TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 453.901 | Formula: C21H16ClN5O3S
H donors: 1 H acceptors: 4 LogP: 3.53 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CSc1nnc2n1nc(cc2)c1ccc(cc1)Cl)NCc1ccc2c(c1)OCO2
InChi: 1S/C21H16ClN5O3S/c22-15-4-2-14(3-5-15)16-6-8-19-24-25-21(27(19)26-16)31-11-20(28)23-10-13-1-7-17-18(9-13)30-12-29-17/h1-9H,10-12H2,(H,23,28)
InChiKey: QPLUCOJAWCSUIK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	protein kinase	0.0031	0.042	0.1231
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.003	0.0406	0.0358
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0234	0.0186
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0096	0.0047
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0108	0.2114	0.8861
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0518	0.1556
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0429	0.5209
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0429	0.5209
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.042	0.0372
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.1972	0.1933
Schistosoma mansoni	glucose transport protein	0.0102	0.1972	0.6386
Onchocerca volvulus		0.0048	0.0798	0.2448
Entamoeba histolytica	protein kinase, putative	0.0031	0.042	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2454	0.4947
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0234	0.2538
Brugia malayi	Thioredoxin reductase	0.0047	0.0778	0.1571
Brugia malayi	hypothetical protein	0.0014	0.0049	0.0099
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0049	0.0099
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0778	0.0732
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.003	0.0406	0.0358
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.042	0.0372
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0096	1
Schistosoma mansoni	glucose transport protein	0.0102	0.1972	0.6386
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0728	0.0682
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.1972	0.1933
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0234	0.0308
Plasmodium falciparum	protein kinase 6	0.0431	0.9233	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0778	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0406	0.1184
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0096	0.0642
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.042	0.0372
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0382	0.0553
Schistosoma mansoni	glucose transport protein	0.0102	0.1972	0.6386
Echinococcus granulosus	neuropeptide receptor A26	0.0466	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0728	0.2255
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0382	0.0553
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0049	0.0099
Leishmania major	trypanothione reductase	0.0047	0.0778	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0431	0.9233	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0108	0.2114	0.8861
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0518	0.1028
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.4951	0.4926
Schistosoma mansoni	hypothetical protein	0.0029	0.0382	0.1104
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.042	0.0404
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.042	0.0848
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.012	0.2379	1
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0234	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0429	0.5209
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0429	0.5209
Leishmania major	protein kinase, putative	0.0031	0.042	0.5088
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0234	0.0614
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.042	0.0404
Brugia malayi	hypothetical protein	0.0123	0.2454	0.4957
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0282	0.3198
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0517	0.0779
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0429	0.1973
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0429	0.5209
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0778	0.1553
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0172	0.0641
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.003	0.0406	0.9253
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0282	0.3198
Plasmodium falciparum	hexose transporter	0.0102	0.1972	0.2094
Giardia lamblia	Prolyl-tRNA synthetase	0.003	0.0406	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Toxoplasma gondii	facilitative glucose transporter GT1	0.0102	0.1972	0.3201
Echinococcus granulosus	peregrin	0.0029	0.0382	0.0334
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.042	0.0372
Loa Loa (eye worm)	hypothetical protein	0.005	0.0844	0.1688
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0382	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0025	0.028	0.0546
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0429	0.5209
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0096	0.0194
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.042	0.0372
Brugia malayi	Bromodomain containing protein	0.0029	0.0382	0.0771
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0728	0.1471
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.003	0.0406	0.1855
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0096	0.0642
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0049	0.0099
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0234	0.0201
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0108	0.2114	0.8861
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0377	0.033
Brugia malayi	jmjC domain containing protein	0.0036	0.0518	0.1046
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0108	0.2114	0.8804
Schistosoma mansoni	protein kinase	0.0031	0.042	0.1231
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0234	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0518	0.0471
Leishmania major	glucose transporter, lmgt1	0.0032	0.0429	0.5209
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0635	0.0589
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0635	0.0589
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0382	0.0752
Brugia malayi	major facilitator superfamily protein	0.0014	0.0049	0.0099
Entamoeba histolytica	protein kinase, putative	0.0031	0.042	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0778	0.0732
Loa Loa (eye worm)	sugar transporter	0.0014	0.0049	0.0079
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0518	0.1556
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0728	0.2255
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.1071	0.2147
Brugia malayi	hypothetical protein	0.0016	0.0088	0.0178
Onchocerca volvulus	Alhambra homolog	0.0029	0.0382	0.1086
Loa Loa (eye worm)	hypothetical protein	0.0153	0.311	0.6275
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.0096	0.0201
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0096	0.0078
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0234	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0031	0.042	0.0829
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.042	0.1927
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0282	0.0254
Toxoplasma gondii	protein kinase, putative	0.0287	0.6057	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0159	0.047
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.042	0.0404
Brugia malayi	hypothetical protein	0.0237	0.4951	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0096	0.0642
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0096	0.0155
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0096	0.1311
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0234	0.0201
Treponema pallidum	NADH oxidase	0.0016	0.0096	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0429	0.1973
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0429	0.5209
Brugia malayi	hypothetical protein	0.0014	0.0049	0.0099
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0096	0.0642
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0096	0.0051
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0164	0.3351	0.3595
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0108	0.2114	0.8861
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0234	0.0614
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0234	0.5182
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.003	0.0406	0.1113
Echinococcus multilocularis	neuropeptide s receptor	0.0466	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0282	0.0254
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.1419	0.4547
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.012	0.2379	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0728	0.2255
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0518	0.0471
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0778	0.0793
Mycobacterium tuberculosis	Probable oxidoreductase	0.012	0.2379	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.042	0.0404
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0096	0.0642
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0382	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Mycobacterium tuberculosis	Probable reductase	0.0108	0.2114	0.8861
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0234	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0429	0.5209
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0728	0.0682
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0517	0.6425
Schistosoma mansoni	hypothetical protein	0.0048	0.0798	0.2488
Mycobacterium tuberculosis	Probable dehydrogenase	0.0108	0.2114	0.8861
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0517	0.6425
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0429	0.5209
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0517	0.6425
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0096	0.0642
Plasmodium falciparum	protein kinase 7	0.0287	0.6057	0.6542
Brugia malayi	Sugar transporter family protein	0.0102	0.1972	0.3984
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0517	0.051
Brugia malayi	Sugar transporter family protein	0.0014	0.0049	0.0099
Plasmodium falciparum	glutathione reductase	0.0016	0.0096	0.0051
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.003	0.0406	0.082
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0382	0.1104
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0096	0.253
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0429	0.5209
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0429	0.5209
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.1972	0.1933
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.042	0.0617
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0429	0.5209
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2454	0.4947
Onchocerca volvulus	Huntingtin homolog	0.0123	0.2454	0.7856
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0049	0.0079
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0096	0.0642
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.042	0.1231
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0798	0.1613
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0517	0.6425
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.042	0.0372
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0382	0.0334
Brugia malayi	glutathione reductase	0.0047	0.0778	0.1571
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0096	0.253
Brugia malayi	hypothetical protein	0.0153	0.311	0.6283
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.042	0.0404
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.042	0.0829
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0096	0.0078
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0096	0.0051
Trypanosoma cruzi	hexose transporter	0.0032	0.0429	0.5209
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0049	0.0079
Trypanosoma brucei	trypanothione reductase	0.0047	0.0778	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.042	0.0617
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0234	0.2538
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0778	0.0793
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0778	0.0793
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0164	0.3351	0.3595
Echinococcus multilocularis	neuropeptide receptor A26	0.0466	1	1
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.4951	0.4926
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.1972	0.1933
Echinococcus multilocularis	General substrate transporter	0.0087	0.1658	0.1617
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0102	0.1972	0.1933
Leishmania major	hypothetical protein, conserved	0.0025	0.0282	0.3198
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0282	0.0388
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0778	0.1553
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.1972	0.1933
Loa Loa (eye worm)	hypothetical protein	0.0237	0.4951	1
Onchocerca volvulus	Huntingtin homolog	0.0123	0.2454	0.7856
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0096	0.0642
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.1972	0.1933
Brugia malayi	PHD-finger family protein	0.0029	0.0382	0.0771
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0096	0.0642
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.042	0.0372
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.1972	1
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0114	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0096	0.0642
Giardia lamblia	PHD finger protein 15	0.0029	0.0382	0.9321
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0778	0.3126
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0164	0.3351	0.5495
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0429	0.1973
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0096	0.0051
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0096	0.0051
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.042	0.0404
Onchocerca volvulus		0.0153	0.311	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0728	0.0682
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0728	0.1454
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0377	0.033
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.042	0.0404
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0159	0.047
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.042	0.0372
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0282	0.3198
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0429	0.1973
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0517	0.6425
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0096	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0234	0.0453
Brugia malayi	hypothetical protein	0.0025	0.0282	0.057
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0096	0.0243
Loa Loa (eye worm)	hypothetical protein	0.003	0.0406	0.0801
Plasmodium vivax	hexose transporter	0.0102	0.1972	0.2094
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0096	1
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0778	0.1212
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.042	0.0404
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0096	0.0051
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0429	0.1973
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0234	0.2538
Schistosoma mansoni	protein kinase	0.0031	0.042	0.1231
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.042	0.0617
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0429	0.5209
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0429	0.1973
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0517	0.051
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0382	0.0362
Brugia malayi	Cam kinase protein 1	0.0031	0.042	0.0848
Leishmania major	glucose transporter, lmgt3	0.0032	0.0429	0.5209
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0382	0.0334
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0096	0.1854	0.1814
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0429	0.1973
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0096	0.1854	0.1814
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.1972	0.1933
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.012	0.2379	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0406	0.0801
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.042	0.0829
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0096	0.0642
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.042	0.5088
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.042	0.0404
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0728	0.0682
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0096	0.253
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0234	0.0339
Brugia malayi	jmjC domain containing protein	0.0096	0.1854	0.3745
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0096	0.0243
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0096	0.0642
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0096	0.0642
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0429	0.5209
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0406	0.1184
Brugia malayi	Sugar transporter family protein	0.0014	0.0049	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0234	0.0473
Brugia malayi	major facilitator superfamily protein	0.0014	0.0049	0.0099
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0096	0.0642
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.003	0.0406	0.082
Echinococcus granulosus	General substrate transporter	0.0087	0.1658	0.1617
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0096	0.0642
Loa Loa (eye worm)	sugar transporter	0.0102	0.1972	0.3972
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0234	0.0961
Brugia malayi	hypothetical protein	0.0014	0.0049	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0429	0.5209
Leishmania major	glucose transporter, lmgt2	0.0032	0.0429	0.5209
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0798	0.2488
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0282	0.0254
Plasmodium falciparum	glutathione reductase	0.0047	0.0778	0.0793
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0429	0.5209
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0079
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0096	0.0047
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0096	0.0642
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0429	0.5209
Schistosoma mansoni	hypothetical protein	0.0102	0.1972	0.6386
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0282	0.0551
Echinococcus multilocularis	peregrin	0.0029	0.0382	0.0334

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 697566