TDR Targets

Basic information

Technical information

TDR Targets ID: 692336
Name: N-(5-fluoro-2-methylphenyl)-2-[[4-oxo-3-(oxol an-2-ylmethyl)-[1]benzoxolo[3,2-d]pyrimidin-2 -yl]sulfanyl]acetamide
MW: 467.513 | Formula: C24H22FN3O4S
H donors: 1 H acceptors: 2 LogP: 4.33 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cc(F)ccc1C)CSc1nc2c3ccccc3oc2c(=O)n1CC1CCCO1
InChi: 1S/C24H22FN3O4S/c1-14-8-9-15(25)11-18(14)26-20(29)13-33-24-27-21-17-6-2-3-7-19(17)32-22(21)23(30)28(24)12-16-5-4-10-31-16/h2-3,6-9,11,16H,4-5,10,12-13H2,1H3,(H,26,29)
InChiKey: WIIHWFAEPJXFDS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(5-fluoro-2-methyl-phenyl)-2-[4-oxo-3-(tetrahydrofuran-2-ylmethyl)benzofurano[3,2-d]pyrimidin-2-yl]sulfanyl-acetamide
N-(5-fluoro-2-methylphenyl)-2-[[4-oxo-3-(2-tetrahydrofuranylmethyl)-2-benzofurano[3,2-d]pyrimidinyl]thio]acetamide
N-(5-fluoro-2-methyl-phenyl)-2-[[4-keto-3-(tetrahydrofurfuryl)benzofurano[3,2-d]pyrimidin-2-yl]thio]acetamide
N-(5-fluoro-2-methyl-phenyl)-2-[[4-oxo-3-(oxolan-2-ylmethyl)-[1]benzoxolo[3,2-d]pyrimidin-2-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Major Facilitator Superfamily protein	0.0048	0.0254	0.1051
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0339	0.2295	0.4227
Echinococcus multilocularis	solute carrier family 22	0.0048	0.0254	0.0467
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0042	0.0212	0.0925
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1439	1	1
Onchocerca volvulus		0.0048	0.0254	1
Onchocerca volvulus		0.0048	0.0254	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.4227
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0038	0.0504
Trypanosoma brucei	sugar transporter, putative	0.0048	0.0254	0.3381
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.6621
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0019	0.0053	0.03
Onchocerca volvulus		0.0048	0.0254	1
Echinococcus multilocularis	neuropeptide s receptor	0.0506	0.3466	0.6384
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0019	0.0053	0.0262
Schistosoma mansoni	ap endonuclease	0.002	0.0058	0.0254
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0048	0.0254	0.1428
Toxoplasma gondii	sugar transporter ST1	0.0048	0.0254	0.0383
Brugia malayi	Sugar transporter family protein	0.0048	0.0254	0.1051
Trypanosoma cruzi	glucose transporter, putative	0.0048	0.0254	0.3381
Toxoplasma gondii	transporter, major facilitator family protein	0.0048	0.0254	0.0383
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0058	0.0777
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0104	0.0647	0.2775
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0557	0.1025
Plasmodium falciparum	threonine--tRNA ligase	0.0019	0.0053	0.0053
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0036	0.0171	0.0965
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0058	0.0901
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0048	0.0254	0.0467
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0017	0.0038	0.0504
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0064	0.037	0.2018
Trypanosoma cruzi	hexose transporter, putative	0.0057	0.0322	0.4296
Brugia malayi	beta-lactamase family protein	0.0039	0.0196	0.0797
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0548	0.3758	0.3758
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Echinococcus granulosus	lysyl tRNA synthetase	0.0076	0.045	0.1298
Trypanosoma cruzi	hexose transporter, putative	0.0105	0.0656	0.8747
Brugia malayi	beta-lactamase	0.0039	0.0196	0.0797
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0196	0.1102
Trichomonas vaginalis	sugar transport protein, putative	0.0048	0.0254	0.1106
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0825
Toxoplasma gondii	sugar transporter ST2	0.0048	0.0254	0.0383
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0038	0.0165
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0058	0.34
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0104	0.0647	0.2819
Giardia lamblia	Sugar-proton symporter	0.0048	0.0254	0.346
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0104	0.0647	0.0647
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0196	0.0565
Schistosoma mansoni	glucose transport protein	0.0339	0.2295	1
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0196	0.096
Onchocerca volvulus	Putative transporter	0.0048	0.0254	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0048	0.0254	0.1106
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.0647	0.2819
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0647	0.2819
Schistosoma mansoni	protein kinase	0.0104	0.0647	0.2819
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0104	0.0647	0.0647
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0014	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0196	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Toxoplasma gondii	sugar transporter ST3	0.0048	0.0254	0.0383
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Onchocerca volvulus		0.0048	0.0254	1
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0104	0.0647	0.0647
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0104	0.0647	0.0647
Onchocerca volvulus		0.0048	0.0254	1
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0019	0.0053	0.0094
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	sugar transporter	0.0048	0.0254	0.1106
Schistosoma mansoni	glucose transport protein	0.0339	0.2295	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0076	0.045	0.196
Trichomonas vaginalis	conserved hypothetical protein	0.0339	0.2295	1
Trypanosoma cruzi	hexose transporter	0.0105	0.0656	0.8747
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0196	0.096
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0119	0.075	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Plasmodium falciparum	lysine--tRNA ligase	0.0076	0.045	0.045
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0105	0.0656	0.8747
Echinococcus granulosus	glycyl tRNA synthetase	0.0019	0.0053	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0058	0.0777
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0102	0.0632	0.2755
Onchocerca volvulus		0.0048	0.0254	1
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0196	0.0196
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0019	0.0053	0.0154
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0058	0.0194
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0038	0.0213
Entamoeba histolytica	hypothetical protein	0.0076	0.045	0.6953
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0196	0.0853
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0019	0.0053	0.2103
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0632	0.2755
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.1867
Trichomonas vaginalis	glucose transporter, putative	0.0105	0.0656	0.286
Echinococcus multilocularis	calcium dependent protein kinase	0.0097	0.0602	0.1109
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0017	0.0038	0.0504
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0102	0.0632	0.2755
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0196	0.1102
Chlamydia trachomatis	lysine--tRNA ligase	0.0076	0.045	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.0557	0.2425
Trypanosoma brucei	cytochrome P450, putative	0.0013	0.0014	0.0188
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Toxoplasma gondii	glycyl-tRNA synthetase	0.0019	0.0053	0.008
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0196	0.096
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.6621
Echinococcus multilocularis	solute carrier family 22	0.0048	0.0254	0.0467
Brugia malayi	glycyl-tRNA synthetase	0.0019	0.0053	0.0172
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0019	0.0053	0.0233
Leishmania major	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0076	0.045	0.5996
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0048	0.0254	0.0732
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0048	0.0254	0.1106
Entamoeba histolytica	protein kinase, putative	0.0104	0.0647	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0196	0.096
Echinococcus multilocularis	General substrate transporter	0.0291	0.1961	0.3612
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0548	0.3758	0.5667
Echinococcus multilocularis	neuropeptide receptor A26	0.0506	0.3466	0.6384
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Brugia malayi	Sugar transporter family protein	0.0339	0.2295	1
Plasmodium vivax	lysine--tRNA ligase, putative	0.0076	0.045	0.045
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0196	0.096
Onchocerca volvulus		0.0048	0.0254	1
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0076	0.045	0.196
Schistosoma mansoni	sugar transporter	0.0048	0.0254	0.1106
Schistosoma mansoni	hypothetical protein	0.0184	0.1212	0.528
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0104	0.0647	0.0976
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0058	0.0777
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0058	0.2298
Toxoplasma gondii	protein kinase, putative	0.0958	0.663	1
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0058	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0196	0.0853
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0058	0.0107
Leishmania major	glucose transporter, lmgt2	0.0105	0.0656	0.8747
Onchocerca volvulus		0.0048	0.0254	1
Giardia lamblia	Hexose transporter	0.0048	0.0254	0.346
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0019	0.0053	0.0825
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Plasmodium vivax	threonine--tRNA ligase, putative	0.0019	0.0053	0.0053
Trichomonas vaginalis	glucose transporter, putative	0.0105	0.0656	0.286
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0048	0.0254	0.1312
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0076	0.045	0.196
Mycobacterium ulcerans	sugar transporter	0.0048	0.0254	0.1428
Schistosoma mansoni	hypothetical protein	0.0184	0.1212	0.528
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0647	0.2819
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0119	0.075	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0786	0.5429	1
Chlamydia trachomatis	proline--tRNA ligase	0.0036	0.0171	0.3811
Toxoplasma gondii	lysine-tRNA ligase	0.0076	0.045	0.0679
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0058	0.0777
Plasmodium vivax	hexose transporter	0.0339	0.2295	0.2295
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0058	0.0085
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0196	0.2658
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Schistosoma mansoni	sugar transporter	0.0048	0.0254	0.1106
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0196	0.096
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0102	0.0632	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0557	0.1606
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0019	0.0053	0.0098
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0252	0.1684	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.0557	0.2378
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0196	0.1102
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Brugia malayi	glutaminase DH11.1	0.0265	0.1777	0.773
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0053	0.0233
Onchocerca volvulus		0.0048	0.0254	1
Echinococcus granulosus	solute carrier family 22	0.0048	0.0254	0.0732
Mycobacterium ulcerans	glutaminase	0.0265	0.1777	1
Brugia malayi	major facilitator superfamily protein	0.0048	0.0254	0.1051
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0233
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.1867
Schistosoma mansoni	ap endonuclease	0.002	0.0058	0.0254
Leishmania major	glucose transporter, lmgt3	0.0105	0.0656	0.8747
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0048	0.0254	0.0467
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0102	0.0632	0.1165
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0017	0.0038	0.0504
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Brugia malayi	hypothetical protein	0.0048	0.0254	0.1051
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Echinococcus granulosus	geminin	0.0184	0.1212	0.3496
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0102	0.0632	0.1824
Schistosoma mansoni	sugar transporter	0.0048	0.0254	0.1106
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0196	0.096
Trichomonas vaginalis	glutaminase, putative	0.0265	0.1777	0.7744
Onchocerca volvulus		0.0048	0.0254	1
Brugia malayi	major facilitator superfamily protein	0.0048	0.0254	0.1051
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0196	0.0853
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0196	0.096
Echinococcus granulosus	calcium dependent protein kinase	0.0097	0.0602	0.1737
Brugia malayi	hypothetical protein	0.0048	0.0254	0.1051
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0557	0.1025
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0019	0.0053	0.2103
Brugia malayi	beta-lactamase family protein	0.0039	0.0196	0.0797
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0048	0.0254	0.1312
Trypanosoma cruzi	hexose transporter, putative	0.0105	0.0656	0.8747
Brugia malayi	Major Facilitator Superfamily protein	0.0048	0.0254	0.1051
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0557	0.2425
Echinococcus granulosus	solute carrier family 22	0.0048	0.0254	0.0732
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0048	0.0254	0.1428
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0196	0.0853
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0014	0.0061
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	glucose transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Trypanosoma cruzi	hexose transporter, putative	0.0105	0.0656	0.8747
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0105	0.0656	0.8747
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0632	0.2755
Mycobacterium ulcerans	lipase LipD	0.0039	0.0196	0.1102
Trichomonas vaginalis	sugar transporter, putative	0.0105	0.0656	0.286
Onchocerca volvulus		0.0048	0.0254	1
Plasmodium falciparum	hexose transporter	0.0339	0.2295	0.2295
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Plasmodium vivax	proline--tRNA ligase, putative	0.0119	0.075	0.075
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0104	0.0647	0.0647
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0557	0.1606
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0076	0.045	0.2532
Trypanosoma cruzi	sugar transporter, putative	0.0048	0.0254	0.3381
Onchocerca volvulus		0.0048	0.0254	1
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0196	0.261
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0019	0.0053	0.0172
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0104	0.0647	0.8623
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0196	0.0853
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0013	0.0014	0.0079
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0104	0.0647	0.1867
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0014	0.0061
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.1192
Brugia malayi	lysyl-tRNA synthetase	0.0076	0.045	0.1911
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Leishmania major	protein kinase, putative	0.0104	0.0647	0.8623
Schistosoma mansoni	sugar transporter	0.0048	0.0254	0.1106
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0196	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0499	0.2173
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0196	0.261
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0557	0.2425
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0102	0.0632	0.9772
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0019	0.0053	0.0172
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0196	0.0853
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0038	0.0165
Brugia malayi	hypothetical protein	0.0048	0.0254	0.1051
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.1192
Mycobacterium ulcerans	integral membrane transport protein	0.0048	0.0254	0.1428
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0019	0.0053	0.0233
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0119	0.075	0.1132
Onchocerca volvulus		0.0048	0.0254	1
Brugia malayi	Sugar transporter family protein	0.0048	0.0254	0.1051
Echinococcus multilocularis	lysyl tRNA synthetase	0.0076	0.045	0.0829
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0196	0.096
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0196	0.0853
Leishmania major	cytochrome p450-like protein	0.0013	0.0014	0.0188
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0105	0.0656	0.8747
Leishmania major	myo-inositol/proton symporter (MIT)	0.0048	0.0254	0.3381
Toxoplasma gondii	YbaK/proline-tRNA ligase associated domain-containing protein	0.0017	0.0038	0.0057
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0196	0.0361
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0104	0.0647	0.0976
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.6621
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0104	0.0647	0.2819
Trichomonas vaginalis	myo-inositol transporter, putative	0.0048	0.0254	0.1106
Echinococcus multilocularis	solute carrier family 22	0.0048	0.0254	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Onchocerca volvulus		0.0048	0.0254	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0076	0.045	0.2532
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0076	0.045	0.6932
Onchocerca volvulus		0.0048	0.0254	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.1192
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0196	0.0853
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	glutaminase	0.0265	0.1777	0.7744
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Schistosoma mansoni	lysyl-tRNA synthetase	0.0076	0.045	0.196
Onchocerca volvulus		0.0048	0.0254	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0048	0.0254	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0196	0.096
Schistosoma mansoni	hypothetical protein	0.0339	0.2295	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0104	0.0647	0.0647
Toxoplasma gondii	exonuclease III APE	0.002	0.0058	0.0088
Trichomonas vaginalis	sugar transporter, putative	0.0105	0.0656	0.286
Schistosoma mansoni	glucose transporter	0.0048	0.0254	0.1106
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0038	0.0165
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0196	0.2658
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0119	0.075	1
Trypanosoma brucei	glucose transporter 1E	0.0105	0.0656	0.8747
Plasmodium falciparum	proline--tRNA ligase	0.0119	0.075	0.075
Plasmodium falciparum	protein kinase 7	0.0958	0.663	0.663
Echinococcus granulosus	neuropeptide receptor A26	0.0506	0.3466	1
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0196	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Echinococcus multilocularis	solute carrier family 22	0.0048	0.0254	0.0467
Schistosoma mansoni	glutaminase	0.0265	0.1777	0.7744
Trypanosoma cruzi	hexose transporter, putative	0.0048	0.0254	0.3381
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0196	0.0853
Echinococcus granulosus	neuropeptide s receptor	0.0506	0.3466	1
Schistosoma mansoni	glucose transport protein	0.0339	0.2295	1
Trichomonas vaginalis	sugar transporter, putative	0.0105	0.0656	0.286
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0196	0.1102
Echinococcus multilocularis	geminin	0.0184	0.1212	0.2232
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0058	0.0124
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0058	0.0168
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0048	0.0254	0.3381
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0102	0.0632	0.2711
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0048	0.0254	0.0254
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0066	0.0385	0.1676
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0014	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Leishmania major	lysyl-tRNA synthetase, putative	0.0076	0.045	0.5996
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0105	0.0656	0.8747
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0196	0.0853
Trichomonas vaginalis	esterase, putative	0.0039	0.0196	0.0853
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.4227
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0064	0.037	0.5587
Leishmania major	hypothetical protein, conserved	0.0017	0.0038	0.0504
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0019	0.0053	0.03
Echinococcus granulosus	synaptic vesicle 2 protein	0.0048	0.0254	0.0732
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0104	0.0647	0.0647
Chlamydia trachomatis	threonine--tRNA ligase	0.0019	0.0053	0.1186
Trypanosoma brucei	glucose transporter 2A	0.0105	0.0656	0.8747
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.0656	0.286
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0557	0.2425
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0038	0.0504
Giardia lamblia	Lysyl-tRNA synthetase	0.0076	0.045	0.6849
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.6621
Brugia malayi	Major Facilitator Superfamily protein	0.0048	0.0254	0.1051
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0019	0.0053	0.008
Treponema pallidum	prolyl-tRNA synthetase	0.0036	0.0171	1
Echinococcus granulosus	solute carrier family 22	0.0048	0.0254	0.0732
Treponema pallidum	threonyl-tRNA synthetase	0.0019	0.0053	0.3113
Giardia lamblia	Prolyl-tRNA synthetase	0.0102	0.0632	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0104	0.0647	0.0647
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0102	0.0632	0.2711
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0119	0.075	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0064	0.037	0.2018
Toxoplasma gondii	ABC1 family protein	0.0039	0.0196	0.0295
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0196	0.0797
Loa Loa (eye worm)	sugar transporter	0.0339	0.2295	1
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0196	0.261
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.4227
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0196	0.0853
Leishmania major	hypothetical protein, conserved	0.0048	0.0254	0.3381
Brugia malayi	Cam kinase protein 1	0.0104	0.0647	0.2775
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0058	0.0254
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0058	0.0058
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0119	0.075	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0548	0.3758	0.3758
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Plasmodium vivax	sugar transporter, putative	0.0048	0.0254	0.0254
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0014	0.0188
Leishmania major	hypothetical protein, conserved	0.0039	0.0196	0.261
Echinococcus granulosus	General substrate transporter	0.0291	0.1961	0.5658
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.0656	0.286
Schistosoma mansoni	protein kinase	0.0104	0.0647	0.2819
Entamoeba histolytica	protein kinase, putative	0.0104	0.0647	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0102	0.0632	0.2755
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.1867
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0104	0.0647	0.0647
Plasmodium vivax	glycine--tRNA ligase, putative	0.0019	0.0053	0.0053
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.1192
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0058	0.0058
Schistosoma mansoni	protein kinase	0.0104	0.0647	0.2819
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0104	0.0647	0.0976
Schistosoma mansoni	glycyl-tRNA synthetase	0.0019	0.0053	0.0233
Leishmania major	hypothetical protein, conserved	0.0017	0.0038	0.0504
Toxoplasma gondii	facilitative glucose transporter GT1	0.0339	0.2295	0.3461
Echinococcus multilocularis	glycyl tRNA synthetase	0.0019	0.0053	0.0098
Leishmania major	glucose transporter, lmgt1	0.0105	0.0656	0.8747
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0196	0.0853
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0058	0.0328
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0076	0.045	0.5996
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Loa Loa (eye worm)	glutaminase 2	0.0265	0.1777	0.7744
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0058	0.0254
Echinococcus granulosus	solute carrier family 22	0.0048	0.0254	0.0732

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 692336