Detailed information for compound 684294

Basic information

Technical information
  • TDR Targets ID: 684294
  • Name: methyl 4-[[1-[(3-methylphenyl)methyl]-2-oxopy ridine-3-carbonyl]amino]benzoate
  • MW: 376.405 | Formula: C22H20N2O4
  • H donors: 1 H acceptors: 3 LogP: 3.15 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)NC(=O)c1cccn(c1=O)Cc1cccc(c1)C
  • InChi: 1S/C22H20N2O4/c1-15-5-3-6-16(13-15)14-24-12-4-7-19(21(24)26)20(25)23-18-10-8-17(9-11-18)22(27)28-2/h3-13H,14H2,1-2H3,(H,23,25)
  • InChiKey: RCSJWLDGQVBJSC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 4-[[1-[(3-methylphenyl)methyl]-2-oxo-pyridine-3-carbonyl]amino]benzoate
  • 4-[[[1-[(3-methylphenyl)methyl]-2-oxo-3-pyridyl]-oxomethyl]amino]benzoic acid methyl ester
  • 4-[[2-keto-1-(3-methylbenzyl)pyridine-3-carbonyl]amino]benzoic acid methyl ester
  • methyl 4-[[1-[(3-methylphenyl)methyl]-2-oxo-pyridin-3-yl]carbonylamino]benzoate
  • ZINC05269673

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0395 0.048
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0761 0.1438
Brugia malayi nuclear receptor NHR-88 0.0011 0.0007 0.0067
Mycobacterium tuberculosis Possible oxidoreductase 0.0027 0.0204 0.0188
Trypanosoma brucei oxidoreductase-like protein 0.0027 0.0204 0.2682
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0129 0.0404
Trypanosoma brucei pteridine reductase 1 0.0027 0.0204 0.2682
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0129 0.0231
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0129 0.0121
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0102 0.0095
Leishmania major oxidoreductase-like protein 0.0027 0.0204 0.1547
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0347 0.0972
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0396 0.4681 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0761 0.2155
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0102 0.1343
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0129 0.0404
Giardia lamblia PHD finger protein 15 0.0031 0.025 1
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0204 0.0223
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0204 0.0223
Brugia malayi beta-lactamase 0.0073 0.0761 0.6958
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0154 0.0114
Loa Loa (eye worm) hypothetical protein 0.0052 0.0514 0.145
Echinococcus multilocularis geminin 0.0677 0.8086 0.8084
Loa Loa (eye worm) hypothetical protein 0.0073 0.0761 0.2155
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0204 0.0223
Brugia malayi hypothetical protein 0.0017 0.0081 0.0745
Onchocerca volvulus Alhambra homolog 0.0031 0.025 0.3216
Echinococcus granulosus importin subunit beta 1 0.0028 0.0218 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.0067
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0027 0.0204 0.0188
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0396 0.4681 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0436 0.053
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0761 0.1217
Plasmodium vivax importin-beta 2, putative 0.0028 0.0218 0.0423
Echinococcus multilocularis cpg binding protein 0.003 0.0244 0.0237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0436 0.0539
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0436 0.0539
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0129 0.0347
Schistosoma mansoni coup transcription factor 0.0011 0.0007 0.0009
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0018 0.0011
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0204 0.0223
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0193 0.2533
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0218 0.2871
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.002 0.0015
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0027 0.0204 0.0223
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0761 0.1587
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0027 0.0204 0.1547
Schistosoma mansoni ap endonuclease 0.0018 0.0102 0.0126
Mycobacterium tuberculosis Probable oxidoreductase 0.0027 0.0204 0.0188
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0007 0.0009
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0007 0.0067
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0193 0.0368
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0328 0.032
Brugia malayi hypothetical protein 0.0036 0.0312 0.2853
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0761 0.1217
Onchocerca volvulus 0.0073 0.0761 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0027 0.0204 0.0188
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0007 0.0009
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.025 0.03
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0204 0.0223
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1093 0.1344
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0204 0.0223
Brugia malayi beta-lactamase family protein 0.0073 0.0761 0.6958
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0009
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0027 0.0204 0.0223
Schistosoma mansoni dihydropteridine reductase 0.0027 0.0204 0.0252
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0027 0.0204 0.1547
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0761 0.1217
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.025 0.0309
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0027 0.0204 0.0223
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0007 0.0009
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0436 0.1225
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0086 0.0106
Brugia malayi PHD-finger family protein 0.0031 0.025 0.2283
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0761 0.1438
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0204 0.0223
Onchocerca volvulus 0.0027 0.0204 0.2611
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0035
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0193 0.0368
Leishmania major hypothetical protein, conserved 0.0073 0.0761 1
Entamoeba histolytica hypothetical protein 0.0036 0.0312 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0027 0.0204 0.0188
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0027 0.0204 0.1867
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0761 1
Schistosoma mansoni hypothetical protein 0.0012 0.002 0.0024
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0761 0.1217
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.0067
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0007 0.0009
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0027 0.0204 0.0252
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0007 0.0009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0347 0.043
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0027 0.0204 0.0223
Mycobacterium tuberculosis Conserved protein 0.0073 0.0761 0.1217
Brugia malayi beta-lactamase family protein 0.0073 0.0761 0.6958
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0027 0.0204 0.0436
Schistosoma mansoni hypothetical protein 0.0677 0.8086 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0761 0.2155
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0027 0.0204 0.0436
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0204 0.0223
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.0067
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0027 0.0204 0.2682
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0007 0.0009
Mycobacterium tuberculosis Conserved protein 0.0073 0.0761 0.1217
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0027 0.0204 0.1547
Leishmania major importin beta-1 subunit, putative 0.0023 0.0154 0.079
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0204 0.0223
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0204 0.0223
Schistosoma mansoni ran 0.0021 0.0129 0.0159
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0102 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0312 0.0386
Onchocerca volvulus 0.0073 0.0761 1
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0761 0.1243
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0204 0.0223
Leishmania major hypothetical protein, conserved 0.0026 0.0193 0.1375
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0102 0.0174
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0027 0.0204 0.0393
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0027 0.0204 0.0393
Trichomonas vaginalis hypothetical protein 0.0396 0.4681 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.025 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.0067
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0027 0.0204 0.0223
Trichomonas vaginalis esterase, putative 0.0073 0.0761 0.1438
Echinococcus multilocularis snurportin 1 0.0299 0.3503 0.3499
Loa Loa (eye worm) hypothetical protein 0.0073 0.0761 0.2155
Loa Loa (eye worm) hypothetical protein 0.0073 0.0761 0.2155
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0018 0.0013
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.025 0.0533
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0204 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.0067
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0761 0.0932
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0204 0.0223
Brugia malayi jmjC domain containing protein 0.01 0.1093 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0761 0.2155
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0761 0.1217
Brugia malayi Importin beta-1 subunit 0.0028 0.0218 0.1998
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0396 0.4681 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.0067
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0761 0.1217
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.3503 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.0067
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0204 0.0223
Entamoeba histolytica hypothetical protein 0.0036 0.0312 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0218 0.0466
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1093 0.1087
Brugia malayi Bromodomain containing protein 0.0031 0.025 0.2283
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0534 0.114
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0436 0.0429
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0204 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0007 0.0067
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0027 0.0204 0.0223
Schistosoma mansoni cpg binding protein 0.0029 0.0224 0.0278
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0007 0.0009
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0027 0.0204 0.1547
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.0067
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0027 0.0204 0.0223
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0193 0.1375
Leishmania major pteridine reductase 1 0.0027 0.0204 0.1547
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0102 0.0271
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0436 0.053
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0347 0.043
Brugia malayi nuclear hormone receptor 0.0011 0.0007 0.0067
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0129 0.015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0312 0.0377
Loa Loa (eye worm) hypothetical protein 0.0031 0.025 0.0693
Brugia malayi jmjC domain containing protein 0.0039 0.0347 0.3177
Echinococcus granulosus peregrin 0.0031 0.025 0.03
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0761 0.6958
Plasmodium falciparum enoyl-acyl carrier reductase 0.0396 0.4681 1
Entamoeba histolytica hypothetical protein 0.0023 0.0154 0.2479
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.0067
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0027 0.0204 0.0223
Schistosoma mansoni hypothetical protein 0.0031 0.025 0.0309
Toxoplasma gondii exonuclease III APE 0.0018 0.0102 0.0218
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0129 0.1692
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0761 0.1438
Schistosoma mansoni ap endonuclease 0.0018 0.0102 0.0126
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0027 0.0204 0.0436
Trichomonas vaginalis ran, putative 0.0021 0.0129 0.0058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0436 0.3985
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0027 0.0204 0.1547
Mycobacterium ulcerans hypothetical protein 0.0073 0.0761 0.1438
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0106 0.0966
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.025 0.0693
Plasmodium falciparum phd finger protein, putative 0.0031 0.025 0.049
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0761 0.1217
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0761 0.0754
Entamoeba histolytica hypothetical protein 0.0036 0.0312 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0154 0.079
Loa Loa (eye worm) retinol dehydrogenase 12 0.0027 0.0204 0.0563
Plasmodium falciparum importin beta, putative 0.0028 0.0218 0.0423
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0027 0.0204 0.0243
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.025 0.0533
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0761 0.1438
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0761 1
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0761 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0204 0.0223
Loa Loa (eye worm) beta-lactamase 0.0073 0.0761 0.2155
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0027 0.0204 0.0223
Leishmania major GTP-binding protein, putative 0.0021 0.0129 0.0404
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0129 0.1802
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0396 0.4681 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0612 0.0757
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0204 0.0223
Brugia malayi steroid hormone receptor 0.0011 0.0007 0.0067
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0218 0.2871
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0761 0.0941
Onchocerca volvulus 0.0029 0.0224 0.2883
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0154 0.0114
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0027 0.0204 0.4859
Loa Loa (eye worm) hypothetical protein 0.0027 0.0204 0.0563
Plasmodium vivax hypothetical protein, conserved 0.0031 0.025 0.049
Echinococcus granulosus snurportin 1 0.0299 0.3503 0.4328
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0396 0.4681 0.8463
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0193 0.1375
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0102 0.0174
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0204 0.0223
Brugia malayi CXXC zinc finger family protein 0.0029 0.0224 0.2054
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0027 0.0204 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0026 0.0193 0.053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0761 0.0941
Mycobacterium tuberculosis Possible oxidoreductase 0.0027 0.0204 0.0188
Echinococcus multilocularis peregrin 0.0031 0.025 0.0242
Loa Loa (eye worm) oxidoreductase 0.0027 0.0204 0.0563
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0073 0.0761 0.2155
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0193 0.0368
Schistosoma mansoni importin beta-1 0.0028 0.0218 0.027
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0129 0.0231
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0027 0.0204 0.0223
Brugia malayi hypothetical protein 0.0026 0.0193 0.1763
Brugia malayi PHD-finger family protein 0.0012 0.002 0.018
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0465 0.5512 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0761 0.1438
Toxoplasma gondii ABC1 family protein 0.0073 0.0761 0.1625
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0154 0.0114
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0102 0.0117
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.002 0.0012
Mycobacterium leprae Probable lipase LipE 0.0073 0.0761 0.1243
Schistosoma mansoni hypothetical protein 0.0299 0.3503 0.4333
Mycobacterium tuberculosis Conserved protein 0.0073 0.0761 0.1217
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0312 0.0305
Mycobacterium ulcerans beta-lactamase 0.0073 0.0761 0.1438
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0218 0.0211
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0204 0.0223
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0436 0.0429
Onchocerca volvulus 0.0027 0.0204 0.2611
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0027 0.0204 0.1547
Schistosoma mansoni cpg binding protein 0.003 0.0244 0.0302
Mycobacterium ulcerans oxidoreductase 0.0027 0.0204 0.0223
Echinococcus granulosus geminin 0.0677 0.8086 1
Entamoeba histolytica hypothetical protein 0.0036 0.0312 1
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0396 0.4681 1
Onchocerca volvulus 0.0073 0.0761 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0761 0.1438
Schistosoma mansoni jumonji domain containing protein 0.008 0.0844 0.1043
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.0604
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0009
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0129 0.0275
Brugia malayi ecdysteroid receptor 0.0011 0.0007 0.0067
Mycobacterium ulcerans lipase LipD 0.0073 0.0761 0.1438
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.0067
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0102 0.0934
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0007 0.0067
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0007 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0007 0.0009
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0347 0.0421
Schistosoma mansoni hypothetical protein 0.0036 0.0312 0.0386
Echinococcus granulosus cpg binding protein 0.003 0.0244 0.0293
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0027 0.0204 0.0188
Brugia malayi RNA, U transporter 1 0.008 0.0844 0.7724
Schistosoma mansoni hypothetical protein 0.0677 0.8086 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0396 0.4681 1
Schistosoma mansoni cpg binding protein 0.003 0.0244 0.0302
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0224 0.0621
Schistosoma mansoni ran 0.0021 0.0129 0.0159
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0204 0.0223
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0644 0.1822
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0193 0.0412
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0129 0.1177
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0027 0.0204 0.0563
Entamoeba histolytica Ran family GTPase 0.0021 0.0129 0.1267
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0027 0.0204 0.0188
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0027 0.0204 0.0197
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0761 0.1438
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0395 0.0388
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0027 0.0204 0.1867
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0436 0.0539

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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