TDR Targets

Basic information

Technical information

TDR Targets ID: 687744
Name: N-(4-ethoxyphenyl)-2-[(5-pyridin-4-yl-4-pyrro l-1-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
MW: 420.488 | Formula: C21H20N6O2S
H donors: 1 H acceptors: 4 LogP: 2.94 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)NC(=O)CSc1nnc(n1n1cccc1)c1ccncc1
InChi: 1S/C21H20N6O2S/c1-2-29-18-7-5-17(6-8-18)23-19(28)15-30-21-25-24-20(16-9-11-22-12-10-16)27(21)26-13-3-4-14-26/h3-14H,2,15H2,1H3,(H,23,28)
InChiKey: ZMWISPDCLSWTJC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-ethoxyphenyl)-2-[[5-(4-pyridyl)-4-pyrrol-1-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide
N-(4-ethoxyphenyl)-2-[[5-(4-pyridyl)-4-(1-pyrrolyl)-1,2,4-triazol-3-yl]thio]acetamide
N-(4-ethoxyphenyl)-2-[[5-(4-pyridyl)-4-pyrrol-1-yl-1,2,4-triazol-3-yl]thio]acetamide
N-(4-ethoxyphenyl)-2-[(5-pyridin-4-yl-4-pyrrol-1-yl-1,2,4-triazol-3-yl)sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0052	0.0604	0.2395
Brugia malayi	nuclear receptor RXR	0.0005	0.0015	0.0028
Trichomonas vaginalis	adenylate cyclase, putative	0.0015	0.0145	0.3189
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0391	0.0625
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0391	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0391	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.2773	0.6676
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0074	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0074	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1692	0.6761
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0074	0.0362
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0405	0.1595
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0266
Loa Loa (eye worm)	ICD-1 protein	0.0034	0.0382	0.1503
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0028
Brugia malayi	PAS domain containing protein	0.0015	0.0145	0.0549
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0704	0.3435
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0058	0.0199
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0059	0.0051
Onchocerca volvulus		0.0035	0.0391	0.6456
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0036	0.0409	0.1608
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0145	0.0002
Schistosoma mansoni	hypothetical protein	0.0166	0.2049	1
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0015	0.0145	0.3189
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0074	0.0266
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0391	0.0625
Brugia malayi	hypothetical protein	0.0052	0.0601	0.2382
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0305	0.1192
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0391	0.0625
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0145	0.0137
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0074	0.1116
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0008	0.0039
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0074	0.0266
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0015	0.0145	0.3189
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0074	0.1116
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0015	0.0028
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0059	0.0205
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0391	0.1538
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0015	0.0145	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0074	0.0266
Onchocerca volvulus		0.0028	0.0305	0.5005
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0391	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0391	0.1538
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0037	0.0029
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0391	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0391	0.1538
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0074	0.0266
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0391	0.1538
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0074	0.0362
Echinococcus granulosus	transcription factor btf3	0.0034	0.0382	0.1834
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0382	0.9761
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0015	0.0145	0.3189
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0145	0.0549
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0391	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0064	0.0756	0.0748
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0391	0.0625
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0036	0.0409	0.1608
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0074	0.0266
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0391	0.0625
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0145	0.0002
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0391	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0028
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0064	0.0756	0.3662
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0015	0.0035
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0145	0.0706
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0059	0.025
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0074	0.0266
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0074	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0028
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0074	0.0266
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0037	0.0144
Brugia malayi	hypothetical protein	0.0005	0.0015	0.0028
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0074	0.0266
Schistosoma mansoni	cpg binding protein	0.003	0.0325	0.1587
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0074	0.0266
Schistosoma mansoni	transcription factor btf3	0.0034	0.0382	0.1866
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0327	0.4081	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0391	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0028
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0327	0.4081	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0015	0.0028
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0202	0.2498	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0074	0.0324
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0202	0.2498	1
Schistosoma mansoni	nuclear receptor	0.0005	0.0008	0.0039
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0391	0.0625
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0037	0.0182
Trichomonas vaginalis	guanylate cyclase, putative	0.0015	0.0145	0.3189
Schistosoma mansoni	hypothetical protein	0.0138	0.1692	0.8255
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0145	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0391	0.1538
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0527	0.2541
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0327	0.4081	1
Onchocerca volvulus		0.0052	0.0601	1
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0074	0.0362
Schistosoma mansoni	hypothetical protein	0.0064	0.0756	0.3687
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0145	0.0549
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0527	0.2541
Echinococcus granulosus	aryl hydrocarbon receptor	0.0052	0.0604	0.2922
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0756	0.3002
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0327	0.4081	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0074	0.0362
Echinococcus multilocularis	GPCR, family 2	0.0064	0.0756	0.0748
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0074	0.0266
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0074	0.1116
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0391	0.0625
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0074	0.0362
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0015	0.0074
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0391	0.0625
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0015	0.0007
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0623	1
Treponema pallidum	hypothetical protein	0.0327	0.4081	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0266
Trichomonas vaginalis	guanylate cyclase, putative	0.0015	0.0145	0.3189
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0037	0.0029
Schistosoma mansoni	cpg binding protein	0.003	0.0325	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0405	0.1595
Onchocerca volvulus		0.0035	0.0391	0.6456
Onchocerca volvulus	Protein cycle homolog	0.0036	0.0409	0.6752
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0391	0.1908
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0015	0.0145	0.3189
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0074	0.0362
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0064	0.0756	0.3662
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0074	0.0362
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0527	0.0519
Schistosoma mansoni	aryl hydrocarbon receptor nuclear translocator homolog (darnt)	0.0036	0.0409	0.1994
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0074	0.0324
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0145	0.0549
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0527	0.2083
Brugia malayi	Latrophilin receptor protein 2	0.0064	0.0756	0.3002
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0391	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0601	0.2382
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0074	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0391	0.1538
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0015	0.0145	0.0002
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0145	0.067
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0008	0.0039
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0391	0.0625
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0391	0.0625
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0145	0.3189
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0074	0.0362
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0074	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0391	0.1538
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0015	0.0145	0.3189
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0074	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0074	0.0266
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0527	0.2571
Brugia malayi	hypothetical protein	0.0036	0.0409	0.1608
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0391	0.1876
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0015	0.0074
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0074	0.0066
Brugia malayi	hypothetical protein	0.0036	0.0405	0.1595
Entamoeba histolytica	hypothetical protein	0.0034	0.0382	0.5
Schistosoma mansoni	hypothetical protein	0.0064	0.0756	0.3687
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0074	0.0266
Brugia malayi	steroid hormone receptor	0.001	0.0074	0.0266
Echinococcus multilocularis	transcription factor btf3	0.0034	0.0382	0.0375
Schistosoma mansoni	single-minded	0.0015	0.0145	0.0707
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0074	0.0266
Brugia malayi	hypothetical protein	0.0005	0.0015	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0145	0.0549
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0382	0.9761
Trichomonas vaginalis	esterase, putative	0.0035	0.0391	1
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0008	0.0039
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0074	0.0266
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0074	0.0066
Brugia malayi	beta-NAC-like protein	0.0034	0.0382	0.1503
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0028
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0036	0.0405	0.1595
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0074	0.0066
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0074	0.0066
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0074	0.0266
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0382	0.9649
Schistosoma mansoni	hypothetical protein	0.0064	0.0756	0.3687
Leishmania major	hypothetical protein, conserved	0.0035	0.0391	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0064	0.0756	0.0748
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0391	0.0625
Echinococcus granulosus	geminin	0.0166	0.2049	1
Schistosoma mansoni	hypothetical protein	0.0166	0.2049	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0074	0.0324
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0074	0.0066
Schistosoma mansoni	nuclear receptor	0.0005	0.0008	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0405	0.1595
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0382	0.9761
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0266
Echinococcus multilocularis	geminin	0.0166	0.2049	0.2043
Schistosoma mansoni	cpg binding protein	0.0028	0.0305	0.1488
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0074	0.0066
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0527	0.2571
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0266
Onchocerca volvulus		0.001	0.0074	0.1116
Entamoeba histolytica	transcription factor BTF3, putative	0.0034	0.0382	0.5
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0145	0.0137
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0037	0.0144
Schistosoma mansoni	zinc finger protein	0.0005	0.0008	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0202	0.2498	1
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0016	0.0148	0.014
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0382	0.9649
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0052	0.0604	0.0597
Echinococcus granulosus	cpg binding protein	0.003	0.0325	0.1554
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0145	0.0137
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0015	0.0145	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0064	0.0756	0.3002
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0016	0.0148	0.0686
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0527	0.2083
Brugia malayi	nuclear receptor NHR-88	0.001	0.0074	0.0266
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0202	0.2498	1
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0074	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0145	0.3189
Brugia malayi	latrophilin 2 splice variant baaae	0.0138	0.1692	0.6761
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0074	0.0066
Schistosoma mansoni	hypothetical protein	0.0064	0.0756	0.3687
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0015	0.0145	0.0002
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0015	0.0145	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0405	0.1595
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0074	0.0266
Toxoplasma gondii	ABC1 family protein	0.0035	0.0391	0.5144
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0074	0.0324
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0074	0.0324
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0266
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0074	0.0266
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0074	0.0324
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0145	0.0002
Trypanosoma brucei	transcription factor BTF3, putative	0.0034	0.0382	0.9649
Plasmodium vivax	basic transcription factor 3b, putative	0.0034	0.0382	0.0603
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0074	0.0266
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0391	0.0383
Brugia malayi	beta-lactamase	0.0035	0.0391	0.1538
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0074	0.0066
Brugia malayi	beta-lactamase family protein	0.0035	0.0391	0.1538
Brugia malayi	ecdysteroid receptor	0.001	0.0074	0.0266
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0036	0.0409	0.1608
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0008	0.0039
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0391	1
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0074	0.0362
Toxoplasma gondii	NAC domain-containing protein	0.0034	0.0382	0.4963
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0391	0.1538
Leishmania major	basic transcription factor 3a, putative	0.0034	0.0382	0.9649
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0527	0.2571
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0074	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0391	0.1538
Leishmania major	protein kinase, putative	0.0015	0.0145	0.0002
Echinococcus multilocularis	cpg binding protein	0.003	0.0325	0.0317
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0266
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0391	1
Onchocerca volvulus		0.0035	0.0391	0.6456
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0074	0.0362
Schistosoma mansoni	aryl hydrocarbon receptor	0.0016	0.0148	0.0723
Brugia malayi	nuclear hormone receptor	0.001	0.0074	0.0266
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0074	0.0362
Plasmodium falciparum	basic transcription factor 3b, putative	0.0034	0.0382	0.0603
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0305	0.1192
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0145	0.3189
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0074	0.0266
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0145	0.0137
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0391	0.1908
Schistosoma mansoni	coup transcription factor	0.001	0.0074	0.0362
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0074	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0391	0.1538
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0527	0.0519
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0064	0.0756	0.3002
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0327	0.4081	1
Leishmania major	protein kinase, putative	0.0015	0.0145	0.0002
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0015	0.0028
Echinococcus granulosus	GPCR family 2	0.0064	0.0756	0.3662
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0008	0.0039
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0074	0.0266

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 687744