Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0048 | 0.0431 | 0.137 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.0168 | 0.225 | 0.5311 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0061 | 0.0188 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0082 | 0.0947 | 0.0947 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.2815 | 1 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0048 | 0.0431 | 0.137 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.0168 | 0.225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0157 | 0.0366 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0142 | 0.0142 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0029 | 0.0152 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0947 | 0.0947 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0021 | 0.0035 | 0.0125 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0152 | 0.0676 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0192 | 0.2607 | 0.8898 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0431 | 0.1002 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0082 | 0.0947 | 0.0947 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.0181 | 0.0806 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0029 | 0.0152 | 0.0676 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0062 | 0.0644 | 0.2861 |
Schistosoma mansoni | apoptosis regulator bax | 0.0082 | 0.0947 | 0.0947 |
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.0168 | 0.225 | 0.7678 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0157 | 0.0157 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0192 | 0.2607 | 0.8898 |
Schistosoma mansoni | kinase | 0.0048 | 0.0428 | 0.0428 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0141 | 0.0141 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.0168 | 0.225 | 0.225 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0029 | 0.0152 | 0.0676 |
Brugia malayi | ThiF family protein | 0.0031 | 0.0185 | 0.0658 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0409 | 0.1262 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0062 | 0.0644 | 0.2861 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0168 | 0.225 | 0.225 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0093 | 0.1121 | 0.1121 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.1121 | 0.4981 |
Plasmodium falciparum | phosphoglycerate kinase | 0.0168 | 0.225 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.1121 | 0.3454 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0031 | 0.0185 | 0.0823 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.2815 | 0.6544 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0084 | 0.0981 | 0.4362 |
Echinococcus multilocularis | SUMO activating enzyme subunit 2 | 0.0031 | 0.0185 | 0.0185 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0029 | 0.0152 | 0.0676 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0044 | 0.038 | 0.1349 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 0.038 | 0.038 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0683 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0085 | 0.0989 | 0.0989 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 0.038 | 0.038 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.1121 | 0.1121 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0029 | 0.0152 | 0.0047 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0157 | 0.0157 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.1121 | 0.3454 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.0935 | 0.332 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.0168 | 0.225 | 0.225 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0084 | 0.0981 | 0.3349 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0142 | 0.0142 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.1121 | 0.4981 |
Schistosoma mansoni | hypothetical protein | 0.0305 | 0.4301 | 0.4301 |
Toxoplasma gondii | thioredoxin reductase | 0.0084 | 0.0981 | 0.2114 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.1121 | 0.3454 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0142 | 0.0632 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0062 | 0.0644 | 0.2861 |
Giardia lamblia | Phosphoglycerate kinase | 0.0168 | 0.225 | 1 |
Brugia malayi | Phosphoglycerate kinase | 0.0062 | 0.0644 | 0.2287 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0084 | 0.0981 | 0.2281 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0142 | 0.0331 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0152 | 0.0676 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0409 | 0.1262 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0093 | 0.1121 | 0.2605 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0061 | 0.0188 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0168 | 0.225 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0157 | 0.0072 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0093 | 0.1121 | 0.1121 |
Schistosoma mansoni | ubiquitin-activating enzyme E1b | 0.0031 | 0.0185 | 0.0185 |
Echinococcus granulosus | snurportin 1 | 0.0305 | 0.4301 | 0.4301 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0093 | 0.1121 | 0.3981 |
Echinococcus granulosus | sumo-activating enzyme subunit 2 | 0.0031 | 0.0185 | 0.0185 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0084 | 0.0981 | 0.3981 |
Toxoplasma gondii | PAN domain-containing protein | 0.0292 | 0.411 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0192 | 0.2607 | 0.8898 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0029 | 0.0152 | 0.0676 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0168 | 0.225 | 0.225 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0157 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.038 | 0.0883 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0029 | 0.0152 | 0.0676 |
Brugia malayi | ThiF family protein | 0.0048 | 0.0431 | 0.1531 |
Leishmania major | ubiquitin-activating enzyme-like protein | 0.0031 | 0.0185 | 0.0823 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.1121 | 0.3454 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0305 | 0.4301 | 1 |
Plasmodium falciparum | SUMO-activating enzyme subunit 2 | 0.0031 | 0.0185 | 0.0204 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0157 | 0.0157 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0029 | 0.0152 | 0.0047 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0142 | 0.0632 |
Mycobacterium tuberculosis | Probable reductase | 0.0192 | 0.2607 | 0.8898 |
Trypanosoma cruzi | ubiquitin-activating enzyme, putative | 0.0027 | 0.0119 | 0.053 |
Loa Loa (eye worm) | glutathione reductase | 0.0084 | 0.0981 | 0.2281 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.1121 | 0.3454 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0152 | 0.0676 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0192 | 0.2607 | 0.8898 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0947 | 0.0947 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.0168 | 0.225 | 0.5311 |
Plasmodium vivax | SUMO-activating enzyme subunit 2, putative | 0.0031 | 0.0185 | 0.0204 |
Brugia malayi | glutathione reductase | 0.0084 | 0.0981 | 0.3485 |
Trypanosoma brucei | trypanothione reductase | 0.0084 | 0.0981 | 0.4362 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0029 | 0.0152 | 0.0676 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0029 | 0.0152 | 0.0025 |
Toxoplasma gondii | ThiF family protein | 0.0031 | 0.0185 | 0.0108 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0029 | 0.0152 | 0.0152 |
Echinococcus multilocularis | snurportin 1 | 0.0305 | 0.4301 | 0.4301 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0157 | 0.0157 |
Trypanosoma cruzi | 3-phosphoglycerate kinase, glycosomal | 0.0062 | 0.0644 | 0.2861 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0168 | 0.225 | 1 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0168 | 0.225 | 1 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.0168 | 0.225 | 1 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0082 | 0.0947 | 0.0947 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0157 | 0.0157 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0157 | 0.0559 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0062 | 0.0644 | 0.2861 |
Plasmodium falciparum | thioredoxin reductase | 0.0084 | 0.0981 | 0.3981 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0048 | 0.0431 | 0.0431 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0061 | 0.0188 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 0.038 | 0.1688 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.038 | 0.1688 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0029 | 0.0152 | 0.0047 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0029 | 0.0152 | 0.0047 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.0168 | 0.225 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0292 | 0.411 | 1 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0168 | 0.225 | 0.6935 |
Treponema pallidum | phosphoglycerate kinase | 0.0168 | 0.225 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0029 | 0.0152 | 0.0676 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0029 | 0.0152 | 0.0676 |
Trypanosoma brucei | phosphoglycerate kinase, putative | 0.0062 | 0.0644 | 0.2861 |
Trypanosoma brucei | polo-like protein kinase | 0.0093 | 0.1121 | 0.4981 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0152 | 0.0676 |
Giardia lamblia | Kinase, PLK | 0.0093 | 0.1121 | 0.4981 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0082 | 0.0947 | 0.3364 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0142 | 0.0505 |
Leishmania major | trypanothione reductase | 0.0084 | 0.0981 | 0.4362 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0061 | 0.0271 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0029 | 0.0152 | 0.0676 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.0181 | 0.0099 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0152 | 0.0676 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0683 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 0.038 | 0.038 |
Plasmodium falciparum | glutathione reductase | 0.0029 | 0.0152 | 0.0047 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0093 | 0.1121 | 0.4981 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0157 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0947 | 0.2201 |
Brugia malayi | Thioredoxin reductase | 0.0084 | 0.0981 | 0.3485 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0093 | 0.1121 | 0.3121 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0029 | 0.0152 | 0.054 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0062 | 0.0644 | 0.2861 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.0181 | 0.0806 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0029 | 0.0152 | 0.0519 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0214 | 0.293 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0093 | 0.1121 | 0.4981 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0152 | 0.0676 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0029 | 0.0152 | 0.0676 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0157 | 0.0038 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.1121 | 0.3454 |
Loa Loa (eye worm) | ThiF family protein | 0.0031 | 0.0185 | 0.043 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0029 | 0.0152 | 0.0676 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.0168 | 0.225 | 1 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0082 | 0.0947 | 0.0947 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0214 | 0.293 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0029 | 0.0152 | 0.0469 |
Trypanosoma cruzi | ubiquitin-activating enzyme, putative | 0.0031 | 0.0185 | 0.0823 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.0168 | 0.225 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0021 | 0.0035 | 0.0125 |
Brugia malayi | Phosphoglycerate kinase | 0.0168 | 0.225 | 0.7991 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.0168 | 0.225 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0029 | 0.0152 | 0.0676 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.0168 | 0.225 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0029 | 0.0152 | 0.0469 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.1121 | 0.3454 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0192 | 0.2607 | 0.8898 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0214 | 0.293 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0084 | 0.0981 | 0.3981 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0061 | 0.0271 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0431 | 0.0728 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0062 | 0.0644 | 0.2861 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0029 | 0.0152 | 0.0152 |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0048 | 0.0431 | 0.0431 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.038 | 0.1688 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0029 | 0.0152 | 0.0676 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0043 | 0.0365 | 0.0365 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0029 | 0.0152 | 0.0025 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0214 | 0.293 | 1 |
Onchocerca volvulus | 0.0234 | 0.3244 | 1 | |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0082 | 0.0947 | 0.2201 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0152 | 0.0676 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 0.3244 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0085 | 0.0989 | 0.0989 |
Plasmodium vivax | glutathione reductase, putative | 0.0084 | 0.0981 | 0.3981 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0142 | 0.0142 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0048 | 0.0431 | 0.0431 |
Plasmodium falciparum | thioredoxin reductase | 0.0029 | 0.0152 | 0.0047 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0152 | 0.0676 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0192 | 0.2607 | 0.5251 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0082 | 0.0947 | 0.0947 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0947 | 0.0947 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.225 | 0.523 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0168 | 0.225 | 0.6935 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0168 | 0.225 | 1 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0061 | 0.0271 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.