Detailed information for compound 69892

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 576.571 | Formula: C34H25FN2O6
  • H donors: 2 H acceptors: 5 LogP: 6.99 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(NC(c1ccccc1)(c1ccccc1)c1ccccc1)COc1c(F)cc(cc1[N+](=O)[O-])c1ccc(cc1)C(=O)O
  • InChi: 1S/C34H25FN2O6/c35-29-20-25(23-16-18-24(19-17-23)33(39)40)21-30(37(41)42)32(29)43-22-31(38)36-34(26-10-4-1-5-11-26,27-12-6-2-7-13-27)28-14-8-3-9-15-28/h1-21H,22H2,(H,36,38)(H,39,40)
  • InChiKey: OTYIPHLVBZIZBW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Get druggable targets OG5_128852 All targets in OG5_128852
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_128852 All targets in OG5_128852
Trypanosoma brucei gambiense 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative Get druggable targets OG5_128852 All targets in OG5_128852
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Entamoeba histolytica steroid 5-alpha reductase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase Get druggable targets OG5_128852 All targets in OG5_128852
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania infantum 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania mexicana 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania donovani 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania braziliensis 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128852 All targets in OG5_128852
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Synaptic glycoprotein SC2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 254 aa 208 aa 28.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus somatostatin receptor 0.0234 0.0311 0.0399
Loa Loa (eye worm) PAN domain-containing protein 0.0205 0.0264 0.0261
Brugia malayi PAN domain containing protein 0.0205 0.0264 0.0261
Onchocerca volvulus 0.0205 0.0264 0.1459
Brugia malayi Integrin alpha pat-2 precursor 0.1598 0.2598 0.2596
Brugia malayi solute carrier family 40, member 1 0.0194 0.0245 0.0242
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0234 0.0311 0.1784
Onchocerca volvulus 0.0234 0.0311 0.1784
Schistosoma mansoni tyrosine kinase 0.0059 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0077 0.0049 0.0046
Brugia malayi hypothetical protein 0.0234 0.0311 0.0309
Schistosoma mansoni opsin-like receptor 0.0234 0.0311 0.0371
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 0.0236 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.0264 0.0261
Schistosoma mansoni tyrosine kinase 0.0088 0.0067 0.0077
Echinococcus multilocularis neuropeptide receptor 0.0234 0.0311 0.0402
Mycobacterium ulcerans hypothetical protein 0.0171 0.0206 0.2522
Echinococcus granulosus rhodopsin orphan GPCR 0.0234 0.0311 0.0399
Echinococcus granulosus neuropeptide receptor A26 0.0234 0.0311 0.0399
Echinococcus multilocularis sex peptide receptor 0.0234 0.0311 0.0402
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0122 0.0123 0.0159
Brugia malayi Trypsin family protein 0.0955 0.1521 0.1518
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0189 0.0236 0.5126
Schistosoma mansoni neurotransmitter gated ion channel 0.0122 0.0123 0.0145
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0058 0.0056
Toxoplasma gondii hypothetical protein 0.0205 0.0264 0.0639
Echinococcus multilocularis epidermal growth factor receptor 0.0093 0.0076 0.0098
Schistosoma mansoni voltage-gated potassium channel 0.0552 0.0846 0.1013
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Onchocerca volvulus 0.0948 0.1509 0.9921
Schistosoma mansoni cercarial elastase (S01 family) 0.0171 0.0206 0.0244
Echinococcus multilocularis kelch ECH associated protein 1 0.0095 0.0079 0.0102
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0552 0.0846 0.1088
Onchocerca volvulus 0.0234 0.0311 0.1784
Schistosoma mansoni hypothetical protein 0.0171 0.0206 0.0244
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0234 0.0311 0.0399
Onchocerca volvulus 0.0234 0.0311 0.1784
Schistosoma mansoni biogenic amine receptor 0.0234 0.0311 0.0371
Onchocerca volvulus 0.02 0.0254 0.1394
Leishmania major hypothetical protein, conserved 0.0295 0.0413 1
Loa Loa (eye worm) hypothetical protein 0.018 0.0221 0.0218
Schistosoma mansoni nAChR subunit 0.0122 0.0123 0.0145
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Brugia malayi neuropeptide F receptor 0.0234 0.0311 0.0309
Onchocerca volvulus 0.0205 0.0264 0.1459
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.005 0.0003 0.0003
Brugia malayi excitatory GABA receptor EXP-1A 0.0255 0.0347 0.0345
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0222 0.0291 0.0376
Schistosoma mansoni hypothetical protein 0.0083 0.0058 0.0067
Toxoplasma gondii PAN/Apple domain-containing protein 0.0205 0.0264 0.0639
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0107 0.0098 0.0123
Echinococcus multilocularis shaker cognate 0.005 0.0003 0.0003
Echinococcus multilocularis potassium voltage gated channel protein 0.0552 0.0846 0.1091
Echinococcus granulosus allatostatin A receptor 0.0234 0.0311 0.0399
Schistosoma mansoni hypothetical protein 0.0234 0.0311 0.0371
Onchocerca volvulus 0.0234 0.0311 0.1784
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0133 0.0143 0.0169
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.0058 0.0075
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0234 0.0311 0.0402
Brugia malayi PAN domain containing protein 0.0205 0.0264 0.0261
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0255 0.0347 0.0448
Schistosoma mansoni integrin alpha 0.1598 0.2598 0.3119
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0325 0.0465 0.06
Onchocerca volvulus 0.0171 0.0206 0.1065
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi AKH receptor 0.0234 0.0311 0.0309
Brugia malayi hypothetical protein 0.0122 0.0123 0.0121
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0259 0.0308
Echinococcus granulosus glutamate receptor 2 0.0077 0.0049 0.006
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0059 0.0019 0.0021
Schistosoma mansoni cercarial elastase (S01 family) 0.0171 0.0206 0.0244
Brugia malayi PAN domain containing protein 0.0205 0.0264 0.0261
Schistosoma mansoni hypothetical protein 0.0234 0.0311 0.0371
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0234 0.0311 0.0371
Onchocerca volvulus 0.0122 0.0123 0.0506
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.005 0.0003 0.0003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0234 0.0311 0.0371
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0122 0.0123 0.0121
Echinococcus granulosus peptide allatostatin:somatostatin 0.0234 0.0311 0.0399
Brugia malayi PAN domain containing protein 0.0205 0.0264 0.0261
Toxoplasma gondii PAN domain-containing protein 0.229 0.3759 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0234 0.0311 0.0399
Echinococcus multilocularis neuropeptide receptor 0.0234 0.0311 0.0402
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0234 0.0311 0.0371
Brugia malayi Trypsin-like protease protein 5 0.0171 0.0206 0.0203
Echinococcus multilocularis G-protein coupled receptor, putative 0.0234 0.0311 0.0402
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0234 0.0311 0.0309
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0234 0.0311 0.0309
Loa Loa (eye worm) voltage-dependent calcium channel 0.0063 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Brugia malayi hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0194 0.0245 0.0242
Echinococcus granulosus metabotropic glutamate receptor 5 0.0077 0.0049 0.006
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 0.0236 0.5126
Loa Loa (eye worm) hypothetical protein 0.0063 0.0025 0.0022
Schistosoma mansoni nAChR subunit 0.0255 0.0347 0.0414
Loa Loa (eye worm) hypothetical protein 0.0077 0.0049 0.0046
Echinococcus granulosus nAChR subunit 0.0255 0.0347 0.0445
Brugia malayi Melatonin receptor type 1A 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Echinococcus multilocularis dro:myosuppressin receptor 0.0234 0.0311 0.0402
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0234 0.0311 0.0309
Toxoplasma gondii microneme protein MIC17C 0.0205 0.0264 0.0639
Brugia malayi EGF-like domain containing protein 0.018 0.0221 0.0218
Loa Loa (eye worm) hypothetical protein 0.1037 0.1657 0.1655
Onchocerca volvulus 0.0194 0.0245 0.133
Loa Loa (eye worm) hypothetical protein 0.0133 0.0143 0.0141
Onchocerca volvulus 0.0255 0.0347 0.2026
Loa Loa (eye worm) hypothetical protein 0.0077 0.0049 0.0046
Brugia malayi hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0255 0.0347 0.0448
Brugia malayi Kelch motif family protein 0.0995 0.1587 0.1585
Echinococcus granulosus neuropeptides capa receptor 0.0234 0.0311 0.0399
Loa Loa (eye worm) hypothetical protein 0.0077 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.0295 0.0413 0.0411
Brugia malayi jmjC domain containing protein 0.0096 0.0081 0.0078
Echinococcus multilocularis glycine receptor subunit beta 0.0255 0.0347 0.0448
Loa Loa (eye worm) hypothetical protein 0.0955 0.1521 0.1518
Loa Loa (eye worm) hypothetical protein 0.0826 0.1305 0.1303
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Brugia malayi Protein kinase domain containing protein 0.0305 0.0431 0.0428
Loa Loa (eye worm) hypothetical protein 0.0189 0.0236 0.0233
Echinococcus granulosus g protein coupled receptor 0.0234 0.0311 0.0399
Schistosoma mansoni neurotransmitter gated ion channel 0.0133 0.0143 0.0169
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Onchocerca volvulus 0.0205 0.0264 0.1459
Schistosoma mansoni adenoreceptor 0.0234 0.0311 0.0371
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0311 0.0309
Brugia malayi G protein-coupled receptor 0.0234 0.0311 0.0309
Echinococcus multilocularis Kelch repeat type 1 0.0096 0.008 0.0103
Schistosoma mansoni hypothetical protein 0.0234 0.0311 0.0371
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0295 0.0413 0.5
Brugia malayi metabotropic glutamate receptor type 2 0.0077 0.0049 0.0046
Echinococcus multilocularis neuropeptide receptor A26 0.0234 0.0311 0.0402
Brugia malayi neuropeptide F receptor 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi ORL1-like opioid receptor 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.018 0.0221 0.0218
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0325 0.0465 0.0462
Loa Loa (eye worm) TK/INSR protein kinase 0.0059 0.0019 0.0016
Loa Loa (eye worm) G-protein coupled receptor 0.0234 0.0311 0.0309
Schistosoma mansoni tyrosine kinase 0.0093 0.0076 0.0088
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Onchocerca volvulus 0.0205 0.0264 0.1459
Echinococcus granulosus rhodopsin orphan GPCR 0.0234 0.0311 0.0399
Echinococcus granulosus tyrosine kinase 0.0088 0.0067 0.0083
Echinococcus multilocularis receptor type guanylyl cyclase 0.0253 0.0343 0.0442
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0255 0.0347 0.0448
Onchocerca volvulus 0.0234 0.0311 0.1784
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0234 0.0311 0.0371
Onchocerca volvulus 0.018 0.0221 0.1169
Onchocerca volvulus 0.02 0.0254 0.1394
Loa Loa (eye worm) TK/ROR protein kinase 0.0305 0.0431 0.0428
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Echinococcus granulosus rhodopsin orphan GPCR 0.0234 0.0311 0.0399
Schistosoma mansoni growth hormone secretagogue receptor 0.0234 0.0311 0.0371
Onchocerca volvulus 0.0234 0.0311 0.1784
Brugia malayi G protein-coupled receptor F59B2.13 0.0234 0.0311 0.0309
Echinococcus granulosus integrin beta 2 0.4671 0.7751 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0234 0.0311 0.0402
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0171 0.0206 0.0265
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0171 0.0206 0.0244
Echinococcus granulosus tissue type plasminogen activator 0.0295 0.0413 0.053
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0529 0.0806 0.1039
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0255 0.0347 0.0414
Echinococcus multilocularis tyrosine kinase 0.0088 0.0067 0.0086
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0255 0.0347 0.0345
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0255 0.0347 0.0445
Onchocerca volvulus 0.0234 0.0311 0.1784
Echinococcus multilocularis integrin alpha 3 0.1146 0.184 0.2374
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0234 0.0311 0.0309
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0234 0.0311 0.0371
Echinococcus granulosus orexin receptor type 2 0.0234 0.0311 0.0399
Loa Loa (eye worm) hypothetical protein 0.0205 0.0264 0.0261
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0234 0.0311 0.0399
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.0058 0.0075
Loa Loa (eye worm) hypothetical protein 0.0223 0.0293 0.0291
Onchocerca volvulus 0.0948 0.1509 0.9921
Schistosoma mansoni histamine h1 receptor 0.0234 0.0311 0.0371
Loa Loa (eye worm) hypothetical protein 0.005 0.0004 0.0001
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0255 0.0347 0.0445
Brugia malayi hypothetical protein 0.0234 0.0311 0.0309
Echinococcus multilocularis rhodopsin orphan GPCR 0.0234 0.0311 0.0402
Giardia lamblia hypothetical protein 0.018 0.0221 0.5
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0255 0.0347 0.0345
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0077 0.0049 0.0046
Loa Loa (eye worm) G-protein coupled receptor 0.0234 0.0311 0.0309
Echinococcus granulosus dro:myosuppressin receptor 0.0234 0.0311 0.0399
Schistosoma mansoni integrin alpha-ps 0.0868 0.1375 0.1649
Echinococcus granulosus enteropeptidase 0.0171 0.0206 0.0262
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0171 0.0206 0.0244
Loa Loa (eye worm) neuropeptide F receptor 0.0234 0.0311 0.0309
Loa Loa (eye worm) LGC-31 protein 0.0255 0.0347 0.0345
Echinococcus multilocularis glycoprotein Antigen 5 0.0171 0.0206 0.0265
Echinococcus granulosus fibrillin 2 0.018 0.0221 0.0282
Onchocerca volvulus 0.0234 0.0311 0.1784
Echinococcus multilocularis neuropeptide s receptor 0.0234 0.0311 0.0402
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0077 0.0049 0.0063
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Schistosoma mansoni neuropeptide receptor 0.0234 0.0311 0.0371
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0122 0.0123 0.0121
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0234 0.0311 0.0402
Brugia malayi PAN domain containing protein 0.0205 0.0264 0.0261
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0093 0.0076 0.0094
Echinococcus multilocularis serotonin receptor 0.0234 0.0311 0.0402
Schistosoma mansoni metabotropic glutamate receptor 0.0077 0.0049 0.0056
Echinococcus multilocularis nAChR subunit 0.0255 0.0347 0.0448
Loa Loa (eye worm) hypothetical protein 0.0133 0.0143 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0234 0.0311 0.0371
Onchocerca volvulus 0.0122 0.0123 0.0506
Schistosoma mansoni amine GPCR 0.0234 0.0311 0.0371
Echinococcus multilocularis rhodopsin orphan GPCR 0.0234 0.0311 0.0402
Brugia malayi Trypsin family protein 0.0171 0.0206 0.0203
Brugia malayi PAN domain containing protein 0.0205 0.0264 0.0261
Echinococcus granulosus 7tm_1 domain containing protein 0.0234 0.0311 0.0399
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0189 0.0236 1
Onchocerca volvulus 0.02 0.0254 0.1394
Giardia lamblia High cysteine protein 0.018 0.0221 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0234 0.0311 0.0371
Echinococcus multilocularis g protein coupled receptor 0.0234 0.0311 0.0402
Onchocerca volvulus 0.0234 0.0311 0.1784
Onchocerca volvulus 0.0205 0.0264 0.1459
Schistosoma mansoni cercarial elastase (S01 family) 0.0171 0.0206 0.0244
Giardia lamblia Tenascin precursor 0.018 0.0221 0.5
Loa Loa (eye worm) hypothetical protein 0.0948 0.1509 0.1507
Loa Loa (eye worm) hypothetical protein 0.0056 0.0013 0.001
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0077 0.0049 0.0063
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0234 0.0311 0.0371
Echinococcus multilocularis sodium channel protein 0.0107 0.0098 0.0126
Echinococcus granulosus tm gpcr rhodopsin 0.176 0.287 0.3701
Echinococcus granulosus glycine receptor subunit alpha 1 0.0255 0.0347 0.0445
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0205 0.0264 0.0639
Loa Loa (eye worm) glutamate receptor 0.0077 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0255 0.0347 0.0448
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0253 0.0343 0.1997
Echinococcus granulosus nmda type glutamate receptor 0.0077 0.0049 0.006
Toxoplasma gondii microneme protein MIC4 0.0205 0.0264 0.0639
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0133 0.0143 0.0169
Loa Loa (eye worm) trypsin family protein 0.0171 0.0206 0.0203
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0077 0.0049 0.0046
Echinococcus multilocularis potassium voltage gated channel protein 0.005 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi G-protein coupled receptor 0.0234 0.0311 0.0309
Echinococcus multilocularis serotonin receptor 0.0234 0.0311 0.0402
Trypanosoma cruzi hypothetical protein, conserved 0.0295 0.0413 1
Brugia malayi hypothetical protein 0.0122 0.0123 0.0121
Onchocerca volvulus 0.0122 0.0123 0.0506
Echinococcus multilocularis neuropeptides capa receptor 0.0234 0.0311 0.0402
Toxoplasma gondii PAN domain-containing protein 0.0205 0.0264 0.0639
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Schistosoma mansoni opsin-like receptor 0.0234 0.0311 0.0371
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0144 0.016 0.3059
Brugia malayi sulfakinin receptor protein 0.0234 0.0311 0.0309
Onchocerca volvulus 0.0205 0.0264 0.1459
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0133 0.0143 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0234 0.0311 0.0402
Echinococcus multilocularis epidermal growth factor receptor 0.0165 0.0196 0.0253
Echinococcus granulosus voltage dependent calcium channel 0.0063 0.0025 0.0029
Onchocerca volvulus 0.0955 0.1521 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0077 0.0049 0.006
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0255 0.0347 0.0445
Brugia malayi hypothetical protein 0.0171 0.0206 0.0203
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0223 0.0293 0.0349
Echinococcus multilocularis G protein coupled receptor 139 0.0234 0.0311 0.0402
Onchocerca volvulus 0.0205 0.0264 0.1459
Echinococcus granulosus potassium voltage gated channel protein 0.0552 0.0846 0.1088
Schistosoma mansoni hypothetical protein 0.0234 0.0311 0.0371
Echinococcus granulosus g protein coupled receptor 0.0234 0.0311 0.0399
Loa Loa (eye worm) hypothetical protein 0.073 0.1143 0.114
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0077 0.0049 0.0063
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi hypothetical protein 0.0234 0.0311 0.0309
Schistosoma mansoni cercarial elastase (S01 family) 0.0171 0.0206 0.0244
Schistosoma mansoni integrin alpha-4 0.0399 0.0589 0.0705
Schistosoma mansoni nAChR subunit 0.0255 0.0347 0.0414
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0255 0.0347 0.0345
Brugia malayi G-protein coupled receptor 0.0234 0.0311 0.0309
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 0.0236 0.5126
Echinococcus granulosus integrin alpha ps 0.0994 0.1587 0.2045
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Echinococcus multilocularis allatostatin A receptor 0.0234 0.0311 0.0402
Toxoplasma gondii microneme protein MIC17B 0.0205 0.0264 0.0639
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0122 0.0123 0.0156
Schistosoma mansoni opsin-like receptor 0.0234 0.0311 0.0371
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0013 0.001
Loa Loa (eye worm) PAN domain-containing protein 0.0205 0.0264 0.0261
Onchocerca volvulus 0.0108 0.0101 0.0352
Echinococcus granulosus nAChR subunit 0.0133 0.0143 0.0181
Loa Loa (eye worm) hypothetical protein 0.0325 0.0465 0.0462
Loa Loa (eye worm) hypothetical protein 0.018 0.0221 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0234 0.0311 0.0371
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0255 0.0347 0.0345
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0234 0.0311 0.0399
Brugia malayi EGF-like domain containing protein 0.018 0.0221 0.0218
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0223 0.0293 0.0378
Echinococcus multilocularis integrin beta 2 0.4671 0.7751 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0133 0.0143 0.0141
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0234 0.0311 0.0371
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0171 0.0206 0.0203
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0133 0.0143 0.0141
Loa Loa (eye worm) PAN domain-containing protein 0.0205 0.0264 0.0261
Toxoplasma gondii subtilisin SUB12 0.0205 0.0264 0.0639
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0077 0.0049 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0234 0.0311 0.0399
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0234 0.0311 0.0371
Echinococcus multilocularis rhodopsin orphan GPCR 0.0234 0.0311 0.0402
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0122 0.0123 0.0159
Loa Loa (eye worm) hypothetical protein 0.0133 0.0143 0.0141
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0234 0.0311 0.0371
Echinococcus granulosus neuropeptide FF receptor 2 0.0234 0.0311 0.0399
Echinococcus multilocularis rhodopsin orphan GPCR 0.0234 0.0311 0.0402
Loa Loa (eye worm) hypothetical protein 0.0205 0.0264 0.0261
Schistosoma mansoni nAChR subunit 0.0255 0.0347 0.0414
Toxoplasma gondii microneme protein MIC17A 0.0205 0.0264 0.0639
Toxoplasma gondii PAN domain-containing protein 0.229 0.3759 1
Schistosoma mansoni tyrosine kinase 0.0083 0.0058 0.0067
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Echinococcus granulosus kelch ECH associated protein 1 0.0095 0.0079 0.0099
Brugia malayi Cation transporter family protein 0.0948 0.1509 0.1507
Onchocerca volvulus 0.02 0.0254 0.1394
Loa Loa (eye worm) TK/EGFR protein kinase 0.0165 0.0196 0.0194
Echinococcus granulosus integrin alpha 3 0.1146 0.184 0.2372
Echinococcus multilocularis protein jagged 2 0.018 0.0221 0.0285
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0234 0.0311 0.0402
Echinococcus multilocularis voltage dependent calcium channel 0.0223 0.0293 0.0378
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0255 0.0347 0.0414
Schistosoma mansoni nAChR subunit 0.0122 0.0123 0.0145
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0234 0.0311 0.0402
Brugia malayi CUB domain containing protein 0.0068 0.0033 0.0031
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0234 0.0311 0.0402
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0223 0.0293 0.0291
Loa Loa (eye worm) integrin beta-2 0.6012 1 1
Echinococcus multilocularis orexin receptor type 2 0.0234 0.0311 0.0402
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus granulosus kelch ECH associated protein 1 like 0.0095 0.0079 0.0099
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus multilocularis fibrillin 2 0.018 0.0221 0.0285
Brugia malayi Furin-like cysteine rich region family protein 0.0165 0.0196 0.0194
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus granulosus rhodopsin orphan GPCR 0.0234 0.0311 0.0399
Onchocerca volvulus 0.0234 0.0311 0.1784
Giardia lamblia High cysteine protein 0.018 0.0221 0.5
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Schistosoma mansoni tyrosine kinase 0.0059 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0255 0.0347 0.0345
Schistosoma mansoni hypothetical protein 0.0051 0.0004 0.0002
Echinococcus multilocularis enteropeptidase 0.0171 0.0206 0.0265
Brugia malayi Trypsin family protein 0.0171 0.0206 0.0203
Echinococcus granulosus glycoprotein Antigen 5 0.0171 0.0206 0.0262
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0255 0.0347 0.0414
Echinococcus granulosus 7TM GPCR rhodopsin 0.0234 0.0311 0.0399
Echinococcus granulosus g protein coupled receptor 0.0234 0.0311 0.0399
Echinococcus multilocularis integrin alpha ps 0.0994 0.1587 0.2047
Echinococcus granulosus neuropeptide Y receptor 0.0234 0.0311 0.0399
Onchocerca volvulus 0.0234 0.0311 0.1784
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Giardia lamblia Tenascin-37 0.018 0.0221 0.5
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0223 0.0293 0.0375
Echinococcus multilocularis neuropeptide Y receptor 0.0234 0.0311 0.0402
Echinococcus granulosus rhodopsin orphan GPCR 0.0234 0.0311 0.0399
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0255 0.0347 0.0345
Brugia malayi hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) ACC-1 protein 0.0255 0.0347 0.0345
Schistosoma mansoni nAChR subunit 0.0255 0.0347 0.0414
Brugia malayi Metabotropic glutamate receptor precursor. 0.0077 0.0049 0.0046
Schistosoma mansoni neuropeptide F-like receptor 0.0234 0.0311 0.0371
Loa Loa (eye worm) integrin alpha pat-2 0.2092 0.3427 0.3425
Loa Loa (eye worm) GABA receptor subunit 0.0133 0.0143 0.0141
Brugia malayi putative neuropeptide receptor NPR1 0.0234 0.0311 0.0309
Schistosoma mansoni cercarial elastase (S01 family) 0.0171 0.0206 0.0244
Loa Loa (eye worm) hypothetical protein 0.02 0.0254 0.0252
Brugia malayi Receptor family ligand binding region containing protein 0.0077 0.0049 0.0046
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1037 0.1657 0.1655
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0122 0.0123 0.0121
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0255 0.0347 0.0345
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0223 0.0293 0.0349
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0234 0.0311 0.0371
Onchocerca volvulus 0.0234 0.0311 0.1784
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0171 0.0206 0.0203
Schistosoma mansoni neuropeptide F-like receptor 0.0234 0.0311 0.0371
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0234 0.0311 0.0371
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus granulosus insulin receptor 0.0059 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0077 0.0049 0.0046
Echinococcus multilocularis neuropeptide FF receptor 2 0.0234 0.0311 0.0402
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0234 0.0311 0.0371
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0255 0.0347 0.0345
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0234 0.0311 0.0402
Loa Loa (eye worm) hypothetical protein 0.1182 0.1901 0.1898
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 0.0236 1
Onchocerca volvulus 0.0171 0.0206 0.1065
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0255 0.0347 0.0345
Schistosoma mansoni protein kinase 0.0253 0.0343 0.0409
Echinococcus granulosus glutamate receptor 2 0.0077 0.0049 0.006
Onchocerca volvulus 0.02 0.0254 0.1394
Onchocerca volvulus Neuropeptide F receptor homolog 0.0234 0.0311 0.1784
Echinococcus granulosus epidermal growth factor receptor 0.0165 0.0196 0.025
Schistosoma mansoni cercarial elastase (S01 family) 0.0171 0.0206 0.0244
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1023 0.1635 0.1961
Toxoplasma gondii hypothetical protein 0.0205 0.0264 0.0639
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0234 0.0311 0.0399
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0234 0.0311 0.0402
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0223 0.0293 0.0378
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0081 0.0101
Onchocerca volvulus 0.0171 0.0206 0.1065
Echinococcus multilocularis g-protein coupled receptor 0.0234 0.0311 0.0402
Schistosoma mansoni serine-type protease inhibitor 0.5013 0.8325 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0234 0.0311 0.0371
Loa Loa (eye worm) hypothetical protein 0.0126 0.0131 0.0128
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0255 0.0347 0.0345
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0133 0.0143 0.0141
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0234 0.0311 0.0402
Echinococcus granulosus glycine receptor subunit beta 0.0255 0.0347 0.0445
Mycobacterium ulcerans hypothetical protein 0.0189 0.0236 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0325 0.0465 0.0596
Schistosoma mansoni alpha-1 adrenergic receptor 0.0234 0.0311 0.0371
Brugia malayi PAN domain containing protein 0.0205 0.0264 0.0261
Brugia malayi hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0223 0.0293 0.0378
Echinococcus granulosus tm gpcr rhodopsin 0.0234 0.0311 0.0399
Onchocerca volvulus 0.0234 0.0311 0.1784
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0234 0.0311 0.0371
Loa Loa (eye worm) hypothetical protein 0.0083 0.0058 0.0056
Onchocerca volvulus 0.0234 0.0311 0.1784
Brugia malayi hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) acetylcholine receptor protein 0.0122 0.0123 0.0121
Echinococcus granulosus neuropeptide Y receptor 0.0234 0.0311 0.0399
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0255 0.0347 0.0345
Toxoplasma gondii PAN domain-containing protein 0.0205 0.0264 0.0639
Brugia malayi Dopamine receptor protein 1 0.0234 0.0311 0.0309
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0171 0.0206 0.0244
Loa Loa (eye worm) hypothetical protein 0.0133 0.0143 0.0141
Schistosoma mansoni neuropeptide receptor 0.0234 0.0311 0.0371
Loa Loa (eye worm) hypothetical protein 0.0068 0.0033 0.0031
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0223 0.0293 0.0375
Loa Loa (eye worm) hypothetical protein 0.0088 0.0067 0.0064
Loa Loa (eye worm) melatonin receptor type 1A 0.0234 0.0311 0.0309
Echinococcus granulosus glycine receptor subunit alpha 1 0.0255 0.0347 0.0445
Toxoplasma gondii microneme protein, putative 0.0205 0.0264 0.0639
Schistosoma mansoni hypothetical protein 0.0171 0.0206 0.0244
Echinococcus granulosus G protein coupled receptor 139 0.0234 0.0311 0.0399
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0255 0.0347 0.0445
Loa Loa (eye worm) hypothetical protein 0.0077 0.0049 0.0046
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0325 0.0465 0.0462
Echinococcus granulosus serotonin receptor 0.0234 0.0311 0.0399
Onchocerca volvulus 0.0205 0.0264 0.1459
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0234 0.0311 0.0399
Brugia malayi Kringle domain containing protein 0.0295 0.0413 0.0411
Loa Loa (eye worm) hypothetical protein 0.0077 0.0049 0.0046
Echinococcus granulosus fmrfamide receptor 0.0234 0.0311 0.0399
Onchocerca volvulus 0.0171 0.0206 0.1065
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0058 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0234 0.0311 0.0371
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0171 0.0206 0.0203
Schistosoma mansoni integrin beta subunit 0.3708 0.6136 0.737
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0255 0.0347 0.0345
Schistosoma mansoni hypothetical protein 0.0416 0.0617 0.0738
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0123 0.0121
Schistosoma mansoni biogenic amine (5HT) receptor 0.0234 0.0311 0.0371
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0123 0.0121
Onchocerca volvulus 0.0255 0.0347 0.2026
Echinococcus granulosus tm gpcr rhodopsin 0.0234 0.0311 0.0399
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0077 0.0049 0.0063
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Brugia malayi larval opioid receptor 0.0234 0.0311 0.0309
Schistosoma mansoni tyrosine kinase 0.0083 0.0058 0.0067
Giardia lamblia Neurogenic locus Notch protein precursor 0.018 0.0221 0.5
Brugia malayi Serotonin receptor 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Schistosoma mansoni metabotropic glutamate receptor 0.0077 0.0049 0.0056
Loa Loa (eye worm) hypothetical protein 0.0133 0.0143 0.0141
Schistosoma mansoni myosin xvIII 0.0234 0.0311 0.0371
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0234 0.0311 0.0371
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0122 0.0123 0.0156
Loa Loa (eye worm) hypothetical protein 0.0133 0.0143 0.0141
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0223 0.0293 0.0378
Echinococcus granulosus glycine receptor subunit beta 0.0255 0.0347 0.0445
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0122 0.0123 0.0159
Brugia malayi putative neuropeptide receptor 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Toxoplasma gondii hypothetical protein 0.018 0.0221 0.0525
Brugia malayi RE15519p 0.0234 0.0311 0.0309
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0325 0.0465 0.06
Echinococcus multilocularis g protein coupled receptor 0.0234 0.0311 0.0402
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0234 0.0311 0.0402
Schistosoma mansoni hypothetical protein 0.0096 0.008 0.0093
Echinococcus granulosus transmembrane protease serine 3 0.0171 0.0206 0.0262
Echinococcus multilocularis integrin alpha ps 0.0868 0.1375 0.1774
Brugia malayi GnHR receptor homolog 0.0234 0.0311 0.0309
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0077 0.0049 0.0063
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0234 0.0311 0.0371
Entamoeba histolytica hypothetical protein 0.0133 0.0143 0.5039
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Loa Loa (eye worm) calcium channel 0.0223 0.0293 0.0291
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0234 0.0311 0.0371
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0223 0.0293 0.0375
Onchocerca volvulus 0.0205 0.0264 0.1459
Brugia malayi SEA domain containing protein 0.02 0.0254 0.0252
Schistosoma mansoni voltage-gated potassium channel 0.0552 0.0846 0.1013
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.0058 0.0072
Loa Loa (eye worm) hypothetical protein 0.0068 0.0033 0.0031
Schistosoma mansoni cercarial elastase (S01 family) 0.0171 0.0206 0.0244
Onchocerca volvulus 0.0295 0.0413 0.2475
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0234 0.0311 0.0402
Loa Loa (eye worm) hypothetical protein 0.0171 0.0206 0.0203
Onchocerca volvulus 0.0234 0.0311 0.1784
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0133 0.0143 0.0141
Echinococcus multilocularis transfer RNA-Gly 0.005 0.0003 0.0003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0081 0.0104
Echinococcus granulosus adam 0.018 0.0221 0.0282
Schistosoma mansoni nAChR subunit 0.0255 0.0347 0.0414
Brugia malayi hypothetical protein 0.0122 0.0123 0.0121
Schistosoma mansoni acetylcholine receptor subunit beta 0.0122 0.0123 0.0145
Schistosoma mansoni neuropeptide receptor 0.0234 0.0311 0.0371
Brugia malayi PAN domain containing protein 0.0205 0.0264 0.0261
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0122 0.0123 0.0121
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi Guanylyl cyclase protein 23 0.0108 0.0101 0.0098
Echinococcus multilocularis fmrfamide receptor 0.0234 0.0311 0.0402
Schistosoma mansoni hypothetical protein 0.02 0.0254 0.0302
Schistosoma mansoni cercarial elastase (S01 family) 0.0171 0.0206 0.0244
Schistosoma mansoni hypothetical protein 0.0083 0.0058 0.0067
Onchocerca volvulus 0.0234 0.0311 0.1784
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0077 0.0049 0.0046
Onchocerca volvulus 0.0784 0.1234 0.8054
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0955 0.1521 0.1824
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Toxoplasma gondii PAN domain-containing protein 0.0205 0.0264 0.0639
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0255 0.0347 0.0448
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Echinococcus granulosus tachykinin peptides receptor 99D 0.0234 0.0311 0.0399
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus granulosus voltage dependent calcium channel 0.0223 0.0293 0.0375
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0077 0.0049 0.0046
Echinococcus multilocularis g protein coupled receptor 0.0234 0.0311 0.0402
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0255 0.0347 0.0345
Schistosoma mansoni amine GPCR 0.0234 0.0311 0.0371
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0059 0.0019 0.0024
Onchocerca volvulus 0.0255 0.0347 0.2026
Giardia lamblia Tenascin-X 0.018 0.0221 0.5
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0578 0.0889 0.0887
Schistosoma mansoni nAChR subunit 0.0255 0.0347 0.0414
Loa Loa (eye worm) hypothetical protein 0.0171 0.0206 0.0203
Onchocerca volvulus 0.0205 0.0264 0.1459
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0122 0.0123 0.0121
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.176 0.287 0.3703
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0077 0.0049 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0171 0.0206 0.0244
Echinococcus multilocularis voltage gated potassium channel 0.005 0.0003 0.0003
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0325 0.0465 0.0596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0234 0.0311 0.0402
Echinococcus granulosus alpha 1A adrenergic receptor 0.0234 0.0311 0.0399
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0255 0.0347 0.0414
Echinococcus multilocularis adam 0.018 0.0221 0.0285
Echinococcus granulosus rhodopsin orphan GPCR 0.0234 0.0311 0.0399
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 0.0236 1
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.0058 0.0072
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0255 0.0347 0.0445
Plasmodium falciparum cysteine repeat modular protein 1 0.0295 0.0413 0.5
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Onchocerca volvulus 0.0948 0.1509 0.9921
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0948 0.1509 0.181
Loa Loa (eye worm) TYRA-2 protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0205 0.0264 0.0261
Brugia malayi PAN domain containing protein 0.0205 0.0264 0.0261
Loa Loa (eye worm) hypothetical protein 0.02 0.0254 0.0252
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0255 0.0347 0.0345
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0255 0.0347 0.0345
Schistosoma mansoni amine GPCR 0.0234 0.0311 0.0371
Loa Loa (eye worm) hypothetical protein 0.0205 0.0264 0.0261
Onchocerca volvulus 0.0133 0.0143 0.0639
Loa Loa (eye worm) hypothetical protein 0.0955 0.1521 0.1518
Loa Loa (eye worm) RGC/RGC protein kinase 0.0253 0.0343 0.034
Loa Loa (eye worm) hypothetical protein 0.0948 0.1509 0.1507
Brugia malayi hypothetical protein 0.0077 0.0049 0.0046
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0048 0.0054
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0234 0.0311 0.0402
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0234 0.0311 0.0399
Loa Loa (eye worm) hypothetical protein 0.018 0.0221 0.0218
Onchocerca volvulus 0.0234 0.0311 0.1784
Brugia malayi Protein kinase domain containing protein 0.0059 0.0019 0.0016
Schistosoma mansoni tyrosine kinase 0.0083 0.0058 0.0067
Echinococcus multilocularis kelch ECH associated protein 1 0.0095 0.0079 0.0102
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0058 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0234 0.0311 0.0402
Echinococcus multilocularis Mastin 0.0171 0.0206 0.0265
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0325 0.0465 0.06
Echinococcus multilocularis potassium voltage gated channel protein 0.005 0.0003 0.0003
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0189 0.0236 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0234 0.0311 0.0402
Loa Loa (eye worm) hypothetical protein 0.0205 0.0264 0.0261
Echinococcus granulosus biogenic amine 5HT receptor 0.0234 0.0311 0.0399
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0234 0.0311 0.0309
Echinococcus granulosus neuropeptides capa receptor 0.0234 0.0311 0.0399
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Onchocerca volvulus 0.0171 0.0206 0.1065
Brugia malayi EGF-like domain containing protein 0.018 0.0221 0.0218
Schistosoma mansoni amine GPCR 0.0234 0.0311 0.0371
Schistosoma mansoni neurotransmitter gated ion channel 0.0122 0.0123 0.0145
Brugia malayi hypothetical protein 0.0122 0.0123 0.0121
Echinococcus granulosus neuropeptide receptor 0.0234 0.0311 0.0399
Schistosoma mansoni biogenic amine receptor 0.0234 0.0311 0.0371
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0255 0.0347 0.0345
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0058 0.0067
Loa Loa (eye worm) PAN domain-containing protein 0.0205 0.0264 0.0261
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0234 0.0311 0.0402
Schistosoma mansoni nAChR subunit 0.0255 0.0347 0.0414
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0234 0.0311 0.0371
Loa Loa (eye worm) hypothetical protein 0.0171 0.0206 0.0203
Onchocerca volvulus 0.0133 0.0143 0.0639
Brugia malayi Tachykinin-like peptides receptor 99D 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Echinococcus granulosus atrial natriuretic peptide receptor 0.0222 0.0291 0.0372
Giardia lamblia Tenascin-like 0.018 0.0221 0.5
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0171 0.0206 0.0265
Loa Loa (eye worm) hypothetical protein 0.0205 0.0264 0.0261
Brugia malayi EGF-like domain containing protein 0.018 0.0221 0.0218
Loa Loa (eye worm) hypothetical protein 0.0077 0.0049 0.0046
Echinococcus granulosus receptor type guanylyl cyclase 0.0253 0.0343 0.0439
Echinococcus multilocularis glutamate receptor 2 0.0077 0.0049 0.0063
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Brugia malayi hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi hypothetical protein 0.0122 0.0123 0.0121
Echinococcus multilocularis nmda type glutamate receptor 0.0077 0.0049 0.0063
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Echinococcus multilocularis tissue type plasminogen activator 0.0295 0.0413 0.0533
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi Cation transporter family protein 0.0255 0.0347 0.0345
Echinococcus granulosus hypothetical protein 0.0234 0.0311 0.0399
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0171 0.0206 0.0244
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0255 0.0347 0.0448
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0234 0.0311 0.0371
Schistosoma mansoni glutamate receptor NMDA 0.0077 0.0049 0.0056
Echinococcus multilocularis voltage dependent calcium channel 0.0223 0.0293 0.0378
Echinococcus multilocularis neuropeptide Y receptor 0.0234 0.0311 0.0402
Toxoplasma gondii PAN domain-containing protein 0.0205 0.0264 0.0639
Echinococcus multilocularis neuropeptides capa receptor 0.0234 0.0311 0.0402
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0171 0.0206 0.0262
Echinococcus granulosus kelch ECH associated protein 1 like 0.0095 0.0079 0.0099
Loa Loa (eye worm) hypothetical protein 0.0963 0.1534 0.1532
Schistosoma mansoni neuropeptide receptor 0.0234 0.0311 0.0371
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0552 0.0846 0.0843
Loa Loa (eye worm) RGC/RGC protein kinase 0.0108 0.0101 0.0098
Echinococcus multilocularis fmrfamide receptor 0.0234 0.0311 0.0402
Schistosoma mansoni voltage-gated cation channel 0.0223 0.0293 0.0349
Loa Loa (eye worm) hypothetical protein 0.0133 0.0143 0.0141
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus granulosus sex peptide receptor 0.0234 0.0311 0.0399
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0013 0.001
Schistosoma mansoni hypothetical protein 0.0295 0.0413 0.0493
Schistosoma mansoni integrin alpha-ps 0.0578 0.0889 0.1065
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.005 0.0003 0.0003
Toxoplasma gondii kringle domain-containing protein 0.0295 0.0413 0.104
Echinococcus multilocularis transmembrane protease serine 3 0.0171 0.0206 0.0265
Brugia malayi Receptor family ligand binding region containing protein 0.0253 0.0343 0.034
Brugia malayi Dopamine receptor protein 2 0.0234 0.0311 0.0309
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0255 0.0347 0.0345
Loa Loa (eye worm) RGC/RGC protein kinase 0.0253 0.0343 0.034
Loa Loa (eye worm) ACC-1 protein 0.0255 0.0347 0.0345
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0948 0.1509 0.181
Echinococcus granulosus neuropeptide receptor 0.0234 0.0311 0.0399
Onchocerca volvulus Putative nachr subunit 0.0325 0.0465 0.2825
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0189 0.0236 0.0233
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0013 0.001
Brugia malayi PAN domain containing protein 0.0205 0.0264 0.0261
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0189 0.0236 0.0564
Brugia malayi Dopamine receptor 0.0234 0.0311 0.0309
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0077 0.0049 0.0063
Schistosoma mansoni serine-type protease inhibitor 0.5013 0.8325 1
Schistosoma mansoni tyrosine kinase 0.0165 0.0196 0.0233
Echinococcus granulosus metabotropic glutamate receptor 2 0.0077 0.0049 0.006
Schistosoma mansoni amine GPCR 0.0234 0.0311 0.0371
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0234 0.0311 0.0371
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Echinococcus multilocularis integrin alpha ps 0.0416 0.0617 0.0796
Loa Loa (eye worm) PAN domain-containing protein 0.0205 0.0264 0.0261
Echinococcus multilocularis insulin receptor 0.0059 0.0019 0.0024
Loa Loa (eye worm) neuropeptide F receptor 0.0234 0.0311 0.0309
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0311 0.0309
Brugia malayi Trypsin family protein 0.0171 0.0206 0.0203
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Brugia malayi Serotonin receptor 0.0234 0.0311 0.0309
Echinococcus granulosus integrin alpha ps 0.0416 0.0617 0.0793
Schistosoma mansoni cercarial elastase (S01 family) 0.0171 0.0206 0.0244
Echinococcus granulosus fibrillin 1 0.018 0.0221 0.0282
Brugia malayi Cation transporter family protein 0.0255 0.0347 0.0345
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0255 0.0347 0.0448
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0123 0.0121
Schistosoma mansoni biogenic amine receptor 0.0234 0.0311 0.0371
Onchocerca volvulus 0.0205 0.0264 0.1459
Schistosoma mansoni tyrosine kinase 0.0093 0.0076 0.0088
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0077 0.0049 0.006
Schistosoma mansoni hypothetical protein 0.0083 0.0058 0.0067
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0234 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus multilocularis fibrillin 1 0.018 0.0221 0.0285
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0255 0.0347 0.0345
Loa Loa (eye worm) hypothetical protein 0.0542 0.0829 0.0826
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0255 0.0347 0.0345
Loa Loa (eye worm) hypothetical protein 0.0552 0.0846 0.0843
Echinococcus multilocularis nAChR subunit 0.0133 0.0143 0.0185
Loa Loa (eye worm) DOMON domain-containing protein 0.02 0.0254 0.0252
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0325 0.0465 0.0596
Echinococcus multilocularis glutamate receptor 2 0.0077 0.0049 0.0063
Loa Loa (eye worm) hypothetical protein 0.0122 0.0123 0.0121
Brugia malayi hypothetical protein 0.0963 0.1534 0.1532
Echinococcus granulosus Mastin 0.0171 0.0206 0.0262
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0171 0.0206 0.0262
Brugia malayi Muscle positioning protein 4 0.02 0.0254 0.0252
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0234 0.0311 0.0309
Echinococcus granulosus epidermal growth factor receptor 0.0093 0.0076 0.0094
Echinococcus multilocularis somatostatin receptor 0.0234 0.0311 0.0402
Schistosoma mansoni cercarial elastase (S01 family) 0.0171 0.0206 0.0244
Loa Loa (eye worm) hypothetical protein 0.0255 0.0347 0.0345
Schistosoma mansoni tyrosine kinase 0.0088 0.0067 0.0077
Loa Loa (eye worm) hypothetical protein 0.0234 0.0311 0.0309
Echinococcus granulosus glycine receptor subunit alpha 1 0.0255 0.0347 0.0445
Echinococcus multilocularis glycine receptor subunit beta 0.0255 0.0347 0.0448
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0255 0.0347 0.0345
Echinococcus granulosus g-protein coupled receptor 0.0234 0.0311 0.0399
Giardia lamblia Neurogenic locus notch-like protein 0.018 0.0221 0.5
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0995 0.1587 0.1585
Schistosoma mansoni acetylcholine receptor-related 0.0122 0.0123 0.0145
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0171 0.0206 0.0244
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0234 0.0311 0.0309
Echinococcus granulosus neuropeptide s receptor 0.0234 0.0311 0.0399

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 92 nM Compound was tested for the inhibition of type 2 5-alpha-reductase of human prostates ChEMBL. 11425544
IC50 (binding) = 92 nM Compound was tested for the inhibition of type 2 5-alpha-reductase of human prostates ChEMBL. 11425544

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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