TDR Targets

Basic information

Technical information

TDR Targets ID: 705358
Name: 4-bromo-N-(2-furan-2-yl-2-thiophen-2-ylsulfon ylethyl)benzenesulfonamide
MW: 476.385 | Formula: C16H14BrNO5S3
H donors: 1 H acceptors: 4 LogP: 3.16 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(cc1)S(=O)(=O)NCC(S(=O)(=O)c1cccs1)c1ccco1
InChi: 1S/C16H14BrNO5S3/c17-12-5-7-13(8-6-12)26(21,22)18-11-15(14-3-1-9-23-14)25(19,20)16-4-2-10-24-16/h1-10,15,18H,11H2
InChiKey: SUWXVLZRBURDNV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-bromo-N-[2-(2-furyl)-2-(2-thienylsulfonyl)ethyl]benzenesulfonamide
4-bromo-N-(2-furan-2-yl-2-thiophen-2-ylsulfonyl-ethyl)benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0137	0.0538
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0136	0.0614	0.2659
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0136	0.0614	0.0928
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0033	0.0468
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0025	0.0016	0.0325
Schistosoma mansoni	glucose transport protein	0.0441	0.2265	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.0043	0.0028
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0054	0.0175	0.0709
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0137	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0217	0.0894
Entamoeba histolytica	hypothetical protein	0.0037	0.008	0.1073
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.0481	0.2122
Brugia malayi	acetyltransferase, GNAT family protein	0.0162	0.0755	0.3288
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0137	0.0538
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0059	0.0201	0.2805
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0162	0.0755	0.3288
Trichomonas vaginalis	sugar transporter, putative	0.0137	0.0621	0.274
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0136	0.0614	0.06
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0614	0.2659
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0132	0.0597	0.2583
Schistosoma mansoni	protein kinase	0.0136	0.0614	0.2659
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.0043	0.0028
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0136	0.0614	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0597	0.2583
Echinococcus granulosus	solute carrier family 22	0.0062	0.0217	0.0894
Brugia malayi	hypothetical protein	0.0037	0.008	0.0285
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0136	0.0614	0.2659
Schistosoma mansoni	hypothetical protein	0.0037	0.008	0.0285
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0621	0.868
Schistosoma mansoni	glucose transport protein	0.0441	0.2265	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Brugia malayi	Major Facilitator Superfamily protein	0.0062	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0137	0.0538
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.003	0.0043	0.0698
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0033	0.0051
Toxoplasma gondii	sugar transporter ST2	0.0062	0.0217	0.0327
Schistosoma mansoni	6-phosphofructokinase	0.0111	0.0481	0.2067
Giardia lamblia	Prolyl-tRNA synthetase	0.0132	0.0597	1
Echinococcus granulosus	calcium dependent protein kinase	0.0127	0.0566	0.2448
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0621	0.868
Plasmodium falciparum	lysine--tRNA ligase	0.0098	0.0414	0.0399
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0059	0.0201	0.2805
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0062	0.0217	0.4507
Brugia malayi	MAP kinase sur-1	0.0059	0.0201	0.0822
Plasmodium falciparum	hexose transporter	0.0441	0.2265	0.2253
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0059	0.0201	0.2805
Trichomonas vaginalis	conserved hypothetical protein	0.0441	0.2265	1
Echinococcus multilocularis	caspase 2	0.0058	0.0198	0.0809
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0098	0.0414	0.8603
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0025	0.0016	0.0262
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0025	0.0016	0.0218
Brugia malayi	major facilitator superfamily protein	0.0062	0.0217	0.0894
Schistosoma mansoni	protein kinase	0.0136	0.0614	0.2659
Trichomonas vaginalis	conserved hypothetical protein	0.0137	0.0621	0.274
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0033	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Trypanosoma cruzi	hexose transporter, putative	0.0137	0.0621	0.868
Loa Loa (eye worm)	phosphofructokinase	0.0111	0.0481	0.2067
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0025	0.0016	0.0069
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.0481	0.7774
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0441	0.2265	1
Echinococcus multilocularis	calcium dependent protein kinase	0.0127	0.0566	0.2448
Onchocerca volvulus		0.0062	0.0217	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0062	0.0217	0.0894
Plasmodium vivax	lysine--tRNA ligase, putative	0.0098	0.0414	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Entamoeba histolytica	hypothetical protein	0.0098	0.0414	0.6652
Schistosoma mansoni	serine/threonine protein kinase	0.0136	0.0614	0.2659
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0048	0.0138	0.0611
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0441	0.2265	1
Brugia malayi	Cam kinase protein 1	0.0136	0.0614	0.2659
Trichomonas vaginalis	glucose transporter, putative	0.0137	0.0621	0.274
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0047	0.0134	0.279
Trypanosoma cruzi	hexose transporter, putative	0.0137	0.0621	0.868
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0137	0.0621	0.868
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0621	0.868
Plasmodium vivax	hexose transporter	0.0441	0.2265	0.2253
Plasmodium falciparum	protein kinase 7	0.1247	0.6618	0.6613
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0137	0.0538
Mycobacterium ulcerans	sugar transporter	0.0062	0.0217	0.4507
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0154	0.0715	1
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0059	0.0201	0.2805
Schistosoma mansoni	glucose transport protein	0.0441	0.2265	1
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0441	0.2265	1
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0201	0.0885
Plasmodium vivax	proline--tRNA ligase, putative	0.0154	0.0715	0.0701
Trichomonas vaginalis	glucose transporter, putative	0.0137	0.0621	0.274
Echinococcus granulosus	apoptotic protease activating factor 1	0.0041	0.0103	0.0387
Schistosoma mansoni	sugar transporter	0.0062	0.0217	0.0894
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0137	0.0538
Trypanosoma cruzi	sugar transporter, putative	0.0062	0.0217	0.303
Onchocerca volvulus		0.0062	0.0217	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0162	0.0755	0.3288
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0043	0.0192
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.0481	0.2122
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Brugia malayi	Major Facilitator Superfamily protein	0.0062	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0198	0.0809
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0441	0.2265	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0132	0.0597	0.2634
Leishmania major	glucose transporter, lmgt3	0.0137	0.0621	0.868
Schistosoma mansoni	hypothetical protein	0.0041	0.0103	0.0387
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0062	0.0217	1
Toxoplasma gondii	glycyl-tRNA synthetase	0.0025	0.0016	0.0024
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0025	0.0016	0.0218
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0201	0.0822
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0441	0.2265	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0136	0.0614	0.06
Trichomonas vaginalis	CAMK family protein kinase	0.0136	0.0614	0.271
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0098	0.0414	0.6932
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Onchocerca volvulus		0.0062	0.0217	1
Echinococcus granulosus	lysyl tRNA synthetase	0.0098	0.0414	0.1769
Leishmania major	lysyl-tRNA synthetase, putative	0.0098	0.0414	0.5783
Onchocerca volvulus	Putative transporter	0.0062	0.0217	1
Trichomonas vaginalis	myo-inositol transporter, putative	0.0062	0.0217	0.0956
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0201	0.0885
Entamoeba histolytica	protein kinase, putative	0.0136	0.0614	1
Brugia malayi	hypothetical protein	0.0062	0.0217	0.0894
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0136	0.0614	0.2659
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0033	0.0018
Loa Loa (eye worm)	sugar transporter	0.0062	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Trypanosoma cruzi	hexose transporter	0.0137	0.0621	0.868
Echinococcus granulosus	synaptic vesicle 2 protein	0.0062	0.0217	0.0894
Giardia lamblia	Lysyl-tRNA synthetase	0.0098	0.0414	0.6849
Echinococcus granulosus	caspase 2	0.0058	0.0198	0.0809
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0048	0.0138	0.0546
Leishmania major	glucose transporter, lmgt1	0.0137	0.0621	0.868
Echinococcus granulosus	solute carrier family 22	0.0062	0.0217	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0217	0.0894
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0136	0.0614	0.2659
Schistosoma mansoni	sugar transporter	0.0062	0.0217	0.0894
Giardia lamblia	Kinase, CMGC MAPK	0.0059	0.0201	0.3183
Loa Loa (eye worm)	6-phosphofructokinase	0.0111	0.0481	0.2067
Echinococcus multilocularis	mitogen activated protein kinase	0.0059	0.0201	0.0822
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0111	0.0481	1
Leishmania major	ATP-dependent phosphofructokinase	0.0111	0.0481	0.6722
Trichomonas vaginalis	6-phosphofructokinase, putative	0.003	0.0043	0.0192
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0048	0.0138	0.0209
Leishmania major	threonyl-tRNA synthetase, putative	0.0025	0.0016	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0033	0.0079
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0132	0.0597	0.9712
Leishmania major	myo-inositol/proton symporter (MIT)	0.0062	0.0217	0.303
Onchocerca volvulus		0.0062	0.0217	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0136	0.0614	0.2659
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0132	0.0597	0.2583
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.0481	0.2122
Leishmania major	glucose transporter, lmgt2	0.0137	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0597	0.2583
Echinococcus granulosus	mitogen activated protein kinase 3	0.0059	0.0201	0.0822
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Loa Loa (eye worm)	sugar transporter	0.0441	0.2265	1
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.003	0.0043	0.0464
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0154	0.0715	1
Schistosoma mansoni	protein kinase	0.0136	0.0614	0.2659
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Schistosoma mansoni	6-phosphofructokinase	0.0111	0.0481	0.2067
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0098	0.0414	0.1826
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0062	0.0217	0.0894
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0086	0.0348	0.1536
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0084	0.0333	0.6935
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0137	0.0538
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0062	0.0217	0.0894
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0062	0.0217	0.0894
Echinococcus granulosus	solute carrier family 22	0.0062	0.0217	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0621	0.868
Onchocerca volvulus		0.0062	0.0217	1
Brugia malayi	major facilitator superfamily protein	0.0062	0.0217	0.0894
Echinococcus granulosus	6 phosphofructokinase	0.0111	0.0481	0.2067
Echinococcus granulosus	solute carrier family 22	0.0062	0.0217	0.0894
Brugia malayi	Major Facilitator Superfamily protein	0.0062	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0059	0.0201	0.0303
Brugia malayi	hypothetical protein	0.0062	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0137	0.0621	0.274
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0062	0.0217	0.0894
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0157	0.0731	0.3179
Trypanosoma cruzi	hexose transporter, putative	0.0062	0.0217	0.303
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0048	0.0138	0.0611
Echinococcus multilocularis	6 phosphofructokinase	0.0111	0.0481	0.2067
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0217	0.0956
Toxoplasma gondii	transporter, major facilitator family protein	0.0062	0.0217	0.0327
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0111	0.0481	1
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0043	0.0192
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0059	0.0201	0.2805
Trypanosoma brucei	glucose transporter 2A	0.0137	0.0621	0.868
Onchocerca volvulus		0.0062	0.0217	1
Trichomonas vaginalis	sugar transporter, putative	0.0137	0.0621	0.274
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0132	0.0597	1
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0025	0.0016	0.0325
Giardia lamblia	Hexose transporter	0.0062	0.0217	0.346
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Plasmodium falciparum	proline--tRNA ligase	0.0154	0.0715	0.0701
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0111	0.0481	0.8057
Schistosoma mansoni	sugar transporter	0.0062	0.0217	0.0894
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0048	0.0138	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0414	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.0043	0.0028
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0084	0.0333	0.5587
Giardia lamblia	Sugar-proton symporter	0.0062	0.0217	0.346
Loa Loa (eye worm)	acetyltransferase	0.0162	0.0755	0.3288
Toxoplasma gondii	sugar transporter ST3	0.0062	0.0217	0.0327
Brugia malayi	hypothetical protein	0.0028	0.0033	0.0079
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0136	0.0614	0.2659
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.008	0.0285
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0048	0.0138	0.0123
Mycobacterium ulcerans	6-phosphofructokinase	0.0111	0.0481	1
Brugia malayi	phosphofructokinase	0.0111	0.0481	0.2067
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.003	0.0043	0.0478
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0154	0.0715	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0111	0.0481	0.2067
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0137	0.0621	0.274
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0154	0.0715	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0098	0.0414	0.1769
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0041	0.0103	0.0387
Brugia malayi	Sugar transporter family protein	0.0441	0.2265	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.008	0.0285
Leishmania major	hypothetical protein, conserved	0.0062	0.0217	0.303
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0136	0.0614	0.06
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0137	0.0538
Plasmodium vivax	sugar transporter, putative	0.0062	0.0217	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0136	0.0614	0.2659
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0033	0.0018
Trypanosoma cruzi	glucose transporter, putative	0.0062	0.0217	0.303
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.0481	0.2122
Mycobacterium ulcerans	integral membrane transport protein	0.0062	0.0217	0.4507
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0136	0.0614	0.06
Trypanosoma brucei	glucose transporter 1E	0.0137	0.0621	0.868
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0154	0.0715	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0713	0.3735	0.5644
Treponema pallidum	prolyl-tRNA synthetase	0.0047	0.0134	0.2548
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0103	0.0387
Echinococcus granulosus	mitogen activated protein kinase	0.0059	0.0201	0.0822
Chlamydia trachomatis	proline--tRNA ligase	0.0047	0.0134	0.2978
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0136	0.0614	0.8584
Toxoplasma gondii	sugar transporter ST1	0.0062	0.0217	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0033	0.0468
Onchocerca volvulus		0.0062	0.0217	1
Schistosoma mansoni	glucose transporter	0.0062	0.0217	0.0894
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0098	0.0414	0.5783
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0154	0.0715	0.108
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0137	0.0538
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0136	0.0614	0.06
Giardia lamblia	Histone acetyltransferase GCN5	0.0044	0.0117	0.1746
Toxoplasma gondii	protein kinase, putative	0.1247	0.6618	1
Onchocerca volvulus		0.0062	0.0217	1
Brugia malayi	hypothetical protein	0.0062	0.0217	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0136	0.0614	0.2659
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0059	0.0201	0.2805
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0713	0.3735	0.3726
Schistosoma mansoni	hypothetical protein	0.0189	0.0903	0.3945
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0136	0.0614	0.06
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0441	0.2265	1
Onchocerca volvulus		0.0062	0.0217	1
Echinococcus granulosus	General substrate transporter	0.0379	0.193	0.851
Brugia malayi	lysyl-tRNA synthetase	0.0098	0.0414	0.1769
Onchocerca volvulus	Cell death protein 3 homolog	0.0058	0.0198	0.8329
Schistosoma mansoni	lysyl-tRNA synthetase	0.0098	0.0414	0.1769
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0025	0.0016	0.0024
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0111	0.0481	0.6722
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0201	0.0885
Echinococcus multilocularis	lysyl tRNA synthetase	0.0098	0.0414	0.1769
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.0481	0.7774
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0062	0.0217	0.0894
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0043	0.0192
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0201	0.0885
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.0043	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Toxoplasma gondii	facilitative glucose transporter GT1	0.0441	0.2265	0.3422
Toxoplasma gondii	6-phosphofructokinase	0.003	0.0043	0.0066
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0043	0.0192
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0098	0.0414	0.5783
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0025	0.0016	0.0325
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0132	0.0597	0.2583
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0136	0.0614	0.2659
Trypanosoma cruzi	hexose transporter, putative	0.0137	0.0621	0.868
Brugia malayi	6-phosphofructokinase	0.0111	0.0481	0.2067
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Onchocerca volvulus		0.0062	0.0217	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0137	0.0621	0.868
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0062	0.0217	0.4507
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Trichomonas vaginalis	glucose transporter, putative	0.0062	0.0217	0.0956
Onchocerca volvulus		0.0062	0.0217	1
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0621	0.868
Chlamydia trachomatis	lysine--tRNA ligase	0.0098	0.0414	1
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.003	0.0043	0.0698
Plasmodium falciparum	histone acetyltransferase GCN5	0.0044	0.0117	0.0102
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0132	0.0597	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Schistosoma mansoni	caspase-7 (C14 family)	0.0058	0.0198	0.0809
Entamoeba histolytica	hypothetical protein	0.0037	0.008	0.1073
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0043	0.0192
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.0481	0.7774
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0025	0.0016	0.0218
Brugia malayi	Sugar transporter family protein	0.0062	0.0217	0.0894
Onchocerca volvulus		0.0062	0.0217	1
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0136	0.0614	0.06
Trypanosoma cruzi	hexose transporter, putative	0.0075	0.0286	0.3994
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0217	0.0956
Onchocerca volvulus		0.0062	0.0217	1
Entamoeba histolytica	protein kinase, putative	0.0136	0.0614	1
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0043	0.0192
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0062	0.0217	0.303
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Schistosoma mansoni	hypothetical protein	0.0189	0.0903	0.3945
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0111	0.0481	0.6722
Echinococcus granulosus	geminin	0.0189	0.0903	0.3945
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0136	0.0614	0.2659
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0136	0.0614	0.2659
Leishmania major	protein kinase, putative	0.0136	0.0614	0.8584
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0132	0.0597	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Onchocerca volvulus		0.0062	0.0217	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0136	0.0614	0.06
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0059	0.0201	0.0822
Trypanosoma brucei	protein kinase, putative	0.0059	0.0201	0.2805
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0084	0.0333	0.6935
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.003	0.0043	0.0066
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0136	0.0614	0.0928
Brugia malayi	hypothetical protein	0.0041	0.0103	0.0387
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0136	0.0614	0.06
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0059	0.0201	0.2805
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0441	0.2265	1
Brugia malayi	Cell death protein 3 precursor	0.0058	0.0198	0.0809
Trichomonas vaginalis	sugar transport protein, putative	0.0062	0.0217	0.0956
Trypanosoma brucei	sugar transporter, putative	0.0062	0.0217	0.303
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.003	0.0043	0.0597
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0137	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.008	0.0285
Onchocerca volvulus		0.0062	0.0217	1
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0062	0.0217	0.4507
Toxoplasma gondii	lysine-tRNA ligase	0.0098	0.0414	0.0625
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0098	0.0414	0.8603
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0059	0.0201	0.0822
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0713	0.3735	0.3726
Entamoeba histolytica	hypothetical protein	0.0037	0.008	0.1073
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0462	0.1987
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0441	0.2265	1
Entamoeba histolytica	acetyltransferase, GNAT family	0.0044	0.0117	0.1696
Toxoplasma gondii	phosphofructokinase PFKII	0.003	0.0043	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Brugia malayi	Sugar transporter family protein	0.0062	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Schistosoma mansoni	sugar transporter	0.0062	0.0217	0.0894
Entamoeba histolytica	hypothetical protein	0.0037	0.008	0.1073
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0033	0.0468
Brugia malayi	6-phosphofructokinase	0.0111	0.0481	0.2067
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0132	0.0597	0.2583
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0217	0.0894
Schistosoma mansoni	hypothetical protein	0.0441	0.2265	1
Onchocerca volvulus		0.0062	0.0217	1
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0062	0.0217	0.0201
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1872	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0025	0.0016	0.0218
Echinococcus multilocularis	geminin	0.0189	0.0903	0.3945
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0217	0.0894
Echinococcus multilocularis	General substrate transporter	0.0379	0.193	0.851
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0137	0.0621	0.868
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0062	0.0217	0.4507
Leishmania major	hypothetical protein, conserved	0.0028	0.0033	0.0468

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 705358