Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0172 | 0.0271 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0332 | 0.2085 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0175 | 0.0527 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.0395 | 0.1825 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0121 | 0.0649 | 0.1959 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.1044 | 0.5006 |
Brugia malayi | glutaminase DH11.1 | 0.0288 | 0.1788 | 0.8563 |
Echinococcus granulosus | geminin | 0.0179 | 0.1044 | 0.315 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0121 | 0.0649 | 0.3113 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0044 | 0.0211 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0208 | 0.1246 | 0.3761 |
Brugia malayi | 6-phosphofructokinase | 0.0121 | 0.0649 | 0.3053 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.006 | 0.0239 | 0.0722 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0053 | 0.019 | 0.0572 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0164 | 0.0947 | 0.4424 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0121 | 0.0649 | 0.2939 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0053 | 0.019 | 0.0572 |
Toxoplasma gondii | Ferredoxin-fold anticodon binding domain-containing protein | 0.0164 | 0.0947 | 0.4424 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0033 | 0.0051 | 0.0036 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0175 | 0.0838 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0332 | 0.2085 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0175 | 0.0527 |
Schistosoma mansoni | glutaminase | 0.0288 | 0.1788 | 0.8576 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.006 | 0.0239 | 0.1071 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0513 | 0.3314 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0053 | 0.019 | 0.0909 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0332 | 0.2085 | 0.6292 |
Onchocerca volvulus | 0.0053 | 0.019 | 0.0981 | |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0044 | 0.0133 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0119 | 0.0488 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0219 | 0.1321 | 0.6112 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0121 | 0.0649 | 0.2939 |
Mycobacterium ulcerans | glutaminase | 0.0288 | 0.1788 | 0.1218 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0053 | 0.019 | 0.0572 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0033 | 0.0051 | 0.0036 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0112 | 0.0593 | 0.2691 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0332 | 0.2085 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.005 | 0.0172 | 0.052 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.1044 | 0.5006 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0208 | 0.1246 | 0.3761 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.0649 | 0.2939 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.0164 | 0.0947 | 0.4541 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.1497 | 1 | 0.5 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0332 | 0.2085 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0288 | 0.1788 | 0.854 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.005 | 0.0172 | 0.052 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0121 | 0.0649 | 0.2939 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0053 | 0.019 | 0.0358 |
Brugia malayi | phosphofructokinase | 0.0121 | 0.0649 | 0.3053 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.0649 | 0.2939 |
Loa Loa (eye worm) | phosphofructokinase | 0.0121 | 0.0649 | 0.2695 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0151 | 0.0164 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.019 | 0.0909 |
Onchocerca volvulus | 0.025 | 0.1527 | 1 | |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0332 | 0.2085 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.0175 | 0.0759 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0332 | 0.2085 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.005 | 0.0172 | 0.0827 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0033 | 0.0051 | 0.0036 |
Brugia malayi | phenylalanyl-tRNA synthetase, mitochondrial precursor, putative | 0.0164 | 0.0947 | 0.4494 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0112 | 0.0593 | 0.2665 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0033 | 0.0051 | 0.0036 |
Brugia malayi | 6-phosphofructokinase | 0.0121 | 0.0649 | 0.3053 |
Echinococcus granulosus | phenylalanyl tRNA synthetase | 0.0164 | 0.0947 | 0.2857 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0239 | 0.0611 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.1497 | 1 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.0307 | 0.1472 |
Loa Loa (eye worm) | glutaminase | 0.0288 | 0.1788 | 0.8489 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.019 | 0.0358 |
Loa Loa (eye worm) | glutaminase 2 | 0.0288 | 0.1788 | 0.8489 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0175 | 0.0527 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0175 | 0.0838 |
Brugia malayi | Pre-SET motif family protein | 0.0219 | 0.1321 | 0.6303 |
Loa Loa (eye worm) | phenylalanyl-tRNA synthetase | 0.0164 | 0.0947 | 0.421 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0332 | 0.2085 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.006 | 0.0239 | 0.0722 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0175 | 0.0527 |
Echinococcus multilocularis | geminin | 0.0179 | 0.1044 | 0.315 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0053 | 0.019 | 0.0981 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0363 | 0.124 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0332 | 0.2085 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0121 | 0.0649 | 0.2695 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0121 | 0.0649 | 0.2939 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.019 | 0.0909 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0044 | 0.0211 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.0175 | 0.0283 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0044 | 0.0126 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0121 | 0.0649 | 0.3113 |
Loa Loa (eye worm) | MBCTL1 | 0.006 | 0.0239 | 0.0611 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.019 | 0.083 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0513 | 0.3314 | 1 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0131 | 0.0723 | 0.3303 |
Trichomonas vaginalis | set domain proteins, putative | 0.025 | 0.1527 | 0.7255 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0121 | 0.0649 | 0.1959 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0513 | 0.3314 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0036 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0137 | 0.0091 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.0649 | 0.2939 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.006 | 0.0239 | 0.0722 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.0101 | 0.0304 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | 0.0164 | 0.0947 | 0.2857 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0112 | 0.0593 | 0.2665 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0332 | 0.2085 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.028 | 0.0845 |
Echinococcus granulosus | neuropeptide s receptor | 0.0513 | 0.3314 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.0101 | 0.0304 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.006 | 0.0239 | 0.0722 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.006 | 0.0239 | 0.1147 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.022 | 0.1322 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.005 | 0.0172 | 0.0827 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0175 | 0.0838 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0332 | 0.2085 | 0.6292 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0121 | 0.0649 | 0.2695 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.1497 | 1 | 1 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0332 | 0.2085 | 1 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0332 | 0.2085 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0322 | 0.2015 | 0.9662 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.019 | 0.083 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0053 | 0.019 | 0.0572 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0332 | 0.2085 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.2085 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.028 | 0.0845 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0033 | 0.0051 | 0.0036 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0112 | 0.0593 | 0.2846 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.0649 | 0.2939 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0164 | 0.0947 | 0.4403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.