Detailed information for compound 689907

Basic information

Technical information
  • TDR Targets ID: 689907
  • Name: N-(5-chloro-2-methoxyphenyl)-2-[(7-fluoro-1,1 -dioxo-4H-benzo[e][1,2,4]thiadiazin-3-yl)sulf anyl]acetamide
  • MW: 429.874 | Formula: C16H13ClFN3O4S2
  • H donors: 2 H acceptors: 3 LogP: 2.93 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)CSC1=NS(=O)(=O)c2c(N1)ccc(c2)F)Cl
  • InChi: 1S/C16H13ClFN3O4S2/c1-25-13-5-2-9(17)6-12(13)19-15(22)8-26-16-20-11-4-3-10(18)7-14(11)27(23,24)21-16/h2-7H,8H2,1H3,(H,19,22)(H,20,21)
  • InChiKey: ADNUKFDDAKTTDM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(5-chloro-2-methoxy-phenyl)-2-[(7-fluoro-1,1-dioxo-4H-benzo[e][1,2,4]thiadiazin-3-yl)sulfanyl]acetamide
  • N-(5-chloro-2-methoxyphenyl)-2-[(7-fluoro-1,1-dioxo-4H-benzo[e][1,2,4]thiadiazin-3-yl)thio]acetamide
  • N-(5-chloro-2-methoxy-phenyl)-2-[(7-fluoro-1,1-diketo-4H-benzo[e][1,2,4]thiadiazin-3-yl)thio]acetamide
  • N-(5-chloro-2-methoxy-phenyl)-2-[(7-fluoro-1,1-dioxo-4H-benzo[e][1,2,4]thiadiazin-3-yl)sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum choline kinase 0.0126 0.2699 1
Schistosoma mansoni choline/ethanolamine kinase 0.0012 0.0164 0.0164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.012 0.0369
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0069 0.0069
Echinococcus multilocularis muscleblind protein 1 0.0151 0.3257 0.3257
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0617 0.3399
Schistosoma mansoni gliotactin 0.0019 0.0305 0.0305
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.012 0.012
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0937 0.0937
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.4008 0.4008
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0151 0.3257 1
Schistosoma mansoni hypothetical protein 0.0455 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1124 0.3452
Schistosoma mansoni hypothetical protein 0.0286 0.6241 0.6241
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1222 0.1222
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.011 0.2331 0.2331
Loa Loa (eye worm) carboxylesterase 0.011 0.2331 0.7158
Onchocerca volvulus Putative choline\/ethanolamine kinase 0.0012 0.0164 0.1755
Schistosoma mansoni thyroid hormone receptor 0.001 0.012 0.012
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0701 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.4008 0.4008
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1222 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.1124 0.3452
Echinococcus multilocularis ethanolamine kinase 2 0.0012 0.0164 0.0164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.012 0.0369
Echinococcus granulosus carboxylesterase 5A 0.011 0.2331 0.2331
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.004
Schistosoma mansoni hypothetical protein 0.0038 0.0735 0.0735
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.004
Echinococcus granulosus GPCR family 2 0.0018 0.0282 0.0282
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0701 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.012 0.012
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0019 0.0305 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.012 0.0369
Echinococcus multilocularis para nitrobenzyl esterase 0.0019 0.0305 0.0305
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0013 0.004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.012 0.0369
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0013 0.0013
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.012 0.012
Schistosoma mansoni nuclear hormone receptor 0.001 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.0369
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0937 0.0937
Brugia malayi mbt repeat family protein 0.0047 0.0937 0.2876
Brugia malayi mbt repeat family protein 0.0047 0.0937 0.2876
Loa Loa (eye worm) hypothetical protein 0.0019 0.0305 0.0935
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0019 0.0305 0.0305
Loa Loa (eye worm) histone methyltransferase 0.001 0.0112 0.0344
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.012 0.012
Brugia malayi Muscleblind-like protein 0.0151 0.3257 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1222 0.1222
Loa Loa (eye worm) steroid hormone receptor 0.001 0.012 0.0369
Loa Loa (eye worm) hypothetical protein 0.011 0.2331 0.7158
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0019 0.0305 0.0305
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1222 1
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0937 0.2876
Loa Loa (eye worm) hypothetical protein 0.0047 0.0937 0.2876
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1124 0.3452
Giardia lamblia Ethanolamine kinase, putative 0.0012 0.0164 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0282 0.0282
Echinococcus multilocularis acetylcholinesterase 0.011 0.2331 0.2331
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.012 0.012
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0937 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.012 0.1284
Loa Loa (eye worm) inositol-1 0.0036 0.0701 0.2153
Onchocerca volvulus 0.001 0.012 0.1284
Loa Loa (eye worm) acetylcholinesterase 1 0.011 0.2331 0.7158
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.012 0.012
Brugia malayi nuclear receptor RXR 0.0005 0.0013 0.004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1222 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0617 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0069 0.0069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.012 0.012
Brugia malayi nuclear receptor NHR-88 0.001 0.012 0.0369
Brugia malayi hypothetical protein 0.0019 0.0305 0.0935
Plasmodium vivax choline kinase, putative 0.0126 0.2699 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0282 0.0282
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0019 0.0305 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.012 0.0369
Brugia malayi hypothetical protein 0.0005 0.0013 0.004
Onchocerca volvulus 0.0019 0.0305 0.3252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0894 0.0894
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1222 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0701 0.0701
Schistosoma mansoni inositol monophosphatase 0.0036 0.0701 0.0701
Schistosoma mansoni hypothetical protein 0.0018 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0038 0.0735 0.2256
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0602 0.1849
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1222 0.4173
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.004
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.0369
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.1081 0.332
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0894 0.0894
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.004
Schistosoma mansoni neuroligin 3 (S09 family) 0.0019 0.0305 0.0305
Schistosoma mansoni cpg binding protein 0.0032 0.0602 0.0602
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.1237 0.4233
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.012 0.012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.012 0.012
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.1081 0.1081
Echinococcus granulosus FTZ F1 alpha 0.001 0.012 0.012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.0369
Loa Loa (eye worm) hypothetical protein 0.0151 0.3257 1
Toxoplasma gondii phosphotransferase enzyme family protein 0.0126 0.2699 1
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.012 0.0369
Brugia malayi Inositol-1 0.0036 0.0701 0.2153
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.012 0.012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0701 1
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0735 0.2256
Echinococcus granulosus acetylcholinesterase 0.011 0.2331 0.2331
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0701 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.1081 0.1081
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.0369
Schistosoma mansoni BC026374 protein (S09 family) 0.0019 0.0305 0.0305
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0019 0.0305 0.0935
Onchocerca volvulus 0.0032 0.0602 0.6428
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.012 0.012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0282 0.0867
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0894 0.0894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.012 0.0369
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0013 0.0013
Brugia malayi ecdysteroid receptor 0.001 0.012 0.0369
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.012 0.012
Schistosoma mansoni hypothetical protein 0.0018 0.0282 0.0282
Brugia malayi Steroid receptor seven-up type 2 0.001 0.012 0.0369
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0701 1
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0701 0.0701
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0701 0.5076
Trichomonas vaginalis spcc417.12 protein, putative 0.0019 0.0305 0.3879
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.012 0.012
Schistosoma mansoni thyroid hormone receptor 0.001 0.012 0.012
Loa Loa (eye worm) carboxylesterase 0.0019 0.0305 0.0935
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0282 0.0867
Loa Loa (eye worm) hypothetical protein 0.0019 0.0305 0.0935
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.012 0.0369
Trichomonas vaginalis choline/ethanolamine kinase, putative 0.0012 0.0164 0.1714
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0013 0.004
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0701 0.0701
Echinococcus granulosus ethanolamine kinase 2 0.0012 0.0164 0.0164
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0701 1
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0937 0.0937
Echinococcus granulosus cpg binding protein 0.0034 0.0643 0.0643
Onchocerca volvulus 0.0047 0.0937 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.012 0.0369
Echinococcus granulosus choline:ethanolamine kinase 0.0126 0.2699 0.2699
Echinococcus granulosus muscleblind protein 0.0151 0.3257 0.3257
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.012 0.012
Brugia malayi Carboxylesterase family protein 0.0019 0.0305 0.0935
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.012 0.012
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.1081 0.1081
Brugia malayi Carboxylesterase family protein 0.0019 0.0305 0.0935
Brugia malayi Carboxylesterase family protein 0.011 0.2331 0.7158
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.012 0.0369
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.012 0.012
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.012 0.012
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0701 0.4323
Brugia malayi nuclear hormone receptor 0.001 0.012 0.0369
Brugia malayi Carboxylesterase family protein 0.011 0.2331 0.7158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.012 0.0369
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.1081 0.1081
Loa Loa (eye worm) choline Kinase A 0.0012 0.0164 0.0505
Loa Loa (eye worm) choline/ethanolamine kinase 0.0012 0.0164 0.0505
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.0369
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0937 0.0937
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.012 0.1284
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0282 0.0282
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0019 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0019 0.0305 0.0935
Echinococcus multilocularis acetylcholinesterase 0.011 0.2331 0.2331
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.012 0.012
Schistosoma mansoni hypothetical protein 0.0018 0.0282 0.0282
Echinococcus multilocularis dnaJ subfamily B 0.0455 1 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1124 0.3452
Echinococcus multilocularis carboxylesterase 5A 0.011 0.2331 0.2331
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0937 0.0937
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.012 0.012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0894 0.0894
Echinococcus multilocularis FTZ F1 alpha 0.001 0.012 0.012
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1222 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0701 1
Echinococcus granulosus BC026374 protein S09 family 0.0019 0.0305 0.0305
Schistosoma mansoni coup transcription factor 0.001 0.012 0.012
Onchocerca volvulus 0.0019 0.0305 0.3252
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0019 0.0305 0.3879
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.012 0.012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0112 0.0112
Echinococcus granulosus neuroligin 0.0019 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0019 0.0305 0.0935
Schistosoma mansoni choline/ethanolamine kinase 0.0012 0.0164 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0894 0.0894
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0894 0.0894
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.0369
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.012 0.012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.012 0.0369
Loa Loa (eye worm) hypothetical protein 0.011 0.2331 0.7158
Schistosoma mansoni choline kinase 0.0012 0.0164 0.0164
Loa Loa (eye worm) carboxylesterase 0.0019 0.0305 0.0935
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.1081 0.1081
Onchocerca volvulus 0.0019 0.0305 0.3252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0894 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.012 0.0369
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0069 0.0069
Loa Loa (eye worm) MBCTL1 0.0053 0.1081 0.332
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0894 0.2745
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0069 0.0069
Brugia malayi CXXC zinc finger family protein 0.0032 0.0602 0.1849
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.012 0.0369
Brugia malayi Carboxylesterase family protein 0.0019 0.0305 0.0935
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0505
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0013 0.004
Brugia malayi steroid hormone receptor 0.001 0.012 0.0369
Brugia malayi Choline/ethanolamine kinase family protein 0.0012 0.0164 0.0505
Brugia malayi Carboxylesterase family protein 0.0019 0.0305 0.0935
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0894 0.2745
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.012 0.0369
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0109 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.012 0.0369
Loa Loa (eye worm) hypothetical protein 0.0053 0.1081 0.332
Loa Loa (eye worm) hypothetical protein 0.0018 0.0282 0.0867
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0112 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.012 0.0369
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0701 0.5
Schistosoma mansoni hypothetical protein 0.0018 0.0282 0.0282
Schistosoma mansoni cpg binding protein 0.0034 0.0643 0.0643
Echinococcus multilocularis cpg binding protein 0.0034 0.0643 0.0643
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.012 0.012
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1222 0.1222
Onchocerca volvulus 0.0012 0.0164 0.1755
Echinococcus granulosus para nitrobenzyl esterase 0.0019 0.0305 0.0305
Loa Loa (eye worm) choline/ethanolamine kinase 0.0126 0.2699 0.8285
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.012 0.1284
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.012 0.0369
Onchocerca volvulus 0.0019 0.0305 0.3252
Brugia malayi Choline/ethanolamine kinase family protein 0.0012 0.0164 0.0505
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0282 0.0867
Echinococcus multilocularis neuroligin 0.0019 0.0305 0.0305
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1222 0.1222
Echinococcus multilocularis BC026374 protein (S09 family) 0.0019 0.0305 0.0305
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.012 0.012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0282 0.0282
Schistosoma mansoni acetylcholinesterase 0.0019 0.0305 0.0305
Echinococcus multilocularis muscleblind protein 0.0151 0.3257 0.3257
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.012 0.0369
Loa Loa (eye worm) hypothetical protein 0.0019 0.0305 0.0935
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0937 0.0937
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.012 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.012 0.0369
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.0369
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0069 0.0069
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0305 0.0935
Brugia malayi hypothetical protein 0.0005 0.0013 0.004
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0937 0.0937
Brugia malayi Choline/ethanolamine kinase family protein 0.0126 0.2699 0.8285
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.012 0.0369
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.0369
Schistosoma mansoni cpg binding protein 0.0034 0.0643 0.0643
Echinococcus multilocularis choline:ethanolamine kinase 0.0126 0.2699 0.2699
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0701 0.2118
Echinococcus granulosus acetylcholinesterase 0.011 0.2331 0.2331
Onchocerca volvulus 0.0019 0.0305 0.3252
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1398 0.1398

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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