinase 0.0032 0.0655 0.0655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0493 0.049
Echinococcus granulosus lamin dm0 0.0026 0.0493 0.0493
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0412 0.0402
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0074 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0074 0.0036
Onchocerca volvulus 0.0032 0.0655 0.0755
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0294 0.7365 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0123 0.2993 0.3854
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0098 0.0058
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0251 0.0251
Plasmodium vivax unspecified product 0.0017 0.0251 0.2757
Loa Loa (eye worm) hypothetical protein 0.0017 0.0263 0.0238
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0215 0.0215
Leishmania major cathepsin L-like protease 0.0123 0.2993 0.3711
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0074 0.0033
Onchocerca volvulus 0.0026 0.0493 0.0545
Leishmania major cathepsin L-like protease 0.0123 0.2993 0.3711
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0033
Echinococcus granulosus GPCR family 2 0.0015 0.0215 0.0215
Echinococcus granulosus FTZ F1 alpha 0.001 0.0074 0.0074
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0146 0.0146
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0655 0.0766
Trypanosoma cruzi cysteine peptidase, putative 0.0123 0.2993 0.3983
Leishmania major cathepsin L-like protease 0.0123 0.2993 0.3711
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0074 0.0033
Brugia malayi steroid hormone receptor 0.001 0.0074 0.0036
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.1063 0.1105
Leishmania major cysteine peptidase A (CPA) 0.0032 0.0655 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0074 0.0036
Leishmania major cathepsin L-like protease 0.0032 0.0655 0.0348
Echinococcus multilocularis geminin 0.0328 0.8243 0.8243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0123 0.2993 0.3854
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0074 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0655 1
Schistosoma mansoni vesicular acetylcholine transporter 0.0309 0.7767 0.7767
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0655 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0182 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0074 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0074 0.0036
Brugia malayi Cathepsin L-like precursor 0.0032 0.0655 0.0664
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0412 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0074 0.0033
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0074 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0123 0.2993 0.3854
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0074 0.0074
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0074 0.0074
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0074 0.0074
Echinococcus multilocularis vesicular acetylcholine transporter 0.0309 0.7767 0.7767
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0251 0.0227
Echinococcus granulosus cysteine protease 0.0017 0.0251 0.0251
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0263 0.5
Schistosoma mansoni hypothetical protein 0.0328 0.8243 0.8243
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0074 0.0036
Brugia malayi vesicular acetylcholine transporter unc-17 0.0309 0.7767 0.8355
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0251 0.0251
Echinococcus granulosus intermediate filament protein 0.0026 0.0493 0.0493
Schistosoma mansoni hypothetical protein 0.0328 0.8243 0.8243
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.045 0.0484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0074 0.0074
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0215 0.0215
Schistosoma mansoni intermediate filament proteins 0.0026 0.0493 0.0493
Onchocerca volvulus 0.0032 0.0655 0.0755
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0251 0.0211
Onchocerca volvulus 0.0022 0.0379 0.0397
Toxoplasma gondii cathepsin CPL 0.0032 0.0655 0.282
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.015 0.3678 0.3931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0412 0.0399
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0074 0.0036
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0104 0.0104
Onchocerca volvulus 0.0026 0.0493 0.0545
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0655 0.0755
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0123 0.2993 0.3854
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0215 0.0215
Echinococcus multilocularis cysteine protease 0.0032 0.0655 0.0655
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0412 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0655 1
Echinococcus granulosus lamin 0.0026 0.0493 0.0493
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0412 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0655 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0123 0.2993 0.3854
Schistosoma mansoni hypothetical protein 0.0015 0.0215 0.0215
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.1063 0.1105
Leishmania major cathepsin L-like protease 0.0032 0.0655 0.0348
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0074 0.0074
Echinococcus granulosus vesicular acetylcholine transporter 0.0309 0.7767 0.7767
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0263 0.139
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0074 0.0074
Onchocerca volvulus 0.0032 0.0655 0.0755
Loa Loa (eye worm) hypothetical protein 0.0048 0.1063 0.1103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0655 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0396 1 1
Plasmodium vivax vivapain-3 0.0017 0.0251 0.2757
Loa Loa (eye worm) fibroinase 0.0032 0.0655 0.0661
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0033
Leishmania major cathepsin L-like protease 0.0032 0.0655 0.0348
Echinococcus multilocularis musashi 0.0026 0.0493 0.0493
Loa Loa (eye worm) cysteine protease 0.0032 0.0655 0.0661
Schistosoma mansoni hypothetical protein 0.0015 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0023 0.0412 0.0399
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0379 0.3182
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0032 0.0655 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0074 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0074 0.0033
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0074 0.0074
Schistosoma mansoni cpg binding protein 0.0029 0.0578 0.0578
Onchocerca volvulus 0.0032 0.0655 0.0755
Echinococcus multilocularis lamin dm0 0.0026 0.0493 0.0493
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0074 0.0074
Brugia malayi Cathepsin L-like precursor 0.0032 0.0655 0.0664
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0412 1
Schistosoma mansoni hypothetical protein 0.0011 0.0104 0.0104
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0074 0.0074
Brugia malayi nuclear receptor NHR-88 0.001 0.0074 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0011 0.0098 0.0061
Schistosoma mansoni cathepsin s 0.0011 0.0098 0.0098
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0412 1
Plasmodium vivax vivapain-2 0.0032 0.0655 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0074 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0123 0.2993 0.3854
Schistosoma mansoni lamin 0.0026 0.0493 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0074 0.0036
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0309 0.7767 1
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0655 0.0755
Plasmodium vivax vivapain-1 0.0017 0.0251 0.2757
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.045 0.0484
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0251 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0123 0.2993 0.3854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0655 1
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0655 0.0664
Brugia malayi hypothetical protein 0.0024 0.045 0.0442
Echinococcus multilocularis cathepsin L 0.0017 0.0251 0.0251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0033 0.067 0.0678
Echinococcus multilocularis GPCR, family 2 0.0015 0.0215 0.0215
Onchocerca volvulus 0.0028 0.0537 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0123 0.2993 0.3854
Leishmania major cathepsin L-like protease 0.0032 0.0655 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0074 0.0036
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0655 0.0655
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0655 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0123 0.2993 0.3854
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0033
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.045 0.6322
Echinococcus granulosus geminin 0.0328 0.8243 0.8243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0123 0.2993 0.3854
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0412 0.3998
Loa Loa (eye worm) hypothetical protein 0.0011 0.0098 0.0058
Brugia malayi cathepsin L-like precursor 0.0022 0.0379 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0263 0.0238
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0655 0.0655
Trypanosoma cruzi cysteine peptidase, putative 0.0123 0.2993 0.3983
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0074 0.0036
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0263 0.0301
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0412 0.3998
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0309 0.7767 0.8355
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0113 0.2718 0.3605
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0032 0.0655 1
Schistosoma mansoni cpg binding protein 0.0029 0.0578 0.0578
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0379 0.0379
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0655 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0251 0.0251
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0251 0.0211
Leishmania major C-8 sterol isomerase-like protein 0.0294 0.7365 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0493 0.0487
Loa Loa (eye worm) hypothetical protein 0.0017 0.0263 0.0238
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0251 0.0211
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0412 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0215 0.0185
Trypanosoma brucei C-8 sterol isomerase, putative 0.0294 0.7365 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.7365 0.792
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0493 0.0487
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0074 0.0033
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0412 0.0402
Brugia malayi Cathepsin L-like precursor 0.0032 0.0655 0.0664
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0251 0.0227
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0412 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0097 0.2314 0.305
Echinococcus multilocularis lamin 0.0026 0.0493 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0074 0.0036
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0655 0.0655
Brugia malayi cathepsin F-like cysteine proteinase 0.0011 0.0098 0.0061
Loa Loa (eye worm) hypothetical protein 0.0022 0.0379 0.0363
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1338 0.1338
Schistosoma mansoni lamin 0.0026 0.0493 0.0493
Entamoeba histolytica cysteine protease, putative 0.0032 0.0655 1
Echinococcus granulosus cpg binding protein 0.0029 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0017 0.0263 0.0238
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.045 0.0439
Echinococcus granulosus cathepsin L 0.0017 0.0251 0.0251
Schistosoma mansoni cpg binding protein 0.0028 0.0537 0.0537
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0493 0.0487
Echinococcus granulosus cathepsin l1 0.0032 0.0655 0.0655
Brugia malayi Cathepsin L-like precursor 0.0022 0.0379 0.0366
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.045 0.0279
Plasmodium vivax vivapain-2 0.0032 0.0655 1
Brugia malayi nuclear hormone receptor 0.001 0.0074 0.0036
Leishmania major hypothetical protein, conserved 0.0024 0.045 0.0054
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0074 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0074 0.0036
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Onchocerca volvulus 0.0032 0.0655 0.0755
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0655 1
Echinococcus multilocularis cysteine protease 0.0032 0.0655 0.0655
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0215 0.0185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0074 0.0033
Brugia malayi CXXC zinc finger family protein 0.0028 0.0537 0.0537
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0146 0.0146
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0098
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0104 0.0104
Brugia malayi Angiotensin-converting enzyme family protein 0.0369 0.9289 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0146 0.0111
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0412 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.045 0.4922
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Brugia malayi Cathepsin L-like precursor 0.0011 0.0098 0.0061
Schistosoma mansoni hypothetical protein 0.0015 0.0215 0.0215
Brugia malayi Cathepsin L-like precursor 0.0032 0.0655 0.0664
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0074 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0033
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0074 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0074 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0379 0.0366
Trypanosoma cruzi cysteine peptidase, putative 0.0123 0.2993 0.3983
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0655 0.0655
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1176 1
Trypanosoma cruzi cruzipain precursor, putative 0.0123 0.2993 0.3983
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0074 0.0074
Echinococcus granulosus cathepsin l1 0.0022 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0033
Mycobacterium ulcerans hypothetical protein 0.0023 0.0412 1
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0215 0.0188
Schistosoma mansoni hypothetical protein 0.0033 0.067 0.067
Echinococcus granulosus cathepsin l cysteine peptidase 0.0032 0.0655 0.0655
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0369 0.9289 1
Brugia malayi ecdysteroid receptor 0.001 0.0074 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0074 0.0036
Brugia malayi hypothetical protein 0.0016 0.0227 0.0202
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0215 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0379 0.3182
Brugia malayi Cathepsin L-like precursor 0.0032 0.0655 0.0664
Schistosoma mansoni thyroid hormone receptor 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0098
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0655 0.0655
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0074 0.0074
Onchocerca volvulus Cathepsin F homolog 0.0032 0.0655 0.0755
Loa Loa (eye worm) hypothetical protein 0.0022 0.0379 0.0363
Onchocerca volvulus 0.0032 0.0655 0.0755
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.067 0.0681
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0026 0.0481 0.0473
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0294 0.7365 0.792
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0655 1
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0379 0.3182
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0032 0.0655 0.0661
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0412 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0033
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0537 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0412 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0015 0.0215 0.0215
Plasmodium falciparum cysteine proteinase falcipain 3 0.0032 0.0655 1
Onchocerca volvulus 0.0023 0.0412 0.044
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0655 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Leishmania major cathepsin L-like protease 0.0032 0.0655 0.0348
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0074 0.0074
Onchocerca volvulus 0.0032 0.0655 0.0755
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.1063 0.1103
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0074 0.0036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0655 0.0661
Loa Loa (eye worm) hypothetical protein 0.0011 0.0098 0.0058
Brugia malayi intermediate filament protein 0.0026 0.0493 0.049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0123 0.2993 0.3854
Brugia malayi Cathepsin L-like precursor 0.0032 0.0655 0.0664
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.045 0.4922
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0655 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0655 0.0661
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0412 0.3998

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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