Detailed information for compound 69026

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 265.244 | Formula: C11H12FN5O2
  • H donors: 3 H acceptors: 5 LogP: -1.54 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: F/C=C/1\C[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N
  • InChi: 1S/C11H12FN5O2/c12-2-5-1-6(9(19)8(5)18)17-4-16-7-10(13)14-3-15-11(7)17/h2-4,6,8-9,18-19H,1H2,(H2,13,14,15)/b5-2+/t6-,8-,9+/m1/s1
  • InChiKey: KOUXHHRRBXETSM-IKRITCMCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adenosylhomocysteinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Trypanosoma congolense S-adenosylhomocysteine hydrolase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Trichomonas vaginalis adenosylhomocysteinase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Toxoplasma gondii S-Adenosyl homocysteine hydrolase Get druggable targets OG5_127233 All targets in OG5_127233
Leishmania mexicana S-adenosylhomocysteine hydrolase Get druggable targets OG5_127233 All targets in OG5_127233
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative Get druggable targets OG5_127233 All targets in OG5_127233
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH Get druggable targets OG5_127233 All targets in OG5_127233
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase Get druggable targets OG5_127233 All targets in OG5_127233
Schistosoma mansoni adenosylhomocysteinase Get druggable targets OG5_127233 All targets in OG5_127233
Schistosoma japonicum ko:K01251 adenosylhomocysteinase [EC3.3.1.1], putative Get druggable targets OG5_127233 All targets in OG5_127233
Plasmodium yoelii adenosylhomocysteinase Get druggable targets OG5_127233 All targets in OG5_127233
Cryptosporidium hominis adenosylhomocysteinase Get druggable targets OG5_127233 All targets in OG5_127233
Loa Loa (eye worm) adenosylhomocysteinase Get druggable targets OG5_127233 All targets in OG5_127233
Leishmania infantum S-adenosylhomocysteine hydrolase Get druggable targets OG5_127233 All targets in OG5_127233
Plasmodium berghei adenosylhomocysteinase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Candida albicans Putative S-adenosyl-L-homocysteine hydrolase Get druggable targets OG5_127233 All targets in OG5_127233
Leishmania braziliensis S-adenosylhomocysteine hydrolase Get druggable targets OG5_127233 All targets in OG5_127233
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) Get druggable targets OG5_127233 All targets in OG5_127233
Entamoeba histolytica adenosylhomocysteinase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Leishmania braziliensis S-adenosylhomocysteine hydrolase Get druggable targets OG5_127233 All targets in OG5_127233
Neospora caninum hypothetical protein Get druggable targets OG5_127233 All targets in OG5_127233
Cryptosporidium parvum S-adenosylhomocysteinase Get druggable targets OG5_127233 All targets in OG5_127233
Trichomonas vaginalis adenosylhomocysteinase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Toxoplasma gondii adenosylhomocysteinase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Theileria parva S-adenosyl-L-homocysteine hydrolase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Candida albicans Putative S-adenosyl-L-homocysteine hydrolase Get druggable targets OG5_127233 All targets in OG5_127233
Brugia malayi Adenosylhomocysteinase Get druggable targets OG5_127233 All targets in OG5_127233
Babesia bovis adenosylhomocysteinase (S-adenosyl-L-homocysteinehydrolase) Get druggable targets OG5_127233 All targets in OG5_127233
Trypanosoma congolense S-adenosylhomocysteine hydrolase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Plasmodium knowlesi adenosylhomocysteinase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Echinococcus granulosus adenosylhomocysteinase Get druggable targets OG5_127233 All targets in OG5_127233
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Leishmania donovani S-adenosylhomocysteine hydrolase Get druggable targets OG5_127233 All targets in OG5_127233
Leishmania major S-adenosylhomocysteine hydrolase Get druggable targets OG5_127233 All targets in OG5_127233
Trypanosoma brucei gambiense S-adenosylhomocysteine hydrolase, putative Get druggable targets OG5_127233 All targets in OG5_127233
Echinococcus multilocularis adenosylhomocysteinase Get druggable targets OG5_127233 All targets in OG5_127233
Plasmodium falciparum adenosylhomocysteinase Get druggable targets OG5_127233 All targets in OG5_127233
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni adenosylhomocysteinase Adenosylhomocysteinase   432 aa 427 aa 51.1 %
Schistosoma japonicum ko:K01251 adenosylhomocysteinase [EC3.3.1.1], putative Adenosylhomocysteinase   432 aa 427 aa 51.3 %
Drosophila melanogaster CG9977 gene product from transcript CG9977-RA Adenosylhomocysteinase   432 aa 428 aa 51.4 %
Schistosoma mansoni adenosylhomocysteinase Adenosylhomocysteinase   432 aa 427 aa 51.1 %
Onchocerca volvulus N-acetyllactosamine synthase homolog Adenosylhomocysteinase   432 aa 436 aa 75.7 %
Schistosoma mansoni adenosylhomocysteinase Adenosylhomocysteinase   432 aa 385 aa 50.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tm gpcr rhodopsin 0.0124 0.0083 0.4426
Schistosoma mansoni adenosylhomocysteinase 0.0156 0.012 0.7478
Brugia malayi hypothetical protein 0.0124 0.0083 0.2494
Echinococcus multilocularis g protein coupled receptor 0.0124 0.0083 0.4426
Schistosoma mansoni hypothetical protein 0.0124 0.0083 0.4426
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0124 0.0083 0.3288
Onchocerca volvulus 0.0124 0.0083 0.5
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Schistosoma mansoni neuropeptide F-like receptor 0.0124 0.0083 0.4426
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0156 0.012 0.0089
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0183 0.015 0.0119
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Loa Loa (eye worm) melatonin receptor type 1A 0.0124 0.0083 0.3288
Echinococcus granulosus orexin receptor type 2 0.0124 0.0083 0.4426
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0124 0.0083 0.4426
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0124 0.0083 0.4426
Brugia malayi Cytochrome P450 family protein 0.0266 0.0242 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Leishmania major cytochrome p450-like protein 0.0266 0.0242 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0124 0.0083 0.4426
Echinococcus granulosus neuropeptide receptor A26 0.0124 0.0083 0.4426
Echinococcus granulosus 7TM GPCR rhodopsin 0.0124 0.0083 0.4426
Brugia malayi AKH receptor 0.0124 0.0083 0.2494
Loa Loa (eye worm) neuropeptide F receptor 0.0124 0.0083 0.3288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0083 0.4426
Mycobacterium tuberculosis Probable histidinol dehydrogenase HisD (HDH) 0.901 1 1
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0156 0.012 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0124 0.0083 0.4426
Brugia malayi G protein-coupled receptor F59B2.13 0.0124 0.0083 0.2494
Plasmodium falciparum adenosylhomocysteinase 0.0156 0.012 1
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0156 0.012 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0156 0.012 1
Echinococcus granulosus neuropeptides capa receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis neuropeptide receptor 0.0124 0.0083 0.4426
Echinococcus granulosus neuropeptide receptor 0.0124 0.0083 0.4426
Echinococcus granulosus peptide allatostatin:somatostatin 0.0124 0.0083 0.4426
Brugia malayi G-protein coupled receptor 0.0124 0.0083 0.2494
Schistosoma mansoni biogenic amine (5HT) receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Onchocerca volvulus Neuropeptide F receptor homolog 0.0124 0.0083 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0124 0.0083 0.4426
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0183 0.015 0.0119
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Echinococcus granulosus neuropeptide receptor 0.0124 0.0083 0.4426
Brugia malayi G-protein coupled receptor 0.0124 0.0083 0.2494
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Trypanosoma cruzi cytochrome P450, putative 0.0266 0.0242 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0124 0.0083 0.4426
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0124 0.0083 0.2494
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0124 0.0083 0.4426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0083 0.4426
Leishmania major cytochrome p450-like protein 0.0076 0.0031 0.0329
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0083 0.4426
Echinococcus granulosus sex peptide receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Schistosoma mansoni myosin xvIII 0.0124 0.0083 0.4426
Schistosoma mansoni neuropeptide receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0124 0.0083 0.4426
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Echinococcus multilocularis dro:myosuppressin receptor 0.0124 0.0083 0.4426
Echinococcus granulosus biogenic amine 5HT receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis neuropeptide receptor A26 0.0124 0.0083 0.4426
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0124 0.0083 0.3288
Echinococcus granulosus biogenic amine 5HT receptor 0.0124 0.0083 0.4426
Schistosoma mansoni biogenic amine receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0124 0.0083 0.4426
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0156 0.012 0.4826
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Schistosoma mansoni growth hormone secretagogue receptor 0.0124 0.0083 0.4426
Brugia malayi hypothetical protein 0.0124 0.0083 0.2494
Onchocerca volvulus 0.0124 0.0083 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0124 0.0083 0.4426
Onchocerca volvulus 0.0124 0.0083 0.5
Schistosoma mansoni histamine h1 receptor 0.0124 0.0083 0.4426
Entamoeba histolytica adenosylhomocysteinase, putative 0.0156 0.012 0.5
Brugia malayi hypothetical protein 0.0124 0.0083 0.2494
Brugia malayi dihydrofolate reductase family protein 0.0183 0.015 0.5635
Brugia malayi ORL1-like opioid receptor 0.0124 0.0083 0.2494
Brugia malayi neuropeptide F receptor 0.0124 0.0083 0.2494
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Echinococcus granulosus g protein coupled receptor 0.0124 0.0083 0.4426
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Schistosoma mansoni adenoreceptor 0.0124 0.0083 0.4426
Echinococcus granulosus 7tm_1 domain containing protein 0.0124 0.0083 0.4426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Schistosoma mansoni alpha-1 adrenergic receptor 0.0124 0.0083 0.4426
Chlamydia trachomatis dihydrofolate reductase 0.0183 0.015 0.5
Echinococcus granulosus fmrfamide receptor 0.0124 0.0083 0.4426
Echinococcus granulosus serotonin receptor 0.0124 0.0083 0.4426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0083 0.4426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Schistosoma mansoni amine GPCR 0.0124 0.0083 0.4426
Echinococcus granulosus g protein coupled receptor 0.0124 0.0083 0.4426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0083 0.4426
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0124 0.0083 0.2494
Schistosoma mansoni neuropeptide F-like receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis g protein coupled receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) G-protein coupled receptor 0.0124 0.0083 0.3288
Echinococcus multilocularis neuropeptide Y receptor 0.0124 0.0083 0.4426
Onchocerca volvulus 0.0124 0.0083 0.5
Echinococcus granulosus hypothetical protein 0.0124 0.0083 0.4426
Schistosoma mansoni amine GPCR 0.0124 0.0083 0.4426
Brugia malayi Serotonin receptor 0.0124 0.0083 0.2494
Brugia malayi neuropeptide F receptor 0.0124 0.0083 0.2494
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0124 0.0083 0.4426
Echinococcus multilocularis G-protein coupled receptor, putative 0.0124 0.0083 0.4426
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.007 0.0023 0.0753
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0266 0.0242 0.0212
Brugia malayi hypothetical protein 0.0124 0.0083 0.2494
Echinococcus granulosus adenosylhomocysteinase 0.0156 0.012 0.7478
Echinococcus granulosus g protein coupled receptor 0.0124 0.0083 0.4426
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0124 0.0083 0.4426
Schistosoma mansoni amine GPCR 0.0124 0.0083 0.4426
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Echinococcus granulosus dihydrofolate reductase 0.0183 0.015 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0124 0.0083 0.3288
Brugia malayi larval opioid receptor 0.0124 0.0083 0.2494
Brugia malayi Dopamine receptor 0.0124 0.0083 0.2494
Echinococcus granulosus G protein coupled receptor 139 0.0124 0.0083 0.4426
Schistosoma mansoni biogenic amine receptor 0.0124 0.0083 0.4426
Echinococcus granulosus somatostatin receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0124 0.0083 0.4426
Onchocerca volvulus 0.0124 0.0083 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0124 0.0083 0.3288
Echinococcus granulosus dro:myosuppressin receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Leishmania major S-adenosylhomocysteine hydrolase 0.0156 0.012 0.4404
Onchocerca volvulus 0.0124 0.0083 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0124 0.0083 0.2494
Echinococcus granulosus tm gpcr rhodopsin 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Brugia malayi GnHR receptor homolog 0.0124 0.0083 0.2494
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0124 0.0083 0.2494
Echinococcus granulosus alpha 1A adrenergic receptor 0.0124 0.0083 0.4426
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0156 0.012 0.0089
Echinococcus granulosus allatostatin A receptor 0.0124 0.0083 0.4426
Brugia malayi putative neuropeptide receptor NPR1 0.0124 0.0083 0.2494
Brugia malayi Melatonin receptor type 1A 0.0124 0.0083 0.2494
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0124 0.0083 0.4426
Schistosoma mansoni adenosylhomocysteinase 0.0097 0.0053 0.1895
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Trypanosoma cruzi cytochrome P450, putative 0.0266 0.0242 1
Schistosoma mansoni hypothetical protein 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Schistosoma mansoni neuropeptide receptor 0.0124 0.0083 0.4426
Brugia malayi sulfakinin receptor protein 0.0124 0.0083 0.2494
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Echinococcus multilocularis dihydrofolate reductase 0.0183 0.015 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Mycobacterium ulcerans histidinol dehydrogenase 0.901 1 1
Echinococcus multilocularis serotonin receptor 0.0124 0.0083 0.4426
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Echinococcus multilocularis fmrfamide receptor 0.0124 0.0083 0.4426
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0076 0.0031 0.0329
Onchocerca volvulus 0.0124 0.0083 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0083 0.4426
Brugia malayi G protein-coupled receptor 0.0124 0.0083 0.2494
Onchocerca volvulus 0.0124 0.0083 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0124 0.0083 0.4426
Echinococcus multilocularis neuropeptide receptor 0.0124 0.0083 0.4426
Schistosoma mansoni hypothetical protein 0.0124 0.0083 0.4426
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0124 0.0083 0.2494
Echinococcus granulosus neuropeptide Y receptor 0.0124 0.0083 0.4426
Schistosoma mansoni opsin-like receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0124 0.0083 0.4426
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0124 0.0083 0.4426
Brugia malayi putative neuropeptide receptor 0.0124 0.0083 0.2494
Echinococcus granulosus neuropeptide s receptor 0.0124 0.0083 0.4426
Brugia malayi Serotonin receptor 0.0124 0.0083 0.2494
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis orexin receptor type 2 0.0124 0.0083 0.4426
Schistosoma mansoni biogenic amine receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis fmrfamide receptor 0.0124 0.0083 0.4426
Onchocerca volvulus 0.0124 0.0083 0.5
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0156 0.012 0.4826
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0183 0.015 0.0119
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Schistosoma mansoni amine GPCR 0.0124 0.0083 0.4426
Toxoplasma gondii adenosylhomocysteinase, putative 0.0156 0.012 1
Loa Loa (eye worm) adenosylhomocysteinase 0.0156 0.012 0.4826
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Brugia malayi hypothetical protein 0.0124 0.0083 0.2494
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0124 0.0083 0.4426
Brugia malayi hypothetical protein 0.0124 0.0083 0.2494
Onchocerca volvulus 0.0124 0.0083 0.5
Schistosoma mansoni adenosylhomocysteinase 0.0097 0.0053 0.1895
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0124 0.0083 0.4426
Echinococcus granulosus tm gpcr rhodopsin 0.0124 0.0083 0.4426
Brugia malayi RE15519p 0.0124 0.0083 0.2494
Brugia malayi follicle stimulating hormone receptor 0.0124 0.0083 0.2494
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0156 0.012 0.4404
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Onchocerca volvulus 0.0124 0.0083 0.5
Echinococcus multilocularis sex peptide receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) TYRA-2 protein 0.0124 0.0083 0.3288
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0076 0.0031 0.0329
Toxoplasma gondii cytochrome p450 superfamily protein 0.0076 0.0031 0.0747
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0124 0.0083 0.4426
Onchocerca volvulus 0.0124 0.0083 0.5
Loa Loa (eye worm) hypothetical protein 0.0189 0.0156 0.6388
Loa Loa (eye worm) cytochrome P450 0.0076 0.0031 0.1058
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0076 0.0031 0.1058
Loa Loa (eye worm) dihydrofolate reductase 0.0183 0.015 0.6097
Echinococcus granulosus neuropeptides capa receptor 0.0124 0.0083 0.4426
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0156 0.012 0.0089
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Brugia malayi Dopamine receptor protein 2 0.0124 0.0083 0.2494
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Schistosoma mansoni neuropeptide receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) cytochrome P450 family protein 0.0266 0.0242 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0076 0.0031 0.1058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0083 0.4426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0124 0.0083 0.4426
Brugia malayi hypothetical protein 0.0124 0.0083 0.2494
Schistosoma mansoni neuropeptide receptor 0.0124 0.0083 0.4426
Schistosoma mansoni adenosylhomocysteinase 0.0097 0.0053 0.1895
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0124 0.0083 0.3288
Schistosoma mansoni biogenic amine (5HT) receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) neuropeptide F receptor 0.0124 0.0083 0.3288
Echinococcus granulosus neuropeptide FF receptor 2 0.0124 0.0083 0.4426
Brugia malayi Adenosylhomocysteinase 0.0156 0.012 0.4214
Brugia malayi Dopamine receptor protein 1 0.0124 0.0083 0.2494
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0076 0.0031 0.1058
Schistosoma mansoni adenosylhomocysteinase 0.0097 0.0053 0.1895
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0124 0.0083 0.5
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Echinococcus multilocularis somatostatin receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis g protein coupled receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Loa Loa (eye worm) CYP4Cod1 0.0266 0.0242 1
Onchocerca volvulus 0.0124 0.0083 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0083 0.4426
Trypanosoma brucei cytochrome P450, putative 0.0266 0.0242 1
Echinococcus multilocularis neuropeptides capa receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) G-protein coupled receptor 0.0124 0.0083 0.3288
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0124 0.0083 0.4426
Schistosoma mansoni opsin-like receptor 0.0124 0.0083 0.4426
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Echinococcus multilocularis G protein coupled receptor 139 0.0124 0.0083 0.4426
Onchocerca volvulus 0.0124 0.0083 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0266 0.0242 1
Leishmania major cytochrome p450-like protein 0.0076 0.0031 0.0329
Loa Loa (eye worm) cytochrome P450 family protein 0.0076 0.0031 0.1058
Echinococcus granulosus neuropeptide Y receptor 0.0124 0.0083 0.4426
Brugia malayi hypothetical protein 0.0124 0.0083 0.2494
Echinococcus multilocularis allatostatin A receptor 0.0124 0.0083 0.4426
Onchocerca volvulus 0.0124 0.0083 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0124 0.0083 0.2494
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis adenosylhomocysteinase 0.0156 0.012 0.7478
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0156 0.012 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0124 0.0083 0.4426
Brugia malayi Dihydrofolate reductase 0.0183 0.015 0.5635
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0124 0.0083 0.4426
Schistosoma mansoni neuropeptide f receptor 76f 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Schistosoma mansoni dihydrofolate reductase 0.0183 0.015 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Echinococcus granulosus g-protein coupled receptor 0.0124 0.0083 0.4426
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Schistosoma mansoni hypothetical protein 0.0124 0.0083 0.4426
Echinococcus multilocularis neuropeptide FF receptor 2 0.0124 0.0083 0.4426
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0124 0.0083 0.4426
Onchocerca volvulus 0.0124 0.0083 0.5
Brugia malayi Cytochrome P450 family protein 0.0266 0.0242 1
Schistosoma mansoni opsin-like receptor 0.0124 0.0083 0.4426
Echinococcus multilocularis neuropeptides capa receptor 0.0124 0.0083 0.4426
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0083 0.4426
Schistosoma mansoni amine GPCR 0.0124 0.0083 0.4426
Onchocerca volvulus 0.0124 0.0083 0.5
Loa Loa (eye worm) hypothetical protein 0.0124 0.0083 0.3288
Brugia malayi hypothetical protein 0.0124 0.0083 0.2494
Echinococcus multilocularis g-protein coupled receptor 0.0124 0.0083 0.4426
Brugia malayi hypothetical protein 0.0124 0.0083 0.2494
Echinococcus multilocularis serotonin receptor 0.0124 0.0083 0.4426

Activities

Activity type Activity value Assay description Source Reference
k2 (binding) = 0.05 min-1 Rate constant of the compound was evaluated against S-adenosylhomocysteine hydrolase ChEMBL. No reference
k2 (binding) = 0.05 min-1 Rate constant of the compound was evaluated against S-adenosylhomocysteine hydrolase ChEMBL. No reference
k2/Ki (binding) = 0.000575 nM-1 min-1 Ratio of rate constant k2 to KI of the compound was calculated ChEMBL. No reference
Ki (binding) = 87 nM Compound was tested for its inhibitory activity against recombinant rat liver S-adenosylhomocysteine hydrolase ChEMBL. No reference
Ki (binding) = 87 nM Compound was tested for its inhibitory activity against recombinant rat liver S-adenosylhomocysteine hydrolase ChEMBL. No reference
Ratio (binding) = 5.75 Apparent inactivation rate constant (k2) for S-adenosyl-L-homocysteine hydrolase ChEMBL. 8691429
Ratio (binding) = 5.75 Apparent inactivation rate constant (k2) for S-adenosyl-L-homocysteine hydrolase ChEMBL. 8691429

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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