TDR Targets

Basic information

Technical information

TDR Targets ID: 686655
Name: N-cyclopropyl-N'-(3-methylsulfanylphenyl)oxam ide
MW: 250.317 | Formula: C12H14N2O2S
H donors: 2 H acceptors: 2 LogP: 1.87 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CSc1cccc(c1)NC(=O)C(=O)NC1CC1
InChi: 1S/C12H14N2O2S/c1-17-10-4-2-3-9(7-10)14-12(16)11(15)13-8-5-6-8/h2-4,7-8H,5-6H2,1H3,(H,13,15)(H,14,16)
InChiKey: YKXPXTOOTHWKSH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-cyclopropyl-N'-[3-(methylthio)phenyl]oxamide
N-cyclopropyl-N'-(3-methylsulfanylphenyl)ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0022	0.0285	0.0237
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0081	0.0112
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0425	0.6848	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0172	0.0172
Trichomonas vaginalis	CAMK family protein kinase	0.0425	0.6848	1
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0022	0.0285	0.0237
Trichomonas vaginalis	CAMK family protein kinase	0.0425	0.6848	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0081	0.0112
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0226	0.0325
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0546	0.0798
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0285	0.0237
Echinococcus granulosus	Serine:threonine protein kinase PLK4	0.0333	0.536	0.7825
Loa Loa (eye worm)	RecQ helicase	0.0024	0.0307	0.0442
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0081	0.0081
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0081	0.0081
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0081	0.0112
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0226	0.0325
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0081	0.0112
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0081	0.0081
Plasmodium falciparum	phosphodiesterase delta, putative	0.0022	0.0285	0.4411
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0603	0.2059
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0081	0.0112
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0022	0.0285	0.041
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0081	0.0112
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0226	0.015
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0172	0.0245
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0022	0.0285	0.041
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0081	0.0112
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0425	0.6848	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0022	0.0285	0.041
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Brugia malayi	PXA domain containing protein	0.0019	0.0226	0.0325
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.2462
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0081	0.0112
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0022	0.0285	0.4411
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0081	0.0112
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0226	0.0226
Schistosoma mansoni	hypothetical protein	0.0016	0.0172	0.0172
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.0307	0.0442
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0022	0.0285	0.4411
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0425	0.6848	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.1874	0.2732
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0022	0.0285	0.041
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0226	0.0325
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0081	0.0112
Trichomonas vaginalis	CAMK family protein kinase	0.014	0.2208	0.3097
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0603	0.0711
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0022	0.0285	0.041
Brugia malayi	TAR-binding protein	0.0062	0.0937	0.1362
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0022	0.0285	0.4411
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0226	0.0325
Schistosoma mansoni	DNA helicase recq1	0.001	0.0079	0.0079
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0226	0.0325
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0081	0.0112
Brugia malayi	acetyltransferase, GNAT family protein	0.0143	0.2248	0.3279
Brugia malayi	RNA binding protein	0.0062	0.0937	0.1362
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0022	0.0285	0.0237
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0937	0.0937
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0081	0.0112
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0226	0.0325
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0081	0.0112
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0172	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0285	0.041
Brugia malayi	ecdysteroid receptor	0.001	0.0081	0.0112
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0081	0.0112
Echinococcus multilocularis	expressed protein	0.0368	0.5919	0.8642
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Schistosoma mansoni	DNA helicase recq5	0.001	0.0079	0.0079
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0081	0.0112
Brugia malayi	nuclear receptor NHR-88	0.001	0.0081	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0226	0.0325
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0185	0.2931	0.2931
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0226	0.0325
Leishmania major	hypothetical protein, conserved	0.0022	0.0285	0.0237
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Loa Loa (eye worm)	hypothetical protein	0.001	0.0081	0.0112
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0226	0.015
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0185	0.2931	0.4276
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0226	0.0325
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0603	0.0711
Loa Loa (eye worm)	hypothetical protein	0.001	0.0081	0.0112
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.072	0.1046
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0022	0.0285	0.0237
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0081	0.0112
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0226	0.0226
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0226	0.0325
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0937	0.1362
Loa Loa (eye worm)	PDE1B protein	0.0022	0.0285	0.041
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.0307	0.0442
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0226	0.0325
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0079	0.0109
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0226	0.0226
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0081	0.0112
Brugia malayi	PXA domain containing protein	0.0019	0.0226	0.0325
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0603	0.0876
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0081	0.0112
Schistosoma mansoni	serine/threonine protein kinase	0.0021	0.0256	0.0256
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0022	0.0285	0.0285
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.072	0.1046
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0081	0.0112
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0546	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0226	0.0226
Brugia malayi	nuclear hormone receptor	0.001	0.0081	0.0112
Brugia malayi	hypothetical protein	0.0019	0.0226	0.0325
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0226	0.0325
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.072	0.1046
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0079	0.0109
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Trypanosoma cruzi	polo-like protein kinase, putative	0.0425	0.6848	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0004	0.0004
Entamoeba histolytica	recQ family helicase, putative	0.0013	0.0126	0.0184
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0226	0.0325
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0081	0.0112
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0022	0.0285	0.0237
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0081	0.0112
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0226	0.0325
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.4411
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0603	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0081	0.0112
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0139	0.2183	0.3184
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Loa Loa (eye worm)	hypothetical protein	0.001	0.0081	0.0112
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.0307	0.0269
Trypanosoma brucei	hypothetical protein, conserved	0.0022	0.0285	0.0237
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0022	0.0285	0.0237
Giardia lamblia	hypothetical protein	0.0022	0.0285	0.0305
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0021	0.0256	0.0369
Giardia lamblia	Hypothetical protein	0.0022	0.0285	0.0305
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0022	0.0285	0.0237
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0185	0.2931	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0081	0.0081
Trichomonas vaginalis	CAMK family protein kinase	0.0425	0.6848	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0081	0.0112
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0226	0.0226
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Schistosoma mansoni	serine/threonine protein kinase	0.0425	0.6848	0.6848
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0081	0.0081
Echinococcus granulosus	expressed protein	0.0368	0.5919	0.8642
Brugia malayi	serine/threonine-protein kinase plk-2	0.0425	0.6848	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0162	0.2564	0.3741
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0081	0.0081
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0226	0.0325
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0225	0.0225
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0937	0.0937
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0019	0.0226	0.015
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0079	0.0109
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0022	0.0285	0.041
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.0307	0.0269
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0004	0.0004
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0049	0.072	0.1046
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0226	0.0325
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0081	0.0112
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0226	0.0325
Entamoeba histolytica	hypothetical protein	0.0019	0.0226	0.0331
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0022	0.0285	0.0237
Trypanosoma cruzi	polo-like protein kinase, putative	0.0425	0.6848	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0022	0.0285	0.041
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0285	0.0237
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0226	0.0325
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0022	0.0285	0.041
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0172	0.0245
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0226	0.0325
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0937	0.0937
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.2462
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0285	0.0237
Trichomonas vaginalis	CAMK family protein kinase	0.0425	0.6848	1
Entamoeba histolytica	hypothetical protein	0.0019	0.0226	0.0331
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0022	0.0285	0.0285
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0226	0.0325
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0079	0.0109
Loa Loa (eye worm)	hypothetical protein	0.001	0.0079	0.0109
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0162	0.2564	0.3741
Schistosoma mansoni	serine/threonine protein kinase	0.0021	0.0256	0.0256
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0226	0.0226
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0081	0.0112
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0226	0.0325
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0079	0.0109
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0081	0.0081
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0285	0.0237
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.026	0.3868
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0425	0.6848	1
Entamoeba histolytica	hypothetical protein	0.0019	0.0226	0.0331
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0081	0.0112
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0285	0.0237
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0226	0.0226
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0226	0.0325
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0022	0.0285	0.041
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0022	0.0285	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0226	0.0325
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0021	0.0256	0.0369
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0285	0.0237
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0162	0.2564	0.3741
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0022	0.0285	0.0285
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0022	0.0285	0.0285
Loa Loa (eye worm)	hypothetical protein	0.001	0.0081	0.0112
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0081	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2931	0.4276
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0021	0.0256	0.0369
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0081	0.0112
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0081	0.0112
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.2462
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0937	0.0937
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0185	0.2931	0.4213
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0081	0.0112
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0226	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0285	0.041
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0081	0.0112
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0022	0.0285	0.041
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0937	0.1362
Schistosoma mansoni	hypothetical protein	0.0034	0.0466	0.0466
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0226	0.015
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0081	0.0112
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0022	0.0285	0.041
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0185	0.2931	0.4276
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0226	0.0226
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0603	0.2059
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0022	0.0285	0.0237
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0162	0.2564	0.3741
Schistosoma mansoni	coup transcription factor	0.001	0.0081	0.0081
Leishmania major	hypothetical protein, conserved	0.0022	0.0285	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0466	0.0675
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0022	0.0285	0.0237
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0172	0.0245
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0937	0.1362
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0226	0.0226
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0226	0.015
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0172	0.0245
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0021	0.0256	0.0369
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0143	0.2248	0.3279
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0226	0.0226
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0081	0.0112
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0185	0.2931	0.4276
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0546	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0226	0.0325
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0022	0.0285	0.0237
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0178	0.0607
Trichomonas vaginalis	CAMK family protein kinase	0.0425	0.6848	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0226	0.015
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0172	0.0245
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0937	0.1362
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0081	0.0112
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0466	0.0675
Loa Loa (eye worm)	hypothetical protein	0.001	0.0081	0.0112
Loa Loa (eye worm)	hypothetical protein	0.001	0.0081	0.0112
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0425	0.6848	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0285	0.0237
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0081	0.0112
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	CAMK family protein kinase	0.0425	0.6848	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0081	0.0112
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0143	0.2248	0.2248
Brugia malayi	steroid hormone receptor	0.001	0.0081	0.0112
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Plasmodium vivax	phosphodiesterase gamma, putative	0.0022	0.0285	0.2462
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0022	0.0285	0.041
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0079	0.0109
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0937	0.1362
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0079	0.0268
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0022	0.0285	0.0285
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0425	0.6848	1
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0937	0.1362
Loa Loa (eye worm)	hypothetical protein	0.001	0.0081	0.0112
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0226	0.015
Echinococcus granulosus	bloom syndrome protein	0.0024	0.0307	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0226	0.0325
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Echinococcus multilocularis	Serine:threonine protein kinase PLK4	0.0333	0.536	0.7825
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0081	0.0112
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0022	0.0285	0.0285
Schistosoma mansoni	serine/threonine protein kinase	0.0021	0.0256	0.0256
Echinococcus granulosus	GPCR family 2	0.0016	0.0172	0.0245
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0022	0.0285	0.0285
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Trichomonas vaginalis	CAMK family protein kinase	0.0425	0.6848	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0172	0.0172
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0226	0.0325
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0022	0.0285	0.041
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0022	0.0285	0.041
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0022	0.0285	0.0285
Brugia malayi	hypothetical protein	0.0019	0.0226	0.0325
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0226	0.0325
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0226	0.0325
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0081	0.0112
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0079	0.0109
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0022	0.0285	0.041
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0081	0.0112
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0081	0.0112
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0081	0.0081
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0081	0.0081
Loa Loa (eye worm)	acetyltransferase	0.0143	0.2248	0.3279
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0172	0.0245
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0285	0.0237
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0021	0.0256	0.0369
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0285	0.4411
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0022	0.0285	0.041
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0226	0.0325
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0185	0.2931	0.4276
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0226	0.0325
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0172	0.0245
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0022	0.0285	0.041
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0081	0.0112
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0022	0.0285	0.041
Trypanosoma brucei	polo-like protein kinase	0.0425	0.6848	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0285	0.041
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0172	0.0245
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0022	0.0285	0.041
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0226	0.0226
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0079	0.0268
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0081	0.0112
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0081	0.0081
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0285	0.0972
Trichomonas vaginalis	CAMK family protein kinase	0.014	0.2208	0.3097
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0081	0.0112
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0285	0.0237
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0022	0.0285	0.0237
Giardia lamblia	Kinase, PLK	0.0425	0.6848	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0022	0.0285	0.0285
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0081	0.0081
Schistosoma mansoni	hypothetical protein	0.0016	0.0172	0.0172
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0022	0.0285	0.0237
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0937	0.0937

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 686655