TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 494.563 | Formula: C25H26N4O5S
H donors: 0 H acceptors: 4 LogP: 4.95 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1nnc2n1n(C(=O)CC)c(c(s2)C(=O)CC)c1ccc(c(c1)OC)OC
InChi: 1S/C25H26N4O5S/c1-6-18(30)23-22(16-10-13-19(33-4)20(14-16)34-5)28(21(31)7-2)29-24(26-27-25(29)35-23)15-8-11-17(32-3)12-9-15/h8-14H,6-7H2,1-5H3
InChiKey: UCFZVVBLBDIPAG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	transporter, major facilitator family protein	0.0031	0.0217	0.0327
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Schistosoma mansoni	glucose transporter	0.0031	0.0217	0.0894
Giardia lamblia	Lysyl-tRNA synthetase	0.0049	0.0414	0.6849
Brugia malayi	Sugar transporter family protein	0.0031	0.0217	0.0898
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0271	0.1144
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Brugia malayi	major facilitator superfamily protein	0.0031	0.0217	0.0898
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0621	0.274
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0271	0.1144
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Onchocerca volvulus		0.0036	0.0271	1
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Treponema pallidum	prolyl-tRNA synthetase	0.0023	0.0134	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0066	0.0597	0.1193
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0077	0.0715	0.1081
Schistosoma mansoni	glucose transport protein	0.0219	0.2266	1
Schistosoma mansoni	sugar transporter	0.0031	0.0217	0.0894
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0271	0.6554
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0271	0.114
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0067	0.0612	0.0597
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0031	0.0217	0.0914
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0271	0.1197
Plasmodium falciparum	lysine--tRNA ligase	0.0049	0.0414	0.0399
Loa Loa (eye worm)	sugar transporter	0.0031	0.0217	0.0898
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0066	0.0597	0.2586
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0031	0.0217	0.0413
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0012	0.0016	0.0066
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0271	0.1144
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0077	0.0715	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0463	0.199
Echinococcus granulosus	synaptic vesicle 2 protein	0.0031	0.0217	0.0413
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0031	0.0217	0.0201
Echinococcus multilocularis	geminin	0.017	0.1728	0.3516
Brugia malayi	hypothetical protein	0.0031	0.0217	0.0898
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Leishmania major	lysyl-tRNA synthetase, putative	0.0049	0.0414	0.5783
Leishmania major	cytochrome p450-like protein	0.0012	0.0015	0.0204
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0049	0.0414	0.5783
Leishmania major	protein kinase, putative	0.0067	0.0611	0.855
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0217	0.0898
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0217	0.0413
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Toxoplasma gondii	sugar transporter ST3	0.0031	0.0217	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.0621	0.274
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0271	0.1136
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.0621	0.868
Toxoplasma gondii	sugar transporter ST2	0.0031	0.0217	0.0327
Trichomonas vaginalis	esterase, putative	0.0036	0.0271	0.1197
Leishmania major	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0271	0.379
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0031	0.0217	1
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0067	0.0612	0.0597
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.1224
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0219	0.2266	0.462
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0271	0.1144
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0271	0.6554
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0031	0.0217	0.5239
Leishmania major	hypothetical protein, conserved	0.0036	0.0271	0.379
Entamoeba histolytica	protein kinase, putative	0.0067	0.0611	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0066	0.0597	0.2583
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0217	0.0956
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0067	0.0612	0.0597
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0271	0.1144
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0066	0.0597	0.2634
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0042	0.0333	0.5587
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Trichomonas vaginalis	CAMK family protein kinase	0.0067	0.0611	0.2699
Chlamydia trachomatis	lysine--tRNA ligase	0.0049	0.0414	1
Brugia malayi	glycyl-tRNA synthetase	0.0012	0.0016	0.0005
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0023	0.0134	0.3243
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0414	0.1773
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0049	0.0414	0.6932
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0005
Echinococcus granulosus	solute carrier family 22	0.0031	0.0217	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0271	0.114
Echinococcus granulosus	calcium dependent protein kinase	0.0063	0.0566	0.1131
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0067	0.0612	0.0925
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0271	0.114
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0031	0.0217	0.5239
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0012	0.0016	0.0005
Trichomonas vaginalis	glucose transporter, putative	0.0068	0.0621	0.274
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0219	0.2266	0.462
Schistosoma mansoni	protein kinase	0.0067	0.0611	0.2648
Brugia malayi	hypothetical protein	0.0031	0.0217	0.0898
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0271	0.1197
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.0621	0.868
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0067	0.0612	0.0597
Onchocerca volvulus		0.0036	0.0271	1
Mycobacterium ulcerans	sugar transporter	0.0031	0.0217	0.5239
Trichomonas vaginalis	glucose transporter, putative	0.0068	0.0621	0.274
Brugia malayi	lysyl-tRNA synthetase	0.0049	0.0414	0.1773
Toxoplasma gondii	facilitative glucose transporter GT1	0.0219	0.2266	0.3424
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0042	0.0333	0.1406
Schistosoma mansoni	hypothetical protein	0.017	0.1728	0.761
Plasmodium vivax	lysine--tRNA ligase, putative	0.0049	0.0414	0.0399
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0217	0.0413
Brugia malayi	beta-lactamase	0.0036	0.0271	0.114
Echinococcus granulosus	solute carrier family 22	0.0031	0.0217	0.0413
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Schistosoma mansoni	hypothetical protein	0.0219	0.2266	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0066	0.0597	0.1193
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Toxoplasma gondii	protein kinase, putative	0.0619	0.6617	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0354	0.3734	0.3724
Trypanosoma brucei	glucose transporter 1E	0.0068	0.0621	0.868
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Schistosoma mansoni	glucose transport protein	0.0219	0.2266	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0354	0.3734	0.5643
Toxoplasma gondii	glycyl-tRNA synthetase	0.0012	0.0016	0.0024
Leishmania major	glucose transporter, lmgt1	0.0068	0.0621	0.868
Plasmodium vivax	proline--tRNA ligase, putative	0.0077	0.0715	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0077	0.0715	1
Schistosoma mansoni	sugar transporter	0.0031	0.0217	0.0894
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0012	0.0016	0.0262
Schistosoma mansoni	sugar transporter	0.0031	0.0217	0.0894
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0069
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0067	0.0611	0.2652
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0067	0.0612	0.0597
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0066	0.0597	1
Echinococcus multilocularis	General substrate transporter	0.0188	0.193	0.3932
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0621	0.274
Brugia malayi	Cam kinase protein 1	0.0067	0.0611	0.2652
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0066	0.0597	0.9752
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.1224
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0611	0.2648
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0067	0.0612	0.0925
Plasmodium falciparum	hexose transporter	0.0219	0.2266	0.2253
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.0621	0.868
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0042	0.0333	0.1406
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0271	0.1136
Echinococcus granulosus	solute carrier family 22	0.0031	0.0217	0.0413
Mycobacterium ulcerans	integral membrane transport protein	0.0031	0.0217	0.5239
Echinococcus granulosus	geminin	0.017	0.1728	0.3516
Leishmania major	hypothetical protein, conserved	0.0031	0.0217	0.303
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0271	0.0256
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0217	0.0898
Giardia lamblia	Sugar-proton symporter	0.0031	0.0217	0.346
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0066	0.0597	0.2583
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0414	0.1769
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0012	0.0016	0.0377
Echinococcus multilocularis	calcium dependent protein kinase	0.0063	0.0566	0.1131
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0271	0.379
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Loa Loa (eye worm)	sugar transporter	0.0219	0.2266	1
Trypanosoma brucei	cytochrome P450, putative	0.0012	0.0015	0.0204
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Plasmodium vivax	hexose transporter	0.0219	0.2266	0.2253
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0012	0.0016	0.0024
Toxoplasma gondii	sugar transporter ST1	0.0031	0.0217	0.0327
Leishmania major	glucose transporter, lmgt3	0.0068	0.0621	0.868
Echinococcus granulosus	neuropeptide receptor A26	0.046	0.4886	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0067	0.0611	0.2652
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0217	0.303
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0271	0.1144
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0031	0.0217	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0271	0.114
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0271	0.1197
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0012	0.0016	0.0005
Trypanosoma brucei	sugar transporter, putative	0.0031	0.0217	0.303
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0217	0.0413
Echinococcus multilocularis	neuropeptide s receptor	0.046	0.4886	1
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0286	0.3994
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0271	0.114
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0067	0.0612	0.0925
Chlamydia trachomatis	proline--tRNA ligase	0.0023	0.0134	0.2978
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0027	0.0175	0.0713
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0067	0.0612	0.0597
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.1224
Trypanosoma cruzi	sugar transporter, putative	0.0031	0.0217	0.303
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0068	0.0621	0.868
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0015	0.0204
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0271	0.0525
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0012	0.0016	0.0377
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0219	0.2266	0.462
Brugia malayi	hypothetical protein	0.0031	0.0217	0.0898
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Brugia malayi	major facilitator superfamily protein	0.0031	0.0217	0.0898
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0219	0.2266	0.462
Giardia lamblia	Hexose transporter	0.0031	0.0217	0.346
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Schistosoma mansoni	glucose transport protein	0.0219	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Plasmodium vivax	CDK-related protein kinase 6, putative	0.093	1	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0271	0.1144
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0219	0.2266	0.462
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.0621	0.274
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0217	0.0898
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.2371	1
Schistosoma mansoni	sugar transporter	0.0031	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Brugia malayi	Sugar transporter family protein	0.0031	0.0217	0.0898
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0217	0.0898
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0049	0.0414	0.5783
Giardia lamblia	Prolyl-tRNA synthetase	0.0066	0.0597	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.0621	0.868
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0271	0.1144
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.0621	0.274
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0271	0.4543
Brugia malayi	beta-lactamase family protein	0.0036	0.0271	0.114
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0012	0.0015	0.0353
Plasmodium vivax	sugar transporter, putative	0.0031	0.0217	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0066	0.0597	0.2586
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0043	0.0348	0.1536
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0597	0.2586
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0611	0.2652
Echinococcus granulosus	lysyl tRNA synthetase	0.0049	0.0414	0.0817
Trypanosoma cruzi	hexose transporter	0.0068	0.0621	0.868
Leishmania major	myo-inositol/proton symporter (MIT)	0.0031	0.0217	0.303
Toxoplasma gondii	ABC1 family protein	0.0036	0.0271	0.041
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.1224
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0031	0.0217	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0597	0.2586
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.1224
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0067	0.0612	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0271	0.114
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.1224
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0271	0.6554
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0271	0.1144
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Trypanosoma cruzi	glucose transporter, putative	0.0031	0.0217	0.303
Trichomonas vaginalis	myo-inositol transporter, putative	0.0031	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0217	0.0413
Brugia malayi	Sugar transporter family protein	0.0219	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Schistosoma mansoni	protein kinase	0.0067	0.0611	0.2648
Trichomonas vaginalis	conserved hypothetical protein	0.0219	0.2266	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0414	0.1769
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Onchocerca volvulus		0.0036	0.0271	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0271	0.1144
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0077	0.0715	1
Plasmodium falciparum	protein kinase 7	0.0619	0.6617	0.6612
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0067	0.0612	0.0597
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0012	0.0016	0.0005
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0067	0.0611	0.2652
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Brugia malayi	beta-lactamase family protein	0.0036	0.0271	0.114
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0049	0.0414	0.1826
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Entamoeba histolytica	hypothetical protein	0.0049	0.0414	0.6679
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0271	0.1197
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0031	0.0217	0.303
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0271	0.114
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0219	0.2266	0.462
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0271	0.379
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0217	0.0898
Schistosoma mansoni	protein kinase	0.0067	0.0611	0.2648
Echinococcus granulosus	General substrate transporter	0.0188	0.193	0.3932
Echinococcus granulosus	neuropeptide s receptor	0.046	0.4886	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0067	0.0611	0.1224
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0271	0.0525
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0354	0.3734	0.3724
Mycobacterium ulcerans	lipase LipD	0.0036	0.0271	0.6554
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0015	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0271	0.114
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0219	0.2266	0.462
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0012	0.0016	0.0005
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0414	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0414	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0077	0.0715	1
Echinococcus multilocularis	lysyl tRNA synthetase	0.0049	0.0414	0.0817
Leishmania major	glucose transporter, lmgt2	0.0068	0.0621	0.868
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0077	0.0715	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0271	0.114
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0271	0.6554
Echinococcus granulosus	solute carrier family 22	0.0031	0.0217	0.0413
Trichomonas vaginalis	sugar transport protein, putative	0.0031	0.0217	0.0956
Schistosoma mansoni	hypothetical protein	0.017	0.1728	0.761
Entamoeba histolytica	protein kinase, putative	0.0067	0.0611	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.1224
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0271	0.4543
Toxoplasma gondii	lysine-tRNA ligase	0.0049	0.0414	0.0625
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0031	0.0217	0.0894
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0031	0.0217	0.0914
Trypanosoma brucei	glucose transporter 2A	0.0068	0.0621	0.868
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0067	0.0612	0.0597
Plasmodium falciparum	proline--tRNA ligase	0.0077	0.0715	0.0701
Echinococcus multilocularis	neuropeptide receptor A26	0.046	0.4886	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0271	0.1197
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0219	0.2266	0.462
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0898
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0067	0.0611	0.855
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 687438