Detailed information for compound 702973

Basic information

Technical information
  • TDR Targets ID: 702973
  • Name: 5-[(2,6-dimethylmorpholin-4-yl)-(3-fluorophen yl)methyl]-2-ethyl-[1,3]thiazolo[2,3-e][1,2,4 ]triazol-6-ol
  • MW: 390.475 | Formula: C19H23FN4O2S
  • H donors: 1 H acceptors: 3 LogP: 3.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nn2c(n1)sc(c2O)C(c1cccc(c1)F)N1CC(C)OC(C1)C
  • InChi: 1S/C19H23FN4O2S/c1-4-15-21-19-24(22-15)18(25)17(27-19)16(13-6-5-7-14(20)8-13)23-9-11(2)26-12(3)10-23/h5-8,11-12,16,25H,4,9-10H2,1-3H3
  • InChiKey: XBNWGJNHMHCLNG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(2,6-dimethylmorpholin-4-yl)-(3-fluorophenyl)methyl]-2-ethyl-thiazolo[2,3-e][1,2,4]triazol-6-ol
  • 5-[(2,6-dimethyl-4-morpholinyl)-(3-fluorophenyl)methyl]-2-ethyl-6-thiazolo[2,3-e][1,2,4]triazolol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.1034 0.477
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0589 0.5368
Loa Loa (eye worm) phosphofructokinase 0.0115 0.1034 0.4686
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0378 0.3175
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0092 0.0014
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.035 0.3652 0.3599
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.0725 0.3226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0473 0.2166
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0067 0.0489 0.1994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0273 0.1234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.033 0.15
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0088 0.0725 0.2065
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0153 0.0838
Entamoeba histolytica hypothetical protein 0.0038 0.0171 0.0833
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0092 0.0014
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Echinococcus multilocularis GPCR, family 2 0.0031 0.0088 0.0049
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0493 0.4373
Brugia malayi hypothetical protein 0.0038 0.0171 0.047
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0092 0.0396
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0216 0.2159 0.6609
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0147 0.0768
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0067 0.0489 0.2113
Schistosoma mansoni hypothetical protein 0.0116 0.1043 0.4648
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0116 0.1043 0.3072
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.1034 0.3044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0088 0.0221
Brugia malayi hypothetical protein 0.003 0.0084 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0084 0.0355
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0489 0.1994
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0493 0.2258
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0217 0.0974
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1079 0.49
Mycobacterium ulcerans lipase LipD 0.0036 0.0147 0.1419
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0092 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0524 0.2402
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0084 0.0112
Leishmania major protein kinase, putative 0.0067 0.0489 0.433
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0378 0.3175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0473 0.2166
Brugia malayi hypothetical protein 0.003 0.0084 0.0051
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Loa Loa (eye worm) beta-lactamase 0.0036 0.0147 0.0497
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0084 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.033 0.15
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0488 0.1988
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0084 0.0051
Loa Loa (eye worm) sugar transporter 0.003 0.0084 0.0199
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0378 0.1589
Plasmodium falciparum hexose transporter 0.0216 0.2159 0.2093
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0147 0.0354
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0378 0.1723
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.4373
Echinococcus granulosus solute carrier family 22 0.003 0.0084 0.0034
Schistosoma mansoni sugar transporter 0.003 0.0084 0.0051
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.2107
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Plasmodium vivax calcium-dependent protein kinase, putative 0.0067 0.0489 0.0409
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0469 0.1897
Loa Loa (eye worm) sugar transporter 0.0216 0.2159 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0067 0.0489 0.0409
Trypanosoma cruzi hexose transporter 0.0067 0.0493 0.4373
Brugia malayi beta-lactamase 0.0036 0.0147 0.0354
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0216 0.2159 0.6609
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0438 0.1156
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0202 0.0622
Brugia malayi beta-lactamase family protein 0.0036 0.0147 0.0354
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.035 0.3652 0.5499
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.0725 0.3124
Schistosoma mansoni thyroid hormone receptor 0.0125 0.1147 0.5148
Trypanosoma brucei target of rapamycin kinase 3, putative 0.007 0.0525 0.4704
Toxoplasma gondii protein kinase, putative 0.0611 0.6573 1
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0073
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0076 0.0589 0.5368
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0092 0.0895
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0493 0.4373
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0283 0.2188
Loa Loa (eye worm) hypothetical protein 0.0061 0.0423 0.1803
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0084 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0084 0.0355
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.1034 0.477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0725 0.3334
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0092 0.0014
Brugia malayi major facilitator superfamily protein 0.003 0.0084 0.0051
Schistosoma mansoni hypothetical protein 0.0038 0.0171 0.047
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0065 0.0469 0.1254
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0092 0.0396
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0147 0.0282
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0067 0.0489 0.0409
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0076 0.0589 0.5368
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0589 0.5368
Loa Loa (eye worm) hypothetical protein 0.0065 0.0469 0.2017
Trichomonas vaginalis esterase, putative 0.0036 0.0147 0.0648
Schistosoma mansoni glucose transporter 0.003 0.0084 0.0051
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.007 0.0525 0.4704
Brugia malayi MAP kinase sur-1 0.0057 0.0378 0.1462
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Echinococcus multilocularis General substrate transporter 0.0186 0.182 0.5533
Leishmania major glucose transporter/membrane transporter D2, putative 0.0067 0.0493 0.4373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0473 0.2166
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0088 0.0725 0.3124
Trypanosoma brucei sugar transporter, putative 0.003 0.0084 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0473 0.2166
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0171 0.047
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0283 0.2188
Loa Loa (eye worm) hypothetical protein 0.0053 0.0333 0.1375
Schistosoma mansoni glucose transport protein 0.0216 0.2159 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0147 0.1419
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0084 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0402 0.1834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0581 0.2668
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0147 0.0648
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0489 0.2239
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0378 0.3175
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0092 0.0138
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0283 0.2739
Schistosoma mansoni sugar transporter 0.003 0.0084 0.0051
Brugia malayi Cam kinase protein 1 0.0067 0.0489 0.1994
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Schistosoma mansoni sugar transporter 0.003 0.0084 0.0051
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0084 0.0809
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0088 0.0049
Brugia malayi 6-phosphofructokinase 0.0115 0.1034 0.4605
Giardia lamblia Prolyl-tRNA synthetase 0.0065 0.0469 0.6005
Mycobacterium ulcerans hypothetical protein 0.0036 0.0147 0.1419
Brugia malayi phosphofructokinase 0.0115 0.1034 0.4605
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0084 0.0034
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.1034 0.4255
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0493 0.4373
Echinococcus granulosus caspase 2 0.0061 0.0423 0.111
Trypanosoma brucei protein kinase, putative 0.0057 0.0378 0.3175
Toxoplasma gondii ABC1 family protein 0.0036 0.0147 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0493 0.2258
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0088 0.0725 0.6783
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0073 0.0306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0293 0.0697
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0065 0.0469 0.1254
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0378 0.1723
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0147 0.0354
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0589 0.5368
Plasmodium falciparum calcium-dependent protein kinase 2 0.0067 0.0489 0.0409
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0084 0.0809
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0378 0.4592
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.1034 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0216 0.2159 0.3198
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0147 0.0497
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0283 0.2739
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0283 0.1538
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.2159 1
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0378 0.0966
Trichomonas vaginalis glucose transporter, putative 0.003 0.0084 0.0355
Echinococcus granulosus General substrate transporter 0.0186 0.182 0.5533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.033 0.15
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0469 0.1897
Plasmodium vivax CDK-related protein kinase 6, putative 0.0917 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0073 0.0306
Schistosoma mansoni protein kinase 0.0067 0.0489 0.1994
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.4373
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0092 0.0396
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0084 0.0809
Brugia malayi Sugar transporter family protein 0.0216 0.2159 1
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0283 0.0666
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0073
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0219 0.0464
Schistosoma mansoni sugar transporter 0.003 0.0084 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0381 0.1736
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0283 0.0201
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0202 0.053
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0084 0.0355
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0092 0.0396
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0293 0.0697
Plasmodium falciparum mitogen-activated protein kinase 2 0.035 0.3652 0.3599
Loa Loa (eye worm) phosphatidylinositol 3 0.0029 0.0073 0.0148
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0493 0.4373
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0293 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0084 0.0355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0324 0.1473
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0092 0.0009
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0092 0.3267
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0088 0.0049
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0147 0.0282
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0489 0.1318
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0489 0.1318
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0378 0.3175
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0084 0.0051
Loa Loa (eye worm) hypothetical protein 0.0065 0.0469 0.2017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0147 0.0497
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0216 0.2159 0.6609
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0147 0.0768
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0283 0.0201
Loa Loa (eye worm) hypothetical protein 0.0067 0.0489 0.2113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0725 0.3334
Loa Loa (eye worm) hypothetical protein 0.0036 0.0147 0.0497
Loa Loa (eye worm) hypothetical protein 0.0036 0.0147 0.0497
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0171 0.031
Trypanosoma cruzi target of rapamycin kinase 3 0.007 0.0525 0.4704
Giardia lamblia GTOR 0.0088 0.0725 1
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0073
Brugia malayi major facilitator superfamily protein 0.003 0.0084 0.0051
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0283 0.0307
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.1034 0.3044
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0084 0.0355
Mycobacterium tuberculosis Conserved protein 0.0036 0.0147 0.0282
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0067 0.0489 0.0625
Brugia malayi 6-phosphofructokinase 0.0115 0.1034 0.4605
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0489 0.1318
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0147 0.0282
Schistosoma mansoni glucose transport protein 0.0216 0.2159 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0147 0.0497
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0147 0.0768
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0147 0.0648
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0216 0.2159 0.6609
Echinococcus multilocularis solute carrier family 22 0.003 0.0084 0.0034
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0041 0.0208 0.1404
Toxoplasma gondii target of rapamycin (TOR), putative 0.0065 0.0473 0.0601
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0092 0.3267
Mycobacterium ulcerans sugar transporter 0.003 0.0084 0.0809
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0283 0.1008
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0084 0.0034
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0493 0.2258
Entamoeba histolytica protein kinase, putative 0.0067 0.0489 0.4212
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0036 0.0151 0.0816
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0283 0.1008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0473 0.2166
Loa Loa (eye worm) hypothetical protein 0.0046 0.0254 0.1005
Echinococcus granulosus tumor protein p63 0.0312 0.323 1
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.1034 0.4605
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0092 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0092 0.0396
Trypanosoma brucei glucose transporter 2A 0.0067 0.0493 0.4373
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0524 0.2402
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0067 0.0489 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0524 0.2402
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0084 0.0034
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Onchocerca volvulus 0.0036 0.0147 0.1856
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.4373
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Entamoeba histolytica protein kinase, putative 0.0067 0.0489 0.4212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0088 0.0725 0.6783
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0832 0.3732
Schistosoma mansoni thyroid hormone receptor 0.0125 0.1147 0.5148
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0092 0.0396
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0084 0.0199
Leishmania major glucose transporter, lmgt1 0.0067 0.0493 0.4373
Loa Loa (eye worm) hypothetical protein 0.0048 0.0283 0.1141
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0065 0.0469 0.1897
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0147 0.0648
Echinococcus multilocularis thyroid hormone receptor alpha 0.0125 0.1147 0.3402
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0073
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0378 0.3175
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0076 0.0589 0.0778
Trypanosoma cruzi sugar transporter, putative 0.003 0.0084 0.0112
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Plasmodium falciparum proline--tRNA ligase 0.0076 0.0589 0.0509
Echinococcus granulosus GPCR family 2 0.0031 0.0088 0.0049
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0088 0.0725 0.6783
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0147 0.0648
Plasmodium vivax hexose transporter 0.0216 0.2159 0.2093
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0088 0.0049
Loa Loa (eye worm) hypothetical protein 0.0097 0.0832 0.3732
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.4373
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0216 0.2159 0.6609
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Entamoeba histolytica hypothetical protein 0.0048 0.0283 0.2025
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Leishmania major glucose transporter, lmgt2 0.0067 0.0493 0.4373
Brugia malayi Sugar transporter family protein 0.003 0.0084 0.0051
Brugia malayi MH2 domain containing protein 0.0119 0.1079 0.4823
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0293 0.0697
Entamoeba histolytica hypothetical protein 0.0038 0.0171 0.0833
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0147 0.0234
Brugia malayi hypothetical protein 0.0043 0.0219 0.0702
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0473 0.2166
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0147 0.0282
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.1034 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0832 0.3638
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.2316 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0216 0.2159 0.6609
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0147 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0073 0.0306
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0116 0.1043 0.3072
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0254 0.0869
Echinococcus multilocularis caspase 2 0.0061 0.0423 0.111
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0092 0.0009
Schistosoma mansoni hypothetical protein 0.0043 0.0219 0.0702
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0088 0.0049
Echinococcus multilocularis tumor protein p63 0.0312 0.323 1
Plasmodium falciparum protein kinase 7 0.0611 0.6573 0.6544
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.1034 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.1034 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.1034 0.4686
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0092 0.0396
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0378 0.0966
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0378 0.1723
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0088 0.0221
Brugia malayi Sugar transporter family protein 0.003 0.0084 0.0051
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0147 0.0282
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0088 0.0725 0.6783
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0088 0.0725 0.6717
Schistosoma mansoni hypothetical protein 0.0216 0.2159 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0067 0.0489 0.0409
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0283 0.2188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0293 0.1055
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0493 0.4373
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0088 0.0725 0.6717
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0147 0.0354
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0378 0.0966
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0493 0.2258
Echinococcus granulosus solute carrier family 22 0.003 0.0084 0.0034
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Plasmodium falciparum calcium-dependent protein kinase 4 0.0067 0.0489 0.0409
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0088 0.0725 0.6783
Brugia malayi Cell death protein 3 precursor 0.0061 0.0423 0.168
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0283 0.1282
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0216 0.2159 0.6609
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Leishmania major glucose transporter, lmgt3 0.0067 0.0493 0.4373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0273 0.1234
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0067 0.0489 0.0409
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.1034 0.477
Trypanosoma cruzi glucose transporter, putative 0.003 0.0084 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0524 0.2402
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0084 0.0199
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0084 0.0034
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0067 0.0489 0.2113
Schistosoma mansoni hypothetical protein 0.0067 0.0488 0.1988
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0147 0.1419
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0493 0.2258
Brugia malayi hypothetical protein 0.003 0.0084 0.0051
Trypanosoma cruzi hexose transporter, putative 0.003 0.0084 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0524 0.2402
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0065 0.0469 0.2144
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0084 0.0051
Echinococcus multilocularis solute carrier family 22 0.003 0.0084 0.0034
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.4373
Schistosoma mansoni protein kinase 0.0067 0.0489 0.1994
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Mycobacterium tuberculosis Conserved protein 0.0036 0.0147 0.0282
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0274 0.1238
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0489 0.1318
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0293 0.1055
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0489 0.1318
Loa Loa (eye worm) hypothetical protein 0.0036 0.0147 0.0497
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0147 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0273 0.1234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0473 0.2166
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.1034 0.477
Onchocerca volvulus 0.0046 0.0254 0.502
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0832 0.3638
Echinococcus granulosus solute carrier family 22 0.003 0.0084 0.0034
Leishmania major hypothetical protein, conserved 0.0036 0.0147 0.0768
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0147 0.0648
Plasmodium falciparum calcium-dependent protein kinase 3 0.0067 0.0489 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0084 0.0355
Schistosoma mansoni protein kinase 0.0067 0.0489 0.1994
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Loa Loa (eye worm) hypothetical protein 0.0043 0.0219 0.084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0324 0.1473
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0378 0.0966
Leishmania major hypothetical protein, conserved 0.003 0.0084 0.0112
Schistosoma mansoni caspase-7 (C14 family) 0.0061 0.0423 0.168
Echinococcus granulosus solute carrier family 22 0.003 0.0084 0.0034
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0489 0.1318
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0489 0.1318
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0293 0.1055
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0378 0.1723
Onchocerca volvulus 0.0036 0.0147 0.1856
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.4373
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Brugia malayi beta-lactamase family protein 0.0036 0.0147 0.0354
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0283 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0067 0.0489 0.0625
Plasmodium vivax proline--tRNA ligase, putative 0.0076 0.0589 0.0509
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0216 0.2159 0.6609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0725 0.3334
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0283 0.1008
Entamoeba histolytica hypothetical protein 0.0038 0.0171 0.0833
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0147 0.0282
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0283 0.3112
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.1034 1
Trypanosoma brucei glucose transporter 1E 0.0067 0.0493 0.4373
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0378 0.0454
Onchocerca volvulus Cell death protein 3 homolog 0.0061 0.0423 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.1034 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0088 0.0725 0.2065
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0378 0.1462
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0493 0.2258
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.0202 0.053
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0088 0.0073
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0067 0.0489 0.1318
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0147 0.0064
Echinococcus multilocularis solute carrier family 22 0.003 0.0084 0.0034
Mycobacterium tuberculosis Conserved protein 0.0036 0.0147 0.0282
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.4373
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0219 0.0464
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0293 0.1055
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1079 0.49
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0073 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0084 0.0355
Entamoeba histolytica hypothetical protein 0.0038 0.0171 0.0833
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0378 0.3175
Onchocerca volvulus 0.0036 0.0147 0.1856
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0147 0.1419
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0065 0.0469 0.3629
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0283 0.0666
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.1034 1
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.1034 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0274 0.1238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0274 0.1238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0274 0.1238
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.4373
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0065 0.0469 0.1897
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0171 0.031
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0067 0.0489 0.433
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0065 0.0469 0.3996
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0088 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0073 0.0306
Onchocerca volvulus 0.0043 0.0219 0.3993
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0493 0.4373
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0067 0.0489 0.0625
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0293 0.1188
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0088 0.0725 0.6783
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0378 0.3175
Trichomonas vaginalis sugar transporter, putative 0.003 0.0084 0.0355
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0438 0.1156
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.1034 0.4605
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0493 0.2258
Loa Loa (eye worm) hypothetical protein 0.0036 0.0147 0.0497
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.1034 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.1034 0.4686
Echinococcus multilocularis solute carrier family 22 0.003 0.0084 0.0034
Schistosoma mansoni glucose transport protein 0.0216 0.2159 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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